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1-Amino-3-Fluorobenzene

1-Amino-3-Fluorobenzene

Hongda Chemical

Specifications

HS Code

166067

Chemical Formula C6H6FN
Molecular Weight 111.117 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 200 - 202 °C
Melting Point 16 - 18 °C
Density 1.152 g/cm³
Flash Point 83 °C
Solubility In Water Slightly soluble
Odor Characteristic aromatic odor
Vapor Pressure Low

As an accredited 1-Amino-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 - amino - 3 - fluorobenzene in 1 - kg bottles, well - sealed for safe storage.
Storage 1 - amino - 3 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly closed container, preferably made of corrosion - resistant material. Label the storage container clearly to prevent misidentification. Avoid storing near incompatible substances to prevent dangerous reactions.
Shipping 1 - amino - 3 - fluorobenzene is shipped in tightly sealed, corrosion - resistant containers. Transport follows strict hazardous chemical regulations. Shipments are carefully monitored to ensure safety during transit, avoiding exposure to heat, moisture, and incompatible substances.
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1-Amino-3-Fluorobenzene 1-Amino-3-Fluorobenzene
General Information
Historical Development
1-Amino-3-fluorobenzene is also an organic compound. Its origin can be traced back to the past. At the beginning, chemists explored the secrets of matter and devoted themselves to the field of organic synthesis.
At that time, science and technology were not as prosperous as they are today, and the research was difficult. However, the public was unyielding. After years of experiments, various reaction mechanisms were analyzed, and the synthesis path of 1-amino-3-fluorobenzene was gradually understood.
Beginning with basic chemical raw materials, with subtle reactions, the atoms were rearranged and combined. Despite repeated setbacks, they were determined. Later, the method became more perfect and the yield gradually increased.
Looking at its development, it is due to the diligent research of chemists of all generations, from ignorance to clarity, that this compound has achieved today, adding brilliance to the field of chemistry and laying the foundation for future research.
Product Overview
1 - Amino - 3 - Fluorobenzene is also an organic compound. It is a colorless to light yellow liquid with a special odor. The molecule contains fluorine atoms and amino groups, giving it unique chemical properties.
This compound has a wide range of uses in the field of organic synthesis. Due to its high electronegativity of fluorine atoms, it can enhance molecular stability and biological activity. Therefore, it is often a key intermediate for the preparation of drugs, pesticides and functional materials.
Through specific chemical reactions, its amino groups can be connected to other functional groups to build complex organic structures. In drug development, it may participate in the synthesis of molecules with specific pharmacological activities for human health and well-being. In material science, with its characteristics, novel functional materials can be created to promote the progress of science and technology. Its value in chemical research and industrial production cannot be underestimated.
Physical & Chemical Properties
1 - Amino - 3 - Fluorobenzene, also an organic compound. Its physical and chemical properties are quite specific. Looking at its color, it is often a colorless to pale yellow liquid, which is slightly glossy under light. Smell it, it has a special aromatic smell, but this taste is not pure and pleasant, and it is slightly irritating.
In terms of its physical properties, the boiling point is within a certain range. Due to the force between molecules, it needs a specific temperature to vaporize. Its melting point is also a specific value, and it condenses when cold. As for solubility, it has good solubility in organic solvents, such as alcohols and ethers, but its solubility in water is quite low. This is due to the matching of molecular polarity and water molecules.
Its chemical properties are active, and amino and fluorine atoms give it unique reactivity. Amino groups can participate in many nucleophilic reactions, and fluorine atoms have strong electronegativity, but they can also change the density distribution of benzene ring electron clouds and cause specific substitution reactions. They are important intermediates in organic synthesis and are indispensable in the preparation of many fine chemicals.
Technical Specifications & Labeling
1 - Amino - 3 - Fluorobenzene is an organic compound, and its preparation process is very critical. To obtain this product, a specific process specification is often followed. First of all, the selection of raw materials needs to be carefully selected, and the proportion of each ingredient must be accurate. This is the foundation for ensuring product quality.
In its process specification, the reaction temperature and duration are strictly defined. An appropriate temperature range can make the reaction proceed smoothly, and precise control of the duration can also ensure the integrity of the reaction. At the same time, the material and cleanliness of the reaction vessel also have a great impact on the reaction.
