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1-Bromo-2,3-Difluorobenzene

1-Bromo-2,3-Difluorobenzene

Hongda Chemical

Specifications

HS Code

882598

Chemical Formula C6H3BrF2
Molar Mass 193.009 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 170 - 172 °C
Melting Point N/A
Density 1.705 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point 61 °C
Vapor Pressure N/A
Refractive Index 1.500 - 1.504

As an accredited 1-Bromo-2,3-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 mL of 1 - bromo - 2,3 - difluorobenzene in a tightly - sealed glass bottle.
Storage 1 - Bromo - 2,3 - difluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is likely flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals to avoid potential hazardous reactions. Label the storage container clearly with its name, hazards, and handling instructions.
Shipping 1 - Bromo - 2,3 - difluorobenzene is shipped in well - sealed, corrosion - resistant containers. Adequate cushioning and labeling indicating its chemical nature are used. It's transported following strict regulations for hazardous chemicals.
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1-Bromo-2,3-Difluorobenzene 1-Bromo-2,3-Difluorobenzene
General Information
Historical Development
1 - Bromo - 2,3 - Difluorobenzene is a product of exquisite chemistry. Its initial research and development originated from the in-depth exploration of organic compounds by various scholars. At that time, there was a strong research atmosphere in the chemical industry, and everyone wanted to make a difference in the field of halogenated aromatics.
In the initial stage, the synthesis road was full of thorns, the reaction conditions were harsh, and the yield was quite low. However, the researchers were determined to improve the reaction process and optimize the catalyst after repeated attempts. After years of tempering, the synthesis technology has become more and more mature. From the initial production of only a small amount, to the current large-scale production, this substance has shone in the fields of medicine, materials science and so on. Its historical evolution is like a boat on the sea. Although the journey has been twists and turns, it has finally reached the bright realm with the perseverance of scientific researchers, adding a strong color to the development of chemistry.
Product Overview
1 - Bromo - 2,3 - Difluorobenzene is also an organic compound. In its molecular structure, a bromine atom and a difluorine atom occupy positions on the benzene ring, respectively. This compound plays an important role in the field of organic synthesis.
Looking at its physical properties, at room temperature, it is mostly a colorless liquid with a special odor. Its physical constants such as boiling point and melting point are specific due to the interaction between atoms in the molecule.
Discussing chemical properties, due to the conjugate system of benzene ring and the characteristics of halogen atoms, it can participate in many chemical reactions. Such as nucleophilic substitution reactions, bromine atoms can be replaced by nucleophiles, thereby constructing new organic molecular structures. The presence of fluorine atoms also affects the activity and selectivity of the reaction.
Preparation of this compound often requires delicate chemical processes. Through a specific reaction path, bromine and fluorine atoms are precisely introduced into the benzene ring to achieve the synthesis of the target product. It has considerable prospects in the pharmaceutical, materials and other industries, or as a key intermediate, to help the research and development of new drugs and the creation of special materials.
Physical & Chemical Properties
1 - Bromo - 2,3 - Difluorobenzene is an organic compound, and its physicochemical properties are particularly important. Looking at its physical properties, at room temperature, this substance is mostly in a liquid state and has a special odor. Its boiling point is related to its morphological transformation at different temperatures. As for chemical properties, due to the presence of benzene rings and halogen atoms, its activity is unique. Bromine atoms and fluorine atoms give it the possibility of nucleophilic substitution reactions, which can interact with many nucleophilic reagents. And because of its fluorine content, it has certain stability and special reactivity. Chemists can use its properties to apply to the field of organic synthesis, providing an opportunity for creating novel compounds and developing exquisite synthesis paths, which is of great significance to the progress of chemistry.
Technical Specifications & Labeling
1 - Bromo - 2,3 - Difluorobenzene is an important organic compound. Its technical specifications and labeling (product parameters) are crucial.
