1-Bromo-2-Chloro-5-Fluorobenzene

Hongda Chemical

Specifications

HS Code	502849
Chemical Formula	C6H3BrClF
Molar Mass	225.44 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	Approximately 180 - 190 °C
Density	Around 1.7 - 1.8 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform
Flash Point	Caution, flammable, flash point likely in the range of 60 - 80 °C
Stability	Stable under normal conditions, but may react with strong oxidizing agents

As an accredited 1-Bromo-2-Chloro-5-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100 g of 1 - bromo - 2 - chloro - 5 - fluorobenzene packaged in a sealed glass bottle.
Storage	1 - Bromo - 2 - chloro - 5 - fluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and vapor release. Store it separately from oxidizing agents and reactive chemicals to avoid potential reactions. Follow proper labeling and safety procedures for handling this hazardous chemical.
Shipping	1 - bromo - 2 - chloro - 5 - fluorobenzene, a hazardous chemical, is shipped in well - sealed, corrosion - resistant containers. It follows strict regulations, with proper labeling indicating its nature, and is transported by carriers compliant with chemical shipping safety standards.

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General Information

Historical Development

1 - Bromo - 2 - Chloro - 5 - Fluorobenzene is an organic compound, and its historical development is very interesting. At the beginning, chemical research was not mature, and the exploration of halogenated aromatics was limited. At that time, the technology was not developed, and the analysis and detection methods were crude, so few people were interested in this compound.
However, science has evolved continuously. With the improvement of instrumental analysis technology, chemists have gained deeper insights into its structure and properties. The synthesis method has also changed from simple to complex. The early synthesis steps are complicated and the yield is low. After repeated research and improvement, new synthesis paths have emerged, and the yield and purity have increased.
In the past, chemical research was often localized, but now it is a global collaboration. Scientists from different regions communicate and discuss, promoting 1-Bromo-2-Chloro-5-Fluorobenzene research. It has emerged in the fields of materials science, medicinal chemistry, etc., and has a wide range of application prospects.

Product Overview

1 - Bromo - 2 - Chloro - 5 - Fluorobenzene is also an organic compound. Its molecular structure is unique, containing bromine, chlorine and fluorine halogen atoms on the benzene ring. The bromine atom occupies one position in the benzene ring, the chlorine atom is in the two position, and the fluorine atom is in the five position.
This substance has stable properties. It is a colorless to light yellow liquid at room temperature and has a special odor. Because it contains a variety of halogens, its chemical activity is quite high and it is widely used in the field of organic synthesis. It can be used as an intermediate to prepare various drugs, pesticides and functional materials.
The preparation method often uses benzene as the starting material. After halogenation reaction, the reaction conditions are precisely regulated, and bromine, chlorine and fluorine atoms are introduced to achieve the synthesis of the The reaction process requires attention to the proportion of reactants, temperature, and catalyst selection to improve yield and purity.
In short, 1-Bromo-2-Chloro-5-Fluorobenzene is an indispensable compound in the world of organic synthesis.

Physical & Chemical Properties

1 - Bromo - 2 - Chloro - 5 - Fluorobenzene is an organic compound, and its physical and chemical properties are very important. Looking at its physical properties, it is a colorless to light yellow liquid under normal conditions, with a special odor. Its boiling point and melting point are related to the existence of the substance. The boiling point is about a certain range, so that the gas-liquid conversion can be realized at the corresponding temperature. The melting point determines the temperature at which it transitions from solid to liquid.
When it comes to chemical properties, the bromine, chlorine and fluorine atoms in this compound give their unique reactivity. The electron cloud structure of the benzene ring is affected by these halogen atoms, and it is prone to electrophilic substitution reactions. Due to the difference in electronegativity of halogen atoms, the reaction check point and activity are different. Fluorine atoms have strong electron-absorbing ability, which decreases the density of the ortho-para-position electron cloud, and makes it easier for electrophilic reagents to attack the interposition. Due to these physicochemical properties, this compound can be used as a key intermediate in the field of organic synthesis and participates in the preparation of many complex organic compounds.

