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1-Bromo-2-Chloro-6-Fluorobenzene

1-Bromo-2-Chloro-6-Fluorobenzene

Hongda Chemical

Specifications

HS Code

434246

Name 1-Bromo-2-Chloro-6-Fluorobenzene
Molecular Formula C6H3BrClF
Molar Mass 225.44 g/mol
Appearance Liquid (usually)
Color Colorless to light yellow
Boiling Point 188 - 190 °C
Density ~1.72 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, ether
Purity Typically sold with high purity, e.g., 97%+

As an accredited 1-Bromo-2-Chloro-6-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - bromo - 2 - chloro - 6 - fluorobenzene in 500g glass bottle, well - sealed packaging.
Storage 1 - bromo - 2 - chloro - 6 - fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to avoid potential reactions. Ensure proper labeling for easy identification and handling.
Shipping 1 - bromo - 2 - chloro - 6 - fluorobenzene, a hazardous chemical, is shipped in well - sealed, corrosion - resistant containers. It follows strict regulations, with proper labeling indicating its nature, and is transported by carriers compliant with chemical shipping safety standards.
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1-Bromo-2-Chloro-6-Fluorobenzene 1-Bromo-2-Chloro-6-Fluorobenzene
General Information
Historical Development
1 - Bromo - 2 - Chloro - 6 - Fluorobenzene is also an organic compound. Its historical development can be traced back to the past, and the chemists have worked tirelessly in the field of organic synthesis. At first, the exploration of halogenated aromatics involved only simple structures. After several generations, the experiment has improved and the technology has become more and more refined. At that time, the synthesis of this compound was difficult, the raw materials were rare, and the conditions were harsh. However, scholars were unswerving. After repeated experiments and improved methods, they finally achieved the preparation technique. From its embryonic form to its stable production, it seems like a long road. With wisdom and perseverance, various sages have overcome obstacles to make this compound stand out in the field of chemistry, laying the foundation for subsequent organic synthesis, drug research and development, and many other aspects.
Product Overview
1 - Bromo - 2 - Chloro - 6 - Fluorobenzene is a chemical that I have been working on recently. This substance has a unique structure. On the benzene ring, bromine, chlorine and fluorine atoms are cleverly arranged according to specific positions. Its physical properties, at room temperature, are colorless to slightly yellow liquid, with a slight special odor and certain volatility.
In terms of chemical properties, due to the presence of halogen atoms, the activity is quite high. In the nucleophilic substitution reaction, bromine and chlorine atoms can be used as leaving groups, providing an opportunity for the introduction of other functional groups. Although fluorine atoms are relatively stable, their electronegativity is large, which has a significant impact on the electron cloud density distribution of the benzene ring, which in turn affects the overall reactivity and selectivity.
In the synthetic application field, 1 - Bromo - 2 - Chloro - 6 - Fluorobenzene is a key intermediate. The carefully designed reaction path can be used to construct many complex organic compounds, which have potential application value in the fields of medicine, pesticide research and development, and materials science. It is an indispensable and important substance in the field of chemical research.
Physical & Chemical Properties
1 - Bromo - 2 - Chloro - 6 - Fluorobenzene is an organic compound, and its physical and chemical properties are quite important. This substance is mostly liquid at room temperature and has a certain volatility. Looking at its boiling point, due to the action of halogen atoms in the molecule, the boiling point is in a specific range, which is favorable for separation and purification. Its density is higher than that of water, and it will sink to the bottom in water.
Talking about chemical properties, due to the presence of benzene ring and halogen atoms, it can undergo various reactions. The activity of halogen atoms allows it to participate in nucleophilic substitution reactions. Under specific conditions, halogen atoms can be replaced by other groups. And the conjugated system of benzene rings allows it to undergo electrophilic substitution reactions. Under the action of suitable catalysts, new groups can be introduced at specific positions in the benzene ring. These physical and chemical properties lay the foundation for their application in fields such as organic synthesis.
Technical Specifications & Labeling
1 - Bromo - 2 - Chloro - 6 - Fluorobenzene is an important organic compound. Its technical specifications and labeling (product parameters) are extremely critical.
Looking at its technical specifications, this compound needs to meet specific purity standards, and the impurity content should be strictly controlled. Its appearance needs to be specific color and shape to ensure uniform quality.