In terms of quality labeling, purity is the key indicator, and high purity 1 - Amino - 3 - Fluorobenzene is the best. The impurity content must be strictly controlled, otherwise it will affect its application in various fields. The color and traits of the product are also important parts of the labeling, so that the quality of the product can be preliminarily judged. Only by strictly following the process specifications and quality labeling can we produce high-quality 1 - Amino - 3 - Fluorobenzene.
Preparation Method
The method of making 1-Amino-3-Fluorobenzene is selected as the first raw material. When a suitable benzene compound is taken as the base, such as fluorobenzene, supplemented by an amino-containing reagent. The preparation process involves the reaction steps. First, fluorobenzene and a specific amination reagent are put in a suitable reactor, and under a specific temperature and pressure, a catalyst is used to promote it.
At the beginning of the reaction, the temperature is adjusted to about one hundred and twenty degrees Celsius, and the pressure is pressed to three megapascals. The catalyst is selected from a copper system to catalyze the amination reaction. After several times, the fluorine atom in fluorobenzene is replaced by an amino group, and the crude product is obtained.
Subsequent purification is very important. First, the volatile impurities are removed by distillation, and then the difficult volatile impurities are removed by chromatography to obtain pure 1-Amino-3-Fluorobenzene. In this way, the obtained product has good purity and yield, which can meet the needs of industry and scientific research.
Chemical Reactions & Modifications
1-Amino-3-fluorobenzene is also an important substance in organic synthesis. Its chemical changes are related to reaction and modification, and are of great importance to the researchers.
The synthesis of this product is often hindered by the method of the past. The reaction conditions are harsh, and the yield is not as satisfactory. If the conventional method is used, the interaction between raw materials has many side reactions, resulting in impure products, which consume a lot and have no effect.
At present, it is different. The researchers are thinking hard, and there are many improvements in the reaction method. Or find a new catalyst to increase its activity, so that the reaction speed and specialization; or adjust the reaction environment, control the temperature, pressure and other factors, so that the process is smooth, the product is easy to separate.
The way of modification is also quite advanced. By chemical modification, change its structure and give it novelty. Or increase its stability, or change its solubility, so that the use is wide. In this way, 1-amino-3-fluorobenzene has a new state in the fields of medicine and materials, and the prospect is promising.
Synonyms & Product Names
1 - Amino - 3 - Fluorobenzene, the synonym and trade name of this substance, is really the focus of my chemical research. Looking at it, its synonyms may vary depending on different regions and research groups. In academic literature, it may be called m-fluoroaniline, which is called because the fluorine atom and the amino group are in an intermediate position in its molecular structure.
As for the trade name, the chemical market is numerous, and different manufacturers have different names to recognize the characteristics of their products. However, no matter what the name is, it is to identify this chemical substance. In the field of fine chemicals, it is often used as a key intermediate in organic synthesis and is widely used. The clarity of its synonyms and trade names is conducive to the accuracy of scientific research exchanges and the accurate docking of supply and demand in the industry. Therefore, we chemical researchers must pay close attention to it.
Safety & Operational Standards
1 - Amino - 3 - Fluorobenzene is an organic compound, and it needs to be treated with caution in terms of its safety and operating practices.
This compound has certain chemical activity. During operation, the first priority is to ventilate the environment. Be sure to make the place where the operation is located well ventilated to prevent the accumulation of harmful gases. If operating indoors, the ventilation equipment must be turned on to allow the air to flow continuously, and the volatile harmful gases should be discharged to the outdoors in time to protect the operator from damage.
Furthermore, the operator's own protection must not be ignored. When wearing professional protective clothing, this clothing needs to be resistant to chemical corrosion, which can effectively block the compound from coming into contact with the body. Protective gloves should also be worn. The material should be able to resist the erosion of 1 - Amino - 3 - Fluorobenzene and avoid contact with the skin of the hands. Face protection is also indispensable. Wear a protective mask to prevent the compound from splashing on the face, hurting the eyes and other parts.
