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1-Bromo-2,4,5-Trifluorobenzene

1-Bromo-2,4,5-Trifluorobenzene

Hongda Chemical

Specifications

HS Code

496554

Chemical Formula C6H2BrF3
Molecular Weight 225.98
Appearance Liquid (usually)
Boiling Point Around 155 - 157 °C
Density Approx. 1.79 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Vapor Pressure Low at room temperature
Flash Point Around 48 °C

As an accredited 1-Bromo-2,4,5-Trifluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - bromo - 2,4,5 - trifluorobenzene in 500 - mL glass bottle for chemical storage.
Storage 1 - Bromo - 2,4,5 - trifluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents and incompatible substances to prevent potential chemical reactions.
Shipping 1 - bromo - 2,4,5 - trifluorobenzene is a chemical. It should be shipped in well - sealed, corrosion - resistant containers, following strict hazardous materials regulations to ensure safe transportation.
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1-Bromo-2,4,5-Trifluorobenzene 1-Bromo-2,4,5-Trifluorobenzene
General Information
Historical Development
1 - Bromo - 2,4,5 - Trifluorobenzene is also an organic compound. Looking back at its historical development, chemistry was first emerging in the past, and many sages dedicated themselves to the exploration of new substances. At that time, the study of halogenated aromatic compounds gradually began.
In the early days, chemists experimented repeatedly in the laboratory to try to synthesize various halogenated benzene derivatives. After long-term exploration, the synthesis technology has gradually improved. For 1 - Bromo - 2,4,5 - Trifluorobenzene, scientists have been able to effectively synthesize this compound after countless optimization of reaction conditions, such as temperature and catalyst screening.
With the passage of time, its potential applications in materials science, medicinal chemistry and other fields have gradually become apparent. The historical development of this compound is a process of unremitting exploration and accumulation of wisdom by chemists, laying the foundation for subsequent scientific research and industrial applications.
Product Overview
1 - Bromo - 2,4,5 - Trifluorobenzene, also an organic compound. It is a colorless to light yellow liquid with a special odor. This substance is widely used in the field of organic synthesis.
Coexisting in its molecular structure, bromine atoms and trifluoride atoms give unique chemical activity. Bromine atoms are active and can participate in various reactions such as nucleophilic substitution. They can introduce various functional groups to form complex organic structures. The introduction of fluorine atoms gives compounds high stability and special physical and chemical properties, such as enhancing fat solubility and changing the electron cloud distribution of compounds.
In the chemical industry, it is often a key intermediate in the synthesis of pharmaceuticals, pesticides and high-performance materials. Through exquisite reaction design, it can be converted into biologically active pharmaceuticals to treat various diseases; or made into high-efficiency pesticides to protect agricultural products from pests. Due to its special properties, it has also emerged in the field of materials science, helping to develop high-performance functional materials.
Physical & Chemical Properties
1 - Bromo - 2,4,5 - Trifluorobenzene is an organic compound, and its physical and chemical properties are worth studying. This substance is liquid at room temperature and has a certain volatility. Looking at its chemical structure, bromine atoms are connected to trifluorophenyl groups, giving it unique chemical activity. In terms of physical properties, due to the strong electronegativity of fluorine atoms, molecular polarity may be reflected, which affects its boiling point and melting point. The existence of fluorine and bromine atoms makes the intermolecular forces different, causing its boiling point to be higher than that of common benzene derivatives. Chemically, bromine atoms can undergo nucleophilic substitution reactions, introducing new groups for organic synthesis. It has a wide range of uses in the field of organic synthesis and can be used as an intermediate to construct complex organic molecular structures through various reactions, providing an important basis for chemical research and industrial production.
Technical Specifications & Labeling
1 - Bromo - 2,4,5 - Trifluorobenzene is an important chemical product. Its preparation process requires strict adherence to specific procedures. The first raw material is selected, and the starting material with extremely high purity is required to ensure the quality of the product.
The synthesis method is often followed by a specific fluorination reaction and a bromination reaction in sequence. The fluorination step first introduces fluorine atoms at specific positions in the benzene ring. This step requires precise control of reaction conditions such as temperature, pressure and catalyst dosage. Then bromide, so that the bromine atoms are successfully connected to the designated check point.
