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1-Bromo-2,3-Dimethyl-4-Fluorobenzene

1-Bromo-2,3-Dimethyl-4-Fluorobenzene

Hongda Chemical

Specifications

HS Code

426696

Name 1-Bromo-2,3-Dimethyl-4-Fluorobenzene
Molecular Formula C8H8BrF
Molar Mass 203.05 g/mol
Appearance Liquid (presumably, typical for many aromatic halides)
Solubility In Water Insoluble (aromatic halides are generally hydrophobic)
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, diethyl ether, and dichloromethane

As an accredited 1-Bromo-2,3-Dimethyl-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1 - bromo - 2,3 - dimethyl - 4 - fluorobenzene packaged in a sealed glass bottle.
Storage 1 - bromo - 2,3 - dimethyl - 4 - fluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents, strong acids, and bases to prevent chemical reactions. Label the storage container clearly for easy identification.
Shipping 1 - bromo - 2,3 - dimethyl - 4 - fluorobenzene is a chemical. Shipping requires proper packaging in accordance with hazardous materials regulations. It should be transported in containers that prevent leakage and ensure safe transit to the destination.
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1-Bromo-2,3-Dimethyl-4-Fluorobenzene 1-Bromo-2,3-Dimethyl-4-Fluorobenzene
General Information
Historical Development
Wenfu 1 - Bromo - 2,3 - Dimethyl - 4 - Fluorobenzene originated from the research of Zhu Xian. At the beginning, the academic community explored the structure and activity of halogenated aromatic hydrocarbons. In the past, the public was dedicated to the synthesis of organic halides.
First of all, the method of organic synthesis is not complete, and it is quite difficult to obtain such halogenated aromatics. However, many scholars were not discouraged. After several years, they found bromination and fluorination methods, and gradually added bromine, fluorine and methyl based on benzene derivatives. In the initial attempt, the yield was not satisfactory and there were many impurities. However, Zhu Xian repeatedly researched and improved the process.
After years of work, optimizing the reaction conditions, temperature control, agent selection, and time adjustment are all ingenious. Therefore, the synthesis of 1-Bromo-2,3-Dimethyl-4-Fluorobenzene has been perfected day by day, with increasing yield and good purity. Its application in medicine, materials, and other fields has also become more promising due to the progress of synthesis.
Product Overview
1 - Bromo - 2,3 - Dimethyl - 4 - Fluorobenzene is a chemical I have been working on recently. It is a colorless and transparent liquid with a special odor. The molecular structure of this substance is unique. Bromo atoms, methyl and fluorine atoms are cleverly connected to the benzene ring, and the structure is exquisite.
In terms of chemical properties, its activity is quite impressive. The presence of bromine atoms makes it easy to participate in nucleophilic substitution reactions, methyl moderately enhances the stability of molecules, while fluorine atoms endow it with unique electronic effects, making the overall chemical activity unique.
Preparation of this product requires fine regulation of the reaction conditions. Based on the specific halogenation reaction and alkylation reaction, high yield and purity can be obtained by precisely controlling the temperature and catalyst dosage.
1-Bromo-2,3-Dimethyl-4-Fluorobenzene has broad prospects in the field of organic synthesis, and can be used as a key intermediate to create new drugs and functional materials, injecting new vitality into the development of many fields.
Physical & Chemical Properties
1 - Bromo - 2,3 - Dimethyl - 4 - Fluorobenzene is an important organic compound. Its physical properties are liquid at room temperature, with a clear and transparent color and a special odor. The boiling point is in a specific range, which is due to the force between molecules. The melting point is also a specific value, reflecting the characteristics of the molecular lattice arrangement.
In terms of chemical properties, due to the conjugated structure of the benzene ring and the substitution of halogen atoms, methyl and fluorine atoms, it has unique reactivity. Bromine atoms have high activity and can participate in nucleophilic substitution reactions. Under appropriate conditions, they can be replaced by nucleophilic reagents. Methyl has a donor electron effect, which can affect the electron cloud density of the benzene ring and change the adjacent para-site reactivity. Fluorine atoms have large electronegativity, which also affects molecular polarity and reaction check point selectivity. All kinds of properties are widely used in the field of organic synthesis.
Technical Specifications & Labeling
There is a product today, named 1 - Bromo - 2,3 - Dimethyl - 4 - Fluorobenzene. Its process specifications and identification (product parameters) are related to the quality of this product, the fineness of the production, and the effectiveness of the use.
