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1-Bromo-2-(Difluoromethyl)Benzene

1-Bromo-2-(Difluoromethyl)Benzene

Hongda Chemical

Specifications

HS Code

547131

Name 1-Bromo-2-(difluoromethyl)benzene
Molecular Formula C7H5BrF2
Molecular Weight 207.015 g/mol
Cas Number 848138-62-3
Appearance Colorless to light yellow liquid
Boiling Point 179 - 180 °C
Density 1.545 g/cm³ at 25 °C
Flash Point 64 °C
Solubility Insoluble in water, soluble in organic solvents like ethanol, ether
Refractive Index 1.4945 at 20 °C
Purity Typically high - purity commercial products around 95%+

As an accredited 1-Bromo-2-(Difluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 1 - bromo - 2 - (difluoromethyl)benzene in a sealed, chemical - resistant bottle.
Storage 1 - Bromo - 2 - (difluoromethyl)benzene should be stored in a cool, well - ventilated area, away from heat sources and open flames to prevent fire risks due to its flammable nature. Keep it in a tightly - sealed container to avoid leakage and contact with air and moisture, which could potentially cause decomposition or reaction. Store it separately from oxidizing agents and incompatible substances.
Shipping 1 - Bromo - 2 - (difluoromethyl)benzene is shipped in specialized, well - sealed containers. Packaging adheres to chemical transport regulations. Shipment is carefully monitored to ensure safety during transit, avoiding exposure to heat, shock, or incompatible substances.
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1-Bromo-2-(Difluoromethyl)Benzene 1-Bromo-2-(Difluoromethyl)Benzene
General Information
Historical Development
1 - Bromo - 2 - (Difluoromethyl) Benzene is an important compound in organic chemistry. Its history can be traced back to the past. At the beginning, the exploration of fluorinated organic compounds in the chemical community was still in its infancy, and many scholars were committed to exploring this field. At that time, it was difficult to synthesize such compounds, and the technical means were limited.
With the passage of time, scientific researchers worked tirelessly, and new synthetic methods and concepts came into being. For 1 - Bromo - 2 - (Difluoromethyl) Benzene, chemists tried various paths, from the original complicated and inefficient method to a more delicate and efficient one. In this process, the precise control of reaction conditions and the optimization of raw material selection have promoted its synthesis to new heights, paving the way for subsequent applications in medicine, materials, and other fields.
Product Overview
1 - Bromo - 2 - (Difluoromethyl) Benzene is a valuable chemical substance. Its appearance is colorless to light yellow liquid with a special odor. This substance is widely used in the field of organic synthesis and is often a key intermediate.
Its preparation process requires specific chemical reactions and strict reaction conditions, such as precise control of temperature, pressure and reactant ratio. In synthesis, due to its unique chemical structure, it can participate in many reactions, such as nucleophilic substitution reactions, and can interact with a variety of nucleophilic reagents to derive a series of organic compounds.
In terms of storage, it must be placed in a cool, dry and well-ventilated place, away from fire sources and oxidants, to prevent dangerous conditions. 1 - Bromo - 2 - (Difluoromethyl) Benzene plays an important role in modern chemical research and industrial production, and has made great contributions to the development of organic synthetic chemistry.
Physical & Chemical Properties
1 - Bromo - 2 - (Difluoromethyl) Benzene is an organic compound. Its physical properties are mostly liquid at room temperature, with a certain degree of volatility, which can be volatilized in the air. Looking at its color, it is usually colorless and transparent or slightly colored. Its density is higher than that of water, and it will sink to the bottom when placed in water.
In terms of chemical properties, the bromine atom in this compound is quite active. Due to the large electronegativity of bromine atoms, it is prone to substitution reactions. Under suitable conditions, nucleophilic substitution can occur with nucleophiles, and bromine atoms are replaced by other groups. At the same time, the presence of difluoromethyl also endows it with unique chemical activity. Difluoromethyl can affect the electron cloud density distribution of the benzene ring, making it more susceptible to reactions at specific locations on the benzene ring. For example, in some electrophilic substitution reactions, it exhibits different reactivity and selectivity from ordinary benzene derivatives.
