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1-Bromo-2,4,6-Trifluorobenzene

1-Bromo-2,4,6-Trifluorobenzene

Hongda Chemical

    Specifications

    HS Code

    364139

    Chemical Formula C6H2BrF3
    Molar Mass 225.0 g/mol
    Appearance Colorless to light yellow liquid
    Boiling Point 142 - 144 °C
    Density 1.729 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like ether, dichloromethane
    Flash Point 46 °C
    Purity Typically Varies by grade, often 97%+ in commercial products

    As an accredited 1-Bromo-2,4,6-Trifluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100 mL of 1 - bromo - 2,4,6 - trifluorobenzene in a sealed glass bottle.
    Storage 1 - bromo - 2,4,6 - trifluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents and reactive chemicals to prevent potential reactions. Ensure proper labeling for easy identification and safety.
    Shipping 1 - bromo - 2,4,6 - trifluorobenzene is shipped in well - sealed, corrosion - resistant containers. Special care is taken to prevent leakage during transit, adhering to strict hazardous chemical shipping regulations for safe transportation.
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    1-Bromo-2,4,6-Trifluorobenzene 1-Bromo-2,4,6-Trifluorobenzene
    General Information
    Historical Development
    1 - Bromo - 2,4,6 - Trifluorobenzene is an important compound in the field of organic synthesis. In the past, chemical pioneers in the process of organic halide exploration deepened their research on aromatic hydrocarbons containing fluorine and bromine. At first, the synthesis of such substances was difficult, the technology was lacking and the understanding was limited. However, the ancestors made unremitting efforts, and through repeated experiments and theoretical derivation, they gradually found an effective synthesis path. With the passage of time, technology has changed with each passing day, and the synthesis process has been continuously refined. From the initial simple method to the current precise and efficient means, the preparation of 1 - Bromo - 2,4,6 - Trifluorobenzene has become more and more mature. This compound has been widely used in many fields such as medicine and material science, and its historical evolution has witnessed the vigorous development and crystallization of chemistry.
    Product Overview
    1 - Bromo - 2,4,6 - Trifluorobenzene is also an organic compound. In its molecular structure, one bromine atom and three fluorine atoms occupy specific positions on the benzene ring. This compound has unique physical and chemical properties. Under normal temperature, it may be a colorless to light yellow liquid, with certain volatility and specific odor.
    In the field of organic synthesis, 1 - Bromo - 2,4,6 - Trifluorobenzene has a wide range of uses. Because it contains halogen atoms, it can participate in many nucleophilic substitution reactions and is an important raw material for the construction of new organic molecules. Chemists often use this compound to introduce specific functional groups to prepare drugs and materials with special properties.
    Synthesis of this compound often requires delicate chemical methods. Or from specific benzene derivatives, through a series of reactions such as halogenation. During the preparation process, the control of reaction conditions is extremely critical, such as temperature, catalyst selection and dosage, which all affect the purity and yield of the product. In short, 1 - Bromo - 2,4,6 - Trifluorobenzene is indispensable in chemical research and industrial production.
    Physical & Chemical Properties
    1 - Bromo - 2,4,6 - Trifluorobenzene is an organic compound, and its physical and chemical properties are worth studying. Looking at its physical properties, it is mostly liquid at room temperature, has a certain degree of volatility, and has good solubility in organic solvents. Its chemical properties are due to the existence of bromine atoms and fluorine atoms on the benzene ring, which makes it have unique reactivity. Bromine atoms can undergo nucleophilic substitution reactions and can interact with many nucleophilic reagents such as sodium alcohol and amines to derive other compounds. The high electronegativity of fluorine atoms reduces the electron cloud density of the benzene ring, which affects the activity and check point of the electrophilic substitution reaction. In addition, the stability of the compound is also affected by the interaction between atoms. Under specific conditions, decomposition or rearrangement reactions may occur. The clarification of its physical and chemical properties provides an important theoretical foundation for the development of synthetic applications and related fields.
