1-Acetoxy-4-fluorobenzene is also an organic compound. It has a wide range of uses and has important applications in many fields.
In the field of medicinal chemistry, this compound is often used as a key intermediate. Because the precise construction of the structure is of paramount importance in the organic synthesis of drugs, the specific functional groups of 1-acetoxy-4-fluorobenzene can be skillfully transformed by chemical means to construct complex and biologically active drug molecular structures. For example, in the synthesis of some new antibacterial drugs, it can be used as a starting material to add specific groups through a series of reactions to give the drug antibacterial effect, and this structure can effectively regulate the solubility, stability and bioavailability of the drug during the drug development process, and help the development of new drugs.
In the field of materials science, 1-acetoxy-4-fluorobenzene is also of great value. It can be used to prepare polymer materials with special functions. Through polymerization, it is introduced into the polymer chain, which can give the material unique properties. Such as the preparation of optical materials sensitive to specific wavelengths of light, the fluorine atom and acetoxy structure can affect the electron cloud distribution of the material and change its optical properties. It may have application potential in optoelectronic devices, such as optical sensors, optical storage media, etc., so that the material can play a role in the perception, storage and transmission of optical signals.
In the field of fine chemicals, it is often an important raw material for the synthesis of fine chemicals. It can be used in the preparation of fragrances, dyes and other products. In the synthesis of fragrances, due to its unique chemical structure, it can be reacted to derive compounds with special aromas, adding a unique flavor to the fragrance formula. In the synthesis of dyes, as a basic structural unit, the color and fastness of dyes can be adjusted after modification to meet different dyeing needs. Overall, the use of 1-acetoxy-4-fluorobenzene in various fields provides key support for the development of related industries.

1-Acetoxy-4-fluorobenzene is also an organic compound. It has various physical properties, as detailed below:
- ** Properties **: Under normal conditions, 1-acetoxy-4-fluorobenzene is a colorless to light yellow liquid. The view is clear and has its own unique phase state.
- ** Boiling point **: The boiling point of this substance is about 220-222 ° C. When heated to this point, the liquid phase gradually turns to the gas phase, and the kinetic energy of the molecule increases greatly, which is enough to break free from the liquid phase.
- ** Melting point **: The melting point is between - 3 - 1 ° C. When the temperature drops, the thermal motion of the molecules slows down, they are arranged in an orderly manner, and solidify from the liquid phase to the solid phase.
- ** Density **: The density is about 1.196 g/mL. Heavier than water, placed in water, it will sink under, which is determined by its molecular weight and the degree of packing compactness.
- ** Solubility **: In organic solvents, such as ethanol, ether, chloroform, etc., 1-acetoxy-4-fluorobenzene is easily soluble and can be mixed with various solvents in any ratio. Due to the similar forces between molecules, it fits the principle of similar compatibility. However, in water, its solubility is not good. Due to the large difference between molecular polarity and water, the hydrogen bonding of water is difficult to cooperate with the interaction between the molecules of the compound, so it is difficult to dissolve.
- ** Refractive index **: The refractive index is about 1.507 - 1.510. When light enters this substance, the propagation direction changes, and the degree of refraction is characterized by this value, which is related to the internal structure and molecular arrangement of the substance.
- ** Odor **: It has a weak aromatic smell and can be sensed by smell. This smell is caused by the special combination of benzene ring and acetoxy group in the molecular structure, which stimulates the olfactory receptors. In summary, 1-acetoxy-4-fluorobenzene has important applications and research value in many fields such as organic synthesis and chemical industry because of its unique physical properties.