The identification of the product is related to many parameters. The appearance is often a colorless to slightly yellow liquid, and the smell has a specific chemical smell. The purity needs to be very high, and the impurity content should be minimal. Precise physical and chemical parameters, such as boiling point, melting point, density, etc., are also key to the identification, which is related to the performance of the product in various application scenarios. Strict control of technical specifications and identification parameters can ensure the quality and application efficiency of 1-Bromo-2,4,5-Trifluorobenzene.
Preparation Method
Now I want to make 1 - Bromo - 2,4,5 - Trifluorobenzene. The preparation method is related to the raw materials and production process, reaction steps and catalytic mechanism.
First take suitable raw materials, such as fluorobenzene compounds, and convert them through specific steps. Initially, the raw materials need to be mixed in precise proportions and put into a special reactor. Temperature control is within the appropriate range, or a catalyst is required to promote the reaction. The reaction steps are rigorous and carried out in sequence.
The production process is also critical, from raw material pretreatment to reaction process monitoring, all must be fine. And the catalytic mechanism can increase the reaction rate and product purity. After many debugging, make each link fit, can obtain high purity of 1 - Bromo - 2,4,5 - Trifluorobenzene. So, according to this method of preparation, can be made.
Chemical Reactions & Modifications
1 - Bromo - 2,4,5 - Trifluorobenzene is an organic compound. Its chemical reaction and modification are the focus of our research. The reaction of this compound often depends on the reaction conditions, such as temperature and the genus of catalysts.
When the temperature is adjusted in a suitable environment and the appropriate catalyst is selected, a specific reaction path can be caused. For example, supplemented by a specific metal catalyst, it may be able to exhibit unique activity in nucleophilic substitution reactions.
As for modification, it is designed to increase its properties or give it new substances. After modifying the structure of its molecules, its solubility and stability may be changed. These are all ways to optimize its properties and hope to be widely used in various fields, such as medicine and materials. We often think of using ancient methods to join new technologies to explore the best reaction and modification methods, hoping to benefit the research of chemistry.
Synonyms & Product Names
1 - Bromo - 2,4,5 - Trifluorobenzene, also an organic compound. Its synonymous name, or 2,4,5 - trifluorobenzene. This substance is also sold in the market under this name. This compound has the properties of halogenated aromatics and is widely used in the field of organic synthesis. It can be used as an intermediate to make medicines, pesticides, materials and other products. Because the molecule contains bromine and fluorine atoms, it gives it special chemical activity and physical properties. Chemists often perform various reactions according to its reaction characteristics during experiments to obtain the desired product. In industry, it is also prepared in large quantities through specific processes. Due to its importance in many fields, scholars continue to study it, hoping to expand its application, increase its effectiveness, and contribute to the progress of the chemical industry.
Safety & Operational Standards
1 - Bromo - 2,4,5 - Trifluorobenzene is a chemical substance. It is related to its safety and operating practices. It is essential and should not be ignored.
On the safe side, this chemical has certain risks. It may pose a potential threat to human health, or irritate the skin, eyes and respiratory tract. If you come into contact with the skin inadvertently, rinse with plenty of water immediately. If you feel unwell, seek medical attention immediately. If it enters the eye, open the eyelids immediately, rinse with flowing water or normal saline, and seek medical attention promptly.
In terms of operating practices, the experimental site should be well ventilated to disperse possible harmful gases. Operators must wear appropriate protective equipment, such as laboratory clothes, protective gloves and goggles, etc., to avoid direct contact.
When taking the substance, use a precise measuring tool, operate strictly according to the amount required for the experiment, and do not increase or decrease at will. After use, properly dispose of the remaining items and do not discard them at will to prevent pollution of the environment.
When storing, it should be placed in a cool, dry and ventilated place, away from fire sources and oxidants, etc., to prevent dangerous reactions. Records of its storage and use should also be detailed and accurate for future inspection.
In conclusion, the treatment of 1 - Bromo - 2, 4, 5 - Trifluorobenzene must strictly adhere to safety and operating standards to ensure the smooth operation of the experiment, and to ensure the safety of personnel and the environment.
