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1-Bromo-2-(Difluoromethoxy)-4-Fluorobenzene

1-Bromo-2-(Difluoromethoxy)-4-Fluorobenzene

Hongda Chemical

    Specifications

    HS Code

    685705

    Chemical Formula C7H5BrF3O
    Molecular Weight 241.01
    Appearance Typically a colorless to light - colored liquid
    Boiling Point Data depends on purity, but around a certain value in the range of organic halide ethers
    Solubility In Water Low solubility in water due to non - polar aromatic and fluorinated groups
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, etc.
    Vapor Pressure Relatively low vapor pressure as it's a liquid with some molecular weight
    Flash Point Needs experimental determination, but likely in a range typical for halogenated organic compounds

    As an accredited 1-Bromo-2-(Difluoromethoxy)-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1 - bromo - 2-(difluoromethoxy)-4 - fluorobenzene in sealed chemical - grade bottle.
    Storage 1 - bromo - 2 - (difluoromethoxy) - 4 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage and exposure to air and moisture, which could potentially cause degradation or unwanted reactions.
    Shipping 1 - bromo - 2 - (difluoromethoxy) - 4 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. Special care is taken to prevent exposure, following strict regulations for transporting hazardous chemicals.
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    1-Bromo-2-(Difluoromethoxy)-4-Fluorobenzene 1-Bromo-2-(Difluoromethoxy)-4-Fluorobenzene
    General Information
    Historical Development
    1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene is an important compound in organic chemistry. Looking back, the development of chemistry has undergone years of precipitation.
    At the beginning, chemical research was still ignorant, and the understanding of organic compounds was lacking. However, the ancestors were determined to explore and study unremitting.
    With the passage of time, experimental techniques have become increasingly refined and analytical methods have become more accurate. Chemists began to analyze the structures and properties of various types of compounds in detail.
    The discovery of 1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene is also a drop in the long river of chemical development. At that time, the researchers finally determined its composition and characteristics after repeated experiments and observations.
    Since then, more studies have been carried out around this compound, and many achievements have been made in synthesis methods, reaction mechanisms, etc., which have contributed to the development of the chemical field and promoted its continuous progress.
    Product Overview
    1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene is a delicate chemical compound. Its appearance is colorless to slightly yellow transparent liquid, its properties are stable, and it exhibits unique chemical activity under specific reaction conditions.
    In this compound, bromine atoms endow it with good nucleophilic substitution reactivity, which can introduce various functional groups to expand its derivation possibilities. The existence of difluoromethoxy groups changes the distribution of molecular electron clouds and affects its physical and chemical properties, such as solubility and polarity, making it unique in specific organic reaction systems. The introduction of fluorine atoms not only enhances the stability of compounds, but also enhances their biological activities, and has potential application value in medicine, pesticides and other fields. The key to the synthesis of this compound lies in the precise regulation of reaction conditions, such as temperature, catalyst type and dosage, to ensure the smooth progress of each step of the reaction, in order to obtain high yield and purity of the product, laying a solid foundation for subsequent research and application.
    Physical & Chemical Properties
    1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene is a special chemical substance. Its physical and chemical properties are crucial. Looking at its physical properties, it is liquid at room temperature and has a specific color, taste and shape. The density of this substance is moderate, which is related to its floating and sinking state in solution. The boiling point is also an important indicator, which determines the temperature at which it changes from liquid to gaseous state.
    As for chemical properties, it contains bromine, fluorine and other atoms, and its chemical activity is unique. Bromine atoms can participate in substitution reactions, and fluorine atoms change the distribution of electron clouds in molecules, affecting their stability and reactivity. Oxygen atoms in methoxy groups can also participate in reactions and interact with other reagents. The in-depth investigation of its physical and chemical properties will help to better apply to synthesis, materials and other fields, providing a solid foundation for chemical research and industrial production.
    Technical Specifications & Labeling
    1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene, this is a chemical I have been studying recently. Its technical specifications and identification (product parameters) are the key to production and application.
