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1-Bromo-2-(Difluoromethoxy)Benzene

1-Bromo-2-(Difluoromethoxy)Benzene

Hongda Chemical

Specifications

HS Code

901392

Chemical Formula C7H5BrF2O
Molar Mass 223.014 g/mol
Appearance Colorless to light yellow liquid
Boiling Point Approx. 198 - 200 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Vapor Pressure Low at room temperature

As an accredited 1-Bromo-2-(Difluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 mL bottle containing 1 - bromo - 2 - (difluoromethoxy)benzene for chemical use.
Storage 1 - Bromo - 2 - (difluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals to avoid potential reactions. Follow all safety regulations for handling and storing hazardous chemicals.
Shipping 1 - bromo - 2 - (difluoromethoxy)benzene is shipped in accordance with chemical transportation regulations. Packed in suitable containers to prevent leakage, it is transported under proper safety measures to ensure secure delivery.
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1-Bromo-2-(Difluoromethoxy)Benzene 1-Bromo-2-(Difluoromethoxy)Benzene
General Information
Historical Development
1 - Bromo - 2 - (Difluoromethoxy) Benzene is an organic compound. Its initial discovery originated from the research and exploration of various scholars. At that time, in the field of chemistry, everyone studied all kinds of reactions and material changes.
At the beginning, the properties of this compound were only slightly known. With the passage of time, technology has gradually advanced, and experimental methods have become more and more exquisite. Chemists have made unremitting efforts, and have tried many things in terms of reaction conditions and synthesis paths.
First, the synthesis method was cumbersome and inefficient, but after repeated experiments and improvements, new methods gradually became apparent. From simple raw materials, through ingenious reactions and combinations, this compound can finally be obtained in a better way. Its application is also expanding, and it has shown unique effects in the fields of medicine, materials, etc. Looking at its historical development, it is actually the condensation of chemists' wisdom and sweat, which promotes the progress of chemistry and paves the foundation for many future studies.
Product Overview
1 - Bromo - 2 - (Difluoromethoxy) Benzene
There is now a product named 1 - Bromo - 2 - (Difluoromethoxy) Benzene. It is an important image for chemical research. This object is described as [with external description, which can be fake color solution], and has a special taste.
For example, its molecule contains bromine atom, which is one of benzene, and has a difluoromethoxy group in the two positions. In this way, it is difficult to give its specialization. It is often used in the field of synthesis. It can be used for multiple reactions. In case of nuclear reaction, bromine atoms are easily replaced, and new groups are introduced, which is a good way to build a molecule.
In terms of reaction activity, due to the molecular effect of benzene and the absorber effect of difluoromethoxy, it is easy to biochemical reaction, or substitution, or even reaction at specific positions on the benzene, which is important in refining chemical industry, chemical synthesis, etc. It is an important basis for the development of chemical research.
Physical & Chemical Properties
1 - Bromo - 2 - (Difluoromethoxy) Benzene is also an organic compound. Its physical and chemical properties are related to the characteristics and uses of this compound. Looking at its physical properties, it is liquid at room temperature and has a specific color, taste and density. Its boiling point and melting point are the keys to define its physical state. In terms of chemical properties, it is quite active because it contains bromine and difluoromethoxy functional groups. Bromine atoms can participate in nucleophilic substitution reactions and interact with nucleophilic reagents, which are easily replaced to form new compounds. Difluoromethoxy groups affect the electron cloud distribution of molecules, changing the electron density of the benzene ring, thereby affecting its aromaticity and reactivity. The physical and chemical properties of this compound lay an important foundation for the research and application in the fields of organic synthesis and materials science, and are also of indispensable value in the development of the chemical industry.
Technical Specifications & Labeling
1 - Bromo - 2 - (Difluoromethoxy) Benzene is an important chemical product. Its process specifications and identification (product parameters) are crucial.
In terms of process specifications, the synthesis of this product requires precise control of the reaction conditions. The ratio of raw materials must be accurate, such as the ratio of brominating agent to benzene-containing substrate, and the appropriate number should be used to ensure the efficient progress of the reaction. The reaction temperature is also an important point, and it needs to be maintained in a specific range to make the reaction occur stably and avoid the growth of side reactions.
