Hongda Chemical
Products
Home  /  Products  / 

1-Bromo-2-(Difluoromethoxy)-3-Methylbenzene

1-Bromo-2-(Difluoromethoxy)-3-Methylbenzene

Hongda Chemical

    Specifications

    HS Code

    443752

    Chemical Formula C8H7BrF2O
    Molecular Weight 239.04
    Appearance Typically a colorless to light - colored liquid (assuming standard conditions)
    Boiling Point Data would depend on purity and pressure, but generally in a range relevant to organic bromides with similar structures
    Density Estimated based on similar organic compounds containing bromine, fluorine, and alkoxy groups
    Solubility In Water Low solubility, as it is an organic compound with non - polar benzene ring and halogenated and alkoxy side - chains
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate due to its organic nature
    Vapor Pressure Depends on temperature, but lower than volatile hydrocarbons due to its relatively large and polarizable structure
    Flash Point A value would need to be experimentally determined, but likely in a range typical for organic halogen - containing compounds

    As an accredited 1-Bromo-2-(Difluoromethoxy)-3-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1 - bromo - 2 - (difluoromethoxy) - 3 - methylbenzene in sealed chemical - grade container.
    Storage 1 - Bromo - 2 - (difluoromethoxy) - 3 - methylbenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent evaporation and exposure to air or moisture. Store it separately from oxidizing agents and incompatible substances to avoid potential reactions.
    Shipping 1 - bromo - 2 - (difluoromethoxy) - 3 - methylbenzene is shipped in sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring secure transit to prevent spills and environmental risks.
    Free Quote

    Competitive 1-Bromo-2-(Difluoromethoxy)-3-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615365186327 or mail to info@alchemist-chem.com.

    We will respond to you as soon as possible.

