1-Bromo-2-Chloro-4-Fluorobenzene

Hongda Chemical

Specifications

HS Code	144827
Chemical Formula	C6H3BrClF
Molar Mass	211.44 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	192 - 194 °C
Melting Point	N/A
Density	1.724 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Flash Point	76 °C
Purity	Typically high - purity available in chemical markets, e.g., 98%+

As an accredited 1-Bromo-2-Chloro-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - bromo - 2 - chloro - 4 - fluorobenzene in 500 - gram glass bottles for chemical packaging.
Storage	1 - Bromo - 2 - chloro - 4 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store it in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics, to prevent leakage and exposure to air or moisture, which could potentially lead to decomposition or unwanted reactions.
Shipping	1 - bromo - 2 - chloro - 4 - fluorobenzene is shipped in tightly sealed, corrosion - resistant containers. These are carefully packed in sturdy outer boxes with appropriate cushioning to prevent damage during transit, following strict chemical shipping regulations.

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General Information

Historical Development

1 - Bromo - 2 - Chloro - 4 - Fluorobenzene is an organic compound. Tracing its historical development, chemists in the past have gradually deepened their research on organic halides. At first, only simple halogenated benzenes could be prepared. Later, with the evolution of technology, the separation and synthesis methods have improved.
In the early days, chemists focused on the study of single halogen substituted benzene, but they were not involved in polyhalogen substitutions. With the deepening of the understanding of the reaction mechanism, the reaction conditions could be regulated to achieve precise synthesis of polyhalogenated benzene. The synthesis of 1 - Bromo - 2 - Chloro - 4 - Fluorobenzene has also emerged. Its synthesis requires clever selection of reaction materials and conditions to achieve specific substitution positions and proportions. The birth of this compound adds a new chapter to organic synthetic chemistry, revealing potential application value in medicine, materials and other fields, and opening a new journey of exploration.

Product Overview

1 - Bromo - 2 - Chloro - 4 - Fluorobenzene is an important organic halogenated aromatic hydrocarbon. Its appearance is colorless to light yellow liquid with a special odor. In the structure of this compound, the substitutions of bromine, chlorine and fluorine atoms on the benzene ring are unique, giving it specific chemical properties.
In the field of organic synthesis, 1 - Bromo - 2 - Chloro - 4 - Fluorobenzene is often used as a key intermediate. Due to the difference in activity of halogen atoms, various functional groups can be introduced through reactions such as nucleophilic substitution, and then complex organic molecular structures can be constructed.
The preparation of 1 - Bromo - 2 - Chloro - 4 - Fluorobenzene involves fine regulation of the halogenation reaction of benzene ring. High selectivity of the target product can be achieved by selecting suitable halogenation reagents and reaction conditions.
When storing and using, pay attention to its chemical activity and potential danger to ensure safe operation. In short, 1 - Bromo - 2 - Chloro - 4 - Fluorobenzene plays an indispensable role in both organic chemistry research and industrial production.

Physical & Chemical Properties

1 - Bromo - 2 - Chloro - 4 - Fluorobenzene is an organic compound, and its physical and chemical properties are very important. Looking at its physical properties, at room temperature, this substance is often in a liquid state, with a specific boiling point and melting point. The boiling point is related to the temperature at which it changes from liquid to gaseous state. This property is crucial in the separation and purification process. The melting point determines the temperature at which it changes from solid to liquid.
On its chemical properties, the presence of bromine, chlorine, and fluorine atoms in its molecular structure gives it unique reactivity. This halogen atom can participate in many chemical reactions, such as nucleophilic substitution reactions. Under suitable conditions, it can be replaced by other nucleophilic reagents, and then a variety of organic compounds can be derived. Its chemical stability is also worth exploring. The stability of its chemical structure may vary in different environments, which is of great significance for the storage and use of this compound. Studying its physical and chemical properties can lay a solid foundation for applications in related fields.

Technical Specifications & Labeling

Today there is a product called 1 - Bromo - 2 - Chloro - 4 - Fluorobenzene. The method of making it is related to the technical specification and identification (product parameters). To make this product, follow the method of precision. In the chemical industry, the ratio of raw materials must be accurate, and the temperature and time of the reaction must also be heavy.
In terms of identification, specify its properties. Such as appearance, or the state of a certain color; purity geometry, related to quality. Its chemical properties, and the reaction under specific conditions should be clearly marked. This technical specification is the standard for producing this product; the parameters shown in the label are the evidence for its quality. Following these two, the production of 1-Bromo-2-Chloro-4-Fluorobenzene can be guaranteed.