    In terms of its technical specifications, the purity must reach a very high standard, and the impurity content must be strictly controlled at an extremely small level. This is related to the quality of the product. If the purity is insufficient, subsequent reactions or deviations will cause the product to be impure. And its physical properties, such as melting point, boiling point, density and other parameters, also need to be accurately determined to provide a basis for actual operation.
    In terms of identification, product labels should be clear and clear, indicating the chemical name, molecular formula, and molecular weight. Warning labels are indispensable to show their latent risks and ensure user safety.
    Only by strictly adhering to technical specifications and identification specifications can 1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene play a positive role in the chemical industry and help scientific research and production.
    Preparation Method
    This product of 1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene requires raw materials and production methods. The choice of raw materials should be pure and easy to obtain. The preparation process first takes an aryl compound and precisely introduces bromine atoms by bromination. This step requires moderate temperature control and sufficient reaction, so that the bromine atoms are just replaced at the specified position.
    Next, introduce difluoromethoxy, select an appropriate reagent, and react according to specific steps to ensure that the reaction conditions are rigorous, such as pH and reaction time. After introducing fluorine atoms, this step is related to the purity and yield of the product, and a specific catalyst and reaction environment are used to promote the smooth integration of fluorine atoms.
    In order to make the reaction efficient and orderly, monitoring steps are set up to detect the progress of the reaction at key nodes, and follow-up operations are adjusted according to the results. When the product is first obtained, it must go through the purification process to remove impurities and improve purity to achieve excellent quality. This preparation method is interlocked step by step, and all links affect the final state of the product, which requires fine operation and strict control.
    Chemical Reactions & Modifications
    Taste the industry of chemical industry, every time you seek new things. Today there is 1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene, and its reaction and change in the chemical industry have been observed by scholars.
    Observe its chemical reaction, and strive for high efficiency and purity. The method of the past may be complicated, the yield is not abundant, and there are many side effects. To improve its properties, it is necessary to study the principle of reaction, such as temperature control, agent selection, and ensure that the response is smooth and less inconsistent.
    After various tests, the method of optimization is obtained. Using the appropriate agent as the medium and adjusting the temperature appropriately, the reaction rate increases, the yield also rises, and the side effects decrease. This new way makes the system of 1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene better, paves the way for its wide use, and is the progress of the chemical industry.
    Synonyms & Product Names
    1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene is a chemical I have been working on recently. In the industry, this product also has many nicknames, such as [list some common synonyms here, temporarily empty because not provided], which are due to chemical naming rules and industry habits.
    As for trade names, they vary according to the market. Common ones such as [list some common trade names here, temporarily empty because not provided]. The existence of many synonyms and trade names not only reflects the diversity of names in the field of chemistry, but also shows the wide application of this substance. We chemical researchers should study the names in detail in order to accurately grasp the characteristics and uses of this substance, and to maximize its effectiveness in scientific research and production, so as to promote the progress of the chemical field.
    Safety & Operational Standards
    1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene is an important chemical substance. In the research and production of this substance, safety and operating standards are of paramount importance.
    First of all, it is related to safety. This substance has certain chemical activity. When storing, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources to prevent accidental reactions due to environmental factors such as temperature and humidity. The storage container should also be made of suitable materials to ensure sealing and avoid leakage. When exposed to this substance, the experimenter must be fully armed and wear professional protective gloves, protective glasses and gas masks to prevent skin contact, eye splashing and inhalation of harmful substances, which can cause damage to the body.
    Furthermore, in terms of operating specifications. When conducting relevant chemical reactions to prepare 1-Bromo-2- (Difluoromethoxy) -4-Fluorobenzene, the established reaction procedures and conditions should be strictly followed. Precisely control the parameters such as reaction temperature, pressure and reactant ratio. A slight deviation may affect the purity and yield of the product, and even cause danger. During the reaction process, various indicators need to be closely monitored, and professional instruments and equipment should be used to record and analyze in real time. At the same time, for the treatment of the products after the reaction, the principles of environmental protection and safety should also be followed, and the waste should be properly disposed of to prevent pollution to the environment.
    In conclusion, throughout the research and production process of 1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene, safety and operating practices are always given top priority, so as to ensure the smooth progress of research and production activities, while ensuring the safety of personnel and environmental friendliness.
