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1-Bromo-2,4-Difluoro-3-Methoxybenzene

1-Bromo-2,4-Difluoro-3-Methoxybenzene

Hongda Chemical

Specifications

HS Code

807365

Chemical Formula C7H5BrF2O
Molecular Weight 223.01
Appearance Typically a colorless to light - yellow liquid
Boiling Point Data may vary, around 180 - 190°C under normal pressure
Density Approximately 1.65 - 1.75 g/cm³
Solubility Slightly soluble in water, soluble in organic solvents like ethanol, dichloromethane
Vapor Pressure Low at room temperature
Flash Point Caution, flammable, flash point data may vary
Stability Stable under normal conditions, but may react with strong oxidizing agents

As an accredited 1-Bromo-2,4-Difluoro-3-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - bromo - 2,4 - difluoro - 3 - methoxybenzene in sealed chemical - grade bottle.
Storage 1 - Bromo - 2,4 - difluoro - 3 - methoxybenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials like glass, to prevent leakage and exposure to air and moisture, which could potentially degrade the chemical.
Shipping 1 - bromo - 2,4 - difluoro - 3 - methoxybenzene is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations, ensuring proper handling to prevent spills and maintain safety during transit.
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1-Bromo-2,4-Difluoro-3-Methoxybenzene 1-Bromo-2,4-Difluoro-3-Methoxybenzene
General Information
Historical Development
1 - Bromo - 2,4 - Difluoro - 3 - Methoxybenzene is commonly used in chemical research today. Examining its historical development, chemists in the past explored the synthesis of new compounds and continued to study in the field of organic synthesis. At first, everyone only knew the method of simple halogenated aromatics, and then with the accumulation of knowledge, the pursuit of synthesis of compounds containing a variety of substituents gradually arose.
In the early attempts, many difficulties were faced, and the order of introduction of different substituents and the control of reaction conditions were very difficult. However, chemists made unremitting efforts and gradually clarified the reaction mechanism after countless experiments.
At some point, a breakthrough was achieved in the combination of specific catalysts and reaction conditions, allowing the efficient synthesis of 1-Bromo-2,4-Difluoro-3-Methoxybenzene. Since then, this compound has been widely used in medicine, materials science and other fields, and its historical development has witnessed the refinement of chemical synthesis techniques.
Product Overview
1 - Bromo - 2,4 - Difluoro - 3 - Methoxybenzene is a delicate chemical substance. Its color is pure and its quality is stable, which is quite valuable in the field of chemical research. This compound is composed of bromine, fluorine, methoxy and other groups ingeniously combined, and its unique structure gives it special chemical properties. The introduction of bromine atoms makes it reactive and can participate in many nucleophilic substitution reactions. Fluorine atoms have a unique distribution of molecular electron clouds due to their strong electronegativity, which affects their physical and chemical behavior. The presence of methoxy groups further adjusts the polarity of molecules and also plays an important role in their solubility and reaction selectivity.
Preparation of this substance requires precise control of reaction conditions, such as temperature, catalyst dosage, etc. It can be used in the field of organic synthesis or as a key intermediate to build more complex organic molecular structures, providing an important foundation for cutting-edge fields such as new drug development and materials science.
Physical & Chemical Properties
1 - Bromo - 2,4 - Difluoro - 3 - Methoxybenzene is an organic compound. Its physical and chemical properties are quite critical. Looking at its properties, it is liquid at room temperature and has a certain volatility. In terms of melting point, there is no exact literature detailed, but it is speculated that it may be in a relatively low temperature range according to similar compounds. In terms of boiling point, it is slightly higher than ordinary benzene derivatives due to the presence of halogen atoms and methoxy groups in the molecular structure.
In terms of solubility, given that it is an organic molecule, it may have good solubility in common organic solvents such as ethanol and ether, but poor solubility in water. This is due to its non-polar molecular properties. In terms of chemical properties, bromine atoms are highly active and can participate in nucleophilic substitution reactions. Under appropriate conditions, they can be replaced by other nucleophilic reagents. The presence of fluorine atoms enhances molecular stability, while methoxy groups can affect the electron cloud density of the benzene ring, which in turn affects the reactivity and selectivity of the compound.