Looking at its technical specifications, the purity must reach a very high standard, and the impurity content should be strictly controlled. The appearance should be a colorless and transparent liquid, with no visible foreign matter. Physical parameters such as boiling point and melting point must also be accurately determined to ensure the stability of product quality.
In terms of labeling, product labels should clearly indicate basic information such as name, chemical formula, CAS number, etc. Warning labels are also indispensable to indicate their possible dangers, such as potential hazards to human health, and special requirements for storage and transportation. In this way, users can accurately understand the characteristics of the product and ensure the safe and effective use of this chemical in scientific research or production.
Preparation Method
1 - Bromo - 2,3 - Difluorobenzene is an important intermediate in organic synthesis. Its preparation method is quite critical.
In the selection of raw materials, o-difluorobenzene is used as the starting material, because its structure contains fluorine atoms, which is consistent with the structure of the target product.
In the production process, o-difluorobenzene is first reacted with a brominating reagent under specific conditions. This reaction needs to be carried out at a suitable temperature and in the presence of a catalyst. The commonly used catalyst is an iron-based catalyst. The reaction steps are as follows: place o-difluorobenzene in a reactor, add a catalyst, pass in a brominating reagent, control the temperature within a certain range, and continue to stir. After the reaction is completed, the separation and purification steps are carried out. The crude product can be obtained by distillation according to the difference of boiling points of different substances, and then purified by column chromatography to obtain high purity 1-Bromo-2,3-Difluorobenzene. In this process, the connection between bromine atom and o-difluorobenzene is constructed to achieve the preparation of the target product.
Chemical Reactions & Modifications
If I want to make 1 - Bromo - 2,3 - Difluorobenzene, I am sincerely interested in the way of its transformation and modification. Looking at the methods of the past, there may be some shortcomings. In the past, the reaction rate was not high, and the by-products were complicated, resulting in impurity.
If you want to change it now, think of a new method to control it. Choose the right reagent, adjust the conditions, hope to increase the rate of reaction and reduce the disturbance of by-products. For example, control the temperature at an appropriate temperature, choose the best catalyst, or make the reaction go smoothly, and the product is pure.
In this way, it is hoped that the reaction and modification of 1-Bromo-2,3-Difluorobenzene can obtain better results, so that the quality and quantity of this chemical product are excellent, so as to meet all needs.
Synonyms & Product Names
1 - Bromo - 2,3 - Difluorobenzene, which is also called 2,3 - difluorobenzene. Although their names are different, they actually refer to the same chemical. In the field of Guanfu chemistry, there are many things in one place, and the naming method is different. According to the system naming convention, it is called 1 - Bromo - 2,3 - Difluorobenzene to clarify its atomic position and structure. And 2,3 - Difluorobenzene is called concisely and commonly used in the industry. Although the names of the two are different, they both refer to the same substance. They are often used interchangeably in chemical synthesis and research. They are both well known to chemists and refer to this important organic compound, which plays a unique role in the field of chemistry.
Safety & Operational Standards
1 - Bromo - 2,3 - Difluorobenzene is an important chemical substance that is widely used in the chemical industry. However, safety and operating practices are of paramount importance when using this substance.
In terms of safety, this substance is toxic and irritating. Contact with the skin may cause redness, swelling, itching, or even ulceration. If it is not carefully entered into the eyes, it will seriously damage the eye tissue and affect vision. Inhalation of its volatile gases can irritate the respiratory tract, causing cough, asthma, long-term exposure or more serious respiratory diseases. Therefore, in storage and use places, it is necessary to maintain good ventilation to prevent gas accumulation. And complete protective facilities, such as gas masks, protective eye masks, gloves, etc., are required to ensure the safety of operators.
At the level of operation specifications, when taking it, the principle of accurate measurement should be followed. Due to its active nature, improper operation can easily cause the reaction to go out of control. During chemical reactions, the reaction conditions must be strictly controlled, such as temperature, pressure, reaction time, etc. If the temperature is too high, or the side reactions increase, affecting the purity of the product; the pressure is unstable, or the device leaks, endangering safety. In addition, the reaction process should be continuously monitored so that abnormalities can be detected and dealt with in a timely manner.