Preparation Method

This product of 1 - Bromo - 2 - Chloro - 4 - Fluorobenzene is the key to raw materials and production process, reaction steps and catalytic mechanism.
To make this product, first take a suitable aromatic hydrocarbon, which has a stable structure and reactivity. Starting with benzene derivatives, bromine, chlorine and fluorine atoms are introduced in sequence. On aromatic hydrocarbons, through halogenation reaction, specific halogenating agents, such as brominating agents, chlorinating agents and fluorinating agents, are selected according to their own characteristics, and temperature and pressure are selected.
First, a brominating agent is used to meet aromatic hydrocarbons, and the temperature is controlled at tens of degrees Celsius. A catalyst, such as an iron-based or aluminum-based catalyst, is used to introduce bromine atoms into a specific position of the aromatic ring to obtain bromoaromatic hydrocarbons. Then a chlorinating agent is used to respond, and the temperature and pressure are adjusted to make the chlorine atoms enter the established position to form bromochloroaromatic hydrocarbons. Finally, a fluorinating agent is used to replace the fluorine atoms in a precise place under harsher conditions, using the power of catalysis to obtain 1-Bromo-2-Chloro-4-Fluorobenzene.
The reaction steps are rigorous and orderly, and the conditions of each step must be fine-tuned to prevent side reactions from occurring, so as to increase the purity and yield In the catalytic mechanism, the catalyst activates the reactants, reduces the energy barrier of the reaction, and promotes the precise substitution of atoms, resulting in the efficient preparation of this chemical.

Chemical Reactions & Modifications

1 - Bromo - 2 - Chloro - 4 - Fluorobenzene is an important compound in organic synthesis. The chemical reaction of its synthesis is related to many chemical changes and improvement of properties.
In the past, the synthesis of this compound was mostly based on the traditional halogenation reaction. However, the traditional reaction has many side reactions and low yield. For example, the choice and dosage of halogenating agent have a great impact on the purity and yield of the product. If the halogenating agent is excessive, although it can promote the reaction, it is easy to cause the formation of polyhalogenated by-products, which increases the difficulty of separation.
Today, chemists are working to improve this reaction. By using new catalysts, the reaction selectivity can be improved and side reactions can be effectively reduced. The new catalyst can precisely adjust the reaction check point, so that the halogen atom replaces the hydrogen atom in the benzene ring according to the predetermined position. At the same time, optimizing the reaction conditions, such as precise control of temperature, pressure and reaction time, also has a profound impact on the performance of the product. The appropriate temperature range can make the reaction rate moderate, avoid the reaction runaway due to high temperature, or the slow reaction and low yield due to low temperature. These improvements aim to improve the synthesis efficiency and product quality of 1-Bromo-2-Chloro-4-Fluorobenzene to meet the needs of chemical, pharmaceutical and other fields.

Synonyms & Product Names

1 - Bromo - 2 - Chloro - 4 - Fluorobenzene is an important chemical substance. Its synonyms and trade names have also attracted much attention in our research field.
This compound, its synonyms may vary according to its chemical structure characteristics. Due to chemical naming rules, there may be aliases that describe its atomic connections and arrangements from different angles.
As for the trade name, merchants often depend on market demand, product characteristics and other factors. Or take a name that is concise and easy to remember for promotion; or associated with product use and quality, hoping to attract consumer attention.
In chemical research, a clear understanding of its synonyms and trade names is conducive to accurate communication, literature review, and Product Research & Development. In this way, misunderstandings caused by name confusion can be avoided, and the research work can be carried out smoothly and in-depth in chemical exploration.