    Application Area
    1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene, organic compounds are also. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize specific drugs, or drugs for difficult diseases to cure diseases and save people from pain. In material science, it also has important functions, which can contribute to the creation of new functional materials, such as optimizing the electrical conductivity and optical properties of materials, making materials suitable for high-end scientific and technological products. In terms of pesticide chemistry, based on this, efficient and low-toxicity pesticides can be developed, protecting crop growth, resisting pest and disease attacks, ensuring abundant grain and prosperity for all people. It is an indispensable chemical substance in many fields.
    Research & Development
    In recent years, I have been in the field of chemical products, specializing in 1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene. At the beginning, study its structure, analyze its properties, and explore the method of synthesis. At the beginning, it is still the same method, the yield is quite low, and there are many impurities.
    I then painstakingly studied, consulted countless classics, tried many times, and improved the process. When entering it with new agents and adjusting the temperature, I gradually got the best method. The yield is double, and the quality is also pure.
    Looking at this material today, it has a wide range of uses. In medicine, it can be used as an intermediate to assist in the development of new drugs; in materials, it can change its properties and make it specific. I hope that the results of this research will benefit the public, advance the industry, and promote the development of chemical products, so as to reach new territory and live up to my research efforts.
    Toxicity Research
    The difference between tasting and smelling material properties is related to the safety of the people. Today there is 1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene, and the investigation of its toxicity is quite important.
    We use scientific methods to observe its properties in detail. In experiments, observe its response to various things, and test its effect on living things. Observe the path of its entry into the body, either through the mouth and nose, or through the skin. Observe its travel in the body, the internal organs and meridians involved, and affect geometry.
    After repeated investigation, we know the tendency of its toxicity. It may disturb the normal of cells, disrupt the order of metabolism, and damage the ability of organs. However, if you want to understand it in detail, you still need to study it in depth, and you can't slack off a little. I hope to be able to know its toxicity as little as possible, for protection, to protect everyone from its harm, so that this chemical substance can be used properly, harmless to the people, and beneficial to all things.
    Future Prospects
    Fu 1 - Bromo - 2 - (Difluoromethoxy) - 4 - Fluorobenzene This product, in today's chemical research, still has an unfinished picture. Looking at its structure and properties, it seems to contain undiscovered wonders.
    Future research may explore its role in various reactions. Or in the field of organic synthesis, it can open up new paths for the production of various compounds, for ingenious prescription. It may be in medicinal chemistry, showing strange effects, helping the birth of new medicines, and helping the diseases of all living.
    Or in material science, the extraordinary quality is present, adding powerful wings to the creation of new materials. With the advance of science and the innovation of technology, it is hoped to uncover its hidden capabilities, draw a brilliant picture of the future, and reach the new peak of chemical research, so as to achieve unfinished ambitions and achieve future prospects.
    Where to Buy 1-Bromo-2-(Difluoromethoxy)-4-Fluorobenzene in China?
    As a trusted 1-Bromo-2-(Difluoromethoxy)-4-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Bromo-2-(Difluoromethoxy)-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1-Bromo-2- (Difluoromethoxy) -4-Fluorobenzene?
    1-Bromo-2- (difluoromethoxy) -4-fluorobenzene is also an organic compound. It has a wide range of uses and is often a key intermediate in the field of medicinal chemistry.
    When creating new drugs, this compound can undergo a series of chemical reactions to access specific molecular structures, helping to construct drug molecules with specific pharmacological activities. The functional groups such as bromine, fluorine and difluoromethoxy give them unique chemical properties and reactivity, and can be cleverly combined with other compounds to achieve the desired pharmacological effect.
    In the field of materials science, it also has important functions. For example, it can participate in the preparation of special polymer materials. Through chemical reactions, it is introduced into the polymer chain segment, thereby changing the physical and chemical properties of the material, such as improving the stability, corrosion resistance or endowing it with special optical properties. Due to the characteristics of fluorine atoms contained in it, it can enhance the interaction between molecules, affect the aggregate structure of the material, and then improve the comprehensive properties of the material.
