1-Benzyloxy-3-Fluorobenzene

Hongda Chemical

Specifications

HS Code	514981
Chemical Formula	C13H11FO
Molecular Weight	202.22
Appearance	Colorless to light yellow liquid
Boiling Point	Around 270 - 275 °C
Density	Approx. 1.13 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Flash Point	Around 110 - 120 °C
Refractive Index	Approx. 1.545 - 1.555

As an accredited 1-Benzyloxy-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 - benzyloxy - 3 - fluorobenzene in 500 - gram sealed bottles for chemical packaging.
Storage	1 - Benzyloxy - 3 - fluorobenzene should be stored in a cool, dry, and well - ventilated area. Keep it away from sources of ignition, heat, and oxidizing agents. Store in a tightly - sealed container to prevent evaporation and contamination. This aromatic compound's storage conditions aim to maintain its chemical integrity and minimize risks associated with its flammability and reactivity.
Shipping	1 - Benzyloxy - 3 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. It's transported by specialized chemical carriers ensuring proper ventilation, following strict safety regulations to prevent any leakage or hazards during transit.

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General Information

Historical Development

In the age of ancient times, those who have studied chemical things are committed to this product of 1-Benzyloxy-3-Fluorobenzene. At the beginning, the road of exploration is full of thorns, and everyone strives for progress in obscure principles and complicated methods. At the beginning, the cognition of its nature was still shallow, and it was difficult to find the right way to make this thing.
However, all researchers are determined, changing over the years, repeated experiments, gradually understanding its nature, and understanding its synthesis method. In the past, many attempts were in vain, but they were not discouraged. With the passage of time, technology advances day by day, and it gradually learns from ignorance. Or improving the process, or innovating techniques, every step is very difficult, but it is also getting closer to success.
Up to now, the research on 1 - Benzyloxy - 3 - Fluorobenzene has been very successful. Looking back on its historical development, it is the hard work of the researchers. After countless setbacks, it has finally reached a bright path and added a bright light to the field of chemistry.

Product Overview

1 - Benzyloxy - 3 - Fluorobenzene is also an organic compound. Its color is pure and clean, and its shape is like a crystal clear body. With an aromatic ring structure, benzyloxy is cleverly connected to fluorine atoms, giving it unique chemical properties.
This compound is widely used in the field of organic synthesis. It can be used as a key intermediate to assist in the construction of complex organic molecules. Due to its structural properties, it can participate in a variety of chemical reactions, such as nucleophilic substitution, coupling, etc.
The preparation method goes through multiple fine processes. The selection of raw materials and the control of the reaction all need to be accurate. Under suitable reaction conditions, the reactants interact with each other, separate and purify to obtain pure 1-Benzyloxy-3-Fluorobenzene.
It has great potential in many fields such as pharmaceutical research and development, materials science, etc. It may be the cornerstone of the creation of new drugs, or the key component of the research and development of new materials, with promising prospects.

Physical & Chemical Properties

1 - Benzyloxy - 3 - Fluorobenzene is also an organic compound. Its physical and chemical properties are quite important to chemists. Looking at its properties, it is mostly liquid at room temperature, with a clear and transparent color and a special odor. Its boiling point and melting point are fixed. The boiling point is about [X] ° C, and the melting point is about [X] ° C. This property is related to its separation and purification.
In terms of solubility, it is soluble in organic solvents such as ethanol and ether, but insoluble in water. This is due to the hydrophobicity of the molecular structure. In terms of its chemical properties, the presence of benzene ring endows it with aromaticity, and the benzyloxy group and fluorine atoms also affect its reactivity. It can participate in the electrophilic substitution reaction. Due to the electron-withdrawing effect of the fluorine atom, the reaction check point has a specific selectivity. And the benzyloxy group can be broken under suitable conditions, and a variety of chemical reactions can be derived, which is widely used in the field of organic synthesis.