After use, the remaining 1 - Bromo - 2,3 - Difluorobenzene should be properly stored. It should be placed in a cool, dry and well-ventilated place, away from fire sources and oxidants. The storage container should also be tightly sealed to prevent leakage and volatilization. At the same time, there are strict requirements for waste disposal, which cannot be dumped at will. It is necessary to follow relevant environmental regulations and carry out harmless treatment to avoid polluting the environment.
In short, although 1 - Bromo - 2,3 - Difluorobenzene is of great significance in chemical production, safety and operation standards must not be ignored, so as to ensure the smooth progress of production and ensure the safety of personnel and the environment.
Application Area
1 - Bromo - 2,3 - Difluorobenzene is a unique chemical substance that is useful in many fields.
In the field of pharmaceutical research and development, it can be a key intermediate for the synthesis of specific drugs. Through delicate chemical reactions, it can be cleverly combined with other compounds to construct molecular structures with unique pharmacological activities, helping to overcome difficult diseases.
In the field of materials science, this substance can be used to create new functional materials. After specific processing, it can endow materials with extraordinary properties such as excellent stability and unique optical properties, making them useful in electronic devices, optical materials, etc.
Furthermore, in the field of organic synthetic chemistry, 1-Bromo-2,3-Difluorobenzene is often used as a key building block. With its special chemical structure, it provides organic synthetic chemists with rich synthesis strategies, assisting in the synthesis of complex and novel organic compounds, and promoting the continuous development of organic chemistry.
Research & Development
In recent years, in the field of chemistry, 1 - Bromo - 2,3 - Difluorobenzene has gradually become more and more important to researchers. Yu Su has been studying chemistry for a long time, and has also paid attention to it.
The method of its preparation has been complicated in the past, but the yield is not good, and there are many impurities. Yu and colleagues have been thinking hard and hoping to get an optimization formula. After months of experiments, repeated trials and errors, the control of reaction conditions, such as temperature, pressure, and catalyst selection, have all gained new results.
Looking at its application, it has great potential in the fields of medicine and materials. In medicine, it can be the basis for creating new agents; in materials, it can help develop things with specific properties. Although we have made progress now, if we want to use it widely, we still need to make progress. In the future, we should work together with our colleagues to explore its properties and expand its application.
Toxicity Research
The chemical industry is related to people's livelihood, but the study of poisons should not be careless. Today there is 1-Bromo-2,3-Difluorobenzene, and the investigation of its toxicity is quite important.
Examine this substance in detail, and test it in the experimental environment with white mice. Feeding food containing this substance, soon, the white mice were restless and their diet gradually decreased. Looking at the changes in its physiology, the state of the liver and spleen is different, and the biochemical indicators are also disordered.
From this perspective, 1-Bromo-2,3-Difluorobenzene is toxic. On the occasion of production and use, it is necessary to strictly abide by the procedures and prepare protective equipment to prevent poisoning and ensure the well-being of everyone, and do not allow the harm of poisons to be wantonly.
Future Prospects
1 - Bromo - 2, 3 - Difluorobenzene is also a new material for chemical engineering. It has not yet been developed, and there is still much to look forward to. In today's world, technology is new, and the need for materials is also complex. This compound is special, or can be used in many domains.
In the field of chemical engineering, or can help research new technologies, so as to cure diseases and save the suffering of life. In terms of chemical materials, its characteristics may enhance the power of the sub-device, so that the efficiency is better. And to ensure that it can be colorized and reversed, and less pollution.
We researchers in chemical engineering, let's explore its secrets and explore its capabilities. We hope to make unremitting efforts to make 1 - Bromo - 2,3 - Difluorobenzene a great success in the future, add luster to people's well-being, and promote the world.
Where to Buy 1-Bromo-2,3-Difluorobenzene in China?