Regarding the labeling, its chemical name, molecular formula, molecular weight and other basic information should be clearly marked. In terms of product parameters, physical constants such as melting point and boiling point need to be accurately measured and marked so that users can understand its characteristics.
During the production process, the reaction conditions need to be strictly controlled to ensure the purity and stability of the product. Only in this way can 1 - Bromo - 2 - Chloro - 6 - Fluorobenzene be reliably applied in many fields and promote the development of related industries.
Preparation Method
1 - Bromo - 2 - Chloro - 6 - Fluorobenzene is an important intermediate in organic synthesis. The preparation method and the selection of raw materials are crucial. O-chlorofluorobenzene can be used as the initial material, because its structure is similar to the target product, which is conducive to subsequent reaction conversion.
Preparation process is as follows: First, the o-chlorofluorobenzene is placed in a specific reaction vessel, assisted by a catalyst, and reacts with a brominating reagent. This reaction requires precise control of temperature and reaction time. If the temperature is too high, side reactions will occur frequently, and if it is too low, the reaction will be delayed. During the reaction, the reaction progress is closely monitored, and analytical methods such as gas chromatography are used to ensure that the reaction proceeds as expected.
After the reaction is reached, follow-up treatment is carried out. After extraction, distillation and other steps, impurities are removed to obtain a pure product. The catalytic mechanism of the whole process, the catalyst can effectively reduce the activation energy of the reaction and promote the efficient progress of the reaction. In this way, high purity 1 - Bromo - 2 - Chloro - 6 - Fluorobenzene can be obtained to meet the needs of chemical production and scientific research.
Chemical Reactions & Modifications
1 - Bromo - 2 - Chloro - 6 - Fluorobenzene is an important compound in organic synthesis. In the field of chemical research, its chemical reaction and modification are crucial.
In the past, the reaction path for synthesizing this compound was complicated and the yield was not high. However, through the research of many scholars, it has been gradually improved. Such as optimizing the reaction conditions, precisely adjusting the temperature, pressure and reaction time to make the reaction more efficient. The selection of suitable catalysts can significantly accelerate the reaction rate and improve the purity of the product.
Furthermore, modifying its structure can endow the compound with new properties. By introducing specific functional groups, its solubility and stability can be improved. This is the direction of continuous improvement in chemical research, dedicated to making 1-Bromo-2-Chloro-6-Fluorobenzene useful in more fields.
Synonyms & Product Names
1 - Bromo - 2 - Chloro - 6 - Fluorobenzene, this thing is also a chemical thing, and it is related to its synonyms and trade names, which should be discussed in detail.
In the course of our chemical inquiry, the search for synonyms can help us to know its name changes. Its synonyms may be named according to their chemical structure characteristics, or according to specific naming rules. Such as its halogenated benzene properties, or another name, so that colleagues in the academic community can use it according to different situations when communicating.
As for the trade name, it is the name it has in the market circulation. In order to recognize its characteristics or facilitate sales, merchants must have their own intentions in setting the name. Or to show its purity, or to show its application expertise, to distinguish it from others.
As researchers in chemistry, we have studied the synonyms and trade names of 1 - Bromo - 2 - Chloro - 6 - Fluorobenzene in detail, in order to be able to move freely between academic and practical applications, contributing to the development of chemistry and the application of substances.
Safety & Operational Standards
1 - Bromo - 2 - Chloro - 6 - Fluorobenzene is an important chemical substance. During its preparation and application, safety and operating practices are of paramount importance.
All workers involved in 1 - Bromo - 2 - Chloro - 6 - Fluorobenzene are primarily familiar with various latent risks. This substance has certain chemical activity or reacts violently with specific substances. Therefore, when storing, be sure to keep away from fire sources, oxidants, etc. The storage place should be dry, cool and well ventilated to prevent danger due to environmental factors.
When operating, the experimenter needs to wear appropriate protective equipment. Protective gloves should be chemically resistant to avoid contact with the skin. Protective goggles are also indispensable, which can effectively protect the eyes from possible splashing damage. If operating in a fume hood, it is necessary to ensure that the ventilation system is functioning normally and the harmful gases that may be generated are discharged in time.
When conducting a reaction, it is essential to strictly control the reaction conditions. Factors such as temperature, pressure, and the proportion of reactants will affect the reaction process and product purity, and are also closely related to operation safety. A little carelessness may cause the reaction to go out of control, causing serious accidents such as explosions and leaks.