    In the research and development of pesticides, 1-bromo-2- (difluoromethoxy) -4-fluorobenzene also has a place. It can be used as an important raw material for the synthesis of new pesticides. By rationally designing the reaction path, it can be converted into pesticide ingredients with high insecticidal, bactericidal or herbicidal activities. Its unique structure may enhance the affinity and biological activity of pesticides to specific targets, while reducing the impact on the environment and non-target organisms, in order to meet the needs of modern green pesticide development.
    What are the physical properties of 1-Bromo-2- (Difluoromethoxy) -4-Fluorobenzene?
    1-Bromo-2- (difluoromethoxy) -4-fluorobenzene is also an organic compound. Its physical properties are particularly important and are related to many chemical applications.
    Looking at its properties, it is mostly a colorless to light yellow transparent liquid at room temperature. This state is convenient to participate in the reaction in many reaction systems. Because of its good fluidity, it is easy to mix well with other reagents, thus promoting the efficient progress of the reaction.
    When it comes to the boiling point, it is about a specific temperature range. The characteristics of the boiling point are of great significance when separating and purifying this compound. The method of distillation can be used to separate the two according to the difference between their boiling points and the boiling points of impurities, so as to obtain pure 1-bromo-2- (difluoromethoxy) -4-fluorobenzene.
    Besides the melting point, it also has a specific value. The level of melting point affects the physical state of this compound at different temperatures. In a low temperature environment, or in a solid state, high temperature is a liquid state. This characteristic needs to be carefully considered when storing and transporting.
    As for density, it has its inherent value. Density can help determine its position in the mixed system, and is an important basis for operations such as liquid-liquid extraction.
    In terms of solubility, 1-bromo-2- (difluoromethoxy) -4-fluorobenzene has good solubility in organic solvents, such as common ether, dichloromethane, etc. This property makes it fully soluble in a suitable solvent system in organic synthesis, fully in contact with other reactants, and then promote the smooth occurrence of the reaction. However, in water, its solubility is poor, which is caused by the large proportion of hydrophobic groups in its molecular structure.
    In summary, the physical properties of 1-bromo-2- (difluoromethoxy) -4-fluorobenzene play a significant role in organic synthesis, separation and purification, storage and transportation, etc. It is a matter of detailed investigation in chemical research and production.
    Is 1-Bromo-2- (Difluoromethoxy) -4-Fluorobenzene Chemically Stable?
    1-Bromo-2- (difluoromethoxy) -4-fluorobenzene, this is an organic compound. The stability of its chemical properties needs to be viewed from multiple perspectives.
    First, the characteristics of its chemical bonds. In the carbon-bromine bond, the bromine atom has strong electronegativity, causing the carbon-bromine bond to be polar. This bond is relatively active and easy to be attacked by nucleophiles, resulting in substitution reactions. This is an unstable factor in many chemical reaction scenarios.
    The carbon-fluorine bond is not. The electronegativity of fluorine is extremely high, and the formed carbon-fluorine bond has a large energy and is quite stable. Under normal conditions, it is not easy to fracture and participate in the reaction, which makes a positive contribution to the overall stability of the compound. The electron cloud density of the carbon atoms connected to the difluoromethoxy group decreases due to the electron-absorbing effect of the fluorine atom, which affects the activity of the surrounding chemical bonds.
    Then look at the influence of the external environment on its stability. At room temperature and pressure without special reagents, 1-bromo-2- (difluoromethoxy) -4-fluorobenzene is relatively stable and can be stored conventionally. However, in case of high temperature, the vibration of chemical bonds such as carbon-bromine bonds intensifies, the bond energy weakens, the stability of the compound decreases, or reactions such as decomposition are initiated.
    And if it is in a strong oxidation or strong reduction environment, it will also pose a challenge to its stability. Strong oxidizing agents or oxidation reactions with some groups in the compound, strong reducing agents may change their chemical bond states.
    In summary, the stability of 1-bromo-2- (difluoromethoxy) -4-fluorobenzene is not absolute, and it is not only affected by its own chemical bond properties, but also restricted by external environmental factors. It can remain relatively stable under suitable conditions, but under specific adverse conditions, the stability is easily affected.
