As a leading 1-[(Aminooxy)Methyl]-2,3,4,5,6-Pentafluorobenzene Hydrochloride (1:1) supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 1- [ (Aminooxy) Methyl] -2,3,4,5, 6-Pentafluorobenzene Hydrochloride (1:1)
The chemical structure of 1 - [ (aminoxy) methyl] -2,3,4,5,6-pentafluorobenzene hydrochloride (1:1) is as follows. The compound is composed of a benzene ring as the backbone, and the 2, 3, 4, 5, and 6 positions on the benzene ring are connected to a fluorine atom to form a pentafluorobenzene structure. In the first position, there is a [ (aminoxy) methyl] group. In this group, the methyl group (-CH-) is connected to the benzene ring 1 position, and the other end of the methyl group is connected to the aminoxy group (-O - NH2). The oxygen atom in the aminoxy group is connected to the methyl group, and there are two hydrogen atoms outside the nitrogen Because it is a hydrochloride salt (1:1), that is, the compound and hydrochloric acid are salted in a 1:1 ratio, and the nitrogen atom of the aminoxy group does not share an electron pair. It can combine with the hydrogen ion in hydrochloric acid to form ammonium ions (-NH), and chloride ions (Cl) form ionic bonds with ammonium ions, thus forming the complete chemical structure of this compound.
What are the main uses of 1- [ (Aminooxy) Methyl] -2,3,4,5, 6-Pentafluorobenzene Hydrochloride (1:1)
(1 - [ (aminoxy) methyl] -2, 3, 4, 5, 6 -pentafluorobenzene hydrochloride (1:1), this substance is mostly used in the field of organic synthesis. In pharmaceutical chemistry, it is often a key intermediate, which can help to construct compounds with special structures and pave the way for the development of novel drugs. In the field of materials science, or participate in the preparation of materials with special properties, such as materials with unique optical and electrical properties.
because its structure contains aminoxy groups and pentafluorobenzene groups, aminoxy groups can participate in various chemical reactions, such as specific reactions with carbonyl groups to form oximes. This reaction is widely used in organic synthesis and can effectively form specific carbon-nitrogen bonds. The pentafluorophenyl group imparts unique electronic effects and steric resistance to the molecule, which can affect the reaction activity and the physicochemical properties of the product. The form of
hydrochloride can improve the solubility and stability of the compound, which is more convenient for practical operation and storage. Therefore, 1- [ (aminoxy) methyl] -2,3,4,5,6-pentafluorobenzene hydrochloride (1:1) has important uses in many fields such as organic synthesis, drug development and material preparation, and has contributed greatly to the advancement of related science and technology.)
What is the synthesis method of 1- [ (Aminooxy) Methyl] -2,3,4,5, 6-Pentafluorobenzene Hydrochloride (1:1)
The method of synthesizing 1- [ (aminoxy) methyl] -2,3,4,5,6-pentafluorobenzene hydrochloride (1:1) can follow the following steps.
First take 2,3,4,5,6-pentafluorobenzoic acid as the starting material, through esterification reaction, make it with suitable alcohols, such as methanol, under the action of catalyst such as sulfuric acid, heat and reflux to obtain 2,3,4,5,6-pentafluorobenzoic acid methyl ester. This step requires temperature control near the boiling point of methanol, about 64-65 ℃, when the number of reactions, until the content of raw materials in the reaction solution reaches the standard, after cooling, purify by separation, distillation and other methods.
Times, methyl 2,3,4,5,6-pentafluorobenzoate is reacted with lithium aluminum hydride in an anhydrous organic solvent, such as anhydrous tetrahydrofuran, at low temperature, such as 0 ° C Slowly add tetrahydrofuran solution of lithium aluminum hydride, drop it, and heat up to room temperature. Lithium aluminum hydride reduces the ester group to alcohol to obtain 2,3,4,5,6-pentafluorobenzyl alcohol. After the reaction is completed, the excess lithium aluminum hydride is quenched with an appropriate amount of water, and then the product is extracted, dried, and distilled to purify.
Subsequently, 2,3,4,5,6-pentafluorobenzyl alcohol is reacted with thionyl chloride to generate 2,3,4,5,6-pentafluorobenzyl chloride. In a suitable solvent such as dichloromethane, a catalyst such as pyridine is added, and thionyl chloride is added dropwise at room temperature. When the reaction is completed, the excess thionyl chloride and the solvent are distilled to obtain the product.