Technical Specifications & Labeling

There is a product today called 1 - Bromo - 2 - Chloro - 5 - Fluorobenzene. To clarify its technical specifications and identification (product parameters), it is necessary to explore in detail.
The technical specifications of this product are related to its chemical composition and physical properties. Its chemical structure is established, and bromine (Bromo), chlorine (Chloro), and fluorine (Fluor) atoms are arranged at specific positions in the benzene ring. This is its fundamental characteristic and also determines its chemical activity and reaction trend. Physical properties such as melting point, boiling point, density, etc., are all factors for measuring specifications and are related to their storage, transportation, and use.
As for the identification (product parameters), it is necessary to clarify its purity geometry and impurity content. The higher the purity, the better the quality, and the more advantageous it is in various application scenarios. And it must be marked with a clear name so that everyone can recognize it, and a safety warning is attached to inform the latent risk. Users must treat it with caution and prevent problems before they occur. In this way, the technical specifications and identification (product parameters) of this object can be made clear for all parties to use.

Preparation Method

In order to prepare 1 - Bromo - 2 - Chloro - 5 - Fluorobenzene, the raw materials and production process, reaction steps and catalytic mechanism are very important.
To make this compound, when the raw materials are selected. Based on compounds containing fluorine, chlorine and bromine, it is selected according to their chemical properties and reaction laws. The reaction step is to first make fluoroaromatics and chlorination reagents meet, control temperature, pressure and reaction, and then substitution reaction to obtain chlorofluorine-containing intermediates.
times, the intermediate is co-placed with the brominated reagent, and the various conditions of the reaction are adjusted to allow the bromine to be replaced smoothly and form the target product 1-Bromo-2-Chloro-5-Fluorobenzene.
The catalytic mechanism is also critical. Finding a suitable catalyst can promote the reaction speed and extract the product rate. Such as metal salts or organic ligands, the activation energy of the reaction can be reduced, making the reaction easy to proceed. After selecting the raw materials, controlling the reaction steps and using the catalytic mechanism, it is expected to efficiently prepare 1-Bromo-2-Chloro-5-Fluorobenzene.

Chemical Reactions & Modifications

Taste the wonders of chemistry, with all kinds of changes, related to reaction and modification, which is really an important task in the academic community. Today, take 1-Bromo-2-Chloro-5-Fluorobenzene as an example. The reactants, under various conditions, have different activities of halogen atoms. Bromine atoms are relatively active and are easily attacked by nucleophiles, causing substitution changes. However, chlorine and fluorine atoms are not idle, and their electronic effects affect the reactivity of the molecule as a whole.
If you want to modify this compound, you can adjust the reaction conditions, such as selecting suitable solvents, temperatures and catalysts. Seek new changes based on the temperature, or introduce other functional groups to give it new properties. This is not only about the ingenuity of synthesis, but also about the development of its talents in materials, medicine and other fields to gain practical ability. The road of exploration is long, and only by unremitting research can we achieve the subtlety of chemistry to meet all needs and become a wonder of creation.

Synonyms & Product Names

1 - Bromo - 2 - Chloro - 5 - Fluorobenzene, in the field of our chemical research, its synonymous name and the name of the commodity are all important for our investigation.
The name of the synonymous husband is obtained from the aspects of chemical structure and characteristics. Because it contains bromine (Bromo), chlorine (Chloro), fluorine (Fluor) elements, and is in a specific position in the benzene ring, it is named according to the chemical nomenclature. Or there are other names for its structural characteristics, but they are all inseparable from its chemical essence.
As for the name of the product, the merchant may name it according to its use and market positioning. Or used in fine chemical synthesis, it is the key raw material for the preparation of special materials, so it is named after its application scenario, and it is expected to recognize its unique value in the market.
Although the synonymous names and trade names are different, they all refer to this 1 - Bromo - 2 - Chloro - 5 - Fluorobenzene. Our chemical researchers should carefully distinguish its name to clarify its nature. It is used in scientific research and production to promote the progress of chemistry and benefit the world.

Safety & Operational Standards

1 - Bromo - 2 - Chloro - 5 - Fluorobenzene is an important chemical substance that is critical to its safety and operating practices.
When preparing this substance, all safety measures must be strictly implemented. First, the experimental site should be kept well ventilated to dissipate harmful gases and avoid their accumulation and danger. Second, the operator must wear complete protective equipment, such as protective clothing, protective gloves and goggles, to prevent the substance from touching the skin and eyes and causing damage. Third, all operations should be done with caution in the fume hood, which can effectively control gas emissions and ensure the safety of the experimental environment.
Discussing the operating specifications, first of all, the weighing and ratio of raw materials must be accurate. A slight deviation may cause the reaction result to not meet expectations, or cause unexpected situations. Secondly, the temperature, pressure and other conditions of the reaction process need to be closely monitored and regulated. If the temperature is too high, the reaction may go out of control; if the pressure is abnormal, there is also a latent risk. Furthermore, the handling of the product after the reaction should not be sloppy. The established process should be followed to properly separate and purify the product, and the waste should be properly disposed of to meet environmental protection requirements.
In terms of storage, 1 - Bromo - 2 - Chloro - 5 - Fluorobenzene should be placed in a cool, dry and well-ventilated place, away from sources of ignition and oxidants. In this way, the stability of the substance can be ensured and safety accidents can be avoided due to improper storage.
In conclusion, the safety and operating specifications of 1 - Bromo - 2 - Chloro - 5 - Fluorobenzene are interlinked and cannot be ignored. Only by strictly following these specifications can the expected experimental or production objectives be achieved on the basis of ensuring the safety of personnel and the environment.