Technical Specifications & Labeling

1 - Benzyloxy - 3 - Fluorobenzene is an important chemical substance. Its technical specifications and identification (product parameters) are crucial. In terms of technical specifications, the purity of 1 - Benzyloxy - 3 - Fluorobenzene needs to be precisely defined, and the impurity content must be strictly controlled to ensure the quality of the product. For example, the purity should reach a very high standard, and impurities must not affect its chemical properties.
In terms of identification, key information such as name, chemical formula, molecular weight, etc. should be clearly marked so that the user can see it at a glance. And the packaging label should also be standardized, indicating storage conditions, hazard warnings, etc., to ensure safe use and proper storage. In this way, 1 - Benzyloxy - 3 - Fluorobenzene can play its due role in the chemical industry.

Preparation Method

1 - Benzyloxy - 3 - Fluorobenzene is an organic compound. The preparation method is related to the raw materials and production process, reaction steps and catalytic mechanism.
The selection of raw materials is very important, and the commonly used ones are fluorophenols and halobenzene compounds. In the production process, the nucleophilic substitution reaction can be achieved. First, the fluorophenol forms a phenoxy negative ion under basic conditions. This is a nucleophilic reagent, and then meets the halobenzyl. The halogen atom of the halobenzene has good departure properties. The phenoxy negative ion then attacks the benzyl carbon and undergoes nucleophilic substitution to generate 1 - Benzyloxy - 3 - Fluorobenzene.
The reaction steps also need to be carefully controlled. In a suitable organic solvent, an appropriate amount of alkali, such as potassium carbonate, is added to promote the deprotonation of phenols. Warm up to the appropriate temperature to make the reaction proceed smoothly. The reaction process is monitored by TLC and other means. When the raw materials are completely consumed, the reaction is terminated.
In terms of catalytic mechanism, bases can accelerate the activation of phenols and form better nucleophiles. Some phase transfer catalysts may improve the reaction efficiency and promote the reaction to occur better in a homogeneous environment, thereby improving the yield and purity, and preparing high-quality 1-Benzyloxy-3-Fluorobenzene.

Chemical Reactions & Modifications

There are currently chemical substances, known as 1 - Benzyloxy - 3 - Fluorobenzene, which can be investigated in the matter of chemical and reverse modification. The chemical and reverse properties of this compound can be determined according to different components. In order to make it have a specific modification, it is necessary to check the environment and use it.
If you want to determine its properties, or you can use a suitable catalyst to help it reverse the desired way. And the degree, force, etc., are also the main reasons for this modification and reverse modification. Or increase the rate of reaction to promote the reaction, or use the balance of the reaction.
Study the anti-modification of 1 - Benzyloxy - 3 - Fluorobenzene, and seek to be subtle in order to obtain exquisite results.

Synonyms & Product Names

1 - Benzyloxy - 3 - Fluorobenzene is an important chemical substance. Its synonyms and trade names are related to the various names of this substance. In the field of chemical research, many substances often have synonyms, and the same substance is called differently due to different research groups, regions or historical reasons. 1 - Benzyloxy - 3 - Fluorobenzene is no exception. Its trade name may vary depending on the manufacturer's marketing and product positioning. In the eyes of our chemical researchers, it is essential to clarify its synonyms and trade names, which is conducive to accurate communication, literature search and experimental research. In this way, we can accurately grasp the characteristics, uses, and related research of this chemical substance, and move forward steadily on the path of chemical exploration, promoting the progress and development of the chemical field.

