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1-Bromo-2,5-Difluorobenzene

1-Bromo-2,5-Difluorobenzene

Hongda Chemical

Specifications

HS Code

550448

Chemical Formula C6H3BrF2
Molar Mass 193.009 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 145 - 147 °C
Density 1.68 g/cm³
Flash Point 47.8 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether

As an accredited 1-Bromo-2,5-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - bromo - 2,5 - difluorobenzene packaged in 500 - gram bottles.
Storage 1 - Bromo - 2,5 - difluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of a material resistant to chemical corrosion. This helps prevent evaporation, leakage, and potential reactions that could pose safety risks.
Shipping 1 - bromo - 2,5 - difluorobenzene, a chemical, is shipped in properly sealed, corrosion - resistant containers. Shipment adheres to strict hazardous material regulations, ensuring safe transport from origin to destination.
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1-Bromo-2,5-Difluorobenzene 1-Bromo-2,5-Difluorobenzene
General Information
Historical Development
1 - Bromo - 2,5 - Difluorobenzene, also an organic compound. At the beginning of its research, beginners sought to know its nature and seek its production. In the past, the method of making this compound was simple and ineffective, and the amount obtained was rare. However, the evolution of science, the unremitting efforts of the people, the gradual change of the method of making. As new techniques are released, the amount obtained is gradually increasing, and the purity is also rising.
Looking at the history of this compound, from its inception to its prosperity, it is all due to the good knowledge and constant research of scholars. Exploration in the past, such as walking at night to find light, was difficult but never stopped. Today's achievements are all the result of the accumulation of a few steps by the predecessors. In the fields of chemical industry, medicine, etc., its use is gradually expanding, and it will develop in the future, and it will not be limited.
Product Overview
1 - Bromo - 2,5 - Difluorobenzene is also an organic compound. Its color is pure and pure, like a clear liquid, with a special smell.
In this compound, bromine atoms and difluorine atoms are cleverly connected to the benzene ring, and the structure is exquisite. The stability of the benzene ring blends with the characteristics of the halogen atom. Bromine, with moderate activity, can initiate various reactions, or nucleophilic substitution, or participate in coupling. The fluorine atom gives it a unique electronic effect, making the polarity and stability of the molecule different.
In the field of organic synthesis, 1 - Bromo - 2,5 - Difluorobenzene has a wide range of uses. It can be used as a key intermediate to build a complex organic structure through a series of reactions, providing an important foundation for the development of medicine, materials, and other fields. It is indeed an existence that cannot be ignored in the research and application of organic chemistry.
Physical & Chemical Properties
1 - Bromo - 2,5 - Difluorobenzene is an organic compound, and its physical and chemical properties are very important. Looking at its physical properties, it is mostly liquid at room temperature, transparent in color, and has a special odor. The boiling point is in a specific range, which is determined by the intermolecular force, and the state of the substance changes at a specific temperature. Its density also has a specific value, which is related to its floating in different media.
When it comes to chemical properties, bromine and fluorine atoms in this compound are highly active. Bromine atoms can undergo nucleophilic substitution reactions. When attacked by nucleophilic reagents, bromine ions leave to form new compounds. Fluorine atoms change the electron cloud density of the benzene ring, which affects the activity and check point of the electrophilic substitution reaction on the benzene ring. The chemical stability of this compound has a certain range. Under specific conditions, reactions such as decomposition may occur. It is of great significance to explore its physical and chemical properties in the fields of organic synthesis.
Technical Specifications & Labeling
1 - Bromo - 2,5 - Difluorobenzene is an important chemical substance, and its technical specifications and labeling (product parameters) are key to production and application.
The appearance of this product should be pure and free of impurities, in a colorless and transparent state, and without odor. Its purity must reach a very high standard, at least 99%, and the impurity content must be minimal. The melting point should be stable within a specific range, about [X] ° C, and the boiling point should also have a precise range of [X] ° C. On the
label, the chemical name "1 - Bromo - 2,5 - Difluorobenzene" must be clearly indicated, and the warning label should be marked according to regulations to prevent harm caused by improper use. Packaging labels should be complete, including production batch, date, and other information, in order to track the origin and ensure the stability and reliability of product quality.
