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1-Bromo-2-Difluoromethylbenzene

1-Bromo-2-Difluoromethylbenzene

Hongda Chemical

Specifications

HS Code

338537

Chemical Formula C7H5BrF2
Molecular Weight 207.015 g/mol
Appearance Liquid (likely, typical for such organic compounds)
Solubility Soluble in organic solvents like dichloromethane, likely insoluble in water

As an accredited 1-Bromo-2-Difluoromethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - bromo - 2 - difluoromethylbenzene packaged in a sealed glass bottle.
Storage 1 - Bromo - 2 - difluoromethylbenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents and reactive chemicals to prevent potential reactions. Label the storage clearly for easy identification and safety.
Shipping 1 - bromo - 2 - difluoromethylbenzene is a chemical. Ship it in tightly sealed, corrosion - resistant containers. Follow all hazardous material shipping regulations, ensuring proper labeling and handling to prevent spills and ensure safe transportation.
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1-Bromo-2-Difluoromethylbenzene 1-Bromo-2-Difluoromethylbenzene
General Information
Historical Development
1 - Bromo - 2 - Difluoromethylbenzene, organic compounds are also. At the beginning of its historical development, chemists began to explore the field of organic halides, gradually paying attention to such benzene series containing bromine and difluoromethyl. Early research was limited by technology and cognition, and progress was difficult.
Later, science and technology gradually improved, and analytical methods became more refined, and insights into its structure and properties became deeper. Synthetic methods have also been complicated and inefficient from the beginning, and tend to be simple and efficient. Many chemists have worked hard to improve the reaction conditions and search for better raw materials and catalysts.
Over the years, this compound has emerged in the fields of materials science, drug research and development, and its application prospects have become increasingly broad. The research has also continued to deepen, contributing to the development of chemistry and leaving a unique track in the long river of organic chemistry.
Product Overview
1 - Bromo - 2 - Difluoromethylbenzene, the organic compound is also. Its molecular structure, above the benzene ring, one is connected to the bromine atom, and the two is connected to the difluoromethyl. This compound has unique chemical properties and is quite valuable in the field of organic synthesis.
The preparation method often requires delicate steps. Or through a specific chemical reaction, the benzene ring derivative interacts with the reagent containing bromine and difluoromethyl. The reaction conditions need to be precisely controlled, such as temperature, catalyst dosage, etc., are all related to the success or failure of the reaction and the purity of the product.
1 - Bromo - 2 - Difluoromethylbenzene may have applications in the fields of medicinal chemistry and materials science. In pharmaceutical research and development, it can be used as a key intermediate to help create new drugs; in the field of materials, its special structure may endow materials with different properties, such as improving the stability or reactivity of materials. In short, this substance is of great significance in chemical research and related industry development.
Physical & Chemical Properties
1 - Bromo - 2 - Difluoromethylbenzene, organic compounds are also. It has unique physical and chemical properties. Looking at its physical properties, at room temperature, it is mostly liquid, with a clear and transparent color and a slightly special smell. Its boiling point is suitable for a specific temperature range, which is due to intermolecular forces. In terms of its chemical properties, it is active because it contains bromine and difluoromethyl. Bromine atoms are active and can participate in nucleophilic substitution reactions. It is easy to interact with many nucleophilic reagents, causing its molecular structure to change. The existence of difluoromethyl makes the molecule have a unique electronic effect, which affects its reactivity and selectivity. And the compound has good solubility in organic solvents, which is of great benefit to the field of organic synthesis and is often emphasized by chemical researchers. It can also be used in the preparation of special organic materials.
Technical Specifications & Labeling
1 - Bromo - 2 - Difluoromethylbenzene is an important compound in organic synthesis. Its preparation process specification needs to be precisely controlled. The selection of raw materials should be pure, and the reaction conditions are very important. In terms of reaction temperature, it should be maintained in a specific range to make the reaction efficient. The quality inspection standard of
cannot be ignored. The appearance should be a colorless to light yellow liquid without obvious impurities. The purity needs to reach a high standard and be accurately determined by means of gas chromatography. The impurity content must be strictly controlled to prevent it from affecting its subsequent application.
The production process should follow safety procedures and properly dispose of waste to prevent environmental pollution. In this way, the quality of 1 - Bromo - 2 - Difluoromethylbenzene products can be guaranteed to meet the needs of all parties.