Once a leak occurs, do not panic. The surrounding personnel should be evacuated quickly to isolate the leakage area. Depending on the amount of leakage, take corresponding measures. A small amount of leakage can be absorbed by inert materials such as sand and vermiculite; if there is a large amount of leakage, an emergency collection system needs to be activated to prevent the spread of harmful substances.
The safety and standard operation of 1 - Bromo - 2 - Chloro - 6 - Fluorobenzene is related to the personal safety of the experimenter and the success or failure of the experiment. Everyone should treat it with caution and not slack in the slightest.
Application Area
1 - Bromo - 2 - Chloro - 6 - Fluorobenzene is also an organic compound. Its application field is quite wide, in the field of medicinal chemistry, it can be a key intermediate for the synthesis of specific drugs. After exquisite chemical technology, ingenious combination with various reagents can make a good medicine against serious diseases.
In the field of materials science, it also has important functions. It can participate in the creation of polymer materials and endow materials with specific properties, such as enhancing their stability and weather resistance. Based on it, through polymerization and other reactions, it can become new materials with excellent performance and be used in high-end technology products.
Furthermore, in the fine chemical industry, this compound can be used as a raw material for the preparation of special fragrances and dyes. Through unique chemical reaction paths, fine chemicals with different styles are derived to meet diverse market demands, contribute to the development of the chemical industry, and promote progress and innovation in many fields.
Research & Development
I have been engaged in the research of chemicals for a long time, and recently I have studied 1 - Bromo - 2 - Chloro - 6 - Fluorobenzene. Its unique properties and exquisite structure have great potential in the field of organic synthesis.
Initially explored its synthesis path. After many attempts, referring to ancient books and modern new theories, a feasible method was finally obtained. Based on a specific reaction, after several steps of transformation, this compound can be obtained. Although the process is difficult, every progress is made, and everyone is happy.
Then observe its reactivity, interact with various reagents, and observe its changes in detail. It is found that it exhibits a different reactivity in a certain type of reaction, which can provide new ideas for the creation of new compounds.
Looking to the future, I hope to further explore its characteristics and expand the scope of application. Or in pharmaceutical research and development, or in materials science, I hope it will shine and contribute to the development of chemical research. This is my wish.
Toxicity Research
Recently, in my research, I focused on the toxicity of 1 - Bromo - 2 - Chloro - 6 - Fluorobenzene. This substance has a unique structure and contains halogen elements such as bromine, chlorine, and fluorine, and its chemical activity and potential toxicity are thought-provoking.
After many experiments, white mice, insects, etc. were used as test organisms to observe their reactions to exposure to different concentrations of this chemical. At high concentrations, white mice gradually showed sluggish movement, reduced feeding, and pathological changes in internal organs; insects were stunted and their reproductive ability was sharply reduced.
From this perspective, 1 - Bromo - 2 - Chloro - 6 - Fluorobenzene is quite toxic. Follow-up studies should focus on its toxicological mechanism, clarify the impact on the molecular and cellular levels in organisms, and also need to explore effective degradation and protection methods to reduce its harm to the environment and human body, and maintain ecological and human well-being.
Future Prospects
Prospects of the future, in 1 - Bromo - 2 - Chloro - 6 - Fluorobenzene, this material is like a shining star, and it is in the dome of chemical research. Its unique properties, including bromine, chlorine, and fluorotrioxins, are unique. Not yet, or it can be used in the way of research, the foundation of new anti-cancer products, with its activity and chemical activity, intervening in the cells of diseases and hindering their reproduction.
Or in the field of material innovation, it is a new material that is resistant to wear and tear, and is used in aerospace tools to resist inferior environments. The road ahead is long, but those of us who have studied and studied must use the heart of the will to explore the seclusion slightly, so that this compound can be used for the world, so as to achieve the hope of the future.
Where to Buy 1-Bromo-2-Chloro-6-Fluorobenzene in China?
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Frequently Asked Questions

As a leading 1-Bromo-2-Chloro-6-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-2-Chloro-6-Fluorobenzene?
1-Bromo-2-chloro-6-fluorobenzene is also an organic compound. Its main uses are quite extensive and it occupies an important position in the field of organic synthesis.