Application Area
1 - Bromo - 2,4,5 - Trifluorobenzene, the essence of chemical. Its use is quite wide, and it is evident in all domains.
The genus of Guanfu Medicine can be used as a raw material for medicine. Based on this, chemists make special agents to treat various diseases. Or as an antibacterial drug, which can remove the disturbance of germs; or as an analgesic agent, which can relieve the invasion of pain.
In the realm of electronics, it also has its own functions. It can help make advanced materials, used in chips, circuit boards, etc. It makes electronic devices better in performance, more stable and faster.
In the field of agriculture, it can be a raw material for pesticides. The pesticides produced can protect crops, eliminate pests, and ensure a good harvest.
is used in 1-Bromo-2,4,5-Trifluorobenzene, which is related to medicine, electronics, agrochemical and other fields. It is an important item in the chemical industry and cannot be underestimated.
Research & Development
I am committed to the research of 1 - Bromo - 2,4,5 - Trifluorobenzene. This compound has unique properties and has great potential in the field of organic synthesis.
At the beginning, the method of its preparation was explored, and many attempts were made. In the conventional halogenation reaction, the yield was often not high and the side reactions were complicated. Then we studied and improved, adjusted the reaction conditions, such as temperature and catalyst ratio, and repeated tests to obtain a more suitable method, and the yield was also improved.
Then, the reactivity was studied. It was found that it exhibited special selectivity in the nucleophilic substitution reaction, and different products could be generated according to different reaction substrates and conditions. This property provides new ideas for the design of organic synthesis routes.
Looking to the future, 1 - Bromo - 2,4,5 - Trifluorobenzene is expected to shine in the fields of drug research and development, materials science and other fields. I will continue to improve my research, hoping to expand its application boundaries and contribute to the academic and industrial circles.
Toxicity Research
Toxicity Study of 1 - Bromo - 2,4,5 - Trifluorobenzene
Modern chemistry has flourished, and various compounds have emerged one after another. 1 - Bromo - 2,4,5 - Trifluorobenzene is also one of them. As a chemical researcher, I have devoted myself to exploring the toxicity of this substance.
At first, looking at its physicochemical properties, 1 - Bromo - 2,4,5 - Trifluorobenzene has unique properties. However, toxicity studies cannot be based on appearances alone. So it is observed by various experiments.
Take animals as samples and apply this substance to observe its physiological changes. It is seen that the test animals are slow to move and their diet has been abandoned. Looking at the dissection, the organs are also damaged. And at the cellular level, it has adverse effects on cell activity and structure.
It can be seen that 1-Bromo-2,4,5-Trifluorobenzene has certain toxicity. During production and use, care should be taken to prevent it from poisoning the human body and harming the environment. Future research should also deepen the understanding of its toxicity and find ways to prevent and resolve it.
Future Prospects
Not yet found in 1 - Bromo - 2, 4, 5 - Trifluorobenzene This thing, my heart is full of hope. In today's world, the day of intensive research, this thing may be used in many new fields.
For research and development, or to create the basis for special effects, to help people break diseases. Its characteristics may lead to the exploration of new methods and new ways.
It can be used as the source of high-tech materials. Its characteristics, such as manufacturing, resistance and special functions, can be used in aerospace and children.
And the way of research, this thing may also be the medium of new reactions. It is possible to stimulate the family's thinking, develop the new synthesis method, and promote the science of chemistry.
, 1 - Bromo - 2,4,5 - Trifluorobenzene has not yet been developed, and it seems that it is possible to wait for our researchers to explore deeply, uncover its brilliance, and use it in the world to create a blessing for the people.
Where to Buy 1-Bromo-2,4,5-Trifluorobenzene in China?
As a trusted 1-Bromo-2,4,5-Trifluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-2,4,5-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-bromo-2,4,5-trifluorobenzene?
1-2,4,5-tribromophenol is an important chemical compound with a wide range of uses.
In the field of synthesis, 1-2,4,5-tribromophenol can be used as a medium. For example, in the synthesis of certain molecules with special properties, it can be used by specific chemical reactions, and other chemical substances can be used occasionally. Molecules with specific biological activities can be produced. This is based on the activity of bromine atoms in its molecules, which can be used for reactions such as nuclear substitution, enabling chemical companies to synthesize the desired compounds.