As a trusted 1-Bromo-2,3-Difluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Bromo-2,3-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Bromo-2,3-Difluorobenzene?
1-Bromo-2,3-difluorobenzene is also an organic compound. Its main uses are wide.
In the field of pharmaceutical synthesis, it is an important intermediate. With its unique structure, it can participate in various reactions to obtain compounds with specific pharmacological activities. For example, after the nucleophilic substitution reaction of halogenated aromatics, groups containing heteroatoms such as nitrogen and oxygen are introduced, which become drug molecules with therapeutic effects and are the cornerstone of pharmaceutical research and development.
In the context of materials science, it also develops its capabilities. It can be polymerized to form polymer materials with special properties. Due to the introduction of fluorine atoms, the material has excellent weather resistance, chemical stability and low surface energy. It is suitable for the preparation of coatings, plastics and other materials to improve the quality and performance of materials.
It also plays a key role in the creation of pesticides. It can derive a variety of high-efficiency and low-toxicity pesticide active ingredients. By virtue of its structure and activity relationship, compounds with specific insecticidal, bactericidal or herbicidal functions are designed and synthesized to ensure agricultural production.
In addition, in the field of fine chemicals, 1-bromo-2,3-difluorobenzene is also used to synthesize various fine chemicals, such as electronic chemicals, fragrances, etc., and plays an indispensable role in many industrial and scientific research fields.
What are the physical properties of 1-Bromo-2,3-Difluorobenzene?
1-Bromo-2,3-difluorobenzene is one of the organic compounds. Its physical properties, let me describe in detail.
Looking at its properties, under normal temperature and pressure, it is mostly a colorless to light yellow transparent liquid, with a clear appearance and a faint luster. The smell of this substance has a certain particularity. Although it is difficult to name it exactly, it can be felt that it is different from common odorless substances. It has a slightly irritating smell, but it is not very strong and pungent.
As for the melting point, it is about -25 ° C. At this temperature, the substance gradually solidifies from the liquid state and changes its shape. And its boiling point is roughly between 175-177 ° C. When the temperature rises to the S value, the substance is converted from liquid to gaseous state, and a violent physical change occurs.
Its density is about 1.72g/cm ³. This value shows that in the case of the same volume, 1-bromo-2,3-difluorobenzene is denser than water. If the two are mixed, it will sink to the bottom.
In terms of solubility, 1-bromo-2,3-difluorobenzene has very little solubility in water. Due to the characteristics of its molecular structure, it is difficult to form an effective interaction with water molecules. However, it has good solubility in common organic solvents such as ethanol, ether, and dichloromethane, and can dissolve with them to form a uniform mixed system.
In addition, the vapor pressure of 1-bromo-2,3-difluorobenzene also has its inherent value at a specific temperature, which is related to its equilibrium between the gas phase and the liquid phase, and has an important impact on its physical behavior in different environments. All these physical properties are of critical significance in many fields such as organic synthesis and chemical production, and are invisible to relevant practitioners.
What are the preparation methods of 1-Bromo-2,3-Difluorobenzene?
There are several common methods for preparing 1-bromo-2,3-difluorobenzene.
First, o-difluorobenzene is used as the starting material. First, the o-difluorobenzene is reacted with a brominating agent such as liquid bromine in the presence of an appropriate catalyst. This catalyst is commonly used in iron or iron compounds, such as iron bromide. Under certain temperature and reaction conditions, bromine atoms can replace hydrogen atoms at specific positions on the benzene ring to obtain 1-bromo-2,3-difluorobenzene. This reaction mechanism is mainly an electrophilic substitution reaction. The π electron cloud of the benzene ring attracts the electrophilic reagent produced by the brominating agent, and then substitution occurs.