In terms of labeling, the product parameters should be clearly marked. Its purity should be indicated by precise values, such as several percent, to prove its quality. The appearance description is also indispensable, it is a colorless liquid or a white solid, etc., so that the user can know at a glance. In this way, this 1-Bromo-2 - (Difluoromethoxy) Benzene product can be used accurately in chemical research and production applications.
Preparation Method
1 - Bromo - 2 - (Difluoromethoxy) Benzene is an important organic compound. The raw material selection is crucial for its preparation. O-bromophenol and difluorobromomethane can be selected as the initial raw materials.
In the preparation process, first dissolve o-bromophenol in an appropriate amount of organic solvent, such as anhydrous ether, and stir well. Then, slowly add difluorobromomethane dropwise. This process requires strict control of the temperature in a low temperature environment, about -10 ° C to 0 ° C. At the same time, an appropriate amount of basic catalyst, such as potassium carbonate, is added to promote the reaction.
The reaction steps are as follows: The phenolic hydroxyl group of o-bromophenol undergoes a nucleophilic substitution reaction with difluoromethoxane, and the bromine ions leave to form the target product 1-Bromo-2 - (Difluoromethoxy) Benzene.
To ensure the efficient completion of the reaction, the reaction time should be controlled at 3 to 5 hours. After the reaction is completed, separation and purification are carried out by means of vacuum distillation to obtain a high-purity product. In this way, 1-Bromo-2 - (Difluoromethoxy) Benzene can be obtained.
Chemical Reactions & Modifications
Wenfu 1 - Bromo - 2 - (Difluoromethoxy) Benzene, in the field of chemistry, its reaction and modification are the focus of our research.
The methods of observing various reactions in the past may have some shortcomings. Some reaction conditions are harsh, requiring high temperature and high pressure, energy consumption is quite huge, and side reactions are plentiful, resulting in impure products and high yield.
In order to improve, we have tried our best. After repeated investigation, we found a new way. Adjust the reaction agent, optimize the reaction environment, and slow down the conditions. In this way, the side reactions are gradually reduced, and the purity and yield of the product are improved.
This modification method is also of great significance in industrial production. The energy consumption is reduced, the cost is reduced, and the benefit is increased. And the quality of the product can meet the needs of more fields. We should make unremitting research, hope to achieve great results in chemistry, and use it for the world.
Synonyms & Product Names
1 - Bromo - 2 - (Difluoromethoxy) Benzene. The study of its heteronym and trade name is related to the fineness of our chemical research.
There are many heteronyms of chemical substances, all of which are due to different research processes, regional differences or use purposes. 1 - Bromo - 2 - (Difluoromethoxy) Benzene, or has aliases based on its structural characteristics, in order to accurately describe its atomic connections and functional group characteristics. Its trade name is mostly considered from marketing activities and application scenarios.
In our research, knowing its many heteronyms can help the smooth flow of literature review and academic exchanges. The clarity of the trade name is related to the convenience of industrial application and material procurement. Therefore, sorting out the synonyms and trade names of 1 - Bromo - 2 - (Difluoromethoxy) Benzene is an indispensable part of chemical research, which lays a solid foundation for subsequent research and application.
Safety & Operational Standards
1 - Bromo - 2 - (Difluoromethoxy) Benzene is an important chemical product. It needs to be explained in detail in terms of its safety and operating practices.
In terms of safety, this compound has specific chemical properties and needs to be properly disposed of. It may be toxic and irritating, so the operator must take comprehensive protective measures. If entering the operation area, when wearing professional protective clothing, this clothing must be able to effectively block the substance from coming into contact with the skin to avoid possible corrosion or penetration. And protective gloves must be worn. The material is selected to be suitable to prevent chemical substances from penetrating and ensure hand safety.
Eye protection is also indispensable. Protective glasses can prevent it from splashing into the eyes and avoid eye damage. Furthermore, the operation should be carried out in a well-ventilated place, because the volatile gaseous components of the substance may have adverse effects on the respiratory tract. The ventilation system can discharge harmful gases in time to maintain the fresh air in the operating environment.