Preparation Method
1 - Bromo - 2,5 - Difluorobenzene is an important organic compound. The method of preparation, the selection of raw materials is very critical. Specific aromatics containing fluorine and bromine can be used as starting materials.
In terms of preparation process, the raw materials are first reacted under certain temperature and pressure conditions in a suitable reaction vessel under the action of a specific catalyst. The first step of the reaction is the substitution reaction between aromatics and bromine-containing reagents, and the reaction conditions are precisely regulated to ensure that bromine atoms are just replaced to the specified position.
Subsequent fluorine-containing reagents are added, and fluorine atoms are successfully introduced through a series of reactions to obtain the target product. In this process, the control of reaction conditions is extremely important, and temperature, pressure, reaction time, etc. need to be fine-tuned.
To improve the purity and yield of the product, a specific purification mechanism can be set up. By distillation, extraction and other means, impurities are removed to obtain pure 1-Bromo-2,5-Difluorobenzene. In this way, the efficient preparation of the product can be achieved.
Chemical Reactions & Modifications
Taste the wonders of chemical industry, related to reaction and modification, which is an important matter in the industry. Today, 1-Bromo-2,5-Difluorobenzene is discussed. The reaction path is related to many variables. In the past, the preparation of this product, or the complicated process, the yield was not high.
However, the wise person researched it, improved the reaction conditions, selected the appropriate catalyst, adjusted the precise temperature, and controlled the appropriate pressure. After this change, the reaction rate was increased, the side reactions were reduced, and the product purity and yield were improved.
If a new catalyst is used, the reaction is more reasonable at a specific temperature and pressure. This not only increases its yield, but also the quality of the product is excellent. Such a change is actually the path of chemical progress. With scientific methods, seeking the goodness of the reaction and achieving the effect of modification, the production of 1-Bromo-2,5-Difluorobenzene has made great contributions.
Synonyms & Product Names
1 - Bromo - 2,5 - Difluorobenzene is also a chemical substance. Its synonyms and trade names are quite important in my chemical research.
Looking at this substance, there are many expressions of synonyms, all of which refer to different titles of this thing, such as [list some possible synonyms, assuming X, Y, Z], which are commonly used names in the academic world. Although the expressions are different, they refer to one.
As for trade names, there are also unique titles. Due to the needs of commercial circulation and application scenarios, each manufacturer gives it a unique name. For example [assume a trade name ABC], merchants sell it under this name and have a unique logo in the market. The investigation of synonyms and trade names has helped us understand the multiple identities of this substance in the academic and commercial fields, and is of great significance in research, production, and trade. It has enabled us to accurately identify and apply this chemical substance and promote the progress of the chemical field.
Safety & Operational Standards
1 - Bromo - 2,5 - Difluorobenzene is an important chemical and requires strict regulations for its laboratory operation and safety.
In the operating area, good ventilation should be maintained, which is the key to ensuring fresh air and timely discharge of harmful gases. Operators must wear appropriate protective equipment, such as laboratory clothes, protective gloves and goggles. Laboratory clothes can prevent chemical spills from spilling on clothing, protective gloves can avoid direct contact with the chemical on the hands, and goggles can effectively protect the eyes from accidental splash damage.
When taking 1 - Bromo - 2,5 - Difluorobenzene, the movement should be precise and careful. Because of its certain chemical activity, improper operation can easily lead to danger. When pouring, it should be slow and steady to prevent liquid from splashing out. The measuring process requires the help of accurate measuring tools to ensure accurate dosage, which not only guarantees the experimental effect, but also avoids waste and danger.
For storage, 1-Bromo-2,5-Difluorobenzene should be placed in a cool, dry place away from fire and oxidants. A cool environment can prevent chemical changes due to excessive temperature. Drying can avoid moisture affecting quality. Keeping away from fire sources and oxidants is to prevent potential fires and violent chemical reactions.
In the event of 1-Bromo-2,5-Difluorobenzene leakage, do not panic. First, evacuate the surrounding personnel quickly to avoid more people from exposure to danger. Afterwards, according to the leakage amount, use suitable adsorption materials for treatment, such as sand, vermiculite, etc., adsorb and collect it properly, and dispose of it according to the specified process. Do not discard it at will to avoid polluting the environment.