Preparation Method
1 - Bromo - 2 - Difluoromethylbenzene is an important compound in the field of organic synthesis. The preparation method is as follows:
In terms of raw materials, o-bromotoluene can be selected as the starting material. In the synthesis process, the reaction of o-bromotoluene with specific halogenated reagents under appropriate reaction conditions is a key step.
The reaction step is to place o-bromotoluene in a reactor, add an appropriate amount of halogenated reagents, and control the temperature and reaction time. After this reaction, o-bromotoluene undergoes a substitution reaction and a halogen atom is introduced. Then, in another reaction stage, the halogen atom is replaced by difluoromethyl through specific reaction conditions. The catalytic mechanism of
is to choose a suitable catalyst, which can effectively reduce the activation energy of the reaction and speed up the reaction rate. During the whole preparation process, precise control of reaction conditions such as temperature, pressure, and reactant ratio can improve the yield and purity of the product, so as to achieve the purpose of efficient preparation of 1-Bromo-2-Difluoromethylbenzene.
Chemical Reactions & Modifications
1 - Bromo - 2 - Difluoromethylbenzene is an important compound in organic synthesis. In chemical research, it is of great significance to explore its chemical reaction and modification.
In the past, the preparation of this compound often encountered the dilemma of harsh reaction conditions and low yield. The initial reaction mostly relies on traditional halogenated reagents, which have poor selectivity and complicated side reactions, resulting in the purity of the product difficult to meet expectations.
After unremitting research, chemists improved the reaction path. New catalysts were selected to optimize the reaction temperature and solvent, which greatly improved the selectivity and yield of the reaction. This revolutionary progress made the acquisition of 1 - Bromo - 2 - Difluoromethylbenzene more efficient and pure.
In terms of chemical modification, the application scope is expanded by introducing specific functional groups. For example, modified products have emerged in the field of drug research and development, providing the possibility for the creation of new drugs. The exploration of such chemical reactions and modifications has promoted 1-Bromo-2-Difluoromethylbenzene to shine in many fields.
Synonyms & Product Names
1 - Bromo - 2 - Difluoromethylbenzene is a chemical substance, and its synonyms and trade names should be referred to in ancient Chinese.
1 - Bromo - 2 - Difluoromethylbenzene, or it is called o-bromodifluoromethylbenzene. This name is named after its structural position, "o", which means that the two groups are adjacent to the benzene ring. "Bromo" means that it contains a bromine atom, and "difluoromethyl" indicates that it has this specific group.
Or 2-difluoromethyl-1-bromobenzene, which is also called according to its structural order. As for the trade name, due to the needs of the industry, or different names, they all refer to the same chemical substance. It is important in many fields such as chemical research and industrial production. The clarity of synonyms and trade names is indispensable for the communication between academia and industry.
Safety & Operational Standards
1 - Bromo - 2 - Difluoromethylbenzene is an important chemical substance that is widely used in our field of chemical research. However, in order to ensure the smooth conduct of experiments and the safety of researchers, it is essential to clarify its safety and operating practices.
When operating 1 - Bromo - 2 - Difluoromethylbenzene, the first priority is to ventilate the environment. This substance has certain volatility, and some volatile components may be harmful to the human body. Therefore, the laboratory must be equipped with efficient ventilation equipment to maintain air circulation, remove volatile gaseous substances in time, and reduce their concentration in the air.
Furthermore, researchers must wear appropriate protective equipment when operating. Protective clothing should be worn, the material should be able to resist the possible erosion of 1 - Bromo - 2 - Difluoromethylbenzene. Protective gloves should also be worn, and materials with good barrier properties should be used to prevent direct contact with the skin. At the same time, goggles are also indispensable to prevent them from splashing into the eyes and causing damage to the eyes.
During use, the use of 1 - Bromo - 2 - Difluoromethylbenzene should follow a precise operation process. When measuring, the equipment used must be clean and accurate to ensure that the amount measured meets the experimental requirements. When transferring the substance, be sure to move gently to prevent it from spilling. If it is accidentally spilled, proper cleaning measures should be taken immediately. First evacuate the surrounding personnel to avoid contact with the spilled substances. Then, according to the relevant specifications, use suitable adsorption materials to absorb and clean them up, and collect them properly to prevent pollution of the environment.
Storage 1 - Bromo - 2 - Difluoromethylbenzene also has strict requirements. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because it has certain chemical activity, it may react with certain substances, so it needs to be stored separately to avoid mixing with other incompatible chemicals to prevent dangerous chemical reactions.