Application Area

1 - Bromo - 2 - Chloro - 5 - Fluorobenzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often a key intermediate. Due to the characteristics of halogen atoms on the benzene ring, it can participate in a variety of chemical reactions to build complex drug molecular structures, help develop new drugs, and cure various diseases.
In the field of materials science, it also has important functions. It can be introduced into polymer materials through specific reactions, giving materials unique physical and chemical properties, such as enhancing the stability of materials, improving their electrical properties, etc., making materials suitable for electronic devices, optical materials and many other aspects.
In the field of fine chemicals, it can be used to prepare special organic reagents and additives. With its unique chemical structure, it can optimize the performance of chemical products, improve product quality, and meet the stringent needs of fine chemicals in different industries. In short, 1 - Bromo - 2 - Chloro - 5 - Fluorobenzene has an indispensable position in many fields and has made great contributions to scientific and technological progress and industrial development.

Research & Development

We are committed to the research and development of 1 - Bromo - 2 - Chloro - 5 - Fluorobenzene. This compound has unique properties and great potential in the field of organic synthesis.
At the beginning, we explored the method of its preparation, and after many attempts. Or improve the old method, or explore a new way, and strive for efficient and pure synthesis. In the process, the choice of raw materials and the control of reaction conditions are all key. Temperature, pressure, and catalyst dosage can affect the quality and quantity of the product if there is a slight difference.
Then, study its reactivity. Observe its reaction with various reagents, study the reaction mechanism, and hope to expand its application. After repeated tests, it has been shown that it can participate in various reactions under specific conditions, providing a new path for the construction of organic molecules.
Looking to the future, we hope to further explore its potential based on this. Or develop novel synthesis strategies, or expand its application in drug development, materials science and other fields, hoping to contribute to the development of related industries and promote the research and development of this compound to a new height.

Toxicity Research

In recent research, there are 1 - Bromo - 2 - Chloro - 5 - Fluorobenzene. This substance is also strong and toxic, and it is very dangerous to the human body and its surroundings.
Looking at its structure, bromine, chlorine, and fluorine atoms are attached to the benzene ring. These atoms are very active, making the chemical properties of the substance extremely unstable. According to toxicology, it may enter the human body, disrupt the metabolism of cells, and harm the function of organs.
Tested on animals, see the animal tested, there is a state of mental exhaustion, loss of diet, and even life-threatening. It is also applied to plants and trees. Looking at its growth, it also shows abnormalities. The leaves are yellow and the branches are withered, and the vitality is gradually dying.
And if this thing flows into the environment, water, soil, and air will all be polluted by it. In water, it poisons water and life, in soil, it damages the fertility of soil, and in qi, it filth the air. Therefore, when studying the poison of this thing, we should be very careful to prevent it from escaping and becoming a disaster to the world. We must find a proper way to control its poison and make good use of it.

Future Prospects

Fu 1 - Bromo - 2 - Chloro - 5 - Fluorobenzene has shown extraordinary quality in today's chemical research. Looking at its structure, the atoms of bromine, chlorine and fluorine are combined on the benzene ring, giving it unique properties and opening up many undiscovered fields.
Looking forward to the future, it is expected to shine in the creation of medicine. With its special chemical activity, it may be the basis for new drugs and break many difficult diseases. In the realm of material science, it can become the essence of materials with unique properties and expand the boundaries of material applications.
And the research on the reactivity of this substance also has unlimited potential. Explore the reaction between it and various reagents, or gain novel reaction paths, adding a new chapter to organic synthesis. In the coming days, with the deepening of research and the advancement of technology, 1 - Bromo - 2 - Chloro - 5 - Fluorobenzene will unleash its great power and become a treasure in the field of chemistry, opening up a new journey in the future, leading everyone to explore the unknown, and drawing a bright grand picture.