After the experimental operation, the used utensils should be cleaned in time and thoroughly. If the residual 1-Bromo-2,5-Difluorobenzene is not washed, it will not only affect the next experiment, but may also react in the utensils, causing potential safety hazards.
Strictly abide by the above safety and operation specifications to ensure the safety of 1-Bromo-2,5-Difluorobenzene during use, ensure the smooth progress of the experiment, and maintain the safety of the experimenter and the environment.
Application Area
1 - Bromo - 2,5 - Difluorobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize specific drugs, treat various diseases, and seek well-being for health. In the field of materials science, it is also very useful. It can be made by special processes to produce materials with outstanding properties, or have good electrical conductivity, or have unique optical properties, which are used in electronic devices, optical instruments and many other aspects. The characteristics of this compound make it important in the process of chemical research. Scientists are working hard to explore its application potential, hoping to open up new frontiers, contribute to industrial development, scientific and technological progress, and promote the prosperity of society, so that this pearl of chemistry can bloom brighter.
Research & Development
In recent years, I have been in the field of chemistry, specializing in the study of 1 - Bromo - 2,5 - Difluorobenzene. Its characteristics are unique, and it is quite useful in organic synthesis.
At the beginning, the preparation method was quite laborious. The choice of raw materials and the reaction rules all need to be carefully considered. After several tests, a method can be obtained to obtain a purer product.
Then, explore its reaction mechanism. Looking at its response to various reagents, studying the change of molecules, and revealing the disconnection of chemical bonds, in order to understand its inner reason.
At present, I am committed to exploring its application. Whether in the creation of medicine, or in the research and development of materials, we are looking for its usefulness. Although the road ahead is long, I firmly believe that with time, we will be able to achieve remarkable results in the research and development of 1-Bromo-2,5-Difluorobenzene, which will add to the progress of chemistry.
Toxicity Research
The observation of taste and smell of physical properties is related to safety. Today there is 1 - Bromo - 2,5 - Difluorobenzene, and the investigation of its toxicity is an important matter.
Look at its production and use, or involve chemical industries. To understand its toxicity, consider its chemical properties and reactions. The structure of this substance is unique, and it is related to bromine and fluorine atoms, or it is metabolized differently in the body. On the way into the body, or through breathing, skin touch, or even diet.
Taste the harm of poison, it can mess up the ability of the viscera and damage the luck of qi and blood. On 1 - Bromo - 2,5 - Difluorobenzene, or injure the liver and spleen, hinder the conduction of nerves, and disturb the order of metabolism. Although there is no widespread disease, it should not be ignored. It must be studied in detail in the experiment, and it must be carefully observed in the environment, so as to prevent the micro and gradually increase, to protect the safety of the living, and not to make the poison invisible.
Future Prospects
The future prospect concerns 1 - Bromo - 2,5 - Difluorobenzene, which is the key to our chemical research. Today's technology is new, and the use of this compound is becoming more and more extensive. In the field of pharmaceutical creation and material innovation, it is expected to shine.
Looking at medicine, its unique structure may open up a new path for the development of new drugs, helping doctors overcome difficult diseases and save patients from sinking diseases. As for the field of materials, with its characteristics, it may give rise to strange new materials, which can be applied to aerospace and electronics, making the equipment more delicate and efficient.
We scientific researchers should study diligently and forget its mysteries. With time, we will be able to fully exploit its potential, seek well-being for future generations, and create a new technological landscape that will live up to our future prospects.
Where to Buy 1-Bromo-2,5-Difluorobenzene in China?
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Frequently Asked Questions

As a leading 1-Bromo-2,5-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-2,5-Difluorobenzene?
1-Bromo-2,5-difluorobenzene is a class of organic compounds. It has a wide range of uses in the field of organic synthesis. Its main uses are generally as follows.
One of them can be used as a key intermediate in pharmaceutical synthesis. The development of pharmaceutical chemistry depends on the delicacy of organic synthesis. 1-Bromo-2,5-difluorobenzene can participate in many reactions due to its unique chemical structure, helping chemists build complex drug molecular structures. For example, in the development and synthesis of some new antibacterial drugs and drugs for the treatment of nervous system diseases, this compound is often relied on as a starting material. After a series of reactions, specific functional groups are added to shape the structure that fits the drug target, so as to obtain drug ingredients with specific biological activities.
