As a leading 1-Bromo-2,6-Bis(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-Bromo-2,6-Bis (Trifluoromethyl) Benzene?
1-Bromo-2,6-bis (trifluoromethyl) benzene is an important raw material for organic synthesis. It has a wide range of uses and has significant contributions in the fields of medicine, pesticides, and materials science.
In the field of medicine, this compound is often a key intermediate. In the process of pharmaceutical synthesis, its special chemical structure can introduce specific functional groups to help build molecules with specific pharmacological activities. If you want to create new antibacterial drugs, the halogen atoms and fluorine-containing groups of 1-bromo-2,6-bis (trifluoromethyl) benzene can interact with targets in organisms, or affect the absorption, distribution, metabolism and excretion of drugs, improving drug efficacy and selectivity.
In the field of pesticides, it is also a key component. When pesticides were created, fluorinated organic compounds were highly efficient, low toxic and environmentally friendly. The fluorine atoms contained in 1-bromo-2,6-bis (trifluoromethyl) benzene can enhance the stability and fat solubility of pesticide molecules, making it easier to penetrate the epidermis of pests or the stratum corneum of plants, improve the efficacy, reduce the application amount, and reduce the impact on the environment.
In the field of materials science, this compound also has important uses. If high-performance fluoropolymer materials are prepared, 1-bromo-2,6-bis (trifluoromethyl) benzene can be used as a monomer to participate in the polymerization reaction. Due to its fluorine-containing structure, the resulting polymer materials may have excellent thermal stability, chemical stability, weather resistance and low surface energy, and are used in high-end fields such as aerospace, electronics and electrical appliances. If aerospace materials need to be lightweight, high-strength and resistant to extreme environments, fluoropolymer materials can just meet these needs.
What are the physical properties of 1-Bromo-2,6-Bis (Trifluoromethyl) Benzene?
1-Bromo-2,6-bis (trifluoromethyl) benzene, its physical properties are as follows:
This substance is mostly liquid at room temperature, and the appearance is clear and transparent, and the color is nearly non-existent. Smell it, there is a specific smell, but this smell should not be smelled rashly to prevent damage to the body.
Its density is greater than that of common water. If it drops on the water surface, it will sink underwater. The boiling point is quite high, and to make it boil and vaporize, it needs to be increased to about 180-190 ° C. The melting point also has a certain value, roughly in the range of -10 ° C to 0 ° C.
1-bromo-2,6-bis (trifluoromethyl) benzene dissolves well in organic solvents, such as with common ether, dichloromethane, etc., and can be miscible in any ratio. However, in water, its solubility is extremely poor and almost insoluble, which is caused by the great difference in polarity between the two.
Its molecule has a certain chemical activity due to the bromine atom and trifluoromethyl, which also affects its physical properties. And because it contains many fluorine atoms, the molecule has unique surface properties and may have special manifestations in interface phenomena.
What are the synthesis methods of 1-Bromo-2,6-Bis (Trifluoromethyl) Benzene?
Let me describe in detail the synthesis method of 1-bromo-2,6-bis (trifluoromethyl) benzene.
First, it can be started from 2,6-bis (trifluoromethyl) aniline. First, it is diazotized with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. This process needs to be carefully controlled to prevent the decomposition of diazonium salts. Then, the resulting diazonium salt is co-heated with a solution of cuprous bromide hydrobromide to undergo a Sandmeier reaction, and the diazonium group is replaced by a bromine atom to obtain 1-bromo-2,6-bis (trifluoromethyl) benzene. This path step is relatively clear, but the diazotization reaction conditions are harsh and require fine operation.
Second, 2,6-bis (trifluoromethyl) benzoic acid is used as the starting material. First, it is converted into an acid chloride, which is commonly used for thionyl chloride. Subsequently, the acid chloride is reacted with lithium bromide in an appropriate solvent, and 2,6-bis (trifluoromethyl) benzoyl bromide can be obtained through the halogen exchange reaction of acyl halides. Then through an appropriate reduction method, such as the use of reducing agents such as lithium aluminum hydride, the benzoyl group is reduced to methyl, and the final product is obtained. This method has a little more steps, but the reaction of each step is more classic and easy to control.