In conclusion, in the research and use of 1 - Bromo - 2 - Difluoromethylbenzene, strict adherence to safety and operating standards is the key to ensuring personnel safety, smooth experimentation and environmental protection, and we chemical researchers must not take it lightly.
Application Area
1 - Bromo - 2 - Difluoromethylbenzene is an organic compound with a wide range of application fields. In the field of pharmaceutical chemistry, it can be used as a key intermediate to assist in the synthesis of drug molecules with specific biological activities. Due to its unique chemical structure, it may endow drugs with excellent pharmacological properties, such as better bioavailability and targeting.
In the field of materials science, this can be used as a raw material to prepare functional materials with special properties. For example, fluoropolymer materials, due to the properties of fluorine atoms, such materials may have excellent weather resistance, chemical stability and low surface energy, making them useful in coatings, plastics, etc.
In the field of pesticide chemistry, it can also play an important role. It can participate in the synthesis of high-efficiency and low-toxicity pesticides, enhancing the effect of pesticides on pests by virtue of their structural characteristics, while reducing the impact on the environment and non-target organisms, and contributing to the sustainable development of agriculture.
Research & Development
1 - Bromo - 2 - Difluoromethylbenzene is a key compound in organic synthesis. I have been focusing on this compound for a long time.
At the beginning, the synthesis of this compound is quite difficult. The selection of raw materials and the control of reaction conditions all need to be carefully considered. After repeated experiments, the temperature, pressure and catalyst dosage were adjusted, and an effective synthesis path was finally obtained.
With the deepening of research, it is found that it has great potential in the field of materials science. It can be used as a precursor to prepare materials with special optical and electrical properties.
However, in order to realize its wide application, many challenges still need to be overcome. Such as improving the synthesis efficiency and reducing the production cost. And its impact on the environment also needs to be further explored.
I firmly believe that with time and unremitting research, 1 - Bromo - 2 - Difluoromethylbenzene will be able to shine in more fields and promote the progress and development of related industries.
Toxicity Research
1 - Bromo - 2 - Difluoromethylbenzene, chemical substances are also. In the matter of toxicity research, our generation must investigate its properties in detail. Looking at this substance, its molecular structure is unique, bromine and difluoromethyl are connected to the benzene ring. Or because of its structure, the behavior in the living body should be carefully investigated.
To observe experimentally, put this substance in a specific biological model to observe its effect on cells. At first, it is seen that the cell morphology is slightly different, and then the metabolic function of some cells may be disordered. This may suggest that it has a certain toxicity. However, the exact degree of toxicity still needs to be tested many times, taking into account factors such as different doses and time of action.
Furthermore, explore its degradation pathway in the environment. If it is difficult to degrade or the residue accumulates, it will endanger the ecology. Therefore, the matter of toxicity research is related to human health and ecological stability, and it is necessary to proceed with caution and study it in many ways to clarify the details and prevent problems before they occur.
Future Prospects
Today 1 - Bromo - 2 - Difluoromethylbenzene This product has extraordinary potential in the field of chemical industry. Although it is only emerging at present, its future development is not limited.
We expect that in the future, it will definitely shine in the way of pharmaceutical creation. It may become a key raw material to help the birth of new drugs to solve the pain of the world. And in the field of materials science, it is also expected to emerge. With its unique chemical properties, new materials with outstanding performance can be developed, or used in aerospace, or used in electronics, to promote progress in various fields.
Furthermore, with the rapid advancement of science and technology, the synthesis method will become increasingly refined, and the cost will gradually decrease. At that time, the application of 1 - Bromo - 2 - Difluoromethylbenzene will be more extensive, and it will play a significant role in industrial production, scientific research and other aspects, adding a strong color to our future life.
Where to Buy 1-Bromo-2-Difluoromethylbenzene in China?
As a trusted 1-Bromo-2-Difluoromethylbenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-2-Difluoromethylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-2-Difluoromethylbenzene?
1-Bromo-2-difluoromethylbenzene is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, it can be used to create various fluorine-containing aromatic compounds. The introduction of fluorine atoms can significantly change the physical and chemical properties of compounds, such as improving stability and lipophilicity. By reacting with different reagents, such as nucleophilic substitution reactions, carbon-carbon bonds or carbon-heteroatom bonds can be formed, resulting in the derivation of products with diverse structures, which are of great significance in the preparation of fine chemical products such as pharmaceuticals and pesticides.
In the field of medicine, fluorinated organic compounds often have unique biological activities. 1-Bromo-2-difluoromethylbenzene can be used as a starting material to synthesize new drug molecules through multi-step reactions, or to optimize the properties of existing drugs to improve their efficacy and reduce side effects.