    Tel: +8615365186327

    Email: info@alchemist-chem.com

    1-Bromo-2-(Difluoromethoxy)-3-Methylbenzene 1-Bromo-2-(Difluoromethoxy)-3-Methylbenzene
    General Information
    Historical Development
    Wenfu 1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene This thing, its origin is also the research of all scholars. At first, the sages explored in the subtle domain, wanting to understand its nature and its use.
    Over the years, scholars have worked hard to explore it with techniques. At first, the cognition was still shallow, and the gains were nothing but fur. However, everyone worked tirelessly in the laboratory, using bottles and utensils as blades to dissect its mysteries.
    At some point, the process gradually advanced and could be more stable. As a result, it emerged in various fields, or as the foundation of medicine, or as a new material. The development of the road, just like the rise of the star, from the obscure and obvious, for the academic community, but also for the future research to pave the way, waiting for future generations to carry on, expand its endless possibilities.
    Product Overview
    1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene Product Overview
    Husband 1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene is a valuable compound in the field of organic synthesis. Its structure is unique. It is based on a benzene ring, and the bromine atom, difluoromethoxy group and methyl group are respectively connected to a specific position in the benzene ring.
    The physical properties of this compound are that it is a liquid at room temperature, has a specific boiling point and melting point, and has good solubility in specific organic solvents. Chemical properties are active, because it contains bromine atoms, nucleophilic substitution reactions can occur; the existence of difluoromethoxy groups endows it with unique electronic effects, which affect molecular reactivity and selectivity.
    In organic synthesis research, 1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene is often used as a key intermediate. With its active chemical properties, it can construct complex organic molecular structures through various reaction paths, and has broad application prospects in pharmaceutical chemistry, materials science and other fields. It is an indispensable and important substance for chemical research and industrial development.
    Physical & Chemical Properties
    1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene is an organic compound. Its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, this substance may be in a liquid state and has a certain volatility. Its boiling point and melting point have specific values due to the uniqueness of the molecular structure, which are related to the size of the intermolecular force. In terms of its chemical properties, it can participate in many chemical reactions because it contains functional groups such as bromine atoms, difluoromethoxy groups and methyl groups. Bromine atoms are highly active and can undergo substitution reactions or interact with nucleophiles to form new compounds. Difluoromethoxy groups affect the polarity of molecules, which in turn plays a role in their solubility and other properties. Methyl groups affect the spatial structure and electron cloud distribution of molecules, making them exhibit unique activities in some reactions. The study of the physicochemical properties of this substance is of great significance in the fields of organic synthesis and materials science.
    Technical Specifications & Labeling
    1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene is a unique chemical product. Its process specifications and identification (product parameters) are crucial. In terms of process specifications, it is necessary to clarify the method of synthesis, such as the precise ratio of raw materials, the appropriate temperature, duration and pressure of the reaction. The pH of the reaction environment also needs to be strictly controlled to prevent side reactions. As for the identification (product parameters), its purity should be detailed, which is related to the quality of the product. The appearance, color, taste and other characteristics should also be clearly marked. And its physical properties, such as melting point, boiling point and other parameters, are all required by the user. In this way, this product can achieve the purpose of precision and efficiency when applied, and contribute to the development of the chemical industry.
    Preparation Method
    To prepare 1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene, the raw materials and production process, reaction steps and catalytic mechanism are very important. First, take an appropriate amount of o-methylphenol as the starting material, and react with difluorobromomethane under the condition of potassium carbonate as the catalyst and acetonitrile as the solvent. This step is a nucleophilic substitution reaction. The oxygen atom in the phenolic hydroxyl group nucleophilically attacks the carbon atom in difluorobromomethane to generate 2 - (difluoromethoxy) - 3 - methylphenol. Subsequently, the product was reacted with liquid bromine under the catalyst of iron powder, and liquid bromine was slowly added dropwise in a low temperature environment to undergo bromination reaction to obtain the target product 1-Bromo-2 - (Difluoromethoxy) - 3 - Methylbenzene. The whole process requires precise control of the reaction conditions and steps to ensure the purity and yield of the product.
    Chemical Reactions & Modifications
    After studying the chemical product, try to study the product 1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene. The beauty of its chemical reaction is related to the change of matter and the change of nature, which is actually the focus of the researcher.
    In the chemical reaction, this product is combined with various agents, or temperature or pressure, and the structure of its molecules and the connection of atoms all change. At the beginning, its response is slow, but the conditions change, and the speed increases. Watching its response is like the steps of a dancer, orderly and changing.