    Technical Specifications & Labeling
    1 - Bromo - 2,4,6 - Trifluorobenzene is an important chemical substance. Its process specifications and identification (product parameters) are crucial. As far as process specifications are concerned, the synthesis process needs to be precisely controlled, from the selection of raw materials, which must be pure and free of impurities, to the setting of reaction conditions, such as temperature, pressure, and catalyst dosage, which must be carefully controlled to ensure the purity and yield of the product.
    When it comes to identification (product parameters), its physical properties, such as melting point, boiling point, density, etc. should be clarified as the basis for identification. Chemical properties cannot be ignored, and their stability and reactivity are all related to the safety and effect of use. And the packaging label should also be clear, indicating the ingredients, content, warning signs, etc., so that users can see at a glance, in order to comply with regulations, ensure safety, and achieve efficient application.
    Preparation Method
    The method of making 1 - Bromo - 2,4,6 - Trifluorobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The selection of raw materials is very important, such as high-purity fluorobenzene. In the production process, fluorobenzene and brominating agent are first reacted under specific conditions, which is a key step. The reaction steps are rigorous, and it is necessary to control temperature and pressure, and accurately grasp the reaction time. In a certain temperature range, the two are mixed to react, so that the bromine atom is just in the designated position of the benzene ring. The catalytic mechanism is also heavy, and the appropriate catalyst is selected to accelerate the reaction process and improve the yield. The catalyst can promote the activity of the brominating agent and make the reaction efficient. In this way, after many adjustments, it is expected to obtain high purity 1-Bromo-2,4,6-Trifluorobenzene.
    Chemical Reactions & Modifications
    To taste the wonders of chemistry is related to the change of substances, and reaction and modification are the gist. Today there is 1-Bromo-2,4,6-Trifluorobenzene, and its reaction path is often studied by scholars.
    The reaction between the reagents and the conditions varies. In case of nucleophilic reagents, halogen atoms can be replaced, which is a common reaction. If you want a better modification, you must carefully investigate the mechanism of the reaction and carefully adjust the conditions. The temperature and the nature of the solvent all affect the rate and direction of the reaction.
    The purpose of modification is either to increase its stability or to give it new energy. In the field of synthesis, by optimizing this reaction, better products can be obtained, which can be used in the fields of medicine and materials. Therefore, scholars should study diligently to understand the secret of its reaction and improve its modification method, so as to achieve a new state of chemistry and be used by the world.
    Synonyms & Product Names
    1 - Bromo - 2,4,6 - Trifluorobenzene is a chemical substance commonly used in organic synthesis. It has many synonyms and has many aliases in the academic world. Its trade name also varies according to different manufacturers and uses.
    This compound has attracted much attention in the chemical industry due to its unique structure. Its synonyms such as "2,4,6 - trifluorobenzene" accurately describe its molecular composition. In terms of trade names, different manufacturers are characterized by different names.
    Chemists often choose synonyms or trade names according to the situation in research and production. If academic research is focused, more general synonyms are used to show rigor; in commercial transactions and industrial applications, it is more convenient to use trade names.
    1 - Bromo - 2, 4, 6 - Trifluorobenzene is a synonym and trade name that reflects the richness and diversity of the chemical field and provides important support for academic exchanges and industrial development.
    Safety & Operational Standards
    1 - Bromo - 2,4,6 - Trifluorobenzene is an important chemical substance that needs to be explained in detail in terms of its safety and operating practices.
    During the preparation process, the first priority is to ensure the safety of the environment. The workshop must be well ventilated to prevent the accumulation of harmful gases. The equipment used for preparation should be clean and dry to avoid the mixing of impurities and affect the purity of the product. And all reaction conditions, such as temperature, pressure and reaction time, must be precisely controlled. The reaction of this substance is often dangerous, the temperature is too high or the reaction is caused by violent reactions, so precise temperature control equipment is required to maintain the reaction temperature within the appropriate range.
    When operating, the experimenter must wear professional protective equipment, including protective clothing, protective gloves and protective goggles. This is because 1 - Bromo - 2,4,6 - Trifluorobenzene may be irritating or even corrosive to the skin and eyes. If inadvertently touched, rinse with plenty of water immediately and seek medical attention in time.
