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1-Bromo-2-Chloro-5-(Trifluoromethoxy)Benzene

1-Bromo-2-Chloro-5-(Trifluoromethoxy)Benzene

Hongda Chemical

Specifications

HS Code

233703

Name 1-Bromo-2-Chloro-5-(Trifluoromethoxy)Benzene
Molecular Formula C7H3BrClF3O
Molecular Weight 275.45
Appearance Colorless to light yellow liquid
Boiling Point Around 188 - 190 °C
Density 1.754 g/mL at 25 °C
Flash Point Around 79.4 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Vapor Pressure Low vapor pressure at room temperature
Stability Stable under normal conditions
Packing & Storage
Packing 100g of 1 - bromo - 2 - chloro - 5 - (trifluoromethoxy)benzene in sealed chemical - grade bottle.
Storage 1 - bromo - 2 - chloro - 5 - (trifluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage and vapor release. Label the storage container clearly with the chemical's name, hazards, and handling instructions for safety.
Shipping 1 - bromo - 2 - chloro - 5 - (trifluoromethoxy)benzene is shipped in sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring secure transport to prevent leaks and environmental or safety risks.
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1-Bromo-2-Chloro-5-(Trifluoromethoxy)Benzene 1-Bromo-2-Chloro-5-(Trifluoromethoxy)Benzene
General Information
Historical Development
1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene is also a chemical substance. Its origin, the first to study, has not yet been made in this fine way. After the month has passed, the multi-family has been able to study its efforts, the nature of matter analysis, and explore the rationale of chemistry.
Early research, we know the outline of the phase of the compound, and we know the whole picture of this fine molecule. However, those who are determined to do so are determined, or consider it in the reaction, or in the ratio of raw materials.
In the recent era, we can borrow new tools, such as light and light, to clarify its molecular framework and the order of its atoms. Ignorant and knowledgeable, to this day, we know its nature and purpose. The history of this chemical object is gathered by the efforts of the chemical family, and the exploration of science is exciting.
Product Overview
1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene is a unique chemical substance. It may be a colorless liquid with specific physical and chemical properties.
In this compound, bromine, chlorine and trifluoromethoxy groups are cleverly connected to the benzene ring. Bromine and chlorine atoms give it the characteristics of halogenated hydrocarbons, which can be used as an active check point in many chemical reactions and participate in nucleophilic substitution and other reactions. The introduction of trifluoromethoxy groups significantly changes the electron cloud distribution and spatial structure of the molecule, which greatly affects its chemical activity and stability.
In the field of organic synthesis, 1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene is often a key intermediary. With its unique structure, it can be carefully designed reaction paths to build more complex and special-function organic molecules, which are of indispensable value in many cutting-edge fields such as medicinal chemistry and materials science.
Physical & Chemical Properties
1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene is an organic compound. Its physical properties are mostly liquid at room temperature and have certain volatility. Looking at its appearance, it is colorless and transparent, or has a microstrip color, and has good solubility in organic solvents, such as ethanol, ether, etc.
When it comes to chemical properties, bromine and chlorine atoms in this compound have high activity and are easy to participate in nucleophilic substitution reactions. Its benzene ring structure imparts certain aromaticity and can carry out electrophilic substitution reactions. The presence of trifluoromethoxy enhances molecular polarity and has a significant impact on its chemical activity and reaction selectivity. In many organic synthesis reactions, 1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene is often used as a key intermediate, which lays the foundation for the preparation of complex organic compounds.
Technical Specifications & Labeling
1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene is an important chemical substance. Its process specifications and labeling (product parameters) are key to production and application. As far as process specifications are concerned, the reaction conditions need to be strictly controlled, and the ratio of raw materials must be accurate. Reactants such as bromine, chlorine and trifluoromethoxy groups must be slightly deviated in proportion to affect the purity of the product. The reaction temperature also needs to be carefully controlled to ensure the smooth progress of the reaction within a specific range.