To make this product, a certain process must be followed. From the beginning of material selection, the proportion of each ingredient is fixed. During operation, factors such as temperature, humidity, and duration should not be ignored. In this way, high-quality products can be obtained.
Identification (product parameters) indicates its characteristics. Such as appearance, purity, geometry, and the amount of impurities contained are all clear. This is the basis for users to judge whether it is usable or not. Therefore, process specifications and identification (product parameters), in 1 - Bromo - 2,3 - Dimethyl - 4 - Fluorobenzene, are of paramount importance, and are also relevant to its application and effectiveness in various fields.
Preparation Method
To prepare 1-Bromo-2,3-Dimethyl-4-Fluorobenzene, the raw materials, production process, reaction steps and catalytic mechanism are the key.
First take an appropriate amount of 2,3-dimethyl-4-fluoroaniline as the starting material, prepare diazonium salt solution with hydrobromic acid and sodium nitrite. This step needs to be controlled at low temperature to prevent the decomposition of diazonium salt. After the formation of the diazonium salt is complete, slowly drop into the hydrobromic acid solution containing cuprous bromide, and the Sandmeier reaction occurs. In this process, the diazonium group is replaced by the bromine atom, so as to obtain the target product 1-Bromo-2,3-Dimethyl-4-Fluorobenzene.
During the reaction, cuprous bromide is the key catalyst, which can reduce the activation energy of the reaction and speed up the reaction rate. At the same time, strictly control the reaction temperature, raw material ratio and drip acceleration to improve the yield and purity of the product, which is the essence of preparing the product.
Chemical Reactions & Modifications
There is a chemical compound today, named 1 - Bromo - 2,3 - Dimethyl - 4 - Fluorobenzene. Its anti-modification, according to the note of our researchers.
The anti-modification of this compound is an important research topic. In its molecule, the presence of bromine, fluorine and dimethyl makes the anti-reactivity characteristic. Bromine atoms have high activity and can easily replace the anti-reactivity. Polyfunctional compounds can be introduced to improve their anti-reactivity. Fluorine atoms have a special activity in some anti-reactivity because of their high reactivity.
The steric resistance of dimethyl also affects the anti-reactivity of the compound. To modify this compound, it can be used to synthesize derivatives with special properties by integrating and reacting components, such as temperature, catalysis, etc., or using its reactive activity to synthesize derivatives with special properties, which can be used in the fields of technology, materials, etc., to explore new avenues of research.
Synonyms & Product Names
1 - Bromo - 2,3 - Dimethyl - 4 - Fluorobenzene, its synonyms and trade names are worth exploring. In the field of my chemical research, knowing its synonyms can help accurate communication. Its synonyms may vary slightly due to different regions and research groups.
As for the trade name, it also has a unique logo in the circulation of the chemical market. Either for commercial promotion or based on product characteristics, the trade name set by the manufacturer can make the product more recognizable in the market.
If you study it carefully in various chemical directories and academic works, you may find a variety of expressions. This is not only about academic rigor, but also closely related to practical application. Accurately grasping synonyms and trade names is beneficial to the smooth progress of chemical production and scientific research experiments.
Safety & Operational Standards
1 - Bromo - 2,3 - Dimethyl - 4 - Fluorobenzene is an important chemical and is essential for its safety and handling practices.
When preparing this chemical, all raw materials and reagents used must be pure and of high quality to prevent impurities from mixing, causing reaction deviation or producing unsafe products. The operating environment must be well ventilated due to the reaction process or the generation of harmful gases. Experimenters should wear appropriate protective clothing, such as protective clothing, protective gloves and goggles, to prevent chemical substances from contacting the skin and eyes.
The reaction device must be stable and well sealed to avoid leakage. The heating process needs to be strictly controlled and adjusted accurately according to the reaction requirements. Too fast or too slow heating rate may affect the quality and yield of the product. Stirring is also indispensable to promote the uniformity of the reaction system and ensure that the reaction is fully carried out.