Safety & Operational Standards

1 - Benzyloxy - 3 - Fluorobenzene is an important chemical product, which is crucial for its safety and operation standards.
During the preparation of this product, the safety of the first place is arranged. The experimental site must be well ventilated to disperse possible harmful gases. And it is necessary to keep away from fire and heat sources. Because the product may be flammable, it is easy to cause fire if it is not careful.
Operators should strictly follow the operating guidelines. Before operation, professional protective equipment, such as protective clothing, protective gloves and goggles, is required to prevent the product from coming into direct contact with the human body, causing skin burns or eye damage. During operation, the action should be steady and accurate to avoid the product spilling.
For storage, 1 - Benzyloxy - 3 - Fluorobenzene should be placed in a cool, dry and ventilated place, away from oxidizers and other substances that may react with it. The storage container should also be well sealed to prevent leakage.
If a leakage accident occurs unfortunately, do not panic. The surrounding personnel should be evacuated immediately and the fire should not be allowed to approach. At the same time, take emergency measures quickly, such as using inert materials to absorb the leakage, and then properly dispose of it.
Only by strictly adhering to safety and operating standards can the production, use and storage process of 1 - Benzyloxy - 3 - Fluorobenzene be ensured smoothly, and the safety of personnel and the environment will not be endangered.

Application Area

1 - Benzyloxy - 3 - Fluorobenzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create new drugs to treat various diseases. In material science, it can be used as a raw material for the synthesis of special materials, endowing materials with unique properties, such as excellent stability and conductivity. In the field of fine chemicals, it can also be used to prepare high-end fragrances, pigments and other products to improve product quality and characteristics. From this point of view, 1 - Benzyloxy - 3 - Fluorobenzene has important value in many fields, and it is an important substance to promote the development of related industries. Its application prospects are also very broad, worthy of our in-depth exploration and development.

Research & Development

Today there is a thing called 1 - Benzyloxy - 3 - Fluorobenzene. We study this thing as a researcher. In the laboratory, we study its properties in detail, explore its structure, and study its reaction rules.
After months of hard work, we have gained insight into its chemical properties and understood its changes in various reactions. This research is not a passing interest, but a long-term development. We hope that through in-depth investigation of this thing, we can open up new paths in the field of chemistry and provide assistance for industrial production, pharmaceutical research and development, and many other aspects.
The research on this thing has achieved some results, but the road ahead is still long. We should maintain our original intention and make unremitting explorations, with the hope of translating this research result into practical application, promoting the progress of chemistry, and bringing benefits to the academic community and the industry, so that the research and development of 1-Benzyloxy-3-Fluorobenzene can reach a new height.

Toxicity Research

Those who taste and study poisons must carefully investigate their properties and carefully investigate their harm. The same is true for 1-Benzyloxy-3-Fluorobenzene today.
Examine its properties in detail, this substance may contain poison. Looking at its structure, the benzene ring is connected, and the benzoxy group is attached to the fluorine atom. The toxicological analysis, the fluorine atom is active, or involved in chemical reactions, in the biological body, it may disturb the balance of biochemistry.
And think about its use, if you accidentally get involved, through breathing, contact or diet, it can be harmful. In the body, or damage the internal organs, disrupt the movement of qi and blood, and disturb the communication of meridians and collaterals.
The way of research, when following the ancient law, be careful to observe its changes, and record its feelings in detail. During the experiment, protection must be taken to avoid its poison invasion, so as to protect the safety of the body. Expect to explore its true meaning, understand its toxicology, and use it for future generations to avoid harm to living beings. This is the responsibility of those who study poisons.

Future Prospects

Today's 1 - Benzyloxy - 3 - Fluorobenzene has a wide range of uses and can be used in the fields of chemical industry and medicine. Although current research has revealed its many characteristics and production methods, there are still vast prospects for future development.
To make this product better, it is necessary to study the synthesis method. Or seek simpler steps to reduce its cost, or explore purer methods to improve its quality. With new technologies and new materials, there will be breakthroughs.
At the application end, the road of medicine may be able to be dug deep. Or it can be used as a new agent to treat various chronic diseases. In the chemical industry, or as a new material, create novel things. In the future, with the wisdom and hard work of everyone, 1 - Benzyloxy - 3 - Fluorobenzene will be able to shine, be used by the world, develop endless possibilities, and become an extraordinary cause. This is the scene that my generation is looking forward to.

Where to Buy 1-Benzyloxy-3-Fluorobenzene in China?

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Frequently Asked Questions

As a leading 1-Benzyloxy-3-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-Benzyloxy-3-Fluorobenzene?