    For storage, it should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. Due to its certain volatility and chemical activity, improper storage or potential safety hazards. Storage containers must also be well sealed to prevent leakage.
    When transporting, strict regulations must also be followed. Packaging must be sturdy to withstand normal vibrations and collisions. And during transportation, avoid high temperature and humid environment to ensure the stability of the material.
    In short, for the safety and operation specifications of 1-Bromo-2,4,6-Trifluorobenzene, from preparation to storage and transportation, every step should not be ignored, so as to ensure the safety of personnel and the smooth progress of experiments and production.
    Application Area
    1 - Bromo - 2,4,6 - Trifluorobenzene is an important compound in organic synthesis. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize drug molecules with special pharmacological activities. Because of its fluorine atom, it can enhance the lipophilicity and stability of drugs, making it easier for drugs to penetrate biofilms and improve drug efficacy. In the field of materials science, this compound can be used to prepare high-performance fluoropolymer materials. The prepared materials have excellent thermal stability, chemical stability and electrical properties, and are used in electronic devices, aerospace and other fields. For example, in aerospace, the material can be used to manufacture high-temperature and corrosion-resistant parts. In the field of pesticide chemistry, high-efficiency, low-toxicity and environmentally friendly pesticides can be synthesized from this raw material, enhancing the control effect of pesticides on pests and reducing the harm to the environment.
    Research & Development
    In recent years, in the field of chemistry, I have devoted myself to the study of 1 - Bromo - 2, 4, 6 - Trifluorobenzene. It is unique in nature and has a wide range of uses. It has potential in medicine and materials industries.
    At the beginning, the preparation method was not good, the yield was low, and the quality was uneven. My colleagues and I studied the classics, tried and tested, and improved the process. After months of hardships, we found the way to optimization, and the yield gradually increased and the quality was also excellent.
    At this time, this product has become the most important in the industry. However, we have not dared to slack off, we are well aware of the new technology, and we should continue to improve. In the future, it is planned to expand its application scope, explore the synergy effect with other things, and hope to open up new horizons and contribute to the development of chemistry, so as to promote this product to shine in various fields and promote the progress and development of the industry.
    Toxicity Research
    Since modern times, chemical refinement has resulted in the emergence of various products. In this sentence, 1 - Bromo - 2, 4, 6 - Trifluorobenzene, the study of its toxicity is crucial.
    This substance also has a unique molecular structure, with bromine and trifluoride atoms coexisting. Looking at its properties, or due to the strong electronegativity of fluorine, its chemical activity is unique. In the investigation of toxicity, the first observation is its interaction with biomolecules. It may combine with proteins, nucleic acids, etc., disturbing its normal physiological function.
    It also considers its environmental behavior. If it escapes from the outside, or is transmitted through water or gas, it will enter the living body. The burden of the food chain may be a disaster to the ecology. Although the relevant research is not abundant at present, the suspicion of toxicity should not be ignored. It is necessary to investigate in detail with a cautious attitude to clarify its toxic nature, protect people's lives and ecology, and prevent diseases before they start.
    Future Prospects
    The future prospect concerns 1 - Bromo - 2, 4, 6 - Trifluorobenzene. I look at this compound, which is unique in nature and has a wide range of uses. In the field of medicine, it may be used as a key intermediate to assist in the development of new drugs, cure various diseases, and relieve the pain of patients. In materials science, it may be able to participate in the creation of high-performance materials, so that materials have specific properties and are applied to cutting-edge technology.
    Although the research is not complete at present, I firmly believe that with time and unremitting research, more potential will be tapped. With technological refinement and process improvement, the production scale can be gradually expanded and the cost may be reduced. At that time, 1 - Bromo - 2, 4, 6 - Trifluorobenzene will surely be able to shine in more fields, bring benefits to the world, and open a new chapter.
    Where to Buy 1-Bromo-2,4,6-Trifluorobenzene in China?
    As a trusted 1-Bromo-2,4,6-Trifluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-Bromo-2,4,6-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    1 - Bromo - 2,4,6 - What is the main use of Trifluorobenzene
    1-Bromo-2,4,6-trifluorobenzene is also an organic compound. It has a wide range of uses and plays an important role in the field of organic synthesis.