In the stage of product separation and purification, appropriate methods should be selected, such as distillation, extraction, recrystallization, etc., to ensure that the purity of the obtained product is up to standard. When storing, it should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. The container must be resistant to chemical corrosion, and clearly marked with information such as chemical names, characteristics and hazards.
During transportation, relevant safety regulations should also be followed, and measures such as shock and leak prevention should be taken to ensure that the product is delivered to the destination safely. Anyone who comes into contact with this chemical should be familiar with its safety and operating practices, so as to ensure the smooth progress of the experiment and the safety of personnel and the environment.
Application Area
1 - Bromo - 2,3 - Dimethyl - 4 - Fluorobenzene is an important organic compound. Its application field is quite wide. In the field of medicinal chemistry, due to its unique chemical structure, it may become a key intermediate for the synthesis of new drugs. Through delicate chemical reactions, it can be combined with many compounds to develop drugs with specific curative effects.
In the field of materials science, this compound may participate in the preparation of materials with special properties. For example, through polymerization, it can form polymer materials with special electrical and optical properties, which are used in electronic devices, optical instruments, etc.
In the field of organic synthesis, it is often used as a starting material to build complex organic molecular structures through various substitution and addition reactions, providing important assistance for the development of organic synthetic chemistry and promoting the continuous development of this field.
Research & Development
In recent years, I have focused on the research of 1 - Bromo - 2,3 - Dimethyl - 4 - Fluorobenzene. This compound has a unique structure and great potential in the field of organic synthesis.
At the beginning, the synthesis process was full of thorns. The ratio of raw materials is slightly different, but the product is a thousand miles away. The control of the reaction conditions is also crucial. The temperature and pressure are slightly different, which affects the yield and purity.
However, I and my colleagues did not give up, and repeated deductions and tried new methods. After much effort, we finally got the optimization method. The yield gradually increased, and the purity also reached the highest.
This achievement lays the foundation for future development. We will explore its application in the fields of drug development, material creation, etc., with the hope of opening up new avenues and contributing to the progress of chemistry, making 1-Bromo-2,3-Dimethyl-4-Fluorobenzene shine.
Toxicity Research
It is very important to study the toxicity of 1 - Bromo - 2,3 - Dimethyl - 4 - Fluorobenzene today. Looking at its structure, bromine, fluorine and other atoms exist in the benzene ring, or have special chemical properties. Past studies have shown that such halogenated aromatic hydrocarbons are mostly toxic.
The benzene ring is stable, and the halogen atom makes it active and easy to react with other substances. Or into the body, it interacts with macromolecules such as proteins and nucleic acids, disturbing normal physiology. In the environment, it is difficult to degrade, accumulates in the ecological, harmful and biological chain.
Although there is no detailed toxicity test of 1-Bromo-2,3-Dimethyl-4-Fluorobenzene, it is inferred that there may be neurotoxicity, genetic toxicity, etc. It is necessary to conduct experiments quickly to analyze its toxicology and dose effect, so as to lay the foundation for protection and pollution control, and ensure ecological and human safety.
Future Prospects
I have tried to study 1 - Bromo - 2,3 - Dimethyl - 4 - Fluorobenzene. Although it has a small success now, the future prospects are still broad.
This compound has a unique structure and different properties. It can be used as a key intermediate in the field of organic synthesis. If it is refined in the future, it may be used to create new drugs to cure various diseases. It is also expected to emerge in materials science and contribute to the research and development of new materials.
Furthermore, although the synthesis method is feasible now, there is still room for improvement. In the future, we should seek simpler and more efficient methods to reduce its cost and increase its yield. In this way, this compound can be more widely used in medicine, materials, and other industries, and it can shine brightly, leading the future development. This is what I really hope for.
Where to Buy 1-Bromo-2,3-Dimethyl-4-Fluorobenzene in China?
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Frequently Asked Questions