Technical Specifications & Labeling
1 - Bromo - 2 - (Difluoromethyl) Benzene is an important chemical product. Its process specifications and identification (product parameters) are extremely critical. The preparation of this product requires a precise chemical process. The selection of raw materials must be pure, and the reaction conditions such as temperature, pressure, and catalyst dosage should be strictly controlled. If the temperature is too high or side reactions occur frequently, if it is too low, the reaction will be delayed. The regulation of pressure is related to the reaction rate and product purity. In terms of
labeling, the chemical name, molecular formula, molecular weight and other basic information should be clearly marked. Product parameters should also be detailed. If the purity should not be lower than a specific value, the impurity content should be strictly limited. Only in this way can we ensure that this chemical is used safely and effectively in industry, scientific research, and other fields, and meets relevant quality and safety standards.
Preparation Method
The preparation method of 1 - Bromo - 2 - (Difluoromethyl) Benzene needs to be studied in detail. The first raw material is to take benzene as the base, supplemented by materials containing bromine and fluorine. The preparation process first encounters benzene with bromine-containing reagents, and then adds a bromine atom to the benzene ring by substitution. This step requires selecting a good agent, controlling temperature and pressure to promote a smooth reaction.
Next, difluoromethyl is introduced. A reagent containing difluoromethyl can be used to connect this group to the benzene ring at the second site according to a specific reaction mechanism. In the reaction step, each step needs to be carefully observed, and the parameters should be adjusted according to its changes.
As for the catalytic mechanism, when finding a suitable catalyst, increase the reaction rate and reduce the energy barrier of the reaction. In this way, after various fine manipulations, 1-Bromo-2- (Difluoromethyl) Benzene can be prepared to become what we need.
Chemical Reactions & Modifications
Modern chemical refinement, especially in the genus of organic research. 1 - Bromo - 2 - (Difluoromethyl) Benzene This compound, its chemical reaction and modification, is the most important of our research.
In the past, the reaction path of this compound was mostly based on conventional methods, but the efficiency was not high, and the product was also mixed. We then thought about the way of innovation, trying new agents and changing conditions. With a new type of catalyst, the temperature control was precise, making the reaction work better.
So easy to change, the reaction rate increased greatly, and the product was pure, and the modification was also exquisite. This change is not only beneficial to 1 - Bromo - 2 - (Difluoromethyl) Benzene, but also to the research of similar compounds, opening up a new path, and looking forward to the later scholars. On this basis, further exploration will make the beauty of chemistry more apparent to the world.
Synonyms & Product Names
1 - Bromo - 2 - (Difluoromethyl) Benzene, its synonymous name and the name of the commodity are quite crucial. In the field of my chemical research, the same substance often has different names due to different situations and uses.
This 1 - Bromo - 2 - (Difluoromethyl) Benzene, or another name, to meet different needs. Its synonymous name, or derived according to its chemical structure characteristics and reaction mechanism, aims to accurately indicate its chemical essence. The name of the commodity, more consideration is given to marketing activities and practical applications.
In the chemical trade, knowing its various names can be communicated without error. In the laboratory, the precise use of synonymous names can ensure that the research is correct. Therefore, it is of great significance to clarify the synonyms and trade names of 1-Bromo-2- (Difluoromethyl) Benzene in chemical research and industrial operation.
Safety & Operational Standards
1 - Bromo - 2 - (Difluoromethyl) Benzene is an important chemical product. During its preparation and use, safety and operating practices are of paramount importance.
This product has certain chemical activity and is prone to danger due to improper contact. Therefore, during operation, the safety of the environment is the first priority. The experimental site should be well ventilated to disperse harmful gases that may escape, and should be kept away from fire and heat sources to prevent the risk of fire and explosion.
When operating, the experimenter must wear appropriate protective equipment. It is necessary to wear protective gloves. The material should be able to resist the erosion of the substance and avoid direct contact with the skin. It is also necessary to wear anti-goggles to protect the eyes from possible splashing damage. At the same time, wear laboratory clothes to prevent the clothing from being contaminated.
When taking this product, follow a precise operation procedure. Use appropriate equipment, such as pipettes, droppers, etc., and take it according to the exact dose to avoid excessive or improper use. The transfer process should be careful to prevent its leakage. If it leaks accidentally, do not panic, and start emergency measures immediately. First, quickly evacuate the surrounding personnel to ensure a safe distance; then, according to the amount of leakage, use corresponding absorbent materials, such as sand, activated carbon, etc. for adsorption and cleaning. The cleaned items need to be properly disposed of and cannot be discarded at will.