It also has important uses in materials science. Due to its bromine content, bromine atoms can emit free radicals at high temperatures, causing ignition and reaction, so they are often used as flame retardants to be added to various polymer materials. For materials such as plastics, rubber, etc., adding 1-2,4,5-tribromophenol can effectively improve the flame retardancy of the material, reduce the flammability of the material in the event of fire, and increase the fire safety performance of the material. It is widely used in areas with high flame retardant requirements such as foreign products and construction materials.
In addition, in the field of chemical analysis, 1-2,4,5-tribromophenol can be used for specific analysis. Using its properties to generate specific properties can be used for chemical or quantitative analysis of specific compounds. For example, in some gold seeds, it can be used to form complexes with specific colors or photochemical properties, thus enabling qualitative and quantitative analysis of gold seeds.
What are the physical properties of 1-bromo-2,4,5-trifluorobenzene?
1-Bifurcation-2,4,5-tribromophenol is an organic compound, and its physical properties are as follows:
Under normal conditions, 1-Bifurcation-2,4,5-tribromophenol is a white to light yellow crystalline powder with a fine texture and its fine granular form can be discerned by the naked eye. This appearance characteristic makes it easy to identify in many substances.
Smell, the compound has a special smell, although it is not strong and pungent, but it is also unique. In a specific environment, it can be used to make a preliminary judgment based on this smell.
Touch it, its melting point is between 120-124 ° C. At this temperature range, 1-dip-2,4,5-tribromophenol in solid state will gradually melt into liquid state. The characteristics of melting point are crucial in the process of material identification, separation and purification, and can be used as one of the key indicators.
Re-discussion of its solubility, 1-dip-2,4,5-tribromophenol is slightly soluble in water, and can only dissolve a small amount in water. Due to the weak force between water molecules and the compound molecules, it is difficult to form a uniform and stable solution system. However, it is soluble in organic solvents such as ethanol, ether, and acetone. In these organic solvents, the intermolecular interaction is appropriate, and it can be well dispersed and dissolved to form a homogeneous system. This difference in solubility is often used for the separation and extraction of substances in chemical experiments and industrial production.
In addition, 1-dip-2,4,5-tribromophenol has a higher density than water. If it is placed in the same container as water, it will settle at the bottom. This density characteristic is of great significance when involving operations such as liquid-liquid separation.
What are the chemical properties of 1-bromo-2,4,5-trifluorobenzene?
1-% pente-2,4,5-triene alkynes are alkynes, which have unique chemical properties and have the dual characteristics of alkenes and alkynes.
Looking at the addition reaction, due to the carbon-containing carbon double bond and carbon-carbon triple bond, both are electron-rich regions, which are easy to interact with electrophilic reagents. In case of hydrogen halide, it can be added according to the Markov rule. At the carbon-carbon double bond, the carbon with more hydrogen atoms is hydrogenated, and the halogen atom is added to the carbon with less hydrogen atoms; the carbon-carbon triple bond can also be added with it, or added in steps, to form a double-bond halide first, and when conditions are appropriate, it can be further added to a saturated halide. In case of bromine water, alkenyne can undergo electrophilic addition with it, causing bromine water to fade, and according to the reaction conditions and the proportion of reactants, the degree of addition can be controlled, or the double bond is added first, or both the double bond and the triple bond are added.
As far as oxidation is concerned, when treated with a strong oxidant such as acidic potassium permanganate, the carbon-carbon double bond and the triple bond will be oxidized and broken. At the double bond, according to its substitution, either carboxylic acid or carbon dioxide and corresponding carbonyl compounds will be formed; at the triple bond, carboxylic acid or carbon dioxide can be formed. If one end of the triple bond is alkynyl hydrogen, it can be oxidized to a carboxyl group.
The stability of this compound is slightly higher than that of partially solitary alkynes due to the delocalization of π electrons or a certain conjugation effect. The conjugation system affects the distribution of electron clouds, which in turn affects its chemical activity and reaction selectivity. In some reactions, the conjugation effect makes its reaction check point and reactivity different from ordinary alkynes.