Safety & Operational Standards

1 - Bromo - 2 - Chloro - 4 - Fluorobenzene Safety and Operation Specifications
Husband 1 - Bromo - 2 - Chloro - 4 - Fluorobenzene, also organic halides. In the field of chemical research and production, its application is becoming more and more extensive, but its safety and operation specifications cannot be ignored.
First word safety. This compound is toxic and irritating, and can cause human damage when exposed to the skin, inhaled its vapor, or taken by mistake. Therefore, when handling this substance, protective equipment, such as gas masks, protective gloves and protective clothing, must be worn to prevent it from coming into contact with the human body. And in a well-ventilated place, it is best to do it in a fume hood to make the steam dissipate quickly and avoid accumulation in the air.
Times and operating specifications. When taking it, when using a precise measuring tool, take it according to the amount required by the experiment, do not take more, so as to avoid waste and risk. When dissolving this substance in a solvent, it should be added slowly and stirred to dissolve it evenly. During the reaction process, pay attention to temperature, pressure and other conditions, and control it according to established procedures. If there is any abnormality, stop the operation immediately, check the cause, and remove hidden dangers.
Also, store this substance in a cool, dry and ventilated place to avoid heat and fire sources. Store it separately with oxidants, strong alkalis and other substances to avoid chemical reactions. After use, the leftovers and waste should be disposed of in accordance with regulations, and should not be discarded at will to prevent pollution of the environment.
In short, those who operate 1 - Bromo - 2 - Chloro - 4 - Fluorobenzene must understand their safety and operating standards, and be rigorous in order to ensure the smooth operation of the experiment and protect people's safety and cleanliness.

Application Area

1 - Bromo - 2 - Chloro - 4 - Fluorobenzene, this chemical substance is useful in various fields. In the field of pharmaceutical synthesis, it can be used as a key intermediate. Due to its unique structure, it can introduce specific functional groups through various reactions to obtain drugs with specific curative effects. For example, some targeted drugs for specific diseases may be used in the synthesis path to build the structure of drug molecules through exquisite reaction steps, so as to benefit human health.
In the field of materials science, it is also quite valuable. By means of chemical modification, it can be integrated into polymer materials and endow materials with novel properties. It can enhance the stability of materials or improve their optical properties, making materials stand out in fields such as optical devices and electronic components, contributing to the development of materials science and the birth and application of new materials.

Research & Development

I am committed to the study of 1 - Bromo - 2 - Chloro - 4 - Fluorobenzene. At first, the molecular structure of bromine, chlorine and fluorine atoms are the key to the study. By means of chemical synthesis, explore a variety of pathways. Or start with a benzene ring, and introduce each halogen atom in sequence through a substitution reaction.
However, the process is not smooth sailing, and the reaction conditions, such as temperature, catalyst type and dosage, need to be carefully regulated. A little carelessness, the product is impure, or the reaction is difficult to advance.
After repeated experiments, a better synthesis method was finally obtained. And study its physical and chemical properties, solubility and stability in different solvents. This achievement is expected to provide assistance for the development of related fields, such as medicine and material synthesis. With time, continuous research may expand its application scope and achieve greater breakthroughs and development.

Toxicity Research

There is a thing today, named 1 - Bromo - 2 - Chloro - 4 - Fluorobenzene. I use the body of a chemist to investigate its toxic properties.
This thing contains halogen atoms and has a unique structure. Its bromine, chlorine, and fluorine atom positions may cause it to have special activities. After various tests, check its response to other things. Under certain circumstances, when it encounters a certain reagent, it causes a violent change, or produces toxic substances.
Watch it enter the body of the living thing, flow through the bloodline, and disturb its normal work in the organs. The metabolism of cells is thus chaotic, and the order of physiology is gradually perverse. And this thing is also difficult to self-dissolve in the environment, and it will accumulate and cause harm over time.
From this perspective, 1 - Bromo - 2 - Chloro - 4 - Fluorobenzene is highly toxic and cannot be ignored. Use it carefully and study it carefully to prevent it from being a disaster to the world.

Future Prospects

I look at this world, chemistry is improving with each passing day. Today there is 1 - Bromo - 2 - Chloro - 4 - Fluorobenzene, which has infinite potential in the field of chemistry.
Looking at the future prospects of the husband, first, or in the way of drug research and development, it shines brightly. With its unique structure, it may be the cornerstone of creating new medicines, conquering intractable diseases and saving all people from diseases. Second, in the way of materials science, it is also possible. It may help to develop materials with specific properties, which can be used in the fields of aerospace and electronics, and promote the leap of science and technology.
Furthermore, with the rise of the concept of green chemistry, how to prepare this substance more efficiently and environmentally friendly should be the focus of future research. If this breakthrough can be made, it will definitely contribute to the sustainable development of the chemical industry. I firmly believe that in time, 1 - Bromo - 2 - Chloro - 4 - Fluorobenzene will be able to bloom on the stage of the future and contribute to the well-being of mankind.

Where to Buy 1-Bromo-2-Chloro-4-Fluorobenzene in China?