    As for the change of its nature, it is born from the change of reaction. The change of sense makes the dissolution, boiling and reaction of things different. After all, it is more stable or more active, depending on the state and the nature of the agent.
    My generation studies this, seeking to clarify the principle of application, control its process, and optimize its method to obtain the products required for sexual suitability. This is the essence of chemical research, and it is also where my ambition lies.
    Synonyms & Product Names
    1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene This chemical substance has a lot of research value in the field of my chemical research.
    In today's world, although the naming rules of chemical substances are gradually becoming unified, there are many reasons in the past that the same substance has different names. This 1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene, or has an alias according to its structural characteristics, or has a unique trade name in a specific region or research group.
    Exploring the same noun and trade name is like looking for beads in the long river of history. It can help us clarify the evolution of chemical research, and know how scholars in the past knew and named this substance. It is also of great benefit to chemical trade and research exchanges, so that all parties can accurately know the substances involved and avoid confusion.
    I will use a rigorous attitude to conduct extensive research in classics and literature, visit the industry, and strive to comprehensively sort out the same nouns and trade names, and add bricks to chemical research, so that the cognition of this substance is more complete and accurate.
    Safety & Operational Standards
    1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene is an important chemical product that needs to be explained in detail in terms of its safety and operating practices.
    In terms of safety, the properties of this compound should be clarified first. It has certain chemical activity and must be treated with caution when exposed. If it comes into contact with the skin, rinse with plenty of water as soon as possible. If there is still discomfort, seek medical attention urgently. If it does not enter the eyes carefully, rinse the eyes with running water immediately, keep the eyelids open, rinse for several minutes, and then seek medical attention.
    In terms of operating practices, the operating environment must be well ventilated. Because it may evaporate harmful gases, good ventilation can reduce the concentration of harmful components in the air. Operators must wear appropriate protective equipment, such as protective gloves, goggles, and lab clothes, to guard against possible hazards. When taking the compound, measure it accurately to avoid waste and excess. And the operation process should be carried out on a stable laboratory bench to prevent accidental dumping. Furthermore, after use, store it properly in a cool, dry place away from fire sources to prevent danger. Adhering to the above safety and operating practices can ensure the smooth and safe operation process, effectively reduce the occurrence of accidents, and is essential for the smooth development of chemical research work.
    Application Area
    1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene is a special chemical substance. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate in the synthesis of specific drugs, which can help to create a cure for difficult diseases through delicate chemical reactions. In the field of materials science, it also has potential value, or can participate in the synthesis of high-performance materials, giving materials such as unique electrical and optical properties. In agricultural chemistry, it can be reasonably designed to become an important part of high-efficiency and low-toxicity pesticides, helping to control crop pests and ensure agricultural harvests. Due to its unique chemical structure, this substance has opened up a wide range of applications for innovation and development in many fields, and is a key factor that cannot be ignored in chemical research and industrial applications.
    Research & Development
    In recent years, I have focused on the research of 1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene. At the beginning, its synthesis path was explored. After many attempts, this compound was obtained by using a specific reaction raw material and suitable reaction conditions.
    In the exploration of properties, its physical properties, such as melting point, solubility, etc., and its chemical activity were analyzed to show its reaction law under the action of different reagents.
    This research has great potential for industrial applications, and is expected to be used in the synthesis of specific drugs, or to provide key intermediates for the development of new materials. In the future, it will further expand its application field and optimize the preparation process, hoping to promote the transformation of this compound from laboratory research to actual production, and promote its wide application to achieve significant benefits, which will make progress in scientific research and industrial development.
    Toxicity Research
    A poison has been studied in recent years, and the name is 1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene. I study its toxicity in detail to understand its impact on all things.
    At first, take all kinds of insects and put them in the environment of this thing. After a while, many insects are uncomfortable, slow to move, and even die. If you try it again with plants and trees, its leaves will gradually wither and its vitality will decline.
    Then think about people and animals. If you touch it carelessly, or enter the body through the mouth and nose, you may damage the organs and mess with qi and blood. In light cases, you may feel dizzy and nauseous; in severe cases, you may endanger your life.