For storage, 1 - Bromo - 2 - (Difluoromethyl) Benzene should be placed in a cool, dry and ventilated place, away from oxidizing agents, reducing agents and other substances that may react with it. Storage containers must be well sealed to prevent leakage and volatilization.
Only by strictly following the above safety and operating practices can we ensure that all activities involving 1 - Bromo - 2 - (Difluoromethyl) Benzene are not endangered, while ensuring the smooth progress of experiments and production.
Application Area
1 - Bromo - 2 - (Difluoromethyl) Benzene is also an organic compound. Its application field involves a wide range of. In the field of medicinal chemistry, this compound can be used as a key intermediate to help create new drugs. Because fluorine atoms have unique electronic properties, they can improve the lipophilic and metabolic stability of drug molecules after introduction, which is expected to lead to better drugs with less side effects.
In the field of materials science, it may be a raw material for the preparation of special functional materials. By chemical modification, the generated materials can have unique optical and electrical properties, such as for organic optoelectronic materials, improve the photoelectric conversion efficiency of materials, and contribute to the development of new display technologies and optoelectronic devices.
Furthermore, in the field of pesticide chemistry, high-efficiency and low-toxicity pesticides can be developed based on this. Using its structural characteristics, it precisely acts on pests, protects the growth of crops, and has little impact on the environment. This is where 1 - Bromo - 2 - (Difluoromethyl) Benzene is important.
Research & Development
In recent years, I have studied 1 - Bromo - 2 - (Difluoromethyl) Benzene compound in the field of organic chemistry. This substance has a unique structure, and its bromine atom and difluoromethyl are connected to the benzene ring, giving it specific chemical properties.
Study its synthesis method, after many attempts, apply halogenation, fluorine substitution and other methods, and gradually get an effective way. Optimize the reaction conditions, control temperature, adjust time, select appropriate solvents and catalysts, so that the yield rises.
Viewing its application, it has potential in medical, agricultural and other industries. In medicine, it can be used as a lead compound to assist the research of new drugs; in agriculture, it can become the basis for efficient pesticides to prevent pests and ensure a bumper harvest.
Our generation should continue to research and explore its more potential, hoping that this compound will develop its growth in various fields, promote the progress of science and technology, and seek the benefit of people's livelihood.
Toxicity Research
1 - Bromo - 2 - (Difluoromethyl) Benzene is an organic compound, which has attracted much attention in today's chemical research, and its toxicity research is also an important topic.
Looking at past toxicity studies, we need to be cautious. The molecular structure of this compound is unique, or it may have specific toxic effects. Studies have shown that it may affect the cells of organisms and interfere with the normal physiological functions of cells.
In animal experiments, if exposed to this compound, certain physiological indicators may be seen. Such as important organs such as liver and kidneys, or the characteristics of abnormal function. However, the appearance of toxicity is often related to the dose and duration of exposure.
More rigorous experiments are needed to clarify its exact toxicity. In-depth exploration of its mechanism of action at the cellular level also needs to be repeatedly verified in different biological models. Only in this way can the toxicity of 1-Bromo-2 - (Difluoromethyl) Benzene be fully and accurately known, providing a solid basis for its safe application and protection.
Future Prospects
In the future, 1 - Bromo - 2 - (Difluoromethyl) Benzene, this thing will be greatly colorful. Its unique nature, its use, and the cornerstone of a wonderful method. I think, together, it will definitely be able to help research strange recipes and solve the suffering of life. Or it can transform decay and magic, and make sinking diseases heal.
In the field of materials, there is also a great ability. It can be used for extraordinary things, so that the utensils are solid and have a wonderful use, such as a celestial artifact, which can resist frost and travel above the nine heavens.
In addition, the way of transformation and synthesis can be used to attract, or it can explore new realms, explore unknown methods of synthesis, and make the field of transformation add bright pearls. Therefore, the exhibition that has not yet been completed is limited, and it will definitely lead us into a new realm.
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Frequently Asked Questions

As a leading 1-Bromo-2-(Difluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 1-bromo-2- (difluoromethyl) benzene?
1 + -ether-2- (diethyl methyl) naphthalene is an organic compound with unique physical properties.
Ether compounds, many have a special odor and high volatility. At room temperature, such substances are often liquid, and the density is generally less than that of water. Its solubility is relatively special, and its solubility in water is limited, but it can be well miscible with many organic solvents. This is due to the structure of ether molecules, which makes it have a certain polar and non-polar regions, so it exhibits such solubility.
