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What are the main uses of 1-Benzyl-4-Fluorobenzene?
1-Benzyl-4-fluorobenzene is widely used. In the field of organic synthesis, it is often a key intermediate. It can interact with many nucleophiles through nucleophilic substitution reactions to form novel carbon-carbon bonds or carbon-heteroatom bonds, and then synthesize complex organic compounds.
In the field of pharmaceutical chemistry, 1-benzyl-4-fluorobenzene also plays an important role. Due to its structural properties, it can participate in the design and synthesis of drug molecules. After modification and modification, compounds with specific biological activities can be obtained, which are expected to be developed into new drugs for the treatment of diseases.
In the field of materials science, 1-benzyl-4-fluorobenzene can be used as a raw material to prepare functional materials. Its participation in polymerization can endow materials with unique properties, such as improving the solubility, thermal stability and optical properties of materials, and has potential applications in polymer materials, optoelectronic materials, etc.
Furthermore, 1-benzyl-4-fluorobenzene is also indispensable in the synthesis of fine chemical products. It can be used to synthesize fragrances, dyes, etc., adding unique properties and application value to products. In conclusion, 1-benzyl-4-fluorobenzene plays a key role in many fields such as organic synthesis, medicine, materials and fine chemicals, and promotes the development and progress of related fields.
What are the physical properties of 1-Benzyl-4-Fluorobenzene?
1-Benzyl-4-fluorobenzene is one of the organic compounds. Its physical properties are unique, and it is crucial for its in-depth understanding in many fields of chemistry.
First of all, its appearance, under room temperature and pressure, 1-benzyl-4-fluorobenzene is often colorless to light yellow liquid, its texture is clear and transparent, just like warm jade liquid, very pure. This appearance feature is convenient for preliminary identification by visual method in actual operation.
Furthermore, the boiling point is between 260-265 ° C. The characteristics of the boiling point are extraordinary in experimental operations such as separation and purification such as distillation. When the mixture containing this substance is distilled, it is possible to accurately separate 1-benzyl-4-fluorobenzene by controlling the appropriate temperature, so that it can be distinguished from other substances with different boiling points.
The melting point is also a key physical property, about - 20 ° C. The value of the melting point is related to the physical state of the substance. Below the melting point, it is in a solid state, and above the melting point, it gradually converts into a liquid state. This property needs to be taken into account during storage and transportation, and a suitable storage method needs to be properly selected according to factors such as ambient temperature. The density of
is about 1.07 g/cm ³, which can help to determine its position in the liquid mixture. If mixed with common solvents such as water, it will sink to the bottom because its density is slightly higher than that of water, which is a characteristic that can be used in liquid-liquid separation operations.
In terms of solubility, 1-benzyl-4-fluorobenzene is insoluble in water, but soluble in organic solvents such as ethanol, ether, and chloroform. This difference in solubility is of great significance in separation methods such as extraction. For example, when 1-benzyl-4-fluorobenzene is to be extracted from an aqueous solution, an effective extraction can be achieved by selecting a suitable organic solvent and taking advantage of the significant difference in solubility between water and organic solvents.
In addition, the vapor pressure of 1-benzyl-4-fluorobenzene cannot be ignored. Although the vapor pressure is low at room temperature, the vapor pressure will increase accordingly when the temperature rises. This property needs to be carefully considered in processes involving gas phase operation, such as gas chromatography analysis, because changes in vapor pressure can affect the behavior of the substance in the gas phase and the accuracy of the analysis results.
1-Benzyl-4-Fluorobenzene chemical synthesis methods
1-Benzyl-4-fluorobenzene is also an organic compound. Its synthesis method has been explored by many parties throughout the ages, and now Chen's method is below.
First, 4-fluorophenylboronic acid and benzyl halide are used as raw materials and prepared by Suzuki coupling reaction. This reaction often requires a palladium catalyst, such as tetra (triphenylphosphine) palladium (0), in an alkaline environment. For alkalis, potassium carbonate, sodium carbonate and the like are all. At the time of reaction, 4-fluorophenylboronic acid, benzyl halide, palladium catalyst and alkali are first dissolved in an appropriate solvent, such as toluene, dioxane, etc., heated and stirred. After a few hours, the reaction is completed. After separation and purification, 1-benzyl-4-fluorobenzene can be obtained. The beauty of this method is that the selectivity is good and the yield is quite high, but the price of palladium catalyst is high, and the cost may increase.