    First, it can be used as a key intermediate in pharmaceutical synthesis. The creation of many drugs relies on it as the starting material, and through a series of chemical reactions, complex drug molecular structures are constructed. Due to the unique activity of bromine and fluorine atoms on the benzene ring, it can guide the reaction in a specific direction to achieve the expected molecular structure, helping to develop drugs with specific curative effects, such as antibacterial and antiviral drugs.
    Second, it is also indispensable in the field of pesticide synthesis. It can be chemically converted to make high-efficiency, low-toxicity and specific targeted pesticides. The introduction of fluorine atoms can often improve the stability and biological activity of pesticides, while bromine atoms can participate in various reactions, endowing pesticides with unique chemical properties, enabling them to effectively kill pests and weeds, and ensure the growth and yield of crops.
    Third, in materials science, 1-bromo-2,4,6-trifluorobenzene is also useful. It can be used to prepare polymer materials with special properties, such as fluoropolymers. Its participation in polymerization reactions can endow materials with excellent properties such as chemical resistance, high temperature resistance, and low surface energy. Such materials are in high demand in high-end fields such as aerospace and electronics.
    Furthermore, in the field of organometallic chemistry, as a ligand precursor or substrate, it participates in many metal-catalyzed reactions. Bromine atoms are prone to metallization reactions, forming stable complexes with metals, and then catalyzing various organic reactions, expanding the methods and paths of organic synthesis, and contributing to the development of organic chemistry. In short, 1-bromo-2,4,6-trifluorobenzene has important uses in many fields, promoting the progress and development of related industries.
    1 - Bromo - 2,4,6 - What are the physical properties of Trifluorobenzene
    1-Bromo-2,4,6-trifluorobenzene is also an organic compound. Its physical properties are quite characteristic, and this is what you described.
    Looking at its properties, under normal temperature and pressure, 1-bromo-2,4,6-trifluorobenzene is a colorless to light yellow liquid, clear and has a special smell. Although this smell is not pungent or intolerable, it is also one of its characteristics, which can be identified by the sense of smell.
    When it comes to the boiling point, it is about 145-147 ° C. The boiling point is the temperature limit for a substance to change from liquid to gas. The boiling point of this compound is within this range, indicating that at this temperature, the thermal motion of the molecules is sufficient to overcome the intermolecular forces and thus vaporize. At this temperature environment, its state will change significantly.
    Melting point is about -34 ° C. When the temperature drops below the melting point, 1-bromo-2,4,6-trifluorobenzene will solidify from liquid to solid, and the molecular arrangement will tend to be orderly. This melting point value shows that it will solidify at lower temperatures.
    In terms of density, it is about 1.826 g/mL. The density is the mass of the substance per unit volume, and this value reflects that it is denser than water. If it is mixed with water, it will sink to the bottom due to its high density.
    In terms of solubility, 1-bromo-2,4,6-trifluorobenzene is insoluble in water. In water, polar solvents are also used, and the compound is non-polar or weakly polar. According to the principle of "similar miscibility", the two are difficult to miscible. However, it is soluble in organic solvents such as ether, chloroform, and dichloromethane. This organic solvent is mostly non-polar or weakly polar, and is similar to the polarity of 1-bromo-2,4,6-trifluorobenzene, so it is compatible.
    In addition, the vapor pressure of 1-bromo-2,4,6-trifluorobenzene also has a certain value at a specific temperature. Vapor pressure is related to its degree of volatilization. Although the specific value varies with temperature, in general, it has a certain degree of volatility at room temperature, and the molecules will escape from the liquid surface and enter the gas phase.
    In summary, 1-bromo-2,4,6-trifluorobenzene has unique physical properties, which are the basis for its application in organic synthesis and related fields.
    Is 1 - Bromo - 2,4,6 - Trifluorobenzene chemically stable?