As far as the operating specifications are concerned, when taking this chemical, it is necessary to use a precise measuring tool. The measuring process needs to strictly follow the prescribed steps to ensure accurate dosage to prevent abnormal reactions due to dosage deviations. When mixing or reacting, reagents should be added in a specific order. This order depends on the principle of chemical reaction and is related to whether the reaction can proceed smoothly. And the reaction process needs to be closely monitored under conditions such as temperature and pressure. Because the reaction involving 1-Bromo-2- (Difluoromethoxy) Benzene is quite sensitive to environmental conditions.
For storage, it should be placed in a cool, dry and ventilated place, away from sources of ignition and oxidants. Due to its active chemical nature, improper storage or danger. Containers must be well sealed to prevent leakage, and labels should be clearly marked, indicating key information such as ingredients and hazards for easy access and management.
All these safety and operating practices are to ensure the safe and effective use of 1 - Bromo - 2 - (Difluoromethoxy) Benzene. Operators should keep it in mind and practice it effectively.
Application Area
1 - Bromo - 2 - (Difluoromethoxy) Benzene is a unique chemical substance with a key application field. In the field of medicinal chemistry, this compound can be used as a key intermediate to help synthesize drug molecules with specific biological activities. Due to its unique chemical structure, it can introduce specific functional groups for drugs to improve drug efficacy and targeting.
In the field of materials science, 1 - Bromo - 2 - (Difluoromethoxy) Benzene also plays a role. It can be used to prepare organic materials with special properties, such as those with excellent optical and electrical properties. Because of its fluorine-containing structure, it can endow materials with special physical and chemical properties to meet the needs of different material applications. In addition, in the production of fine chemicals, this compound may be an important raw material, participating in the synthesis of a variety of fine chemicals, providing basic support for the development of related industries, and playing an indispensable role in many fields.
Research & Development
In recent years, I have specialized in chemical substances, especially 1 - Bromo - 2 - (Difluoromethoxy) Benzene. The properties of this substance are particularly delicate, its structure is unique, and it contains ingenuity.
At the beginning, I explored the preparation method, and many attempts were made, but after twists and turns. Or due to the purity of the raw materials, or the subtle deviation of the conditions, the results were not as desired. However, I was not discouraged. After repeated consideration, I finally got the right method, controlled its yield, and the quality became better.
Viewing its application, the prospect is broad. In the field of medicine, it can be used as a key intermediate to help the research and development of new drugs; in terms of materials, it can also add unique properties and expand the use of materials.
I am well aware that the road to scientific research is long, and I want to make in-depth progress in this object and make it increasingly perfect for the benefit of the world. In the future, I hope to join hands with colleagues to promote its development and contribute to the progress of chemistry.
Toxicity Research
To taste the chemical industry, the study of toxicants is essential. Today there is 1 - Bromo - 2 - (Difluoromethoxy) Benzene. The study of its toxicity is related to people's livelihood and the safety of the industry.
Research, the first look at its properties. This substance has halogenated benzene and fluoroether structure, or is fat-soluble, easy to enter the biofilm. After entering the body, I am afraid that cell metabolism will be hindered. Oral ingestion may damage the gastrointestinal mucosa, causing nausea and vomiting. Percutaneous absorption, or irritation of the skin, causing redness, swelling and itching.
Repeat its long-term effects. In animal experiments, long-term exposure may cause liver and kidney dysfunction and interfere with enzyme system activity. In the environment, degradation is slow, or accumulated in organisms, enrichment along the food chain, endangering the ecology.
Therefore, toxicity research should not be ignored. Practitioners should strictly abide by regulations, take comprehensive protection, protect their own health, and protect the safety of the environment.
Future Prospects
The vision of the future, we are all concerned about it. In this paper, 1 - Bromo - 2 - (Difluoromethoxy) Benzene is mentioned, and its application in the field of technology is limited.
This material is very special and exquisite. It can be used in new research. With its characteristics, it may be able to form an important basis for the molecules of the product, which helps to solve the problems of life. Or it is exposed in the material science, so that the new material has special properties, which can be used in many aspects, such as sub-devices, aerospace.
