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What are the main uses of 1-bromo-2-chloro-3- (trifluoromethyl) benzene?
(1) Gan is the meaning of water entering the boat, and it also has the solution of fishing. Its use in life, in the past, it was necessary to travel on the water, waterproof into the cabin. The word "Gan" refers to the safety of the boat and the fisherman's livelihood. If the boat leaks, it needs to be blocked quickly to ensure that the navigation is safe, which is the key to water transportation and fishing. Fishermen depend on the boat for a living, and the integrity of the boat is related to their livelihood. The things expressed by "Gan" maintain the smooth water activities.
(2) Alkane is a class of organic compounds, mostly gases, liquids or solids. In industry, it is an important chemical raw material. Take methane as an example. It is the main component of natural gas and is used as a fuel to supply energy. It is indispensable for people's livelihood and industrial production. Many alkanes are used to synthesize plastics, rubber, fibers and other materials, such as polyethylene plastics, which are derived from ethylene, and ethylene is obtained by cracking alkanes. These materials are widely used in packaging, building materials, daily necessities and other fields, which greatly affect life and industrial processes.
(III) (triethylamino) naphthalene, a nitrogen-containing heterocyclic compound. In the field of medicine, or biologically active, it can be used as an intermediate for drug research and development. Drug research and development often requires such compounds to build special structures to obtain specific pharmacological effects. In materials science, or used to prepare functional materials, such as materials with special optical and electrical properties, used in optoelectronic devices, sensors, etc. Because of its special molecular structure, it endows materials with unique properties and meets the diverse needs of scientific and technological development.
What are the physical properties of 1-bromo-2-chloro-3- (trifluoromethyl) benzene
(1) Color
The color of this (triethylamino) naphthalene is often colorless or slightly yellowish when it is pure. Under natural light, it is as clear as jade, with a soft luster and no dazzling radiance. However, if it contains impurities, the color may change, be deep or miscellaneous, like a pearl dusted, losing its original purity.
(2) state
Under normal conditions, (triethylamino) naphthalene is a crystalline body. Its crystal structure is regular, like a miniature castle made in heaven, and it is orderly. The crystal shape is mostly flake or columnar, with neat edges, hard and brittle texture. If you hit it lightly, it will be easily broken, and the fragments also have regular geometric shapes, like delicate masonry.
(3) Flavor
Close to the fine smell, (triethylamino) naphthalene has a special smell, neither fragrant nor smelly, and it is difficult to name it exactly. This smell is irritating to a certain extent. If you smell it for too long, the nose and respiratory tract will feel uncomfortable, as if there is a subtle needle light thorn, so when smelling, you should be cautious.
(4) Solubility
(triethylamino) naphthalene has very little solubility in water, just like the ping on water, and it is difficult to blend. Water is clear to pure, while (triethylamino) naphthalene does not mix with it and floats on the water surface, forming its own. However, in organic solvents such as ethanol and ether, it has good solubility and can be rapidly dispersed and dissolved, just like ice and snow meet warm spring, instantly disappearing and invisible, and integrating with the solvent to form a uniform solution.
(5) Melting boiling point
(triethylamino) The melting point of naphthalene is about a specific temperature range. When the temperature gradually rises to the melting point, its solid state gradually melts, just like the melting of spring snow, transforming from a hard crystal to a flowing liquid state. And its boiling point is also in a certain range. When it reaches the boiling point, the liquid is violently churned, turning into a gaseous state and escaping, such as clouds rising, showing the wonderful change in the state of matter. This melting boiling point characteristic is a key consideration in its separation, purification and related process applications.
Is 1-bromo-2-chloro-3- (trifluoromethyl) benzene chemically stable?
Alas! To know whether the chemical properties of (1-cyanogen-2-chloro-3- (trifluoromethyl) pyridine) are stable, it is necessary to explore in detail.
Looking at this compound, cyanyl (-CN) has high reactivity, and its carbon-nitrogen triple bond can participate in many reactions, such as nucleophilic addition, hydrolysis, etc. Under suitable conditions, cyanyl groups are vulnerable to attack by nucleophiles, resulting in structural changes.