1-Acetoxy-4-fluorobenzene is an organic compound with unique chemical properties, which is of great significance in the field of organic synthesis.
In this compound, acetoxy and fluorine atoms are connected to the benzene ring. Fluorine atoms have strong electronegativity, causing the electron cloud density of the benzene ring to change, so that the electron cloud density of the benzene ring is reduced and the meta-position is relatively increased. This electronic effect affects its reactivity and selectivity. In the electrophilic substitution reaction, the reactivity of the fluorine atom decreases slightly compared with that of benzene due to the electron-withdrawing induction effect of the fluorine atom, and the substituent tends to enter the intersite of the fluorine atom.
Acetoxy group has the effect of electron conjugation, which also affects the distribution of the electron cloud Its interaction with fluorine atoms makes the chemical properties of 1-acetoxy-4-fluorobenzene more complex. In hydrolysis reactions, acetoxy groups can be hydrolyzed under acidic or alkaline conditions to form p-fluorophenol and acetic acid or acetate salts. Under alkaline conditions, the hydrolysis rate is usually faster. Due to the strong nucleophilicity of hydroxide ions, it is easy to attack carbonyl carbons in acetoxy groups, which promotes the reaction.
In nucleophilic substitution reactions, although the fluorine atoms on the benzene ring are affected by electron-withdrawing groups, the nucleophilic substitution reaction activity is not very high due to the high carbon-fluorine bond energy. However, under specific conditions and the action of strong nucleophilic reagents, fluorine atoms can be replaced to form new organic compounds. The chemical properties of 1-acetoxy-4-fluorobenzene are determined by the interaction of benzene ring, acetoxy group and fluorine atom. These properties make it a key intermediate in drug synthesis, materials science and other fields for the construction of complex organic molecular structures.

There are several methods for synthesizing 1-acetoxy-4-fluorobenzene.
First, it can be prepared by the acylation reaction of p-fluorophenol and acetyl chloride. This reaction needs to be carried out in a suitable alkaline environment, and organic bases such as pyridine are often used as acid binding agents. The phenolic hydroxyl group of p-fluorophenol is nucleophilic, while the carbonyl carbon of acetyl chloride is electrophilic. When the two meet, the phenolic hydroxyl group attacks the carbonyl carbon of acetyl chloride, and the chlorine atom leaves to generate 1-acetoxy-4-fluorobenzene. When reacting, it is necessary to pay attention to control the reaction temperature and the ratio of raw materials. If the temperature is too high, side reactions may occur, and improper ratio will affect the yield.
Second, with p-fluoroanisole as the starting material, p-fluorobenzoic acid is first oxidized to obtain p-fluorobenzoic acid, then converted into acid chloride, and then reacted with alcohols (such as methanol) to form esters, and finally the target product is prepared by demethylation reaction. The oxidation step can use a suitable oxidant, such as potassium permanganate, etc. This route step is slightly complicated, but the reaction conditions of each step are relatively mild, and the intermediate product is easier to separate and purify.
Third, p-fluorophenyl magnesium bromide is prepared from p-fluorobromobenzene through Grignard reaction, and then reacts with acetyl chloride to obtain 1-acetoxy-4-fluorobenzene. The Grignard reaction needs to be carried out in an anhydrous and oxygen-free environment, which requires high reaction equipment and operation. However, this method can effectively construct carbon-carbon bonds and is quite commonly used in organic synthesis.
The above methods have advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider many factors such as the availability of raw materials, the difficulty of reaction conditions, cost and yield, and choose the appropriate one.

1-Acetoxy-4-fluorobenzene is in the market, and its price range is difficult to determine. The price varies due to many reasons, such as the quantity of production, the quality of quality, and the amount of purchase, and the time is easy to change, and the price is also variable.
Looking at the past market conditions, if the purchase quantity is small, or for experimental use, the price is high. In this case, the price per gram may reach tens of gold, or even more than 100 gold. Due to its preparation, it may require exquisite methods, and when it is produced in small quantities, the cost also increases.
If the purchase volume is huge, it is for industrial use, and the price can be reduced. When mass production, the effect of scale is obvious, and the cost is reduced. The price per kilogram can range from hundreds to thousands of gold. And there are many producers, and the competition is fierce, which can also cause the price to decline.
Also, its price is related to quality. Those with high purity, the price must be high; those with less quality, the price is slightly lower. However, the quality of the market is different, and the price varies greatly.
And the dynamics of the market, the trend of supply and demand, can make the price fluctuate. If supply exceeds demand, the price may fall; if supply exceeds demand, the price will rise. In order to know the exact price, when you consult the chemical raw material suppliers and observe the real market conditions, you can get a more accurate price.