In terms of labeling, key information such as the name, chemical formula, and CAS number must be clearly marked on the product label to prevent confusion and misuse. Warning labels should be attached to the packaging because the substance may be dangerous. Precise process specifications and clear labeling are the cornerstones of ensuring the quality and safe application of 1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene products.
Preparation Method
1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene is an important organic compound. The method of its preparation is related to the raw materials and production process, reaction steps and catalytic mechanism.
To prepare this compound, the first raw material is selected. Compounds containing bromine, chlorine and trifluoromethoxy groups are used as starting materials, and their purity is very high to ensure smooth reaction. In the production process, the control of reaction conditions is extremely critical. Temperature, pressure and reaction time are all finely regulated. If the temperature is too high or too low, the product can be impure or the yield can be low.
The reaction steps should be gradual. First, the benzene ring compound containing bromine and chlorine meets the reagent containing trifluoromethoxy group. Under a specific catalytic mechanism, the catalyst can reduce the activation energy of the reaction and promote the combination of the two. This catalytic mechanism may be metal catalysis, and the special electronic structure of the metal leads the reaction to the formation of the target product. In this way, high-purity 1-Bromo-2-Chloro-5 - (Trifluoromethoxy) Benzene can be obtained after careful handling of the raw materials, precise control of the production process, sequential completion of the reaction steps, and optimal use of the catalytic mechanism.
Chemical Reactions & Modifications
1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene is an important compound. In chemical research, its chemical reaction and modification are extremely critical.
Looking at the reaction, many reaction conditions can affect the process. Such as temperature and solvent selection, the reaction rate and product purity will be affected. At a suitable temperature, the reaction can be carried out efficiently to obtain an ideal product; however, the temperature is not appropriate, or the side reactions may occur frequently, and the product is impure.
Talking about modification, the purpose is to optimize its performance. Through specific chemical means, such as the introduction of specific functional groups, it can be made to have different physical or chemical properties. This may expand its application in materials science, drug development and other fields.
In the field of chemistry, the chemical reaction and modification of 1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene still need to be continuously studied by researchers to uncover more mysteries and contribute to the development of related fields.
Synonyms & Product Names
1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene is an important chemical substance. In my field of chemical research, synonyms and trade names related to this substance need to be explored in detail.
The name of the chemical substance covered often varies depending on the region and industry habits. As far as 1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene is concerned, or there are aliases, these aliases may appear in academic exchanges and industrial applications. If it is recorded in some literature, or if it is called by another name, it refers to the same substance.
The situation of the trade name is more complicated. Different manufacturers produce this substance, or give it a unique trade name according to their own marketing strategies and product characteristics. Exploring these synonyms and trade names will help us fully understand the application and dissemination of this substance in the market and research, and avoid mistakes in research and production due to name confusion. Therefore, it is of great significance to sort out the synonyms and trade names of 1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene.
Safety & Operational Standards
1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene is an important chemical. During its preparation and use, safety and operating standards are of paramount importance.
All operations involving this substance must be carried out in a well-ventilated ring. Because the chemical may be volatile to a certain extent, it is easy to cause gas accumulation in closed spaces, endangering the health of the operator. Ventilation equipment can effectively disperse harmful gases and maintain fresh air.
When operating, wear appropriate protective equipment. Such as laboratory clothes, protective gloves and goggles are indispensable. Experimental clothing can prevent chemical substances from splashing on clothing, protective gloves can avoid direct contact with the hands to prevent skin absorption or corrosion. Goggles can protect the eyes from accidental splashes.
Storage should be placed in a cool, dry place away from fire sources and oxidants. The properties of this substance may change due to high temperature and humidity, and contact with fire sources and oxidants is more likely to cause dangerous reactions.