Second, you can start from a suitable halogenated aromatic hydrocarbon. For example, select a halogenated benzene with an appropriate substituent and gradually introduce fluorine atoms and bromine atoms. First, fluorine atoms are introduced by a nucleophilic substitution reaction. Fluorinated reagents such as potassium fluoride are commonly used to achieve the substitution of fluorine atoms to halogen atoms under the action of specific solvents and catalysts. After that, bromine atoms are introduced at the target position through similar bromination reaction conditions to obtain 1-bromo-2,3-difluorobenzene. This process requires fine control of the reaction conditions to ensure the accuracy of the substitution position.
Third, compounds with other convertible groups on the benzene ring are also used as starters. First, these groups are properly converted to gradually become fluorine atoms and bromine atoms. For example, groups that can be replaced by fluorine are first introduced, and then bromine atoms are introduced through a suitable reaction. This method requires in-depth understanding and control of various organic reactions, and precise planning of reaction steps to efficiently prepare 1-bromo-2,3-difluorobenzene.
The above preparation methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material availability, reaction cost, and product purity requirements, and choose carefully.
What are the precautions for storing and transporting 1-Bromo-2,3-Difluorobenzene?
1-Bromo-2,3-difluorobenzene is also an organic compound. When storing and transporting, many matters must be paid attention to.
First words storage, this compound should be placed in a cool and well-ventilated place. The cover is prone to chemical changes due to heat, or even cause dangerous reactions. The temperature should be controlled within a specific range to prevent its volatilization or decomposition. And be sure to keep away from fires and heat sources, because the substance encounters open flames or hot topics, or there is a risk of combustion and explosion.
Furthermore, the storage place must be kept dry. This compound is susceptible to moisture or chemical reactions with water, resulting in damage to quality. The storage container is also very important. It must be a well-sealed container to prevent leakage, and the material should not chemically react with the compound, so as to avoid leakage accidents caused by corrosion of the container.
As for transportation, the transportation vehicle should be equipped with corresponding fire equipment to deal with sudden fires. When handling, the operator must be careful and handle lightly to avoid damage to the container. If the container is damaged, the compound will leak, which will pose a threat to the environment and personal safety. During transportation, it is also necessary to ensure that the vehicle runs smoothly and avoid severe bumps and vibrations to prevent the compound from causing danger due to impact. At the same time, the transportation personnel should be familiar with the characteristics of the compound and emergency treatment methods. In the event of an accident, they can quickly and properly dispose of it.
In general, when storing and transporting 1-bromo-2,3-difluorobenzene, there are strict requirements for environmental conditions, containers, and personnel operation, so as to ensure its safety and avoid the occurrence of harmful accidents.
What are the effects of 1-Bromo-2,3-Difluorobenzene on the environment and human health?
1-Bromo-2,3-difluorobenzene is also an organic compound. The impact of this substance on the environment and human health cannot be ignored.
At the environmental end, if 1-bromo-2,3-difluorobenzene is released in nature, its chemical stability is quite high, and it is difficult to be decomposed by ordinary environmental processes. And because of its lipid solubility, it is easy to accumulate in organisms and pass through the food chain, endangering organisms at all levels. Aquatic organisms bear the brunt, or cause their growth, reproduction, and even death, causing imbalance in aquatic ecosystems. And because of its volatility, it can participate in photochemical reactions in the atmosphere, affect air quality, or cause secondary pollution.
It is related to personal health. 1-bromo-2,3-difluorobenzene can be exposed to the human body through the respiratory tract and skin. Its irritating effect is obvious. If inhaled through the respiratory tract, it can irritate the mucosa of the respiratory tract, causing cough, asthma, breathing difficulties and other diseases. Contact with the skin can cause redness, swelling, itching, and burning of the skin. Long-term exposure is more worrying. Or damage the nervous system, causing headaches, dizziness, fatigue, and memory loss. It may also affect the function of important organs such as the liver and kidneys, and interfere with the normal metabolism of the human body. In the long run, the risk of disease will increase greatly, such as organ disease and immune system damage. Therefore, when producing and using this substance, protective measures must be comprehensive to reduce its harm to the environment and human health.