As for (diethyl) naphthalene, naphthalene is a thick ring aromatic hydrocarbon with a special aromatic odor. On this basis, the introduction of diethyl methyl has greatly changed its physical properties. In terms of melting point, compared with naphthalene itself, due to the introduction of side chains, the intermolecular force changes, and the melting boiling point may change accordingly. In general, the presence of side chains will change the intermolecular distance, hinder the tight arrangement of molecules, and then affect the melting boiling point.
From the perspective of solubility, (diethylmethyl) naphthalene increases nonpolarity due to the introduction of side chains, and its solubility may increase in nonpolar solvents, while it may further decrease in polar solvents such as water. And due to the change of molecular structure, its density will also be different from that of naphthalene.
In terms of volatility, the presence or decrease of side chains makes it more difficult for molecules to escape from the liquid surface because side chains increase the relative mass and steric resistance of molecules. In general, the physical properties of 1 + -ether-2- (diethylmethyl) naphthalene are determined by the structure of ether bonds and (diethylmethyl) naphthalene in its molecular structure. In practical application and research, these physical properties need to be fully considered.
What are the chemical properties of 1-bromo-2- (difluoromethyl) benzene?
1 + -Cyanogen-2 - (diethylamino) naphthalene is an organic compound, and its chemical properties are as follows:
Physical properties related
This substance may have a certain melting point and boiling point. At room temperature, or as a solid crystal, due to intermolecular forces and structural characteristics, it has a specific state. Its solubility is different or different, in organic solvents such as ethanol and ether, or has a certain solubility. Due to the principle of similar miscibility, its organic structure is compatible with organic solvents; however, in water, due to polar differences, the solubility may be very small.
Chemical properties related
1. ** Cyano reaction **: Cyano is the active group. Hydrolysis reaction can occur. Under acidic or alkaline conditions, the cyanyl group can be gradually converted. When acidic, the cyanyl group is first hydrolyzed to amide, and then further hydrolyzed to carboxylic acid and ammonia ions; when alkaline, carboxylic salts and ammonia are formed. For example, in a strong alkali sodium hydroxide solution, the cyanyl group can react with water and hydroxide ions to obtain carboxylic salts. At the same time, the cyanyl group can participate in the nucleophilic addition reaction, because its carbon atom has a certain positive electricity and is vulnerable to attack by nucleophilic reagents. For example, under the action of alcohols in catalysts, nitrile ether compounds can be formed.
2. ** Diethylamino-related reactions **: Diethylamino groups have the property of electors, which can affect the electron The electron cloud density of the adjacent and para-position of the naphthalene ring increases, and it is more prone to electrophilic substitution reactions. For example, when reacted with bromine water, bromine is more likely to replace the adjacent and para-position hydrogen atoms activated by diethylamino on the naphthalene ring. And the nitrogen atom in the diethylamino group has a lone pair of electrons, which can be combined with protons and is alkaline to a certain extent. It can react with acids to form corresponding salt compounds.
3. ** Naphthalene ring characteristics **: The naphthalene ring is aromatic and relatively stable. However, under certain conditions, reactions such as addition and oxidation can occur. For example, at high temperature, high pressure and in the presence of a catalyst, an addition reaction can occur with hydrogen to partially or fully hydrogenate the naphthalene ring to generate products with different degrees of hydrogen In the oxidation reaction, the strong oxidant can cause the naphthalene ring to break and form oxygen-containing compounds.
In what fields is 1-bromo-2- (difluoromethyl) benzene used?
1 + - - 2 - (diethyl methyl) ether, which is used in many places. In the field of medicine, it can be used as a solvent to assist in the dissolution of drug components, in order to facilitate the preparation and application of drugs. Because of its specific solubility, it can make insoluble drugs uniformly disperse, improve drug stability and bioavailability.
In chemical synthesis, 1 + - - 2 - (diethyl methyl) ether is often an important intermediate. Through a series of chemical reactions, many organic compounds can be derived from this compound, such as ethers and esters with special structures, which are widely used in the synthesis of fragrances, pesticides and polymer materials.
In the fragrance industry, its unique chemical properties can participate in the fragrance synthesis reaction, giving the fragrance a unique aroma and stability. Some natural fragrances are difficult to extract or expensive, and can be chemically synthesized to simulate natural fragrances or create novel aroma components by borrowing 1 + -2- (diethyl methyl) ether as raw materials.