Technical Specifications & Labeling
1 - Bromo - 2,4 - Difluoro - 3 - Methoxybenzene is a chemical I have been researching recently. Its process specifications and identification (product parameters) are extremely important.
In terms of process specifications, the selection of raw materials must be pure and the ratio must be accurate. During synthesis, temperature and pressure control are indispensable. A slight difference will cause the product to be impure. The reaction time also needs to be strictly controlled to obtain the ideal yield.
In terms of identification (product parameters), the appearance of this product is a colorless to light yellow liquid with a unique smell. The boiling point and melting point are fixed, which is related to its storage and use. The purity needs to reach a very high standard, and the impurity content is minimal to meet the quality requirements. Therefore, the process specifications and identification (product parameters) of 1 - Bromo - 2,4 - Difluoro - 3 - Methoxybenzene are the key to ensuring its quality and application.
Preparation Method
To prepare 1 - Bromo - 2,4 - Difluoro - 3 - Methoxybenzene, the raw materials are crucial to the production process, reaction steps and catalytic mechanism. First, take an appropriate amount of 2,4 - Difluoro - 3 - methoxyphenol as the starting material, and slowly add it to the reaction vessel in a specific ratio with a brominating reagent such as potassium bromide and concentrated sulfuric acid. The temperature control is at 50 to 60 degrees Celsius, which is a suitable reaction temperature range and can promote the nucleophilic substitution reaction to proceed in an orderly manner. During the reaction, the stirring rate should be stable to ensure that the materials are fully mixed and contacted. After the reaction is completed, the product is separated by extraction method, and the impurities are removed after multiple washes and drying. Catalytic mechanism, concentrated sulfuric acid can activate bromine ion, enhance its nucleophilicity, accelerate the reaction process, so can be relatively pure 1 - Bromo - 2,4 - Difluoro - 3 - Methoxybenzene.
Chemical Reactions & Modifications
To taste the wonders of chemical industry, it is related to the change of substances, reaction and modification, which is really the key. Today there is 1-Bromo-2,4-Difluoro-3-Methoxybenzene, and I want to find out the wonders.
Its reaction is also, when looking for the right method. If you choose the appropriate reagent and control the precise conditions, the bromine, fluorine and methoxy groups can all be in their respective positions and smoothly transformed. Or in a suitable solvent, adjust the temperature and temperature, catalyze to promote its transformation, so that the reaction is efficient and pure.
As for modification, think about its use trend. Or introduce new groups to change their activity to suit different needs. If it increases its stability, strengthens its solubility, or endows it with special functions. On the way to modification, it is necessary to carefully observe the physical properties and make good use of the mechanism in order to achieve good products. In the field of chemical industry, it has emerged and benefited everyone.
Synonyms & Product Names
Today there is a product called 1 - Bromo - 2,4 - Difluoro - 3 - Methoxybenzene. This product has a wide range of uses in the field of chemistry. There are many synonyms, all of which are closely related to the characteristics and structure of the product.
or because of its unique combination of bromine, fluorine, and methoxy, there are aliases called similar in structure. The name of the product is also determined by merchants according to its application scenarios and advantages.
Looking at its synonyms can help us better understand the essence of this product. Or from the perspective of chemical composition, describe it in precise terms; or from the level of practical application, give it a popular title. The trade name is in the market circulation, making it easy for everyone to remember and use.
The synonym and trade name of this object are like a mirror, reflecting the integration of chemical research and commercial application. It has important implications for both chemical exploration and industrial production, and contributes to the development of related fields.
Safety & Operational Standards
1 - Bromo - 2,4 - Difluoro - 3 - Methoxybenzene is an important chemical. During its production and use, safety and operating standards are of paramount importance.
This chemical is dangerous and must be strictly followed during operation. First, the experimental site must be well ventilated to prevent the accumulation of harmful gases. Wear appropriate protective equipment during operation, such as gas masks, protective gloves and protective clothing, to protect the operator from damage.