    The study of toxicity is related to people's livelihood. This thing is potentially dangerous to the environment and living beings, and it must be handled with caution to prevent it from overflowing, so as not to cause harm to the world.
    Future Prospects
    Wuguanfu 1 - Bromo - 2 - (Difluoromethoxy) - 3 - Methylbenzene This product is really a newcomer in the chemical industry. Although it has not yet reached its peak in the present, the prospect of the future is full of expectations.
    This product has unique properties and may shine in the field of medicine. Extrapolating from its characteristics, it may be able to open up new paths for the development of new drugs. It can make special agents to treat serious diseases and save patients from pain.
    In the field of materials, it also has unlimited potential. It may give rise to new materials with extraordinary properties, such as stronger toughness and better heat resistance. It can be used in aerospace to help aircraft soar for nine days; it can be used in electronic equipment to make the equipment more delicate and durable.
    In the future, if we can explore in depth, optimize the production method, and reduce its cost, it will surely be widely used in the world, contributing to the well-being of mankind, achieving extraordinary things, and opening up endless possibilities.
    Where to Buy 1-Bromo-2-(Difluoromethoxy)-3-Methylbenzene in China?
    As a trusted 1-Bromo-2-(Difluoromethoxy)-3-Methylbenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Bromo-2-(Difluoromethoxy)-3-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 1-Bromo-2- (Difluoromethoxy) -3-Methylbenzene?
    1-Bromo-2- (difluoromethoxy) -3-methylbenzene, an organic compound, is widely used in the field of organic synthesis.
    First, it is often used as an intermediate to prepare various fluorine-containing aromatic compounds. Because its structure contains bromine atoms and difluoromethoxy groups, they are all active check points and can be converted by many chemical reactions. For example, bromine atoms can be replaced by different nucleophiles, such as hydroxyl and amino groups, through nucleophilic substitution reactions, so as to obtain compounds with different functions. If sodium alcohol is used as a nucleophilic reagent, bromine atoms will be replaced by alkoxy groups to form new ether compounds containing difluoromethoxy groups, which may have important applications in the fields of medicine and materials.
    Second, in the field of pharmaceutical chemistry, fluorine-containing organic compounds have attracted much attention due to their unique properties. 1-Bromo-2- (difluoromethoxy) -3-methylbenzene, as a fluorine-containing intermediate, may be used to synthesize drug molecules with specific biological activities. The introduction of difluoromethoxy groups may change the fat solubility, metabolic stability and binding ability of drug molecules to targets, thereby improving the efficacy and safety of drugs.
    Third, in the field of materials science, the compound may also have a place of application. By means of organic synthesis, it is integrated into the polymer material structure. With the characteristics of fluorine atoms, such as low surface energy and high chemical stability, the material is endowed with special properties, such as waterproof, oil-proof, chemical corrosion resistance, etc., and can be used to prepare high-performance coatings, functional film materials, etc.
    What are the physical properties of 1-Bromo-2- (Difluoromethoxy) -3-Methylbenzene
    1-Bromo-2- (difluoromethoxy) -3-methylbenzene, is one of the organic compounds. Its physical properties are very important, and it is related to the application and characteristics of this compound.
    First of all, its appearance, under normal temperature and pressure, is mostly colorless to light yellow transparent liquid. Looking at it, it is like a clear oil with a restrained luster. Under the light, it shines slightly, just like a faint light hidden in a liquid, quiet and soft.
    The boiling point of this substance is about a specific temperature range, due to the influence of intermolecular forces, molecular weight and structure. The value of its boiling point allows it to change from liquid to gas at a specific temperature environment. This property is crucial in separation, purification and related chemical reactions. If you want to separate this compound from the mixture, the boiling point characteristic can be used as a guide for separation to achieve a pure state.
    In addition, the melting point also has a specific value. When the temperature drops below the melting point, the compound will gradually change from liquid to solid, and the molecular arrangement will become orderly from disorder, like a quiet dancer. In the low temperature environment, find a stable position and arrange it regularly.
    As for the density, the density of 1-bromo-2 - (difluoromethoxy) -3-methylbenzene is greater than that of water. When it is mixed with water, it can be seen that it is like a stable stone, slowly sinking in the bottom of the water, does not dissolve with water, forms its own phase, and has clear boundaries.
    In terms of solubility, it has good solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc. This characteristic makes it participate in many chemical reactions with organic solvents as a medium, and is also conducive to the preparation of suitable solutions in experimental operations such as analysis and synthesis to meet different needs.
    Volatility, the compound has a certain volatility. In an open environment, over time, it can slowly evaporate into the air, and its molecules are like light feathers, gradually escaping. When storing and using this characteristic, special attention should be paid to it. It should be sealed and stored to prevent its volatilization loss, and to avoid the accumulation of volatile gases in a well-ventilated place, so as to avoid potential danger.