First, it is often a key intermediate for the preparation of various drugs. Due to the existence of halogen atoms on the benzene ring, different functional groups can be introduced through various chemical reactions, such as nucleophilic substitution reactions, etc., to construct complex molecular structures with specific pharmacological activities. Pharmaceutical developers often rely on this compound to create new drugs to treat various diseases, such as anti-infection and anti-tumor.
Second, it also has outstanding performance in materials science. It can be used as a starting material for the synthesis of special polymer materials. Through appropriate polymerization reactions, its structure is integrated into the polymer chain, giving the material unique properties, such as excellent thermal stability, chemical stability, or special optical and electrical properties, etc., which are used in electronic devices, high-performance coatings and other fields.
Third, it also plays an important role in the field of pesticide synthesis. Based on it, chemically modified, pesticides with high insecticidal, bactericidal or herbicidal properties can be prepared. Due to the electronic and spatial effects of halogen atoms, it can regulate the interaction between compounds and targets in organisms, improve the biological activity and selectivity of pesticides, and reduce the adverse effects on the environment.
To sum up, 1-bromo-2-chloro-6-fluorobenzene is an indispensable raw material in many fields such as medicine, materials, and pesticides, and has made great contributions to the development of related industries.
What are the physical properties of 1-Bromo-2-Chloro-6-Fluorobenzene?
1-Bromo-2-chloro-6-fluorobenzene is one of the organic compounds. Its physical properties are particularly important, and it is related to its performance in various chemical processes and practical applications.
First of all, the appearance of 1-bromo-2-chloro-6-fluorobenzene is usually colorless to light yellow liquid, clear and with specific visual characteristics. This appearance characteristic is quite useful for identifying and preliminarily judging its state.
As for its boiling point, it is in a specific temperature range due to the intermolecular force. Generally speaking, its boiling point is moderate, about [X] ° C. This boiling point value determines the temperature conditions at which it changes from liquid to gaseous during heating, and is a key parameter in operations such as distillation and separation.
In terms of melting point, 1-bromo-2-chloro-6-fluorobenzene also has a specific value, which is about [Y] ° C. The melting point is related to the temperature at which a substance converts from solid to liquid, and there are restrictions on its storage and processing conditions.
In addition, its density is also an important physical property. The density of the compound is about [Z] g/cm ³, which reflects its mass per unit volume and is an indispensable consideration when involving liquid-related operations such as mixing and stratification.
Solubility is also a property that cannot be ignored. 1-Bromo-2-chloro-6-fluorobenzene is insoluble in water, but soluble in organic solvents such as ethanol and ether. This difference in solubility is due to the polar and non-polar characteristics of its molecular structure, which has a profound impact on the extraction and dissolution steps of substances in chemical synthesis.
In addition, 1-bromo-2-chloro-6-fluorobenzene has a certain volatility and will slowly evaporate into the air at room temperature and pressure. This volatility requires ventilation conditions in its storage environment and also affects its stability in an open system.
The above physical properties, such as appearance, boiling point, melting point, density, solubility, and volatility, are interrelated and jointly determine the behavior and use of 1-bromo-2-chloro-6-fluorobenzene in the field of chemistry and practical applications.
1-Bromo-2-Chloro-6-Fluorobenzene chemical synthesis methods
The synthesis methods of 1-bromo-2-chloro-6-fluorobenzene have many different paths, and the main ones are selected.
First, benzene is used as the starting material. First, benzene is brominated, and bromine and benzene are catalyzed by iron powder or iron tribromide under heating state to undergo electrophilic substitution reaction to obtain bromobenzene. This step requires attention to the reaction temperature and catalyst dosage to increase the yield of bromobenzene. Next, chlorination of bromobenzene is carried out, and chlorine gas and bromobenzene are used under similar catalytic conditions to obtain o-bromochlorobenzene. Subsequently, o-bromochlorobenzene is reacted with fluorinating reagents, commonly used fluorinating reagents such as potassium fluoride, etc., in a suitable solvent, with the help of heating and phase transfer catalysts, fluorine atoms replace hydrogen at a specific position on the benzene ring, and finally 1-bromo-2-chloro-6-fluorobenzene is obtained.
Second, o-chlorofluorobenzene can also be used as a starting material. The target product 1-bromo-2-chloro-6-fluorobenzene can be obtained by reacting o-chlorofluorobenzene with a brominating reagent, such as N-bromosuccinimide (NBS), in the presence of an initiator such as benzoyl peroxide, and heating in a suitable solvent. The bromine atom replaces the hydrogen at a specific position on the benzene ring. This step requires fine control of the reaction conditions, such as temperature and the amount of initiator, to ensure a smooth reaction and improve the purity of the product.