1-% E-2,4,5-trialkynes have a unique structure and can be used as a key intermediate in the field of organic synthesis. With its addition, oxidation and other reactions, a variety of complex organic molecular structures can be constructed, adding a powerful tool for organic synthesis chemistry.
What are the methods for preparing 1-bromo-2,4,5-trifluorobenzene?
To prepare 1-bromo-2,4,5-trifluorobenzene, the method is as follows:
First, 2,4,5-trifluorobenzene is used as the starting material, and it is obtained by diazotization and Sandmeier reaction. First, dissolve 2,4,5-trifluorobenzene into an appropriate amount of inorganic acid, usually hydrochloric acid or sulfuric acid, and cool it to a low temperature, generally 0-5 ℃. Then slowly add sodium nitrite solution dropwise, carry out diazotization reaction to generate 2,4,5-trifluorobenzene diazonium salt. This process requires strict temperature control to prevent the decomposition of diazonium salts. Then the diazonium salt solution is dropped into the hydrobromic acid solution containing cuprous bromide. After the Sandmeier reaction, the diazonium group is replaced by the bromine atom, and then 1-bromo-2,4,5-trifluorobenzene is obtained. After the reaction is completed, the product is extracted with an organic solvent, such as dichloromethane, ether, etc., and then purified by washing, drying, and distillation.
can also be prepared by reacting 2,4,5-trifluorophenylboronic acid with brominated reagents. Mix 2,4,5-trifluorophenylboronic acid with an appropriate amount of brominated reagents, such as N-bromosuccinimide (NBS) or bromine, in suitable solvents, such as dichloromethane and tetrahydrofuran, and add an appropriate amount of catalyst, such as copper salt or palladium salt. During the reaction, the temperature and reaction time need to be adjusted according to the selected reagent and catalyst. After the reaction is completed, regular separation methods, such as filtration, extraction, distillation, etc., can obtain pure 1-bromo-2,4,5-trifluorobenzene.
In addition, halogenated derivatives of 2,4,5-trifluorobenzene can also be achieved through halogen exchange reactions. Select suitable halogenated 2,4,5-trifluorobenzene derivatives, such as chloro or iodine, and react with brominating reagents under specific conditions. Commonly used brominating reagents include potassium bromide, sodium bromide, etc., and phase transfer catalysts can be added to increase the reaction rate. The target product 1-bromo-2,4,5-trifluorobenzene can also be prepared by reacting with appropriate solvents and temperatures through separation and purification steps.
What are the precautions for storing and transporting 1-bromo-2,4,5-trifluorobenzene?
In the process of storage of 1-% -2,4,5-tribromobenzene, the following things should be paid attention to:
First, this is a chemical substance, with specific chemical properties. If it is not stored, it must be dried up, passed and lost. Due to moisture or its biochemical reactions, it will affect the product. In case of water vapor, or reactions such as hydrolysis, it should be changed.
Second, it should be stored separately. 1-% -2,4,5-tribromobenzene or oxidized benzene, even if it causes ignition, explosion and other hazards. If the oxidizing agent is placed in one layer, the oxidizing property of the oxidizing agent may promote some chemical reactions in 1-% -2,4,5-tribromobenzene to crack, releasing a lot of energy.
Third, it is necessary to follow the phase method in the final process. Hazardous chemicals that are not used are not used, and they should be equipped with safe application of phase, such as fire and so on. People also need to be trained, familiar with the dangerous characteristics and emergency treatment methods of 1-% 2,4,5-tribromobenzene. In the event of an accident such as leakage on the way, it can be quickly and properly treated to avoid damage.
Fourth, the storage container should be well sealed. To prevent 1-% 2,4,5-tribromobenzene from polluting the surrounding environment, and to prevent external objects from entering and affecting its safety. It is important to use a combined storage container, such as corrosion-resistant materials, because 1-% 2,4,5-tribromobenzene or some materials are corrosive.
Therefore, the storage of 1-%-2,4,5-tribromobenzene requires compliance with phase safety standards and caution in order to ensure that people's safety environments are not contaminated and to ensure the characterization of chemical substances in the entire process.