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Frequently Asked Questions

As a leading 1-Bromo-2-Chloro-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 1-Bromo-2-Chloro-4-Fluorobenzene?

1-Bromo-2-chloro-4-fluorobenzene, this is an organohalogenated aromatic hydrocarbon with unique chemical properties.
Its reactivity is highly affected by halogen atoms. Bromine, chlorine and fluorine atoms all have electron-absorbing induction effects, which can reduce the electron cloud density of the benzene ring, making the electrophilic substitution activity of the benzene ring inferior to that of benzene. However, different halogen atoms have different electron-absorbing abilities. Fluorine has the strongest electronegativity, and the electron-absorbing induction effect is the most significant. Chlorine is followed by bromine. In the electrophilic substitution reaction, the new substituents tend to enter the ortho-site or para-site of the halogen because the halogen is an ortho-site group. However, in view of the steric hindrance and electronic effect, the proportion of substitution products in each position varies.
In nucleophilic substitution reactions, although fluorine atoms have strong electron-absorbing ability, the nucleophilic substitution reaction activity is not as good as that of bromine and chlorine due to the large bond energy of C-F bonds. The carbon-halogen bond attached to the bromine atom is relatively easy to break, and under appropriate conditions, it is more likely to be replaced by nucleophilic reagents.
1-bromo-2-chloro-4-fluorobenzene also participates in metal-catalyzed reactions, such as palladium-catalyzed cross-coupling reactions. In such reactions, it can be coupled with carbon-containing nucleophilic reagents to form carbon-carbon bonds and generate
In addition, its physical properties, because the molecule contains multiple halogen atoms, the relative density is greater than that of water, insoluble in water, soluble in common organic solvents, such as ether, dichloromethane, etc. Its boiling point and melting point are affected by the intermolecular forces. Multiple halogen atoms enhance the intermolecular forces, and the melting boiling point is relatively high.
In short, the chemical properties of 1-bromo-2-chloro-4-fluorobenzene are determined by the benzene ring and the connected halogen atoms, and have important application value in the field of organic synthesis.

What are the common uses of 1-Bromo-2-Chloro-4-Fluorobenzene?

1-Bromo-2-chloro-4-fluorobenzene is also an organic compound. Its common uses are wide.
First, in the field of pharmaceutical synthesis, this compound is often a key intermediate. Due to the properties of halogen atoms, various chemical reactions, such as nucleophilic substitution reactions, can be used to introduce various functional groups to construct complex drug molecular structures. For example, nucleophiles such as nitrogen and oxygen can be reacted with to prepare compounds with specific pharmacological activities, paving the way for the creation of new drugs.
Second, in the field of pesticide research and development, 1-bromo-2-chloro-4-fluorobenzene also occupies an important position. The structure of halogenated aromatics endows it with certain biological activities, and it can be chemically modified to develop pesticides with high efficiency in killing or inhibiting pests. Due to its unique structure, it may improve the selectivity and environmental compatibility of pesticides and reduce the impact on non-target organisms.
Furthermore, in the field of materials science, this compound can participate in the synthesis of polymer materials. By polymerizing with other monomers, it can give materials special properties, such as improving the thermal stability and chemical stability of materials. For example, in the preparation of some high-performance engineering plastics, the introduction of such halobenzene ring structures can optimize the mechanical properties and chemical corrosion resistance of the materials.
In addition, in the basic research of organic synthetic chemistry, 1-bromo-2-chloro-4-fluorobenzene is a commonly used model compound. Chemists can explore new reaction mechanisms and synthesis methods by studying its reactivity, promote the development of organic synthetic chemistry, and provide theoretical basis and practical guidance for the efficient synthesis of more complex organic compounds.

What are 1-Bromo-2-Chloro-4-Fluorobenzene synthesis methods?