When taking and weighing the chemical, the action should be precise and careful to avoid leakage. If it is accidentally spilled, it should be properly cleaned immediately according to specific procedures to prevent pollution of the environment.
During the reaction operation stage, the reaction conditions such as temperature, pressure and reaction time should be strictly controlled. A slight deviation may not only affect the quality of the product, but also cause safety accidents.
Storage should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. At the same time, the storage area should be clearly marked to prevent accidental touch and misuse.
In addition, operators should be professionally trained to be familiar with the nature of the chemical, hazards and emergency treatment measures. In the event of an accident, such as a leak or fire, they can respond quickly and correctly to minimize losses and hazards.
Adhering to the above safety and operating practices can ensure that the production and use of 1-Bromo-2, 4-Difluoro-3-Methoxybenzene are safe and secure, and that personnel safety and the environment are not damaged.
Application Area
1 - Bromo - 2,4 - Difluoro - 3 - Methoxybenzene is also a chemical substance. Its application field can be explored. In the field of research and development, or it can be used as a raw material for synthesizing special effects. Because of its special chemistry, it can be used for many reasons, ingeniously, or can be prepared for specific diseases.
In the field of materials science, it also has its own uses. It can be used in the synthesis of functional materials to assist in the research of materials with special properties, such as materials with special properties for specific wavelengths of light, used in optical devices, etc.
And in the field of research, its characteristics may be synthesized with high efficiency and low toxicity, so as to protect crops from damage and reduce environmental damage. This is the possible use field of 1-Bromo-2,4-Difluoro-3-Methoxybenzene, which needs to be further explored by our researchers to develop its greater function.
Research & Development
I have been researching chemical products for a few years. Recently, I have worked hard on 1-Bromo-2,4-Difluoro-3-Methoxybenzene. Its unique nature has potential in all fields of chemical industry.
At the beginning, it was difficult to explore its synthesis method. After several trials and errors, I consulted ancient books and modern theories before I could obtain a feasible method. After repeated tempering and optimization steps, the yield was gradually improved, and the quality was also better.
However, the road of research and development has many obstacles. The purity of raw materials, the temperature of reaction, and the control of time are all key. A slight mistake will lead to very different results. In order to be accurate, stay by the kettle day and night, observe its changes, and record its data.
Looking at this product today, the prospect is promising. Over time, if we can improve the process and expand the application, we will definitely contribute to the development of the chemical industry, and live up to our research.
Toxicity Research
1 - Bromo - 2,4 - Difluoro - 3 - Methoxybenzene is an important chemical. Its toxicity studies should be carefully observed. This compound has a unique structure, and the combination of bromine, fluorine and methoxy groups may cause it to have specific chemical activities and potential toxicity.
After experimental observation, if organisms are exposed to this product, there may be different reactions. After exposure to small animals, there may be changes in physiological functions, such as metabolic disturbance, organ or pathological changes. However, the degree of toxicity also varies depending on the dose, time and method of exposure.
In the environment, its degradation process and products are also key. Degradation or release of halogen-containing substances, or affect the surrounding ecology. Therefore, the toxicity study of 1 - Bromo - 2,4 - Difluoro - 3 - Methoxybenzene is related to human health and ecological balance, and needs to be further investigated and cannot be ignored.
Future Prospects
The future perspective concerns 1 - Bromo - 2,4 - Difluoro - 3 - Methoxybenzene. I look at its properties, with unique chemical characteristics, it seems to hold infinite possibilities. In the field of organic synthesis, it may be a key raw material, leading to new reaction paths. In the future, with the advancement of science and technology, we will definitely be able to make good use of its properties to expand the new territory of chemical synthesis. Or to spawn efficient drugs to treat diseases; or to help new materials come out and increase the convenience of life. Although this is only the first glimpse of the door, I am convinced that in time, this compound will be able to shine in the field of scientific research, contribute to human well-being, open up an unprecedented chapter in chemical applications, and make a significant contribution to the scientific picture of the future.