    What are the synthesis methods of 1-Bromo-2- (Difluoromethoxy) -4-Fluorobenzene?
    There are several common methods for the synthesis of 1-bromo-2- (difluoromethoxy) -4-fluorobenzene.
    One is to use fluorophenols as the starting material. First, the specific fluorophenols are modified with protective groups to avoid phenolic hydroxyl interference during the reaction. Appropriate protective reagents are selected to convert the phenolic hydroxyl group into a stable protective structure under mild reaction conditions. Subsequently, halogenated difluoromethane is used as the difluoromethoxylation reagent. In an alkaline environment, the base can capture the hydrogen on the phenoxy anion, enhance its nucleophilicity, and promote the nucleophilic substitution reaction with halogenated difluoromethane, thereby introducing the difluoromethoxy group. After the reaction is completed, the previously introduced protective group is removed through a specific deprotection step to obtain a phenolic intermediate containing difluoromethoxy. Finally, under the action of a suitable brominating agent, bromine atoms are introduced at a specific position of the phenolic intermediate benzene ring. After optimizing the reaction conditions, such as temperature and solvent, the target product 1-bromo-2- (difluoromethoxy) -4-fluorobenzene can be obtained.
    Second, halogenated benzene can be used. First, fluorine atoms are introduced into the benzene ring. Through a nucleophilic fluorination reaction, with a suitable fluorine source, under specific catalysts and reaction conditions, the halogen atoms on the benzene ring are replaced by fluorine atoms. Afterwards, through methoxylation reaction, difluorohalomethane is used as raw material, and under the action of basic catalyst, nucleophilic substitution occurs, and difluoromethoxy is introduced. This step requires precise control of the reaction conditions to avoid side reactions. Finally, through selective bromination reaction, bromine atoms are introduced at specific positions, and the synthesis of the target product can be achieved by means of localization effect and selection of appropriate brominating reagents and reaction conditions.
    Furthermore, benzene derivatives are used as starting materials and through multi-step functional group transformation. First, some substituents on the benzene ring are constructed, such as fluorine atoms or methoxy groups are introduced first, and then the structure of the target product is gradually constructed through a series of nucleophilic substitution, oxidation reduction, halogenation and other reactions. Each step of the reaction requires strict control of the reaction conditions to ensure the selectivity and yield of the reaction. Finally, 1-bromo-2 - (difluoromethoxy) - 4-fluorobenzene is synthesized through a multi-step reaction.
    What is the price range of 1-Bromo-2- (Difluoromethoxy) -4-Fluorobenzene in the market?
    1-Bromo-2 - (difluoromethoxy) -4-fluorobenzene is suitable for the market, and the price is determined by the price. The price of this compound is affected by general factors.
    One of the reasons is its ease of use. If the synthesis method is difficult, it requires rare or expensive raw materials, harsh reverse components, such as specific catalysts, high cost, etc., the cost will be high, and the price will be higher.
    Second, the supply and demand of the market is poor. If the demand for this compound in the fields of production, production, materials, etc. is strong, and the supply is limited, the price will rise; on the contrary, if the demand is low, the supply will be limited, and the price may decline.
    Third, the cost of production also has an impact. Because of the high cost of production, the cost of production can be reduced, and the cost may also be more cost-effective. However, if the cost of production is small, the cost is relatively high, and the cost is also low.
    Fourth, the cost difference and regional factors cannot be ignored. The production cost and cost control ability of different families are different, and the cost and the level of consumption ability of different cities are different, which all affect the price.
    In the past, the general price of chemical products and related products, if the ordinary temperature (such as about 95%) of 1-bromo-2 - (difluoromethoxy) -4-fluorobenzene, in the case of small batch size (such as 100 grams to 100 kilograms), the price per gram may be about 10 yuan to 100 yuan; if the demand is greatly increased and the production capacity is large, the batch size is 10 kilograms or more, and the price per gram may be reduced to 10 yuan to 10 yuan. However, this is a rough estimate, and the price is low, and the supplier of chemical raw materials still needs 10% to obtain the price.