Then react 2,3,4,5,6-pentafluorobenzyl chloride with sodium nitrite and hydrochloric acid in water to form 2,3,4,5,6-pentafluorobenzyl nitrite. Control the temperature at 0-5 ° C, slowly add sodium nitrite solution, complete the reaction, extract with organic solvent, and dry to obtain the product.
Finally, 2,3,4,5,6-pentafluorobenzyl nitrite reacts with hydroxylamine hydrochloride under alkaline conditions, such as in methanol, adding potassium carbonate to adjust pH, when the reaction number, 1- [ (aminoxy) methyl] -2,3,4,5,6-pentafluorobenzene can be obtained. After forming a salt with hydrochloric acid, in a suitable solvent, hydrogen chloride gas is introduced or concentrated hydrochloric acid is added to obtain the target product 1- [ (aminoxy) methyl] -2,3,4,5,6-pentafluorobenzene hydrochloride (1:1), purified by recrystallization or the like.
What are the physical properties of 1- [ (Aminooxy) Methyl] -2,3,4,5, 6-Pentafluorobenzene Hydrochloride (1:1)
1 - [ (Aminooxy) Methyl] -2, 3, 4, 5, 6 - Pentafluorobenzene Hydrochloride (1:1), this is an organic compound. Its physical properties are quite important, and it is related to the application of this compound in various scenarios.
First of all, the appearance is usually white to off-white crystalline powder. Such appearance characteristics can be used as an important basis for the identification and preliminary judgment of the substance. The powder-like form makes it easier to disperse and handle in certain operations.
Besides solubility, this compound has a certain solubility in common organic solvents such as methanol and ethanol. This property makes it more convenient to participate in many organic reactions and interact with other reagents in solution environments. In the synthesis process, the appropriate choice of solvent has a great impact on the reaction process, and the solubility of the compound in alcoholic solvents provides convenience for this.
Melting point is also a key physical property. Its melting point is within a specific range, and accurate melting point data is of great significance to confirm the purity of the compound. If the purity of the compound is high, the melting point will be relatively concentrated and close to the theoretical value; if it contains impurities, the melting point is often reduced and the melting range becomes wider. By measuring the melting point, the purity status of the compound can be preliminarily evaluated.
In addition, its stability also reflects physical properties to a certain extent. Under conventional storage conditions, the compound can remain relatively stable, but care should be taken to avoid contact with strong oxidizing agents, strong acids and other substances to prevent chemical reactions from occurring and changing its structure and properties. During storage and transportation, stability considerations are crucial, and appropriate protective measures need to be taken according to their characteristics to ensure that the quality of the compound is not affected.
What is the market outlook for 1- [ (Aminooxy) Methyl] -2, 3, 4, 5, 6-Pentafluorobenzene Hydrochloride (1:1)?
Today, there are 1- [ (aminoxy) methyl] -2, 3,4,5,6-pentafluorobenzene, hydrochloride (1:1), and the market prospect of this product is quite promising. Looking at the current demand situation of chemical materials, such fluorinated organic compounds have emerged in many fields, and the prospect is like the rising sun, and the light is gradually rising.
In the field of pharmaceutical research and development, fluorine-containing structures often endow drugs with unique activities and excellent pharmacokinetic properties. 1 - [ (aminoxy) methyl] -2, 3,4,5,6-pentafluorobenzene, hydrochloride or can be used as key intermediates, paving the way for the creation of new specific drugs. Its unique structure may be able to precisely target specific biological targets, helping to develop high-efficiency and low-toxicity new drugs, so in the pharmaceutical chemical market, demand is expected to rise.
Furthermore, in the field of materials science, fluorinated compounds are eye-catching for their excellent chemical stability, corrosion resistance and low surface properties. This compound may be cleverly modified and applied to the preparation of high-end materials, such as high-performance coatings, special functional films, etc. With the vigorous development of cutting-edge industries such as electronics and aerospace, the demand for such special materials is increasing day by day, and its market potential is like an endless abyss, which is difficult to measure.
However, it is also necessary to be clear that the development of this compound market also faces many challenges. The synthesis process may be complicated and costly. If we want to achieve large-scale production, we must focus on optimizing the process, reducing costs and increasing efficiency. And the market competition is becoming increasingly fierce, we need to seize the opportunity and improve quality in order to stabilize the tide in the market wave. Although the road is long and difficult, the future is bright. With time and careful operation, we will be able to shine brightly in the market and reap rich rewards.