In the specific operation process, weighing, transfer and other steps need to be extra careful. Accurate weighing can ensure that the reaction proceeds as expected and avoid abnormal reactions due to improper dosage. The transfer process should prevent the leakage of the substance. If there is any leakage, it should be cleaned up immediately according to established procedures to prevent pollution of the environment and cause safety accidents.
In waste disposal, it must not be discarded at will. Relevant environmental regulations must be followed, sorted and collected, and properly disposed of to reduce the harm to the environment. Strictly abide by safety and operating standards to ensure the smooth and safe operation of 1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene.
Application Area
Today there is a product, named 1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene, which is quite wonderful in various application fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help synthesize specific drugs, cure various diseases, and save patients from pain. In the context of material science, it can be a modifier, optimize material properties, make materials stronger and more durable, and have a wide range of uses. In the world of fine chemicals, it is also an indispensable raw material, making many fine products to meet the daily and industrial needs of the world. From this point of view, this product has important value in various application fields, and it is something that cannot be underestimated.
Research & Development
The rise of modern chemistry, the study of the properties and changes of substances, is related to people's livelihood and national plans. Today there is 1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene, a substance that our chemists have studied.
At the beginning, it was difficult to synthesize this substance. After many experiments, trying different reagents and conditions, it was obtained. The reaction mechanism is based on the ingenious combination of halogenation reaction and etherification reaction.
In terms of application, this substance has broad prospects. It can be used in the preparation of new materials, because of its special structure, giving the material unique properties, or it can be used in electronic devices to improve its performance.
Furthermore, the study of the process of this substance has also promoted the development of chemical theory. It has deepened our understanding of organic reactions. In the future, we should continue to study and expand its applications, promote the progress of the field of chemistry, and seek the well-being of the world.
Toxicity Research
Since modern times, chemical refinement has emerged, and various compounds have emerged one after another. Today, 1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene, the toxicity of this substance is quite important.
Examine this substance in detail, its molecular structure is unique, bromine, chlorine and trifluoromethoxy groups are combined in the benzene ring. Such structures may lead to special chemical activities, which in turn is related to toxicity.
Experiments have been carried out using white mice as models and feeding them a diet containing this substance. During menstruation, the white mice gradually showed abnormal symptoms, slowed down, and did not eat well. Analyze their bodies, organs are damaged, especially liver and kidney.
Look at the surrounding environment. If this thing is released outside or sewage soil, it will endanger life. Therefore, when it is produced and used, strict precautions should be set up to avoid its poison invading all living beings, so as to ensure the safety of the whole ecology.
Future Prospects
1 - Bromo - 2 - Chloro - 5 - (Trifluoromethoxy) Benzene, the future prospect of this chemical is related to many fields. In material science, it is expected to develop new materials with excellent performance, which may endow materials with extraordinary stability and functionality due to their unique chemical structure. In the field of pharmaceutical chemistry, it has been delicately modified and derived, or has become a key intermediate for innovative drugs, bringing hope for the conquest of difficult diseases. In the field of fine chemicals, it can derive a series of high-value-added products, promoting the industry towards high-end. Although the road ahead may face challenges such as synthesis process optimization and cost control, with time and dedication, we will be able to emerge from the abyss like a hidden dragon and bloom in the future, injecting majestic impetus into the development of many industries and opening up a new world.
Frequently Asked Questions
What are the main uses of 1-Bromo-2-Chloro-5- (Trifluoromethoxy) Benzene?
1-Bromo-2-chloro-5- (trifluoromethoxy) benzene is also an organic compound. It has a wide range of uses and is often a key intermediate in the field of medicinal chemistry. Due to the structure of the special halogen atom and trifluoromethoxy group, it is endowed with unique chemical activity and physical properties. It can participate in various chemical reactions to synthesize drug molecules with specific biological activities.
In the field of pesticide chemistry, it is also an important starting material. With its structural characteristics, after a series of transformations, efficient and selective pesticide ingredients can be prepared to help agricultural pest control.