As a leading 1-Bromo-2,3-Dimethyl-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

1-Bromo-2, what is the main use of 3-Dimethyl-4-Fluorobenzene?
1-Bromo-2,3-dimethyl-4-fluorobenzene is also an organic compound. It has a wide range of main uses and is an essential intermediate in the field of organic synthesis.
In the process of organic synthesis, various chemical reactions can be performed to produce a variety of organic compounds. For example, it can perform nucleophilic substitution reactions with nucleophiles, and bromine atoms are replaced by other groups, which are commonly used in the construction of carbon-carbon bonds and carbon-heteroatomic bonds. For example, interacting with carbon-containing nucleophiles, such as Grignard reagents, can form compounds with new carbon frameworks. This is a key step in the synthesis of complex natural products or drugs.
Furthermore, this compound is also useful in materials science. After appropriate chemical modification, materials with special photoelectric properties may be prepared, such as used in organic Light Emitting Diodes (OLEDs), organic solar cells and other fields. With its specific structure and properties, the properties of materials may be improved.
In the field of pharmaceutical chemistry, 1-bromo-2,3-dimethyl-4-fluorobenzene may be a key structural unit of lead compounds. By modifying and optimizing its structure, drugs with high activity and high selectivity may be developed, opening up new avenues for pharmaceutical research and development.
In conclusion, 1-bromo-2,3-dimethyl-4-fluorobenzene has significant application value in many fields such as organic synthesis, materials science, and medicinal chemistry due to its unique chemical structure, and has made great contributions to promoting progress in related fields.
1-Bromo-2, what are the physical properties of 3-Dimethyl-4-Fluorobenzene
1-Bromo-2,3-dimethyl-4-fluorobenzene is one of the organic compounds. Its physical properties are very important, and it is related to many chemical processes and practical applications.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow liquid, this color and state is easy to identify. It has a special smell, although it is difficult to describe accurately, but in chemical experiments and industrial scenes, this smell can be a clue to distinguish.
When it comes to the boiling point, it has been experimentally determined to be in a certain temperature range. The value of this boiling point is of great significance for its separation and purification. In operations such as distillation, it can be effectively separated from the mixture according to this boiling point. The melting point of
is also a key property. At a specific low temperature, the substance will change from liquid to solid. The characteristics of this melting point should be paid attention to during storage and transportation to ensure its stable state.
In terms of density, there is a specific value, which is higher or lower than the density of water. This property is crucial in operations such as liquid-liquid separation. The different densities can make the substance stratified with other liquids to achieve the purpose of separation.
Solubility cannot be ignored. In organic solvents, such as ethanol and ether, its solubility is quite good, and it can be miscible with them to form a uniform solution. However, in water, its solubility is poor, and this difference has a profound impact on its reaction and application in different systems.
In addition, the volatility of this substance also has characteristics. In a normal temperature environment, there is a certain degree of volatility. Although the volatilization rate is not extremely fast, it should be treated with caution in a poorly ventilated environment to prevent its vapor accumulation from causing safety problems.
In summary, the physical properties of 1-bromo-2,3-dimethyl-4-fluorobenzene cover appearance, odor, boiling point, melting point, density, solubility and volatility. Each property is related to determine its behavior and application in the chemical field.
What are the synthesis methods of 1-Bromo-2, 3-Dimethyl-4-Fluorobenzene
The synthesis of 1-bromo-2,3-dimethyl-4-fluorobenzene follows several paths. First, the benzene derivative containing the corresponding substituent can be initiated. First, the benzene ring is brominated at a specific position with a suitable halogenating agent, such as a brominating agent. Under specific reaction conditions, such as in the presence of a catalyst, bromine atomic energy is precisely added to a predetermined position. In this case, the catalyst may be iron filings or its halides. The reaction environment also needs to be considered, and temperature and solvent are affected.
Furthermore, when methyl is introduced, or an alkylation reaction is used. With an appropriate alkylating agent, such as a haloalkane, methyl is introduced into the benzene ring under the action of a catalyst such as Lewis acid. The introduction of fluorine atoms, or nucleophilic substitution reaction can be used. A fluorine-containing nucleophilic reagent, under appropriate reaction conditions, replaces the appropriate leaving group on the benzene ring, and then generates the target product 1-bromo-2,3-dimethyl-4-fluorobenzene.