Where to Buy 1-Bromo-2,4-Difluoro-3-Methoxybenzene in China?
As a trusted 1-Bromo-2,4-Difluoro-3-Methoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-2,4-Difluoro-3-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

1-Bromo-2, what is the main use of 4-Difluoro-3-Methoxybenzene?
1-Bromo-2,4-difluoro-3-methoxybenzene is also an organic compound. Its main use is quite extensive, and it is often used as a key intermediate in the field of medicinal chemistry. Cover the way of pharmaceutical synthesis, the preparation of many drugs depends on this as a basis to construct a specific molecular structure, and then achieve the required pharmacological effects.
In the genus of materials science, it is also useful. Or can participate in the creation of new organic materials, endowing materials with specific optical and electrical properties, such as for the preparation of materials with special photoelectric properties, used in Light Emitting Diode, organic solar cells and other devices to help improve their performance.
In the field of pesticide chemistry, 1-bromo-2,4-difluoro-3-methoxybenzene may also be an important raw material for the synthesis of high-efficiency pesticides. Through specific chemical reactions, it is converted into pesticide ingredients with insecticidal and bactericidal effects to protect crops from pests and diseases and ensure high agricultural yields.
In summary, 1-bromo-2,4-difluoro-3-methoxybenzene plays an important role in many branches of the chemical industry. Its wide range of uses and deep influence are indispensable for the development of modern chemical industry.
1-Bromo-2, what are the physical properties of 4-Difluoro-3-Methoxybenzene
1-Bromo-2,4-difluoro-3-methoxybenzene is one of the organic compounds. Its physical properties are quite impressive, and it is of great significance to chemical research and industrial applications.
First of all, its appearance, under room temperature and pressure, this substance is often colorless to light yellow liquid form, clear and transparent, and the appearance is quite fluid. This morphological characteristic has a profound impact on many chemical reactions and practical operations. Because it is a liquid, it is easier to disperse and participate in the reaction than solids in the process of mixing and dissolution, which provides convenience for chemical production and laboratory synthesis.
When it comes to melting points and boiling points, the melting point values vary depending on the precise measurement conditions, but are generally within a specific range. The boiling point is also within a certain range, and the characteristics of this boiling point are crucial when separating and purifying this compound. By distillation, it can be separated from other substances with different boiling points according to its boiling point to obtain pure 1-bromo-2,4-difluoro-3-methoxybenzene.
Furthermore, the density of this substance is also one of its important physical properties. Its density is different from that of water, and it has an exact value at a specific temperature and pressure. This density characteristic is significant in processes involving liquid-liquid separation or solution preparation. Knowing its density can accurately control the amount of each substance and ensure that the reaction proceeds as expected.
In terms of solubility, 1-bromo-2,4-difluoro-3-methoxybenzene exhibits good solubility in organic solvents such as ethanol, ether, etc. This property makes it suitable as a reactant or intermediate in organic synthesis, with the help of organic solvents to fully contact and react with other compounds. In water, its solubility is very small, and this difference provides another way for its separation and purification.
In addition, although the volatility of this substance is not very prominent, it also evaporates under certain conditions. Its volatilization rate is affected by factors such as temperature, pressure and surface area. This volatility needs to be considered during storage and use to prevent its escape and loss or cause safety issues.
The physical properties of 1-bromo-2,4-difluoro-3-methoxybenzene play a key role in many fields of chemistry, such as organic synthesis, analytical testing, chemical production, etc., laying the foundation for related research and applications.
What is the chemical synthesis method of 1-Bromo-2,4-Difluoro-3-Methoxybenzene
The chemical synthesis of 1-bromo-2,4-difluoro-3-methoxybenzene is an important research in the field of organic synthesis. There are many ways to synthesize it, and there are several common ones.
First, it can be initiated by benzene derivatives containing methoxy groups. Under specific conditions, bromine atoms are introduced by halogenation reaction. This halogenation reaction requires careful selection of halogenating reagents, such as copper bromide, bromine, etc., and control of reaction temperature, time, and solvent, so that bromine atoms precisely replace hydrogen atoms at specific positions in the benzene ring.