Where to Buy 1-Bromo-2-Chloro-5-Fluorobenzene in China?

As a trusted 1-Bromo-2-Chloro-5-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 1-Bromo-2-Chloro-5-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 1-bromo-2-chloro-5-fluorobenzene?

Mercury, bromine, gallium, and cesium are all unique substances, each with its own physical properties.
Mercury is a liquid at room temperature and is the only liquid metal. It is like a silver-white flowing pearl, shining with luster. Its density is quite high, reaching 13.59 grams/cubic centimeter, and it is abnormally heavy. The melting point of mercury is -38.87 ° C and the boiling point is 356.6 ° C. This melting point allows it to maintain a liquid state at low temperatures. Mercury has excellent fluidity, resembling smart water, but it is heavy and unique.
For bromine, it is a dark reddish-brown smoky liquid at room temperature and pressure, emitting a strong pungent smell, as if warning everyone of its danger. The density of bromine is 3.119 grams/cubic centimeter, which is heavier than water. Melting point -7.2 ℃, boiling point 58.78 ℃, this characteristic makes it a liquid in the common temperature range, but it is also easy to evaporate into reddish-brown vapor, and its vapor toxicity is quite strong.
The characteristics of gallium are also interesting. When solid, it is soft and can be easily cut with a knife, which seems to be different from the hardness of common metals. Its melting point is extremely low, only 29.78 ℃. If it is slightly warm, it will turn into a liquid in the palm of your hand, which is amazing. The boiling point of gallium is as high as 2403 ℃, and the difference between the melting boiling points is rare in the world. Its liquid range is extremely wide, with a density of 5.904 grams/cubic centimeter.
Cesium is active, silver-white and slightly golden in color, soft as wax, and can be deformed with light force. The melting point of cesium is as low as 28.44 ° C, which is similar to body temperature. It melts into a liquid state when heated slightly. Its density is 1.8785 grams per cubic centimeter, which is among the lighter metals. Its chemical properties are extremely active, and it reacts violently when exposed to water, and even causes an explosion.

What are the chemical properties of 1-bromo-2-chloro-5-fluorobenzene?

The chemical properties of mercury, bromine, astatine, and thallium are as follows:
Mercury, commonly known as mercury, is the only metal that is liquid at room temperature. Its chemical properties are relatively stable, and it does not react with non-oxidizing acids such as dilute hydrochloric acid and dilute sulfuric acid, but can react with oxidizing acids such as concentrated sulfuric acid and concentrated nitric acid. Mercury can quickly combine with sulfur powder at room temperature to form mercury sulfide, which is often used to treat spilled mercury. Mercury also easily forms amalgams with many metals, and amalgams are used in metallurgy and other fields.
Bromine is the only non-metallic elemental substance that is liquid at room temperature and pressure. It has a strong pungent odor and strong oxidizing properties. Bromine can react with metals, such as iron, to form iron bromide. Bromine can also react with some non-metals, such as reacting with hydrogen under certain conditions to form hydrogen bromide. In organic chemistry, bromine is often used as a brominating agent to introduce bromine atoms into organic compounds, such as addition reactions with olefins.
astatine, a halogen element, is radioactive. Due to its short half-life and minimal yield, the study of its chemical properties is limited. Based on the progressive law of halogen elements, astatine is less oxidizing than bromine, chlorine, etc. It should be able to react with metals to form astatine compounds. It may also be used as a halogen agent in organic reactions, but the reactivity may be lower than other halogen elements.
thallium, is a heavy metal element. The chemical properties of thallium are relatively active, can react with oxygen, and are easily oxidized on the surface in the air. Thallium can react with acids to replace hydrogen. Most of the compounds of thallium are highly toxic, and their common valence in compounds is + 1 and + 3, and the + 1 valence compounds are relatively stable. Some salts of thallium, such as thallium sulfate and thallium nitrate, are easily soluble in water, which makes thallium easy to migrate in the environment and be absorbed by organisms, causing serious environmental and health problems.

In what fields is 1-bromo-2-chloro-5-fluorobenzene used?