1-Benzyloxy-3-fluorobenzene has a wide range of uses and is a crucial intermediate in the field of organic synthesis. It plays a key role in medicinal chemistry. It is used as the starting material for the preparation of many drugs. Through a series of delicate chemical reactions, molecular structures with specific pharmacological activities can be constructed.
For example, in the development of some antibacterial drugs, 1-benzyloxy-3-fluorobenzene can be used as a key building block to change the spatial configuration and electron cloud distribution of molecules by introducing different functional groups, thereby giving the final product excellent antibacterial properties. The presence of benzyloxy and fluorine atoms in its structure provides rich possibilities for subsequent reactions. The unique electronic effect of fluorine atoms can enhance the stability and biological activity of molecules, and the benzyloxy group can be removed at an appropriate time to create conditions for further modification of molecules.
In the field of materials science, 1-benzyloxy-3-fluorobenzene also has extraordinary performance. It can be used to synthesize special polymer materials, which often have unique physical and chemical properties, such as excellent thermal stability, mechanical properties or optical properties. Taking the synthesis of high-performance liquid crystal materials as an example, 1-benzyloxy-3-fluorobenzene can participate in the construction of the rigid core structure of liquid crystal molecules, regulate the orientation and arrangement of molecules, and then affect the liquid crystal phase behavior of the material, so that it shows potential application value in display technology and other aspects.
In addition, in the preparation of fine chemical products, 1-benzyloxy-3-fluorobenzene can be used to synthesize various functional additives, such as in some special coatings or inks, as an additive, it can improve the leveling, adhesion and other properties of the product, and improve the quality and application effect of the product. Overall, 1-benzyloxy-3-fluorobenzene plays an indispensable role in many important fields due to its unique chemical structure, promoting technological progress and product innovation in related fields.

What are the physical properties of 1-Benzyloxy-3-Fluorobenzene?

1-Benzyloxy-3-fluorobenzene, this is an organic compound with unique physical properties. Its appearance is mostly colorless to light yellow liquid, which exists stably at room temperature and pressure.
Looking at its melting point, the literature states that it is about -15 ° C. Due to the moderate intermolecular force, it changes from solid to liquid below this temperature. The boiling point is about 290 ° C, indicating that the intermolecular force is relatively strong, and higher energy is required to vaporize it.
The compound has a density of about 1.12 g/cm ³, which is slightly heavier than water, so it will sink to the bottom when placed in water.
In terms of solubility, 1-benzyloxy-3-fluorobenzene is insoluble in water. This is because water is a polar molecule, while the molecular polarity of this compound is weak. According to the principle of "similar miscibility", the two are difficult to dissolve. However, it is soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc., because these organic solvents are similar to their intermolecular forces and can be miscible with each other.
In addition, 1-benzyloxy-3-fluorobenzene has a certain volatility. Although the volatilization rate is not extremely fast, its vapor will accumulate in the air in a poorly ventilated environment. Its vapor has a stimulating effect on the eye and respiratory mucosa, so pay attention to protection when operating.
In conclusion, the physical properties of 1-benzyloxy-3-fluorobenzene have a significant impact on its storage, transportation, and use, and must be properly handled according to its characteristics during operation to ensure safety and smooth experimentation and production.

What are 1-Benzyloxy-3-Fluorobenzene synthesis methods?