Second, 4-fluorotoluene and benzyl chloride are used as starting materials to synthesize by Fu-gram alkylation reaction. The reaction requires Lewis acid such as aluminum trichloride and zinc chloride as catalysts. First, 4-fluorotoluene is mixed with a catalyst, and benzyl chloride is slowly added dropwise at low temperature, and then the reaction is heated up. After the reaction is completed, the product can be obtained through hydrolysis, extraction, distillation and other steps. This method is slightly simpler, but the reaction conditions are more harsh, and there are many side reactions, which affect the purity and yield of the product.
Third, 4-fluorobenzaldehyde is reacted with benzyl Grignard reagent, and then obtained by reduction. Benzyl Grignard reagent is prepared first, and magnesium chips are reacted with benzyl halide in anhydrous ethyl ether. Then 4-fluorobenzaldehyde is reacted with it to form an alcohol intermediate, which is then reduced with a reducing agent such as sodium borohydride, and finally 1-benzyl-4-fluorobenzene is obtained. There are slightly more steps in this path, but the reaction of each step is relatively mild and easy to control.
All these methods have advantages and disadvantages. When synthesizing, it is necessary to choose carefully according to the availability of raw materials, cost considerations, product requirements and other factors to achieve the best synthetic effect.
What is the price range of 1-Benzyl-4-Fluorobenzene in the market?
The price of 1-benzyl-4-fluorobenzene in the market is difficult to determine. This compound has various uses, and its price varies greatly depending on quality, purity, purchase quantity and source.
If you want low purity or small amount, you can use it in ordinary chemical reagent shops, or only need a few gold per gram. However, if the required quantity is large and the purity requirements are strict, and it is used in scientific research or industrial preparation, the price will increase sharply.
In the place where chemical raw materials are traded, there are many buyers, and the quantity is quite large. Its price may fluctuate due to changes in supply and demand. High purity of 1-benzyl-4-fluorobenzene, the price per gram or more than tens of gold.
Furthermore, the price is different when purchased in different places. Prosperous cities, prosperous business, convenient supply, price or slightly lower; remote places, difficult transportation, cost increase, price or slightly higher.
To get a confirmed price, when consulting chemical reagent suppliers, chemical raw material traders, or visiting online chemical trading platforms, the approximate price range can be known in detail.
1-Benzyl-4-Fluorobenzene what are the precautions during use
1-Benzyl-4-fluorobenzene is also an organic compound. When using, there are several precautions that need to be kept in mind by practitioners.
One is related to safety protection. This compound has certain chemical activity or is harmful to the human body. Therefore, when using, be sure to wear appropriate protective equipment. Protective clothing can prevent it from coming into direct contact with the body and protect the skin from invasion; protective gloves need to be selected with good chemical resistance to prevent it from penetrating through the gloves; goggles can protect the eyes from splashing and causing damage. And the operation should be in a well-ventilated place. If conditions permit, it should be placed in a fume hood to prevent the accumulation of harmful gases and damage to the respiratory organs.
Second, about storage conditions. 1-Benzyl-4-fluorobenzene should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources, because of its flammability, it is at risk of open flame, hot topic or combustion or even explosion. At the same time, it needs to be stored separately from oxidants, acids, alkalis, etc., to avoid chemical reactions caused by mixed storage and endanger safety.
Third, the operation process also needs to be cautious. When taking it, the action should be stable and accurate to prevent it from spilling. If it is accidentally spilled, it should be dealt with immediately according to scientific methods. A small amount of sprinkling can be absorbed by inert materials such as sand and vermiculite, and properly disposed of after collection; if a large amount is sprinkled, personnel need to be evacuated, the scene must be sealed, and handled by professionals. And the utensils used in the operation must be washed and dried after use for next use.
Fourth, it is also necessary to pay attention to its impact on the environment. Waste after use cannot be discarded at will. It should follow relevant environmental protection regulations, collect it by category, and hand it over to professional treatment institutions. Because it may cause pollution to environmental factors such as soil and water sources, it will endanger the ecological balance.