For storage, 1 - Amino - 3 - Fluorobenzene should be placed in a cool, dry and ventilated place. Keep away from fire and heat sources, as it is exposed to open flames, hot topics or the risk of combustion and explosion. Storage containers should also be well sealed to prevent leakage. Objects of different chemical properties must not be mixed with them to avoid chemical reactions and safety accidents.
During operation, strictly follow the standard procedures. When taking it, measure it accurately to avoid waste and unnecessary leaks. If you accidentally leak, don't panic, and start emergency measures immediately. Small leaks can be absorbed by inert materials such as sand and vermiculite, and properly disposed of after collection. If there are large leaks, it is necessary to evacuate personnel in time, delineate a warning area, and deal with it by professionals.
In short, the safety and operation specifications of 1-Amino-3-Fluorobenzene need all-round attention, so as to ensure the safety of personnel and smooth operation.
Application Area
1 - Amino - 3 - Fluorobenzene is a unique chemical substance with a wide application field and extraordinary significance. In the field of pharmaceutical research and development, this substance can be used as a key intermediate. Due to its unique chemical structure, it can help synthesize a variety of specific drugs, or have antibacterial and antiviral effects, which can solve the pain of the world.
In the field of materials science, 1 - Amino - 3 - Fluorobenzene also plays an important role. Through specific chemical reactions, it can be integrated into the construction of new materials. Materials made in this way may have excellent physical properties, such as better stability and flexibility, opening up new frontiers for the application of materials.
Furthermore, in the field of organic synthesis, as an active reagent, it can lead to unique reaction paths. Chemists can ingeniously design reactions according to their characteristics to create novel organic compounds, promote the progress of organic chemistry, and lay the foundation for the development of many industries.
Research & Development
I have been engaged in the research of chemical products for a long time, and recently I have been studying 1-Amino-3-Fluorobenzene. Its unique properties have potential applications in many fields.
After repeated experimental investigations, it has been shown that its reaction properties can be prepared through specific reaction paths. And observe its changes under different conditions, and know the relationship between its stability and activity.
The future development of this substance has great potential. In the field of medicine, it may help the research and development of new drugs; in materials science, it may also give birth to new materials. We shall continue to study and strive to expand its application scope, promote it from the laboratory to practical application, and contribute to the development of the chemical field, hoping to make achievements and benefit the world.
Toxicity Research
The industry of chemical industry is related to people's livelihood, but the study of poisons must be observed. Today there is 1-Amino-3-Fluorobenzene, and the study of its toxicity is particularly important.
Guanfu 1-Amino-3-Fluorobenzene, which is occasionally involved in chemical production. The nature of this product may be toxic. If people accidentally touch it, it may cause skin discomfort, and in severe cases, it may endanger the viscera.
In the experimental environment, white mice were tested and fed a diet containing 1-Amino-3-Fluorobenzene. Soon, the white mice gradually showed a state of weakness, lazy diet, and lost hair. And its organs are also abnormal, with signs of damage to liver and kidney function.
From this point of view, the toxicity of 1-Amino-3-Fluorobenzene cannot be underestimated. During production and use, strict precautions should be taken to ensure everyone's well-being and not to make poisons a disaster to the world.
Future Prospects
Looking at the world today, science and technology are changing day by day, and there are many innovations in chemical products. Today there is 1 - Amino - 3 - Fluorobenzene, a chemical product, and its future development is quite promising.
This product is also unique, and it can be used in the way of medical research and development, or it can be used as a sharp tool to cure diseases and save people. Looking back at the past, the emergence of new chemicals often led to changes in medicine. This product may also be the same, creating a new way for the treatment of many diseases.
And in the field of material science, it may endow materials with new qualities, making them stronger and tougher, or have specific properties, and be suitable for various new technologies. In the future, or because of it, new industries will be developed, and unlimited business opportunities will be opened up.
Although the road ahead is uncertain, I am convinced that in time, 1 - Amino - 3 - Fluorobenzene will emerge, contribute to the progress of the world, and show its extraordinary posture on the stage of the future.
Where to Buy 1-Amino-3-Fluorobenzene in China?
As a trusted 1-Amino-3-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1-Amino-3-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1-amino-3-fluorobenzene?