During the reaction process, each step needs to be fine-tuned. The proportion of reactants, reaction temperature, and reaction time are all key elements. Improper ratio, or increased side reactions; temperature discomfort, reaction rate may be affected, and even different products may be formed; poor time control, and it is difficult to obtain high-purity target products. And after each step of the reaction, the separation and purification of the product is also an important link. Distillation, recrystallization, column chromatography and other means can be selected to obtain pure 1-bromo-2,3-dimethyl-4-fluorobenzene.
1-Bromo-2, 3-Dimethyl-4-Fluorobenzene What are the precautions during storage and transportation?
1-Bromo-2,3-dimethyl-4-fluorobenzene is an organic chemical. When storing and transporting, be careful to avoid danger.
First, this substance is chemically active and should be stored in a cool, dry and well-ventilated place. Keep away from fires and heat sources to prevent chemical reactions such as decomposition and combustion caused by rising temperatures. Because of its sensitivity to heat, heat can easily lead to changes in molecular structure, which in turn affect quality and stability.
Furthermore, it needs to be stored separately from oxidants, acids, bases, etc. This is due to the violent chemical reaction of 1-bromo-2,3-dimethyl-4-fluorobenzene or with it, or the risk of fire and explosion. In case of strong oxidizing agent, or oxidation reaction occurs, causing the system to lose control.
When transporting, be sure to ensure that the packaging is complete and sealed. To prevent leakage, pollution of the environment, and pose a threat to the health of transporters. The containers used should be resistant to chemical corrosion and can withstand certain pressure and vibration.
In addition, the transportation and storage places should be equipped with suitable fire fighting equipment and leakage emergency treatment equipment. If a leak unfortunately occurs, it can respond quickly and reduce the harm. Such as adsorption materials, neutralizers, etc., for timely cleaning and disposal.
At the same time, those who are engaged in relevant operations should be professionally trained and familiar with their characteristics, safety operating procedures and emergency treatment methods. The operation process should strictly follow the specifications and wear appropriate protective equipment, such as protective glasses, gloves, protective clothing, etc., to protect their own safety.
In short, the storage and transportation of 1-bromo-2,3-dimethyl-4-fluorobenzene requires thorough consideration of its chemical properties and strict adherence to safety regulations to ensure the safety of personnel, the environment and property.
1-Bromo-2, 3-Dimethyl-4-Fluorobenzene impact on the environment and human health
1-Bromo-2,3-dimethyl-4-fluorobenzene is also an organic compound. Its impact on the environment and human health is related to many aspects, as detailed below.
In the environment, if this compound is released outside, or stored in the air, water, and soil. It decomposes in the air, or with air flow, partially or due to photolysis, but its decomposition rate may vary depending on environmental conditions. As for water, its solubility is limited, or it is adsorbed on suspended particles, moves with water flow, or settles into underwater sediments. In the soil, or is adsorbed by soil particles, affecting the ecological environment of the soil, or degrades slowly. Its migration and transformation between environmental media, or affect the surrounding biological communities. For example, if aquatic organisms are exposed to this compound, or ingested through gill respiration, body surface penetration, etc., it will affect their growth, reproduction and survival. Some organisms may accumulate this compound in their bodies due to long-term exposure, and it is transmitted through the food chain, resulting in higher trophic level organisms being implicated, which affects the balance and stability of the ecosystem.
As for human health, 1-bromo-2,3-dimethyl-4-fluorobenzene may invade the human body through various channels. Through respiration, the compound in the air can enter the lungs, then spread to the blood, and circulate throughout the body. If it comes into contact with the skin, it may penetrate the skin barrier and enter human tissue. Ingestion of food or water contaminated with this compound is also a common route of invasion. After its entry into the body, it may interfere with the normal physiological functions of the human body. Some halogenated aromatic hydrocarbons are potentially toxic, or affect the nervous system, causing symptoms such as headache, dizziness, fatigue, etc. It may also cause damage to important organs such as the liver and kidneys, affecting their metabolic and excretory functions. Long-term exposure to this compound may increase the risk of certain diseases in the human body, such as cancer. Although there is no conclusive evidence that 1-bromo-2,3-dimethyl-4-fluorobenzene will cause cancer, the presence of halogen atoms and benzene rings in its structure may be potentially carcinogenic and cannot be ignored.