Second, it also plays an important role in the synthesis of pesticides. Agriculture is the foundation of the country, and pesticides are of great significance in ensuring crop yield and preventing pests and diseases. 1-Bromo-2,5-difluorobenzene can contribute to the synthesis of high-efficiency, low-toxicity, and environmentally friendly pesticides. Through organic reactions, it can be converted into pesticide active ingredients with insecticidal, bactericidal, and weeding effects, which can help the sustainable development of agriculture.
Third, it also has its application in the field of materials science. With the progress of science and technology, the demand for special performance materials is increasing. This compound can participate in the synthesis of polymer materials, giving materials such as excellent heat resistance and chemical stability. For example, in the preparation of some high-performance engineering plastics and liquid crystal materials, 1-bromo-2,5-difluorobenzene can be used as a structural unit to participate in the polymerization reaction, optimize material properties, and meet the special needs of electronics, optics and other fields.
From this perspective, 1-bromo-2,5-difluorobenzene is indispensable in the fields of medicine, pesticides and materials science, and has a profound impact on the development of related industries.
What are the physical properties of 1-Bromo-2,5-Difluorobenzene?
1-Bromo-2,5-difluorobenzene is also an organic compound. It has unique physical properties and is worth studying.
Looking at its properties, at room temperature, 1-bromo-2,5-difluorobenzene is often a colorless to light yellow transparent liquid with a clear appearance. It can be seen like a mirror, refracting light and shining. Its smell is specific, although it is not pungent and intolerable, it also has a unique smell, and its existence can be slightly sensed by the sense of smell.
When it comes to the melting point, it is about -20 ° C. At this low temperature, its molecular movement gradually slows down, and it gradually becomes critical from liquid to solid state. When the temperature drops below the melting point, the force between the molecules increases, binding each other, and then solidifying into a solid state.
The boiling point is roughly in the range of 175 ° C - 180 ° C. At this temperature, the molecules are sufficiently energized to break free from the shackles of the liquid phase, escape into the gas phase, and turn into curling steam. This boiling point characteristic is of key guiding significance in the separation and purification process.
The density of 1-bromo-2,5-difluorobenzene is about 1.7 g/cm ³, which is heavier than water. If it is combined with water, it will sink to the bottom of the water, just like a pearl falling into the abyss, and it is distinct.
In terms of solubility, it has good solubility in organic solvents, such as ethanol, ether, acetone, etc., and can be fused with it, just like water. However, in water, the solubility is very small, and the two are similar to the Chu River and Han borders, and are difficult to miscible, which is due to the difference in molecular polarity.
In addition, the vapor pressure of 1-bromo-2,5-difluorobenzene cannot be ignored. At a specific temperature, its vapor pressure reflects its volatilization difficulty. The higher the vapor pressure, the more volatile it is, and the faster it diffuses in the air. This property needs to be carefully considered when storing and using to prevent its volatilization and dissipation, resulting in loss or safety risks.
What are the synthesis methods of 1-Bromo-2,5-Difluorobenzene?
There are many ways to synthesize 1-bromo-2,5-difluorobenzene. The most common one is that 2,5-difluoroaniline is used as the starting material. It is diazotized with sodium nitrite and hydrochloric acid at low temperature. This process needs to be carefully controlled to prevent side reactions from breeding. After the diazonium salt is formed, the cuprous bromide is added, and then the Sandmeier reaction occurs. The diazo group is replaced by the bromine atom to obtain 1-bromo-2,5-difluorobenzene. Although this method is a little complicated, the raw materials are relatively easy to obtain, and the reaction conditions are still mild, which is quite suitable for laboratory synthesis.
Second, 2,5-difluorophenylboronic acid can be used to react with brominated reagents. If N-bromosuccinimide (NBS) is used as the bromine source, the bromination reaction of arylboronic acid is carried out in the presence of appropriate catalysts and solvents. This process requires the selection of the right catalyst, such as palladium catalyst, to make the reaction proceed smoothly. This method has good selectivity, high product purity, and only some reagents have slightly higher costs, which may need to be weighed in large-scale production.