    1-Bromo-2,4,6-trifluorobenzene, its chemical properties are relatively stable. Because of its molecular structure, the benzene ring has a conjugated system, which reduces the molecular energy and enhances the stability. Although bromine atoms have certain activity, nucleophilic substitution reactions can occur. However, the existence of three fluorine atoms on the benzene ring, due to the strong electronegativity of fluorine atoms and the good ability to attract electrons, reduces the electron cloud density of the benzene ring, making it more difficult for nucleophilic reagents to attack and inhibits the activity of bromine atoms to a certain extent.
    Fluorine atoms are connected to the benzene ring to strengthen molecular stability. And the C-F bond energy is large, so it requires high energy to break, and it is not easy to
    In addition, 1-bromo-2,4,6-trifluorobenzene is difficult to spontaneously react under normal temperature and pressure without specific conditions, such as suitable catalysts, reactants, reaction temperatures, pressures, etc., further indicating that its chemical properties are relatively stable. However, under specific conditions, such as high temperature and strong catalysts, some chemical reactions can still occur, showing the reactivity of organic compounds.
    What are the preparation methods of 1 - Bromo - 2,4,6 - Trifluorobenzene
    There are many different ways to prepare 1-bromo-2,4,6-trifluorobenzene. The common one can be started from 2,4,6-trifluoroaniline. Shilling 2,4,6-trifluoroaniline is diazotized with sodium nitrite and hydrobromic acid at low temperature. This reaction needs to be carefully controlled to prevent side reactions from happening. The resulting diazonium salt is unstable, followed by the addition of cuprous bromide, a Sandmeier reaction occurs, the diazonium group is replaced by a bromine atom, and then 1-bromo-2,4,6-trifluorobenzene is obtained.
    Furthermore, it can be prepared from 2,4,6-trifluorobenzoic acid. First, 2,4,6-trifluorobenzoic acid is converted into acyl chloride, and thionyl chloride is often used to react with it to obtain 2,4,6-trifluorobenzoyl chloride. Then it is treated with sodium hypobromite by Hoffman degradation reaction to convert the amide group into an amino group, and at the same time reduce one carbon atom to generate 2,4,6-trifluoroaniline. Then according to the above diazotization and Sandmeier reaction steps, the final product is 1-bromo-2,4,6-trifluorobenzene.
    Another route is to use 2,4,6-trifluorobromobenzene as raw material. If the position of bromine atoms on the benzene ring needs to be adjusted, nucleophilic substitution reactions or metal-catalyzed coupling reactions can be used. According to specific reaction conditions and reagent selection, 1-bromo-2,4,6-trifluorobenzene can also be prepared. These various methods have their own advantages and disadvantages, and the appropriate preparation path should be carefully selected according to actual needs, such as raw material availability, cost, yield and purity requirements.
    1 - Bromo - 2,4,6 - Trifluorobenzene in storage and transport
    For 1 + -bromo-2,4,6-trifluorobenzene, many things need to be taken care of during storage and transportation.
    First priority safety protection. This material has certain chemical activity and potential danger, and contact can cause human damage. Therefore, the storage place must be well ventilated, and it should be kept away from fire and heat sources. Fireworks are strictly prohibited to prevent fire and explosion. Operators must wear appropriate protective equipment, such as protective clothing, gloves and goggles, to avoid contact between skin and eyes. If they accidentally touch it, they should quickly rinse with plenty of water and seek medical attention in time.
    Second words storage conditions. It should be placed in a cool, dry place to prevent moisture and deterioration. Due to its active chemical properties, it needs to be stored separately from oxidizing agents, alkalis and other substances to avoid chemical reactions caused by mixed storage. Storage containers should be made of corrosion-resistant materials, such as specific glass bottles or plastic bottles, and ensure that they are well sealed to prevent leakage.
    In addition to transportation links. Transportation vehicles should have corresponding qualifications and complete facilities in the vehicle to ensure stability during transportation. When transporting, relevant regulations and standards must also be followed, such as properly posting hazard signs to ensure that the transportation route avoids densely populated areas and environmentally sensitive areas. During loading and unloading, operators must be careful and handle light to prevent material leakage caused by damage to the container.
    In short, the storage and transportation of 1-bromo-2,4,6-trifluorobenzene is related to personnel safety and environmental stability, and all aspects must be strictly followed and cannot be slack.