And the refinement of the chemical technology, the synthesis method must be efficient and guaranteed. This product can be obtained in a more energy-efficient and less pollution way, increasing its quantity and reducing its cost. In this way, without promoting research, it is more able to show its skills in the world, lead to the innovation of the transformation phase, and achieve the same achievements.
Where to Buy 1-Bromo-2-(Difluoromethoxy)Benzene in China?
As a trusted 1-Bromo-2-(Difluoromethoxy)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-2-(Difluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-bromo-2- (difluoromethoxy) benzene?
1-% E6% BA% B4 is glycerol, 2- (diethylaminoethoxy) naphthalene, both of which have important uses in different fields.
Glycerol, which is widely used. In the field of medicine, it is often used as a solvent and excipient. Because of its good water absorption, it can maintain the humidity of the drug and ensure the stability of the drug effect. When making ointments, the drug can be evenly dispersed for easy application and absorption; in syrup preparations, it can increase sweetness and viscosity and improve taste. In the food industry, glycerin is a common moisturizer and sweetener. Adding glycerin to baked goods such as bread and cakes can retain moisture, prolong shelf life, and make the food soft and delicious; in candy production, it can prevent the candy from drying and cracking and improve the taste. In the field of cosmetics, glycerin is a basic moisturizing ingredient that can absorb moisture from the air, hydrate the skin, and keep the skin hydrated. It is commonly used in creams, lotions, toners and other products.
2- (diethylaminoethoxy) naphthalene, is a key intermediate in organic synthesis. It can participate in a variety of chemical reactions, build complex organic molecular structures, and synthesize compounds with specific physiological activities, providing possibilities for the development of new drugs. For example, in the synthesis of some new antihistamines, it can be used as a starting material to construct the core structure of the drug through multi-step reactions. In the field of materials science, functional materials based on the synthesis of 2- (diethylaminoethoxy) naphthalene have unique optical and electrical properties. It can be used to prepare organic Light Emitting Diode (OLED) materials, improve luminous efficiency and stability, and improve display effect.
What are the physical properties of 1-bromo-2- (difluoromethoxy) benzene?
1-% mercury-2- (diethylamino) naphthalene, this physical property is particularly important and has its use in many fields.
Mercury is a liquid metal at room temperature, with a silver-white and metallic luster. Its density is quite high, about 13.59 grams/cubic centimeter, and it is easy to flow. The melting point of mercury is -38.87 ° C, and the boiling point is 356.6 ° C. Mercury has good electrical conductivity, but its chemical properties are relatively stable. It does not react with oxygen at room temperature. When heated, it can combine with oxidation to form mercury oxide. However, mercury and its compounds are many toxic. Accidentally inhaling mercury vapor or accidentally ingesting mercury-containing substances can cause human poisoning and damage the nervous system, kidneys and other organs.
As for 2- (diethylamino) naphthalene, it is an organic compound. The appearance is often white to light yellow crystalline powder. Its melting point is about 96-98 ° C. 2- (diethylamino) naphthalene is soluble in common organic solvents, such as ethanol, ether, etc., but difficult to dissolve in water. In the field of organic synthesis, it is often used as an important intermediate and participates in many organic reactions to prepare various organic compounds with special properties. And because of its nitrogen-containing element in its molecular structure, it is endowed with certain alkalinity and unique performance in some acid-base reaction systems. The physical properties of the two are significantly different, and the application scenarios are also different. They have their own capabilities in industry, scientific research and many other aspects.
Is 1-Bromo-2- (difluoromethoxy) benzene chemically stable?
1-%E6%BA%B4-2-%28%E4%BA%8C%E6%B0%9F%E7%94%B2%E6%B0%A7%E5%9F%BA%29%E8%8B%AF%E7%9A%84%E5%8C%96%E5%AD%A6%E6%80%A7%E8%B4%A8%E5%9D%9A%E4%B8%8D%E7%A8%B3%E5%AE%9A.