Another method of direct bromination with 2,5-difluorobenzene as the substrate. However, it is necessary to choose suitable bromination reagents and reaction conditions, such as liquid bromine reacting under the catalysis of Lewis acid (such as ferric chloride). However, this direct bromination method has poor regioselectivity or is prone to the formation of other brominated isomer impurities, and subsequent separation and purification are a little difficult. Therefore, in actual synthesis, the appropriate synthesis path is carefully selected according to specific needs, raw material availability, cost considerations and other factors.
What to pay attention to when storing and transporting 1-Bromo-2,5-Difluorobenzene
1-Bromo-2,5-difluorobenzene is an organic compound. When storing and transporting, many aspects must be paid attention to.
When storing, the first choice of environment. It should be placed in a cool and ventilated place, because the compound is prone to chemical changes due to heat, or even cause dangerous reactions. If the temperature is too high, or its volatilization is intensified, it will not only damage its quality, but also the volatile gaseous substances may be dangerous. At the same time, the humidity should also be strictly controlled to avoid storage in a humid environment, because it may react with water and cause the product to deteriorate.
Furthermore, it needs to be stored separately from oxidants, acids, bases and other substances. The chemical properties of 1-bromo-2,5-difluorobenzene determine that it comes into contact with the above substances or triggers severe chemical reactions, such as oxidation reactions, acid-base neutralization, etc. Such reactions may cause serious consequences such as fire and explosion.
Packaging is also a key link. The packaging materials used must have good sealing to prevent product leakage. The packaging material should also be able to withstand the corrosion of the compound to avoid product leakage due to damaged packaging.
When transporting, the safety performance of the transportation vehicle should be ensured first. Vehicles must be equipped with perfect fire protection equipment and leakage emergency treatment equipment to prevent accidents during transportation.
The loading and unloading process must be handled lightly to avoid collisions and falls. The packaging of 1-bromo-2,5-difluorobenzene is easily damaged by collision or drop, which can lead to product leakage.
During transportation, drivers and escorts should pay close attention to the status of the goods. If any signs of damage or leakage are detected in the packaging, emergency measures should be taken immediately, such as evacuating the crowd, sealing the scene, and reporting to the relevant departments in time.
All of these are essential points for the storage and transportation of 1-bromo-2,5-difluorobenzene, so as to ensure the safety of personnel and the environment are not endangered, and at the same time ensure the quality of the product.
What are the effects of 1-Bromo-2,5-Difluorobenzene on the environment and the human body?
1-Bromo-2,5-difluorobenzene is also an organic compound. Although the impact of the environment and the human body has not been detailed in ancient books, it can be deduced from today's scientific principles to get one or two.
Let's talk about the environment first. If this compound is released in nature, its structure contains halogen atoms, its properties are relatively stable, and it is not easy to decompose rapidly for common natural processes. Or stay in the soil, causing gradual changes in soil physical and chemical properties, preventing plant roots from absorbing nutrients and water, and hindering plant growth and breeding. If it enters the water body, it can migrate with the water flow and get tired of aquatic organisms. After ingesting aquatic organisms, it may cause physiological disorders, damage their nervous system, reproductive system, etc., and amplify through the food chain, endangering higher trophic organisms and disrupting ecological balance.
As for the impact on the human body. If the human body is exposed to this substance through breathing, skin contact or accidental ingestion, the chemical activity of bromine and fluorine atoms may cause health risks. Respiratory tract contact, or irritate the airway, causing cough, asthma, breathing difficulties and other symptoms. Penetration through the skin can cause dermatitis symptoms such as skin allergies, redness, swelling, and itching. If ingested by mistake, it may damage the digestive system, causing nausea, vomiting, abdominal pain, diarrhea, etc., and even affect the function of important organs such as liver and kidney. Long-term exposure may be potentially carcinogenic, teratogenic, and mutagenic, because halogenated aromatics often interfere with normal cell metabolism and genetic information transmission in the human body. In short, 1-bromo-2,5-difluorobenzene is potentially harmful to both the environment and the human body, and it needs to be handled with caution to prevent its escape and adverse consequences.