Furthermore, in the field of materials science, it also has potential applications. The polymers or organic materials that participate in the synthesis, or exhibit special electrical, optical and thermal properties, are expected to be used in electronic devices, optical materials and many other aspects. For example, when synthesizing conjugated polymers with specific photoelectric properties, this compound can be introduced as a structural unit to regulate the electronic structure and properties of the material.
In short, 1-bromo-2-chloro-5 - (trifluoromethoxy) benzene is of great value in the fields of medicine, pesticides and materials science. It is a basic raw material for many organic synthesis work and promotes research and development in various fields.
What are the physical properties of 1-Bromo-2-Chloro-5- (Trifluoromethoxy) Benzene?
1-Bromo-2-chloro-5- (trifluoromethoxy) benzene is a kind of organic compound. Its physical properties are quite characteristic and closely related to its own structure.
Looking at its appearance, it is usually a colorless to light yellow liquid. This color characteristic may be related to the functional groups such as bromine, chlorine and trifluoromethoxy contained in the molecular structure. The introduction of bromine atoms and chlorine atoms may cause the molecule to absorb and reflect external light, resulting in such a color.
The boiling point of this compound is within a certain range. Due to the existence of various forces between molecules, such as van der Waals forces and dipole-dipole forces generated by halogen atoms, the interaction between molecules is enhanced, so the boiling point is relatively high. The exact boiling point value will vary slightly due to differences in experimental conditions, but it is roughly within a certain range. The range of this interval is determined by the stability of the molecular structure and the strength of the intermolecular forces.
In terms of melting point, 1-bromo-2-chloro-5- (trifluoromethoxy) benzene also has a specific value. The symmetry and regularity of the molecule have a significant impact on the melting point. The molecular structure of this compound causes it to have a certain regular molecular arrangement in the solid state, thus forming a specific lattice structure. Intermolecular forces maintain the stability of the lattice. When the external temperature rises to a certain extent, the lattice is destroyed and the substance changes from solid to liquid, and this temperature is the melting point.
In terms of solubility, 1-bromo-2-chloro-5- (trifluoromethoxy) benzene exhibits good solubility in organic solvents. Due to its molecular structure, the benzene ring is hydrophobic, and the presence of bromine, chlorine atoms and trifluoromethoxy groups makes the molecule have a certain polarity. The polarity of the organic solvent matches the polarity of the molecule and follows the principle of similar miscibility, so it can be dissolved in organic solvents such as ether and dichloromethane. However, its solubility in water is poor. Due to the large difference between the polarity of water and the molecular polarity of the compound, it is difficult to form an effective interaction between water molecules and compound molecules, so it is not easy to dissolve in water.
Density is also one of its important physical properties. The density of the compound is related to the relative molecular weight and molecular structure. The relative atomic weight of bromine and chlorine atoms in the molecule is relatively large, and the structure of benzene ring and trifluoromethoxy group makes the molecular weight increase and the structure is relatively compact. Therefore, the density is relatively high, which is larger than that of some common organic compounds, showing a specific value. This value is quite valuable in chemical production and experimental operations.
Is 1-Bromo-2-Chloro-5- (Trifluoromethoxy) Benzene Chemically Stable?
The stability of the chemical properties of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene is related to many factors. In this compound, bromine, chlorine and trifluoromethoxy are connected to the benzene ring. The benzene ring has a conjugated system, which endows it with certain stability. However, bromine and chlorine are halogen atoms, which have electron-absorbing induction effects, which can reduce the electron cloud density of the benzene ring. In the trifluoromethoxy group, the fluorine atom has extremely high electronegativity and is also a strong electron-absorbing group, which further decreases the electron cloud density of the benzene ring.