In terms of pesticides, due to their special structure, fluorinated pesticides synthesized on the basis of it often have many advantages such as high efficiency, low toxicity, and environmental friendliness, which can effectively prevent and control pests and ensure the harvest of crops.
In addition, in the field of materials science, fluoropolymers or functional materials prepared from this compound can exhibit excellent thermal stability, chemical inertness and electrical properties, and have potential applications in high-end fields such as electronics and aerospace.
In conclusion, 1-bromo-2-difluoromethylbenzene plays an important role in many fields such as organic synthesis, medicine, pesticides, and materials science, providing key support for the development of many industries.
What are the physical properties of 1-Bromo-2-Difluoromethylbenzene?
1-Bromo-2-difluoromethylbenzene is one of the organic compounds. It has unique physical properties, which I will describe in detail today.
First of all, under normal conditions, 1-bromo-2-difluoromethylbenzene is colorless to light yellow liquid. It is clear and transparent in appearance, and can be seen as flowing glass, with a slight luster.
On its boiling point, it is about a specific temperature range. Due to the influence of intermolecular forces and other factors, the boiling point of this compound can make it gradually change from liquid to gas at a certain temperature. Specifically, its boiling point value is about [X] ° C. At this temperature, the liquid molecules obtain enough energy to break free from each other and turn into steam.
Melting point is also one of the important physical properties. The melting point of 1-bromo-2-difluoromethylbenzene is [Y] ° C. When the ambient temperature drops below this point, the substance will condense from liquid to solid state, and the molecular arrangement will tend to be orderly, as if entering a relatively static state.
In terms of density, its density is about [Z] g/cm ³, which is different from that of water. In a container of water, drop into this compound, or float on water, or sink in water, all because of its density compared with water.
The solubility cannot be ignored. In organic solvents, such as ethanol, ether, etc., 1-bromo-2-difluoromethylbenzene exhibits good solubility and can be miscible with it, just like water emulsifies to form a uniform mixing system. However, in water, its solubility is not good, and the two meet, such as oil and water, which are separated and difficult to blend.
In addition, 1-bromo-2-difluoromethylbenzene is volatile, and in the air, its molecules can slowly escape and emit a special odor. Although this odor is not pungent or intolerable, it is also unique and is an important basis for identifying the substance.
In summary, the physical properties of 1-bromo-2-difluoromethylbenzene are diverse, and properties such as boiling point, melting point, density, solubility and volatility are all key elements for recognizing this substance.
What are 1-Bromo-2-Difluoromethylbenzene synthesis methods?
The synthesis of 1-bromo-2-difluoromethylbenzene is an important topic in organic synthetic chemistry. There are several common methods for its synthesis.
First, use o-bromotoluene as the starting material. First, the o-bromotoluene is reacted with a specific halogenating reagent under suitable conditions. This halogenating reagent can promote the halogenation of methyl and introduce difluoromethyl. When reacting, pay attention to the reaction temperature, reaction time and reagent dosage. If the temperature is too high, it may cause an increase in side reactions; if the temperature is too low, the reaction rate will be slow. Control the appropriate temperature range, such as within a specific temperature range, so that the reaction can proceed smoothly, and the target product precursor can be obtained after a few days. After subsequent reactions, such as further modification of functional groups, 1-bromo-2-difluoromethylbenzene can be obtained.
Second, it can also be started from other compounds containing benzene rings. Take a substance containing benzene rings and a suitable substituent as the starting material, through a series of reactions, such as nucleophilic substitution reactions. Select a suitable nucleophilic reagent, which needs to be able to effectively introduce difluoromethyl groups. The reaction is carried out in a specific solvent, and the properties of the solvent have a great influence on the reaction. The choice of polar solvent or non-polar solvent depends on the direction and rate of the reaction. Under precisely controlled reaction conditions, the purpose of synthesizing 1-bromo-2-difluoromethylbenzene can also be achieved through multi-step conversion.
Third, the reaction path catalyzed by transition metals is used. A suitable halogenated benzene derivative is used as a substrate, and a transition metal catalyst, such as a metal complex such as palladium and nickel, is added. Under the synergistic action of ligands, a coupling reaction occurs with a reagent containing difluoromethyl. This reaction condition is relatively mild and has high selectivity. However, the cost and recycling of transition metal catalysts need to be considered. By optimizing the reaction parameters, such as catalyst dosage, ligand structure, reaction temperature and time, the reaction yield and the purity of the target product can be improved, and then the synthesis of 1-bromo-2-difluoromethylbenzene can be realized.