The synthesis method of 1-benzyloxy-3-fluorobenzene, as mentioned in the ancient books, has various paths to follow. First, it can be obtained from the nucleophilic substitution reaction of 3-fluorophenol and benzyl halide in the presence of bases. Among them, bases are commonly used in potassium carbonate, sodium hydroxide, etc., in suitable organic solvents such as N, N-dimethylformamide (DMF), acetone, heated and stirred, the halogen atom leaves, and the benzyl group is connected to phenoxy to form the target product.
Second, 3-fluorophenylboronic acid can also be synthesized with benzyl halide or benzyl alcohol by a palladium-catalyzed coupling reaction. Palladium catalysts such as tetra (triphenylphosphine) palladium (0), ligands, bases, etc. are also indispensable. This reaction condition is relatively mild and has good selectivity, which is quite commonly used in the field of organic synthesis. And if benzyl alcohol is used as raw material, the method of catalytic oxidative coupling can also be used to avoid the use of halides, which is more environmentally friendly.
Furthermore, starting from fluorine-containing benzene ring derivatives, benzoxy groups are introduced through multi-step reactions. First, the specific position of the benzene ring is functionalized, and then the benzoxy group is introduced under suitable reaction conditions. However, there are many steps in this path, and each step needs to be carefully controlled to achieve a higher yield.
Each of these methods has advantages and disadvantages. In actual synthesis, the appropriate method should be carefully selected according to the availability of raw materials, the difficulty of reaction conditions, and cost considerations.

What 1-Benzyloxy-3-Fluorobenzene need to pay attention to when storing and transporting

1-Benzyloxy-3-fluorobenzene is also an organic compound. When storing and transporting it, many matters need to be paid attention to.
Bear the brunt. When storing, it should be placed in a cool and well-ventilated place. This compound is easy to decompose when heated, and high temperature may cause it to deteriorate. Therefore, choose a cool place to ensure the stability of its chemical properties. The temperature of the warehouse should be controlled within a specific range, and it must not be too high.
Furthermore, ensure that the storage environment is dry. Because it is quite sensitive to moisture, moisture invasion, or chemical reactions such as hydrolysis can damage the purity and quality of the compound. Therefore, it is necessary to use desiccants to maintain a dry environment.
In addition, when storing, it should be stored separately from oxidants, acids, alkalis and other substances. Contact with these substances can easily induce chemical reactions, or cause hazards such as combustion and explosion.
As for transportation, appropriate packaging materials should be used. Packaging should be strong and well sealed to prevent leakage during transportation. During transportation, it is also necessary to avoid heat and moisture, drive according to the specified route, and stay away from densely populated areas. Transportation vehicles must be equipped with emergency treatment equipment. If there is an accident such as leakage, it can be responded to in time to reduce hazards. In short, when storing and transporting 1-benzoxy-3-fluorobenzene, it is necessary to follow relevant specifications and requirements, and operate with caution to ensure safety.

1-Benzyloxy-3-Fluorobenzene safety precautions

1-Benzyloxy-3-fluorobenzene is an organic compound. During the experimental operation, many safety precautions must be observed.
The first thing to pay attention to is that it has certain toxicity. Contact with this substance, or by inhalation, skin contact and swallowing, can cause harm to the human body. During operation, be sure to wear strict protective equipment, such as gas masks, protective gloves and laboratory clothes, to prevent it from coming into contact with the human body. The operation room should also be well ventilated, and an effective ventilation device should be installed to allow volatile harmful gases to be quickly discharged outdoors, so as not to accumulate indoors and endanger personal safety.
Secondly, 1-benzyloxy-3-fluorobenzene is flammable. In case of an open flame or hot topic, there is a risk of combustion and explosion. Therefore, in the place of storage and use, fireworks are strictly prohibited, and they are kept away from fire and heat sources. The electrical equipment involved in operation should also be explosion-proof to prevent accidents caused by electrical sparks.
Furthermore, its chemical properties are active, or it reacts violently with other chemical substances. Before use, make sure to clarify its compatibility with the reagents used. Do not mix unknown chemicals rashly to prevent unexpected chemical reactions, such as explosions and toxic gases. When mixing substances, you should also add them slowly, stirring while adding them, and keep an eye on the reaction situation.
Also, after the experiment is completed, the residual 1-benzyloxy-3-fluorobenzene and related waste must be properly disposed of in accordance with regulations. Do not dump at will to avoid polluting the environment. It should be placed in a specific container and handed over to a professional organization for disposal according to the chemical waste treatment process.
In short, when handling 1-benzyloxy-3-fluorobenzene, safety must be the priority, operating procedures must be strictly followed, and precautions must be carefully checked to ensure the smooth operation of the experiment, and personnel and the environment are safe.