From the perspective of reactivity, its electron cloud density of the benzene ring decreases, and the activity of electrophil However, in the nucleophilic substitution reaction, the halogen atom can be used as the leaving group. Bromine atoms are more likely to leave than chlorine atoms, because the C-Br bond energy is less than the C-Cl bond energy. When encountering nucleophilic reagents, bromine atoms can be substituted, causing molecular structure changes.
When the temperature increases, the thermal motion of the molecule intensifies, the reactivity also increases, and the stability decreases. In a specific solvent, if the solvent forms a hydrogen bond or has a strong polarity with the compound, its stability and reactivity can be affected. For example, polar solvents are conducive to the nucleophilic substitution reaction, because they can stabilize the transition state.
In summary, the chemical properties of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene are not absolutely stable, and may exhibit different reactivity and stability changes under different conditions.
What is the production process of 1-Bromo-2-Chloro-5- (Trifluoromethoxy) Benzene?
The production process of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene is an important issue in the field of chemical preparation. The process is complex and delicate, and it involves a variety of reaction conditions and operation skills.
The selection of starting materials is crucial. Benzene derivatives containing specific substituents are usually selected, supplemented by bromide, chloride and reagents containing trifluoromethoxy. At the beginning of the reaction, it is often necessary to create a suitable reaction environment, such as precise regulation of reaction temperature, pressure and reaction medium. Temperature may fluctuate in a specific range, pressure must also be maintained stable, and the nature of the reaction medium also affects the reaction process, or it may be a polar solvent to facilitate the dissolution of the reagents and the reaction. In the
reaction process, halogenation reaction is an important step. In the bromination and chlorination steps, high-efficiency halogenating reagents and catalysts need to be selected. When brominating, or using liquid bromine and a suitable catalyst, the catalyst can accelerate the reaction, so that the bromine atom precisely replaces the hydrogen atom at a specific position in the benzene ring. The chlorination process is the same, ensuring that the chlorine atom is replaced at a predetermined position and avoiding excessive halogenation.
The step of introducing trifluoromethoxy is more complicated. Or using a nucleophilic substitution reaction, using a nucleophilic reagent containing trifluoromethoxy to attack the benzene ring. This step requires strict reaction conditions, and the reaction time and temperature control are slightly deviated, which affects the purity and yield of the product.
After the reaction is completed, the Column chromatography, recrystallization method, etc. are commonly used. Column chromatography uses the action of stationary phase and mobile phase to separate products and impurities; recrystallization method is based on the difference in solubility of products and impurities in different solvents to achieve the purpose of purification. After many fine operations, high purity 1-bromo-2-chloro-5- (trifluoromethoxy) benzene can be obtained.
What is the price range of 1-Bromo-2-Chloro-5- (Trifluoromethoxy) Benzene in the market?
The price of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene in the market is difficult to determine. The range of its price often varies due to multiple reasons.
First, the price of raw materials is the main reason. If the price of the raw material for making this product fluctuates, the price of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene will follow. If the raw material is dilute and expensive, the price of this product will also be high; conversely, if the raw material is sufficient and the price is flat, the price of this product may drop.
Second, the craftsmanship is also related to its price. Sophisticated craftsmanship can reduce consumption and increase production, reduce its cost, and the price may decrease; if the craftsmanship is crude, consume more and produce less, the cost will increase, and the price will be difficult to suppress.
Third, the ups and downs of market demand are the cardinal of the price. When demand is prosperous, demand exceeds supply, and prices often rise; when demand is declining, supply exceeds demand, and prices fall more.
Fourth, the different sellers have different prices. Big or because of large purchases and excellent craftsmanship, the cost is slightly lower, and the price is cheaper; small merchants or because of various reasons, the price is slightly higher.
Generally speaking, in today's market, the price of 1-bromo-2-chloro-5- (trifluoromethoxy) benzene ranges from tens to hundreds of yuan per gram, but this is only an approximate amount. The actual price shall be subject to the current market price. Buyers who want to know the exact price can consult a chemical raw material supplier or visit a chemical trading platform to find out.