Third, the nucleophilic substitution reaction strategy of aryl halides can be used. Select a suitable bromine-containing reagent to react with a benzene derivative with a suitable leaving group and 2,6 positions have been introduced into trifluoromethyl. Appropriate bases and solvents need to be selected during the reaction to promote the smooth progress of the nucleophilic substitution reaction. This approach requires careful selection of reactants and reaction conditions to ensure the selectivity and yield of the reaction.
All these synthesis methods have advantages and disadvantages. In actual operation, it is necessary to comprehensively weigh and weigh many factors such as raw material availability, reaction conditions, yield and purity requirements, and make a careful choice to achieve the best synthesis effect.
What are the precautions for 1-Bromo-2,6-Bis (Trifluoromethyl) Benzene in storage and transportation?
1-Bromo-2,6-bis (trifluoromethyl) benzene is a kind of organic compound. During storage and transportation, there are several urgent matters that need to be paid attention to.
Store first. This substance should be placed in a cool, dry and well-ventilated place. In a cool environment, it can be avoided from changing due to excessive temperature. If it is exposed to high temperature, it may cause its volatilization to intensify, and even cause chemical reactions that damage its quality. Drying is also key, covering it with water or moisture, or reactions such as hydrolysis, causing changes in composition. And well ventilated, it can prevent the accumulation of harmful gases and keep the environment safe.
Furthermore, the storage place should be away from fire and heat sources. This compound may be flammable. In case of open flames and hot topics, it is easy to cause combustion and endanger the surroundings. At the same time, it must be stored separately from oxidants and alkalis. Because of its active chemical properties, it may come into contact with various substances or react violently.
As for transportation, the first thing to ensure is that the packaging is in good condition. If the packaging is damaged and the substance leaks, it will not only cause its own losses, but also pollute the environment and endanger the transportation personnel and surrounding people. The transportation process should be smooth, avoid bumps and vibrations, and prevent damage to the packaging. And the transportation vehicle should be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. In case of emergencies, it can be responded to in time. During transportation, relevant transportation regulations must also be strictly observed to ensure the safety of transportation. Only in this way can 1-bromo-2,6-bis (trifluoromethyl) benzene be properly stored and transported to avoid disasters.
What is the market price range for 1-Bromo-2,6-Bis (Trifluoromethyl) Benzene?
1-Bromo-2,6-bis (trifluoromethyl) benzene, the price of this product in the market is difficult to determine due to a variety of reasons. The range of its price is determined by market conditions, supply and demand, quality and purchase quantity.
Changes in market conditions have a huge impact on its price. If the industry has a high demand for this product, but the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price may drop.
On the supply and demand side, if the demand for this product increases at some time in the industry, such as the wide use of new pharmaceutical and chemical research and development, the demand is greater than the supply, and the price will rise. And if the production technology advances, resulting in an increase in output, oversupply, price or decline.
Quality is also the key to the price. High quality, due to the difficulty of refining, the quality of raw materials, the price is always higher than ordinary ones. Purchase quantity is also related to price. If the batch is large, the supplier may give a discount, and the price is low; if you buy a small amount, the price may be high.
At present, in the market, the price of 1-bromo-2,6-bis (trifluoromethyl) benzene ranges from tens of yuan to hundreds of yuan per gram. If the purchase quantity is in kilograms, the unit price may be reduced, and the price per kilogram may be in the range of several thousand yuan. However, this is only an approximation, and the actual price depends on the current market conditions, the status of supply and demand, and the negotiation between the buyer and the supplier. The market is volatile, and the price is also constantly changing. If you want to know the exact price, you should consult the chemical raw material supplier to obtain a real-time and accurate quotation.