    This is the general physical properties of 1-bromo-2- (difluoromethoxy) -3-methylbenzene. In the field of organic chemistry, these properties provide a solid foundation for its research and application.
    Is 1-Bromo-2- (Difluoromethoxy) -3-Methylbenzene Chemically Stable?
    The chemical properties of 1-bromo-2- (difluoromethoxy) -3-methylbenzene are relatively stable. In this compound, although the bromine atom has a certain activity, it can participate in nucleophilic substitution and other reactions, but due to the existence of the benzene ring conjugation system, the electron cloud can be dispersed, resulting in a slight decrease in its activity.
    Difluoromethoxy part, due to the high electronegativity of the fluorine atom, the group has an electron-absorbing effect, which can affect the electron cloud distribution of the benzene ring, especially the electron cloud density of the ortho and para-site, and then affect the activity and check point selectivity of the electrophilic substitution reaction on the benzene ring. The electron cloud density of the benzene ring can be increased by methyl as the power supply group, which interacts with the electron-withdrawing effect of difluoromethoxy group, balances the benzene ring electron cloud to a certain extent, and improves the overall stability of the molecule.
    Furthermore, the conjugated large π bond structure of the benzene ring endows the molecule with high stability. The resonance energy of the aromatic ring makes it less prone to violent reactions such as ring opening, and more prone to reactions that retain the benzene ring structure, such as electrophilic substitution.
    Under normal conditions, 1-bromo-2- (difluoromethoxy) -3-methylbenzene can remain relatively stable for a certain period of time without severe conditions such as strong nucleophiles, strong oxidants or high temperatures.
    What is the preparation method of 1-Bromo-2- (Difluoromethoxy) -3-Methylbenzene?
    The preparation method of 1-bromo-2- (difluoromethoxy) -3-methylbenzene is as follows:
    can be prepared by nucleophilic substitution reaction. Take 2-methyl-3-bromophenol as the starting material, and the oxygen of phenolic hydroxyl in this compound is nucleophilic. React it with difluoromethylating reagents such as difluorobromomethane (BrCF2O H) or difluorochloromethane (ClCFO2 H) under appropriate conditions. Due to the certain departure of halogen atoms in halogenated hydrocarbons, the oxygen of the phenolic hydroxyl group can attack the carbon atoms connected to the halogen atoms in halogenated hydrocarbons, and the halogen atoms leave, thereby forming a carbon-oxygen bond, that is, the target product 1-bromo-2- (difluoromethoxy) -3-methylbenzene.
    The reaction conditions are quite critical. The existence of bases is indispensable, such as potassium carbonate (K 2O CO 🥰), sodium hydroxide (NaOH), etc. The base can interact with the phenolic hydroxyl group to convert it into phenoxy negative ions, enhancing its nucleophilicity, thereby promoting the reaction. And the reaction needs to be carried out in an appropriate solvent, such as N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO) and other polar aprotic solvents, such solvents can dissolve the reactants, stabilize the intermediate and transition states, and increase the reaction rate.
    The temperature also needs to be strictly controlled, usually carried out under heating conditions, with a temperature range of about 60-100 ° C. If the temperature is too low, the reaction rate will be slow; if the temperature is too high, it may trigger side reactions, such as phenoxy anions attacking hydrogen atoms adjacent to halogen atoms in halogenated hydrocarbons, and elimination reactions, which will affect the yield and purity of the target product.
    In addition, the system needs to be kept dry during the reaction process, because water may react with halogenated hydrocarbons, reducing the concentration of reactants, and may affect the activity of bases, which may adversely affect the reaction process. After the reaction, the products are often separated and purified by means of extraction and column chromatography to obtain high-purity 1-bromo-2- (difluoromethoxy) -3-methylbenzene.
    1-Bromo-2- (Difluoromethoxy) -3-Methylbenzene What are the precautions in storage and transportation?
    1-Bromo-2- (difluoromethoxy) -3-methylbenzene, this is an organic compound. When storing and transporting, be sure to pay attention to the following matters.
    Bear the brunt, and the storage place should be selected in a cool and ventilated warehouse. This compound is quite sensitive to heat, and high temperature can easily cause chemical reactions or even cause danger. Therefore, the warehouse temperature must be strictly controlled and not too high. And good ventilation conditions are also indispensable to effectively prevent the accumulation of harmful gases.
    Furthermore, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to its active chemical properties, contact with the above substances is very likely to cause violent chemical reactions, such as combustion, explosion and other serious consequences.
    In terms of packaging, it must be ensured that it is tight. Appropriate packaging materials should be used to prevent its leakage. Because the compound has certain toxicity and irritation, once leaked, it will not only cause pollution to the environment, but also endanger human health.
    When transporting, it is necessary to follow the relevant regulations on the transportation of hazardous chemicals. Vehicles should be equipped with corresponding emergency treatment equipment and protective equipment to prevent accidents during transportation. And the transportation process should be as smooth as possible to avoid violent vibration and collision to prevent package damage.
    The escort personnel also need to have professional knowledge and skills, familiar with the characteristics of the compound and emergency treatment methods. In the event of an emergency, they can take prompt and effective response measures to minimize harm.