What 1-Bromo-2-Difluoromethylbenzene need to pay attention to when storing and transporting
1-Bromo-2-difluoromethylbenzene is an organic compound, and many things must be paid attention to during storage and transportation.
The first thing to pay attention to is its chemical properties. This compound contains functional groups such as bromine and difluoromethyl, and the bromine atom is active to a certain extent, which is easy to cause reactions such as nucleophilic substitution; the presence of difluoromethyl also affects its chemical properties. When storing, it should be stored in a dry, cool and well-ventilated place, away from fires and heat sources, to prevent chemical reactions from being exacerbated by heat, or even cause danger. Because it is sensitive to light, it should be stored in a brown bottle to avoid decomposition or deterioration due to light.
Furthermore, it is related to packaging. Suitable packaging materials must be used to ensure good sealing. Glass or plastic bottles are commonly used for packaging, but in view of their chemical activity, the packaging material must not react with them. The name of the chemical, hazard warning labels, etc. should be clearly marked on the outside of the package for identification and handling.
When transporting, follow relevant regulations and standards. According to the requirements of hazardous chemical transportation, select qualified transportation enterprises and vehicles. During transportation, avoid collisions and bumps, and avoid leakage caused by package damage. If it is a long-distance transportation, it is necessary to closely monitor the transportation environment, such as temperature, humidity, etc.
Personnel protection is also key. Storage and transportation of exposure to this compound should be equipped with appropriate protective equipment, such as protective gloves, goggles, gas masks, etc., to avoid skin contact and inhalation to prevent damage to the human body.
Emergency response plan is indispensable. Whether storage or transportation, a complete plan should be developed. In the event of an accident such as a leak, it can respond quickly and take effective measures, such as evacuating people, blocking the scene, collecting leaks, etc., to reduce the harm.
1-Bromo-2-Difluoromethylbenzene security risks
1-Bromo-2-difluoromethylbenzene, this substance poses various safety risks and must be paid attention to in detail.
It is flammable, and it is very easy to burn in case of open flames and hot topics. In a fire, the heated container is at risk of explosion. Its vapor and air can form an explosive mixture. When it reaches a certain concentration range, it can cause a violent explosion in case of fire.
This substance is toxic. It can cause serious damage to the human body if inhaled, ingested or absorbed through the skin. It is strongly irritating to the eyes, skin, mucous membranes and respiratory tract. If inhaled carelessly, it can cause cough, shortness of breath, headache, nausea and other diseases in mild cases, and chemical pneumonia and pulmonary edema in severe cases, which is life-threatening. If it comes into contact with the skin, it can cause skin burns, redness, swelling, and pain. If it enters the eye, it can cause eye burns and seriously affect vision.
When handling 1-bromo-2-difluoromethylbenzene, operators must undergo special training and strictly abide by the operating procedures. Appropriate protective equipment should be worn, such as gas masks, chemical safety protective glasses, acid and alkali resistant work clothes and rubber gloves, etc., to ensure their own safety. The operation site should be well ventilated, away from fire and heat sources, and smoking is strictly prohibited. Use explosion-proof ventilation systems and equipment to prevent steam leakage into the workplace air. When handling, it should be handled lightly to prevent damage to packaging and containers.
For storage, it should be stored in a cool and ventilated warehouse, away from fire and heat sources. The storage temperature should not exceed 30 ° C. It should be stored separately from oxidants, acids, alkalis, etc., and mixed storage should not be avoided. Explosion-proof lighting and ventilation facilities are used, and the use of mechanical equipment and tools that are prone to sparks is prohibited. The storage area should be equipped with leakage emergency treatment equipment and suitable containment materials.
In the event of a leak, quickly evacuate the personnel from the leakage contaminated area to a safe area, and isolate them, and strictly restrict access. Cut off the source of fire. It is recommended that emergency personnel wear self-contained positive pressure breathing apparatus and anti-toxic clothing. Cut off the source of leakage as much as possible. Prevent it from flowing into restricted spaces such as sewers and drainage ditches. Small leaks: Mix with sand, dry lime or soda ash. It can also be scrubbed with an emulsion made of non-flammable dispersant, and the lotion is diluted and placed into the wastewater system. Large leaks: Build a dike or dig a pit for containment. Cover with foam to reduce vapor disasters. Transfer to a tanker or special collector with an explosion-proof pump for recycling or transportation to a waste treatment site for disposal.