Furthermore, chlorine atoms (-Cl) are also active groups. In nucleophilic substitution reactions, chlorine atoms can be replaced by other nucleophilic groups, because carbon-chlorine bonds have a certain polarity, chlorine atoms are easy to leave in the form of chloride ions.
And trifluoromethyl (-CF
), although it has high electronegativity, has a significant impact on the distribution of molecular electron clouds, which can stabilize the molecular structure to a certain extent. However, when it coexists with cyano and chlorine atoms, the interaction between each group is complex.
In common chemical environments, (1-cyanogen-2-chloro-3- (trifluoromethyl) pyridine) or difficult to say stable. In case of nucleophiles, cyano reacts with chlorine atoms or first; in case of extreme conditions such as high temperature, strong acid, and strong base, its structure is more prone to change.
It is important to note that the chemical properties of this compound are difficult to say stable under most conventional scenarios, and its active groups are prone to chemical reactions and structural changes.
What are the synthesis methods of 1-bromo-2-chloro-3- (trifluoromethyl) benzene?
To prepare 1-bromo-2-chloro-3- (trifluoromethyl) benzene, the following ancient method can be used.
First, benzene is used as the starting material. First, benzene and bromine are brominated under the action of a catalyst such as iron bromide to obtain bromobenzene. In this reaction, bromine atoms replace hydrogen atoms on the benzene ring, which is an electrophilic substitution reaction. Bromobenzene is then reacted with chlorine under appropriate catalysts and conditions. The chlorine atoms can replace hydrogen atoms in the ortho or para-position of bromobenzene to obtain o-chlorobromobenzene or p-chlorobromobenzene. This is also an electrophilic substitution reaction. Then, the resulting product is combined with a trifluoromethylation reagent, such as trifluoromethyl halide magnesium, etc., through a process such as Grignard reaction, trifluoromethyl is introduced to obtain the target product 1-bromo-2-chloro-3- (trifluoromethyl) benzene.
Second, chlorobenzene can also be used as the beginning. Chlorobenzene reacts with bromine first, and under the action of a suitable catalyst, to obtain o-bromochlorobenzene or p-bromochlorobenzene. The subsequent steps are similar to the operation after starting with benzene to obtain chlorobromobenzene, that is, reacting with a trifluoromethylation reagent to introduce trifluoromethyl to achieve the synthesis of the target product. < First prepare benzene derivatives containing trifluoromethyl, and then introduce bromine atoms and chlorine atoms in an orderly manner. For example, using trifluorotoluene as a raw material, bromine atoms are introduced first and then chlorine atoms are introduced through the guidance of specific positioning groups, and attention should be paid to the control of reaction conditions and the utilization of positioning effects to obtain 1-bromo-2-chloro-3- (trifluoromethyl) benzene. Each method requires fine control of reaction conditions, such as temperature, catalyst dosage, reactant ratio, etc., to achieve the target product with higher yield and purity.
What to watch for when storing and transporting 1-bromo-2-chloro-3- (trifluoromethyl) benzene
If you want to store and lose (triethylpropyl) ether, you need to pay attention to the following things:
First, it is related to storage. (triethylpropyl) ether is highly volatile and flammable, so you should find a cool and well-ventilated place to place it, and you must not be near fire and heat sources to prevent the risk of fire. Also keep away from oxidants, because if you come into contact with it, or react violently, it will cause disaster. Furthermore, the storage container must be tightly sealed to avoid volatilization and escape, which will not only damage its quality, but also may cause environmental pollution and personal harm.
Second, about transportation. During transportation, the selected container must be sturdy and durable, able to withstand certain pressure and shocks, to ensure that it will not be damaged and leaked during transportation. And take protective measures, such as wrapping buffer materials. Transport vehicles must also meet safety standards and be equipped with fire extinguishing, leakage emergency treatment and other equipment. Transport personnel should be professionally trained and familiar with the dangerous characteristics of (triethyl propyl) ether and emergency treatment methods. Once there is a leak on the way, emergency measures should be taken immediately, evacuate the surrounding people, strictly prohibit fireworks, and quickly absorb inert materials such as sand and vermiculite, and properly clean them up. Do not let them flow into water bodies, soil, etc., to avoid environmental pollution.