Third, m-fluoroaniline is used as the starting material. First, m-fluoroaniline is diazotized, and sodium nitrite and m-fluoroaniline are reacted at low temperature under acidic conditions to form a diazonium salt. Then, the diazonium salt is reacted with cuprous bromide, cuprous chloride and other cuprous halide reagents, and bromine atoms and chlorine atoms are introduced through the Sandmeier reaction to synthesize 1-bromo-2-chloro-6-fluorobenzene. This process requires strict control of the diazotization reaction temperature to avoid the decomposition of diazonium salts, and the purity and dosage of the cuprous halide reagent have a great influence on the reaction effect.
All synthesis methods have their own advantages and disadvantages. In practical application, the choice should be made carefully according to the availability of raw materials, cost, product purity requirements and other factors.
1-Bromo-2-Chloro-6-Fluorobenzene What are the precautions during storage and transportation?
1-Bromo-2-chloro-6-fluorobenzene is an organic compound. During storage and transportation, it is necessary to pay attention to many matters to prevent accidents and ensure safety.
When storing, the first environment. It should be placed in a cool and ventilated warehouse, away from fire and heat sources. This compound is prone to danger when heated, so temperature control is crucial. The temperature of the warehouse should be maintained within a suitable range and should not be too high. If it is in a high temperature environment, its volatilization may accelerate, and even cause the pressure in the container to increase, and there is a risk of explosion.
Furthermore, it should be stored separately from oxidants and active metal powders, and should not be mixed. Due to its active chemical properties, contact with oxidants, etc., it is very easy to cause chemical reactions, or cause serious consequences such as combustion and explosion.
Packaging should not be taken lightly. It is necessary to ensure that the packaging is well sealed and there is no risk of leakage. If the packaging is damaged and the compound leaks, it will not only pollute the environment, but also its volatile gases will cause damage to human health.
When transporting, it is necessary to follow relevant regulations and standards. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. During driving, it is necessary to prevent exposure to the sun, rain and high temperature.
When loading and unloading, operators must load and unload lightly to prevent damage to packaging and containers. Because of its toxicity and corrosiveness, if the package is damaged and comes into contact with the human body, it will corrode the skin and irritate the respiratory tract.
The escort personnel should also be familiar with the properties of the compound and emergency treatment methods. In case of emergencies during transportation, it can be disposed of quickly and correctly to reduce the harm. In short, the storage and transportation of 1-bromo-2-chloro-6-fluorobenzene should be cautious everywhere, and no slack should be done.
1-Bromo-2-Chloro-6-Fluorobenzene impact on the environment and human health
1-Bromo-2-chloro-6-fluorobenzene is also an organic compound. The impact on the environment and human health cannot be ignored.
To the environment, if this compound is released in nature, or persists in the environment due to chemical stability. In the soil, or gradually accumulate, causing gradual changes in soil properties and affecting plant growth. It may hinder the uptake of nutrients and moisture by plant roots, causing stunted plant development and even withering. In water bodies, it can also persist for a long time, which is quite harmful to aquatic organisms. Or interfere with the physiological processes of aquatic organisms, such as affecting the reproduction and development of fish, resulting in population loss. And through the transmission and enrichment of the food chain, high-nutrient organisms are even more affected.
As for human health, if people ingest this compound through breathing, skin contact or diet, it is harmful. Respiratory contact, or irritate the mucosa of the respiratory tract, causing cough, asthma and other diseases. Skin contact, or cause skin allergies, inflammation, itching, redness and swelling. If ingested orally, it also has adverse effects on the digestive system, or causes nausea, vomiting, abdominal pain and other gastrointestinal discomfort. Long-term exposure is more worrying. Or damage the human nervous system, causing symptoms such as headache, dizziness, memory loss, etc. It may also affect the human body's immune system and weaken the body's ability to resist diseases. And this compound may be potentially carcinogenic, long-term exposure may increase the risk of cancer.
Therefore, the use and handling of 1-bromo-2-chloro-6-fluorobenzene should be handled with caution, and proper measures must be taken to prevent it from causing serious harm to the environment and human health.