In this substance, the structure of 1-hydroxy-2- (dihydroxymethylamino) ethanol is relatively special. Among them, the hydroxy group (-OH) has a certain activity and is prone to substitution, oxidation and other reactions. The dihydroxymethyl amino part, due to the existence of amino group (-NH -), has lone pair electrons on its nitrogen atom, which makes it alkaline and can react with acids.
From the overall structure, the substance has multiple activity check points, which affect each other, making its chemical properties more active. In different chemical environments, different types of reactions may occur. For example, in an acidic environment, amino groups may be protonated; in an alkaline environment, hydroxyl groups may participate in the reaction to form corresponding salts or other transformations. This active chemical property indicates that it is difficult to maintain an absolutely stable state under normal conditions, and it is easy to interact with substances in the surrounding environment, resulting in changes in its own structure or properties. Therefore, the chemical properties of 1-hydroxy-2- (dihydroxymethylamino) ethanol are not stable.
What are the synthesis methods of 1-bromo-2- (difluoromethoxy) benzene?
To prepare 1-ether-2 - (diethylaminoformyl) naphthalene, there are various methods.
First, naphthol derivatives can be used as starting materials. First, naphthol is reacted with suitable halogenated hydrocarbons under alkaline conditions to form the corresponding ether structure. This process requires the selection of appropriate bases, such as potassium carbonate, sodium hydroxide, etc., and the reaction temperature and time are controlled to ensure the smooth etherification reaction. Then, the obtained ether-containing intermediate is reacted with diethylaminoformylation reagents. The commonly used reagent is diethylaminoformyl chloride. In the presence of an organic base such as triethylamine, the nucleophilic substitution reaction occurs between the two, and the diethylaminoformyl group is introduced at a specific position in the naphthalene ring to obtain the target product.
Second, other derivatives of naphthalene are used as starting materials. If there is a suitable substituted naphthalene, it can be functionally converted first, and a group that can react with etherification reagents and diethylaminoformylation reagents can be introduced. For example, a halogen atom is first introduced into the naphthalene ring, and then it reacts with a nucleophilic reagent containing ether oxygen to form an ether bond. The subsequent operation is similar to the above, that is, it reacts with diethylam
Furthermore, the reaction path catalyzed by transition metals can be tried. For example, the coupling reaction catalyzed by palladium is used to couple the halogenate or borate containing the naphthalene ring with the reagent related to the ether structure and diethylaminoformyl group. This method requires the selection of suitable palladium catalysts, ligands and reaction solvents, and the precise regulation of the reaction conditions, so that the reaction can be carried out efficiently and selectively to obtain the required 1-ether-2- (diethylaminoformyl) naphthalene. Each method has its own advantages and disadvantages, and the optimal synthesis path needs to be weighed according to the actual situation, such as the availability of raw materials, cost, and difficulty of reaction conditions.
What are the precautions for storing and transporting 1-bromo-2- (difluoromethoxy) benzene?
In the storage of 1-% -2- (diacetoxy) boron, the following things should be paid attention to:
First, because of its certain chemical activity, the storage environment is very important. It is stored in a dry, dry and well-connected environment, and it is a source of ignition and pollution. If the environment is humid, it may cause its moisture to react biochemically, affecting the product; high temperature, it may also lead to unstable reactions, and even have safety problems.
Second, oxidizing substances and acidic substances need to be stored separately. Oxidative substances or oxidizing substances can be destroyed and destroyed; acidic substances may be neutralized or other chemical reactions, resulting in sexual changes.
Third, in terms of safety, it is necessary to ensure that the package is complete and sealed. The packaging material has good corrosion resistance and sealing properties to prevent leakage. If there is a leakage, it will not cause the loss of the material, the leakage will be connected to the external objects, or it will cause a dangerous reaction.
Fourth, avoid shock and collision during the process. The shock may cause the package to be damaged, and it may also cause the modification of its chemical properties due to physical effects. People also need to be familiar with its chemical characteristics and emergency treatment methods, so that accidents can be caused, and measures can be taken quickly and properly to reduce the harm.
Fifth, the emergency treatment of the fire equipment that is stored and matched with each other. According to its chemical characteristics, an appropriate fire should be arranged to effectively rescue the fire; the emergency treatment of leakage can quickly control the situation in the leakage and reduce the pollution and harm.