In the paint and ink industry, 1 + -2- (diethyl methyl) ether can be used as a solvent or diluent. It can adjust the viscosity of paint and ink, make the application or printing process smoother, and help to form a uniform film, improve product quality and appearance.
In addition, in laboratory research, it is also a commonly used reagent for organic synthesis experiments, separation and purification, etc. Because of its stable physical and chemical properties, it is often used as a reaction medium or extractant to help researchers achieve experimental purposes and provide convenience for chemical research. In short, 1 + -2- (diethyl methyl) ether plays a key role in many fields and is of great significance to the development of various industries.
What is the synthesis of 1-bromo-2- (difluoromethyl) benzene?
To prepare 1-bromo-2- (diethylamino) benzene, you can follow the following ancient method:
Take benzene as the starting material, blend concentrated sulfuric acid with concentrated nitric acid, and nitrate it at the appropriate temperature to obtain nitrobenzene. This step requires careful temperature control to prevent side reactions from occurring. Cover nitric acid has strong oxidizing properties, and sulfuric acid can promote the reaction process. The two cooperate to replace the hydrogen on the benzene ring with the nitro group.
Next, the nitrobenzene is converted into an amino group with iron powder and hydrochloric acid as a reducing agent to obtain aniline. Iron powder and hydrochloric acid create a reducing atmosphere, and nitro electrons are gradually changed to amino groups. Then, under suitable conditions, the bromine atom selects to replace the hydrogen on the benzene ring to obtain 2-bromoaniline by reacting with aniline and bromine. In this reaction, the amino group is the ortho-para locator, so that the bromine atom mainly enters the ortho-site and the para-site, and 2-bromoaniline can be the main product after regulation.
Then 2-bromoaniline reacts with dimethyl sulfate, and the hydrogen on the amino group is replaced by methyl to obtain N, N-dimethyl-2-bromoaniline. Dimethyl sulfate is a methylating agent with high activity and needs to be handled carefully.
Finally, N, N-dimethyl-2-bromoaniline reacts with sodium ethyl alcohol in ethanol solution, bromine atoms leave, and diethylamino is introduced at the same time, resulting in 1-bromo-2 - (diethylamino) benzene. Sodium ethyl alcohol provides an alkaline environment to promote the reaction, bromine ions are separated, and diethylamino is connected to the corresponding check point. Each step of the reaction requires fine control of temperature, reagent dosage, reaction time, etc., in order to improve the yield and obtain a pure product.
What are the precautions during the use of 1-bromo-2- (difluoromethyl) benzene?
Those who use (diethyl) ether, that is, 1,1-oxa-2- (diethyl) ether, need to pay attention to many things.
First, this ether is volatile and flammable. In the place of use, be sure to keep away from open flames, hot topics and other fire sources. If there is something burning nearby, even if a little spark splashes, this ether will ignite immediately, and the fire will spread in an instant, causing a catastrophe. When storing, it should also be placed in a cool and well-ventilated place. Do not store it in a place with high temperature or direct sunlight to prevent it from evaporating due to rising temperature, increasing the risk of explosion.
Second, it is related to toxicity. Although its toxicity is lower than that of some highly toxic substances, it cannot be ignored. If exposed to this ether vapor environment for a long time, or accidentally inhaled in excess, it will cause damage to the human body. In light cases, it may cause dizziness, nausea, fatigue and other discomfort, and in severe cases, it may involve the nervous system and respiratory system, affecting physical health. When operating, it is necessary to ensure that the ventilation conditions are good. It should be carried out in a fume hood. If the conditions are not available, it should also be operated in an open and well-ventilated place. Wear suitable protective equipment, such as gas masks, to prevent the inhalation of harmful vapors.
Third, pay attention to its chemical properties. This ether can chemically react with certain substances. During use, do not mix with unknown chemicals at will. For example, if it encounters a strong oxidizing agent, it is very likely to cause a violent reaction or even an explosion. Before using it with other chemicals, it is necessary to clarify whether the two will react and operate with caution to prevent accidents.
Fourth, the access and storage links are also exquisite. When taking it, the action should be precise and moderate to avoid spilling and dripping. If it is accidentally spilled, it needs to be cleaned up immediately to prevent it from evaporating in the air, causing the concentration to rise and forming a safety hazard. When storing, choose a suitable container to ensure a good seal to prevent leakage. Labels must be clearly marked, indicating its name, nature, hazards and other key information for easy access and management.