Mercury, alum, and mirabilite are used in many places.
Mercury, also known as mercury, is a liquid metal. In the art of alchemy, the ancients believed in its miraculous effect and wanted to use it to refine the medicine of longevity. Many alchemists took mercury as their main purpose and smelted it in an alchemy furnace. Although they did not obtain the magic of longevity, they promoted the development of this technique. Mercury is also used in medicine, and can be used to make external drugs to treat scabies and other diseases. In the field of metallurgy, amalgamation can extract gold and silver, and use mercury and gold and silver to form amalgams, which are then heated and separated to obtain pure gold and silver.
Alum, taking alum as an example, is widely used. In the paper industry, it is a sizing agent, which can make the paper difficult to ink in contact with water, improving the quality of writing and printing. In food processing, alum is often used as a leavening agent, such as when frying fritters, which is heated to decompose and produce gas, making the fritters expand and crispy. In water treatment, alum is hydrolyzed to form an aluminum hydroxide colloid, which can absorb suspended impurities in water and clarify the water.
Mirabilite, that is, sodium sulfate crystalline hydrate. In medicine, it has the effect of purging heat, which can treat heat stagnation and dry stool. In the chemical industry, it is an important raw material for the manufacture of sodium sulfide, sodium silicate and other chemical products. In glass manufacturing, it can be used as a flux to reduce the melting point of glass raw materials, promote glass formation, and improve glass quality.
It can be seen that mercury, alum, and mirabilite played an important role in the ancient people's life, production, and medicine, reflecting the understanding and utilization of material properties and uses at that time.

What is the synthesis of 1-bromo-2-chloro-5-fluorobenzene?

To prepare 1-mercury-2-bromo-5-hydroxynaphthalene, the method is as follows:
First take an appropriate amount of naphthalene and sulfonate it with concentrated sulfuric acid. When sulfonating, pay attention to the reaction temperature and time, so that the specific position of the naphthalene can be sulfonated to generate the corresponding sulfonic acid derivative. The key to this step is to precisely control the reaction conditions to ensure the accuracy of the sulfonation check point.
Following the bromination reaction with bromine. In an appropriate reaction system, slowly drop bromine and closely monitor the reaction process. By observing the color change of the reaction and using specific analytical methods, etc., it is possible to ensure that the bromine atom is replaced in the specific position as expected to obtain the bromosulfonic acid derivative naphthalene.
Then the bromosulfonate naphthalene derivative is hydrolyzed under alkaline conditions to convert the sulfonic acid group into a hydroxyl group. During the hydrolysis process, the concentration of the base, the reaction temperature and time are all important factors, and should be carefully regulated to obtain the intermediate of the target product.
Finally, with a suitable reducing agent and under a suitable reaction environment, mercury ions at a specific location in the intermediate product are introduced. This process requires strict control of the reaction conditions to avoid the occurrence of side reactions and ensure that mercury atoms are precisely bound to the specified position, so as to successfully obtain 1-mercury-2-bromo-5-hydroxynaphthalene.
Separation and purification of the product between each step of the reaction is also crucial. Recrystallization, extraction, column chromatography, etc. can often be used to remove impurities and improve the purity of the product to meet the requirements of final synthesis.

What are the precautions during the use of 1-bromo-2-chloro-5-fluorobenzene?

"Tiangong Kaiwu" says: Mercury, that is, mercury, is also in the same body as silver. Its quality is in the same body as salt, and it will soar when it enters the fire, and it will no longer be in the same body. Where mercury is used, care must be taken.
Mercury is toxic and volatile. When using mercury, the first thing to pay attention to is ventilation. Because of its volatilization of mercury gas, if inhaled into the human body for a long time, it will be harmful and damage the organs and nerves. Therefore, mercury must be placed in a well-ventilated place to install a wind cabinet to promote air circulation and reduce the accumulation of mercury gas.
Furthermore, avoid direct contact with mercury. Mercury touches the skin and can seep into the body, causing the risk of poisoning. When handling mercury, it is advisable to use protective equipment, such as gloves, and do not touch it directly with your hands.
Also, if mercury is spilled, deal with it quickly. Because of its good fluidity, it is easy to disperse into small beads and difficult to collect. Once it is spilled, it can be covered with sulfur powder. Mercury and sulfur quickly dissolve mercury sulfide, which greatly reduces toxicity, and then carefully sweep it up and dispose of it properly.
When using mercury utensils, be sure to choose carefully. Do not use utensils made of materials that are easy to react with mercury to prevent damage to the utensils and prevent mercury from mutating. And utensils need to be well sealed to prevent mercury volatilization.
Furthermore, people who use mercury should be familiar with its properties and emergency measures. If you have symptoms of mercury poisoning, such as headache, dizziness, fatigue, etc., seek medical attention immediately. Daily mercury management, it is advisable to always prepare antidote drugs, just in case.
The use of mercury is related to life and things, and must not be taken lightly. You need to pay attention everywhere and follow the law to ensure safety.