There are several common methods for the synthesis of 1-bromo-2-chloro-4-fluorobenzene.
One is the halogenation reaction path. Using benzene as the starting material, bromine atoms are introduced through a bromination reaction. Usually liquid bromine is used as the bromination reagent. Under the action of iron powder or iron tribromide catalyst, benzene and bromine undergo an electrophilic substitution reaction to generate bromobenzene. This step requires attention to the reaction temperature and catalyst dosage to prevent the formation of polybrominated by-products.
Then bromobenzene is chlorinated. Chlorine is selected as the chlorination agent. In the presence of light or Lewis acid catalyst, bromobenzene can be chlorinated and chlorine atoms can be introduced at specific positions on the benzene ring. In this process, the reaction conditions need to be precisely controlled to achieve the purpose of chlorination at specific positions. Finally, fluorine atoms are introduced through fluorination reaction. Nucleophilic substitution is often used to react with chlorine and bromine intermediates in polar aprotic solvents with suitable fluorine sources, such as potassium fluoride, to achieve the substitution of fluorine atoms to halogen atoms at specific positions, thereby preparing 1-bromo-2-chloro-4-fluorobenzene.
The second is an aromatic hydrocarbon containing a specific substituent as the starting material. If the starting aromatic hydrocarbon already contains some of the desired substituents, the target molecular structure can be gradually constructed through selective halogenation, functional group conversion and other steps. For example, starting from an aromatic hydrocarbon with a suitable positioning group, using the guiding effect of the positioning group, the subsequent halogenation reaction selectively occurs at the desired position, and then after appropriate conversion and modification, 1-bromo-2-chloro-4-fluorobenzene can be obtained. This path requires in-depth understanding of the structure and reactivity of the starting aromatic hydrocarbon, and clever use of positioning effects to effectively synthesize the target product.
When synthesizing 1-bromo-2-chloro-4-fluorobenzene, regardless of the method used, attention should be paid to the precise control of reaction conditions, the inhibition of side reactions, and the separation and purification of the product to improve the yield and purity of the product.

What do 1-Bromo-2-Chloro-4-Fluorobenzene need to pay attention to when storing and transporting?

1-Bromo-2-chloro-4-fluorobenzene is also an organic compound. When storing and transporting it, many matters must be paid attention to.
First words storage, this compound should be placed in a cool and well ventilated place. Cover its properties or change due to heat, under high temperature, or cause decomposition, volatilization, and even cause dangerous chemical reactions. Therefore, choose a cool place to ensure the stability of its chemical properties. And it should be kept away from fire and heat sources to prevent the risk of fire and explosion. Fire and heat sources can easily cause the temperature of the compound to rise sharply, triggering uncontrollable reactions.
Furthermore, the storage place must be dry. Because water or moisture can react with 1-bromo-2-chloro-4-fluorobenzene, its purity and quality are affected. If the environment is humid, water vapor adheres to the compound, or reactions such as hydrolysis occur, changing its chemical structure.
In addition, this compound should be stored separately from oxidants and bases. Oxidants are highly oxidizing and meet 1-bromo-2-chloro-4-fluorobenzene, or cause severe oxidation reactions; alkali substances may also chemically react with it, damaging their original properties.
As for transportation, be careful when handling. Lightly pack and unload to avoid collisions and falls. If the packaging of the compound is damaged, the substances in it may leak, or cause harm to the environment and human body. And during transportation, appropriate temperature and humidity conditions should also be maintained, as required during storage. The transportation vehicle should also ensure that it is clean and free of other substances that can react with it to prevent pollution and accidental reactions. In this way, the safety and stability of 1-bromo-2-chloro-4-fluorobenzene during storage and transportation are guaranteed.

What are the effects of 1-Bromo-2-Chloro-4-Fluorobenzene on the environment and human health?

1-Bromo-2-chloro-4-fluorobenzene is one of the organohalogenated aromatic hydrocarbons. The impact of this substance on the environment and human health cannot be ignored.
In the environment, 1-bromo-2-chloro-4-fluorobenzene is difficult to naturally degrade and easy to accumulate due to its stable chemical structure. If released in water bodies, it can cause water pollution and harm aquatic organisms. It may affect the reproduction, development and survival of aquatic organisms, and reduce biodiversity. And it can be enriched through the food chain, causing the concentration of high trophic level organisms to gradually rise, endangering the balance of ecosystems.
In terms of human health, 1-bromo-2-chloro-4-fluorobenzene is potentially harmful. If ingested by humans through breathing, diet or skin contact, it may endanger health. Animal experiments have shown that it may be hepatotoxic and nephrotoxic, impairing liver and kidney functions. And this substance may be a potential carcinogen, and long-term exposure increases the risk of cancer. It is also neurotoxic, or affects the normal function of the nervous system, causing headache, dizziness, fatigue, etc.
Therefore, in the production, use and disposal of 1-bromo-2-chloro-4-fluorobenzene, care should be taken to prevent it from polluting the environment and harming human health. Strict control and effective protection are implemented to ensure ecological safety and personal health.