The main uses of 1-amino-3-naphthol are involved in many fields. In the dye industry, it is a key intermediate. Due to its special chemical structure, it can undergo a series of chemical reactions to obtain dyes with bright color and good fastness. It can be used for dyeing various fiber fabrics such as cotton, hemp, silk, and wool, making the fabric show rich and brilliant colors to meet the diverse needs of the world for fabric color.
In the field of medicine, 1-amino-3-naphthol also plays an important role. It is often used as a raw material for the synthesis of various drugs, or participates in the construction of drug molecules. Due to its certain biological activity, it is helpful for the treatment or prevention of certain diseases, or provides a basic chemical structural unit for the development of new drugs, helping medical workers to create drugs with better curative effect and less side effects.
In chemical analysis, 1-amino-3-naphthol can be used as an analytical reagent. Because it can have a color reaction with specific metal ions, and the reaction is sensitive and selective, it is often used for qualitative and quantitative analysis of metal ions. By observing the color change after the reaction with metal ions, the content of specific metal ions in samples can be accurately determined, and it is widely used in environmental monitoring, ore analysis and other fields.
In addition, in the field of organic synthesis, 1-amino-3-naphthol is also a commonly used building block for organic synthesis. Chemists can combine it with other organic compounds through ingenious chemical reactions to construct more complex organic molecular structures, expand the scope of organic synthesis, and provide powerful tools for the research and development of new materials and new compounds.
What are the physical properties of 1-amino-3-fluorobenzene?
The physical properties of 1-amino-3-naphthol are as follows:
The outer surface is usually crystalline, and the color is either white or white. Under normal conditions, this substance is determined. In terms of melting, it usually depends on a specific degree of solubility, and having a value is one of its important physical properties, but it is different from the degree of solubility or microwave.
In terms of solubility, 1-amino-3-naphthol can be dissolved to a certain extent in some solvents. In water, its solubility is limited, and this property is due to the basic properties of its molecules. The amino group and naphthol group of its molecule make it have certain properties, but they are not highly soluble. Therefore, the solubility in water such as water is not good, and in some of the suitable solubility, it can have a good dispersion and dissolution table.
Furthermore, its density is also an important physical property. The density reflects the amount of the material in the position, and the density of 1-amino-3-naphthol. It can help to provide information in terms of its dosage and mixing ratio in the process of multiplexing or operation.
In addition, this material may have a certain taste, taste or not very strong, but it is also a physical property.
In addition, under external conditions such as light irradiation, its physical properties such as color or crystal form can be changed, or it can be changed slowly. This is due to factors such as photochemical reactions, and it also affects its physical properties under specific circumstances. Therefore, the physical properties of 1-amino-3-naphthol are of great significance for research and application in chemical industry, chemical industry, and other fields.
Is 1-Amino-3-fluorobenzene chemically stable?
The chemical properties of 1-amino-3-naphthol are quite stable. Under normal conditions, the compounds formed by the two rarely change spontaneously.
Amino groups have the property of electron conductors, which can enhance the density of molecular electron clouds and change the activity of the atoms connected to them. It can participate in many reactions, such as nucleophilic substitution, because the amino nitrogen atom has an isolated pair of electrons, it can attack electrophilic reagents. However, in the general environment, if there is no specific reagent or condition to excite, the amino group is relatively stable.
In 3-naphthol, the naphthalene ring is a conjugated system with stable properties. The phenolic hydroxyl group is conjugated with the naphthalene ring, which makes the phenolic hydroxyl hydrogen atom more active, and can weakly ionize hydrogen ions, showing weak acidity. However, this kind of acidity is very weak, and the change is not significant in the general acid-base environment. Moreover, the naphthalene ring has a certain stability due to the existence of conjugated large π bonds and the uniform distribution of electron clouds.
When 1-amino and 3-naphthol are connected, the two affect each other. The electron supply effect of amino groups cooperates with the conjugated system of naphthol to stabilize the molecular structure. In common chemical environments, such as ordinary room temperature, normal pressure, no strong oxidants, strong acids and bases, 1-amino-3-naphthol rarely undergoes chemical changes, and the whole shows relatively stable chemical properties. However, under specific reaction conditions, such as high temperature, specific catalysts, and strongly reactive reagents, the active sites in the molecule, such as amino groups and phenolic hydroxyl groups, will participate in the reaction and exhibit diverse chemical activities.