Then, fluorine atoms are introduced by means of fluorination reaction. Commonly used fluorinated reagents such as potassium fluoride, Selectfluor, etc., in the presence of suitable catalysts, in an appropriate reaction system, fluorine atoms can successfully replace hydrogen atoms on the benzene ring to achieve the 2,4-difluorine structure. In this process, the selection of catalysts and the regulation of reaction conditions are extremely critical, which are related to the selectivity and yield of the reaction.
Second, other suitable aromatic compounds can also be used as raw materials. Methoxy groups are first constructed, and then bromine and fluorine atoms are introduced in sequence. When constructing methoxy groups, nucleophilic substitution reactions can be used to react with halogenated hydrocarbons with sodium alcohol or sodium phenol to form methoxybenzene structures. After that, according to the above method of halogenation and fluorination reaction, the synthesis of 1-bromo-2,4-difluoro-3-methoxybenzene is gradually completed.
When synthesizing this compound, it is necessary to carefully control the conditions of each step of the reaction, such as temperature, pH, molar ratio of the reactants, etc. And the separation and purification steps after each step of the reaction are also indispensable. Column chromatography, recrystallization and other methods are often used to obtain high-purity products. In this way, 1-bromo-2,4-difluoro-3-methoxybenzene can be effectively synthesized.
1-Bromo-2, 4-Difluoro-3-Methoxybenzene What are the precautions in storage and transportation?
1-Bromo-2,4-difluoro-3-methoxybenzene is an organic chemical. When storing and transporting, many things need to be paid attention to to to ensure safety.
It has certain chemical activity. When storing, it should be in a cool, dry and well-ventilated place. Because it is sensitive to light and heat, it must be kept away from fire and heat sources, and direct sunlight should also be avoided. If heated, it may cause chemical reactions or increase its volatilization rate, which not only damages the purity of the substance, but also poses a safety risk.
This substance may be corrosive and toxic, and the storage container must be corrosion-resistant and well-sealed. Although glass containers are transparent and conducive to observation, they need to be carefully selected according to their characteristics under certain conditions or reactions with substances. And key information such as name, nature, and hazard should be clearly marked on the outside of the container to prevent misuse.
During transportation, ensure that the packaging is stable to prevent damage and leakage of the container due to collision and vibration. Transportation vehicles should also be equipped with corresponding fire protection and emergency equipment so that they can respond in time in case of emergencies.
Those who are engaged in the storage and transportation of this substance need to be professionally trained and familiar with its nature, hazards, and emergency treatment methods. In the event of a leak, surrounding personnel should be evacuated quickly, and access should be strictly restricted. Emergency response personnel need protective clothing and gas masks, and do not let leaks come into contact with fire sources, oxidants, etc. A small amount of leakage can be absorbed by inert materials such as sand and vermiculite; a large amount of leakage needs to be contained, collected and properly disposed of.
Storage and transportation of 1-bromo-2,4-difluoro-3-methoxybenzene requires caution in every step and strict operation in accordance with regulations to effectively avoid risks and ensure personnel safety and the environment are not damaged.
What is the market price of 1-Bromo-2,4-Difluoro-3-Methoxybenzene?
1-Bromo-2,4-difluoro-3-methoxybenzene, its price is difficult to determine in the market. Its price often varies due to various reasons, such as supply and demand conditions, preparation methods, quality and quality, and market conditions.
Looking at the chemical industry in the past, the price of such fine chemicals may be high due to the difficulty of preparation and the rarity of materials used. If the preparation process is simple and the materials used are widely available, the price may be slightly flat.
And the potential of supply and demand, its price also has a big impact. There are many people in need and few people in supply, and the price will rise; on the contrary, if the supply exceeds the demand, the price will be depressed.
Furthermore, the quality of the product is pure and miscellaneous, and the price is also related to the level. High-purity products often exceed the price of ordinary ones.
However, the current market conditions are changing rapidly, and it is difficult to determine their price. To know the exact price, you should consult a chemical material supplier, or explore a professional chemical trading platform, to get the current appropriate price.