What are the production methods of 1-amino-3-fluorobenzene?
The method of preparing 1-amino-3-bromobenzene has been different throughout the ages. There are three methods, which are detailed as follows:
First, benzene is used as the starting material, and nitrobenzene is obtained by nitrification. Then iron powder and hydrochloric acid are used as the agent to reduce nitrobenzene to aniline. Then a brominating agent, such as liquid bromine and an appropriate amount of catalyst, can be reacted under specific conditions to obtain 1-amino-3-bromobenzene. During this process, the temperature of nitration needs to be precisely controlled to maintain the purity of the product; when reducing, the amount of iron powder and hydrochloric acid also needs to be weighed to make the reaction smooth.
Second, aniline is used as the starting material. Aniline is first acetylated to protect the amino group from over-bromination in subsequent reactions. The commonly used acetylation reagent is acetic anhydride, and the two react to form acetaniline. After bromine is used as a brominating agent, acetaniline is brominated under the action of suitable solvents and catalysts to obtain p-bromoacetaniline. Finally, acid or base is used as a hydrolyzer to hydrolyze p-bromoacetaniline and re-release the amino group to obtain 1-amino-3-bromobenzene. In this path, the conditions of acetylation, bromination and hydrolysis steps, such as temperature, time, reagent concentration, etc., are all related to the yield and purity of the product.
Third, nitrobenzene is used as the initial raw material, first brominated to obtain m-bromonitrobenzene. Then catalytic hydrogenation or chemical reduction method is used to reduce the nitro group of m-bromonitrobenzene to amino group, and then 1-amino-3-bromobenzene is obtained. When catalyzing hydrogenation, it is necessary to select a suitable catalyst, such as palladium carbon, and adjust the reaction pressure and temperature; the principle of chemical addition requires the selection of suitable reducing agents, such as stannous hydride, etc., and pay attention to the control of the reaction conditions.
These three production methods have their own advantages and disadvantages. According to the actual needs, the cost of raw materials, the difficulty of reaction, the purity and yield of the product and other factors should be weighed, and the best should be followed.
What are the precautions for storing and transporting 1-amino-3-fluorobenzene?
1-Amino-3-naphthol needs to pay attention to many key matters during storage and transportation.
First, because it has certain chemical activity, it has strict requirements on packaging materials. Corrosion-resistant packaging should be selected, such as specific plastic materials or containers lined with special coatings, to prevent material leakage due to packaging erosion. If it is packaged in simple ordinary packaging, under transportation vibration or long-term storage, the packaging is vulnerable and the material is spilled, which is not only wasted, but also may pollute the environment and endanger the safety of surrounding personnel.
Second, temperature and humidity have a great impact on it. This substance is suitable for storage in a cool and dry place. If the temperature is too high, it may cause its chemical reaction and cause it to deteriorate; if the humidity is too high, it may make it deliquescent and change its physical and chemical properties. For example, in the humid and hot places in the south, if the storage environment is not well controlled by temperature and humidity, the quality of the material will be difficult to guarantee.
Third, during transportation, it is necessary to avoid mixing with oxidizing substances. 1-Amino-3-naphthol encounters strong oxidizing agents, which are prone to violent reactions, or cause combustion or even explosion. For example, sulfur and strong oxidizing agents are transported together, and they are prone to danger when colliding and rubbing. The same is true for both.
Fourth, handle with care when handling. Due to the form of the substance or a fragile state such as crystals, the package is damaged due to rough handling. At the same time, it may also cause chemical reactions due to friction and impact.
Fifth, the storage place should be kept away from fire and heat sources. 1-Amino-3-naphthol is a flammable or flammable chemical. In case of open flames and hot topics, there is a risk of combustion, which threatens the safety of life and property.
Sixth, the logo must be clear. On the package, its chemical name, dangerous characteristics, emergency treatment methods, etc. should be clearly marked to facilitate staff identification and emergency response, and avoid misoperation.