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1,4-Difluoro-2-Methoxybenzene

1,4-Difluoro-2-Methoxybenzene

Hongda Chemical

Specifications

HS Code

490883

Chemical Formula C7H6F2O
Molar Mass 144.12 g/mol
Appearance Colorless liquid
Boiling Point 155 - 157 °C
Density 1.184 g/cm³
Flash Point 49 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Odor Characteristic aromatic odor

As an accredited 1,4-Difluoro-2-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1,4 - difluoro - 2 - methoxybenzene packaged in a sealed glass bottle.
Storage 1,4 - difluoro - 2 - methoxybenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive substances to avoid potential chemical reactions. Ensure proper labeling for easy identification.
Shipping 1,4 - difluoro - 2 - methoxybenzene is shipped in sealed, corrosion - resistant containers. It's carefully packed to prevent leakage. Shipment follows strict chemical transport regulations, ensuring safety during transit.
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1,4-Difluoro-2-Methoxybenzene 1,4-Difluoro-2-Methoxybenzene
General Information
Historical Development
1,4-Difluoro-2-methoxybenzene belongs to the chemical industry. Since its origin, people have been studying chemistry at the beginning, and they have gradually come into contact with this kind of compound. In the past, science and technology were not developed, and research was difficult. However, the sages worked tirelessly to clarify its nature.
At that time, the experiments were simple, and the masters repeatedly explored with perseverance. After long-term trial, the method of its synthesis was known. The initial yield was quite low, but after improvement, the skills became more and more refined.
With the passage of time, the use of this compound has gradually increased. In the fields of medicine and materials, it has shown its ability. The efforts of the past have finally led to its vigorous development. In this world, it is an indispensable thing in the chemical industry. Its historical evolution is the evidence of the wisdom and sweat of the sages.
Product Overview
1,4-Difluoro-2-methoxybenzene is an organic compound. It may be a colorless liquid with a special odor. The molecular structure of this substance contains a difluoro atom and a methoxy group, which are connected to the benzene ring.
In terms of its properties, it has certain volatility and is soluble in organic solvents. Its boiling point, melting point and other physical properties are specific values, which are related to its state under different conditions.
In the chemical industry, 1,4-difluoro-2-methoxybenzene is widely used. It is often a key intermediate in organic synthesis and can be converted into various compounds with special properties through various chemical reactions. It can be used in drug synthesis to help create new types of pharmaceuticals, or in materials science to contribute to the preparation of special materials. Its reactivity and structural properties make it indispensable in the stage of chemical synthesis, providing an important material basis for many scientific research and industrial applications.
Physical & Chemical Properties
1,4-Difluoro-2-methoxybenzene, this substance has unique physical and chemical properties. Its properties are colorless to light yellow liquid with a special odor. The melting point is quite low, about -20 ° C, it is liquid at room temperature and has good fluidity. The boiling point is moderate, nearly 170 ° C, and it is easy to gasify when heated.
In terms of solubility, it is slightly soluble in water, because water is a polar solvent, and the polarity of this substance is weak, according to the principle of similar miscibility. However, it is easily soluble in common organic solvents, such as ethanol, ether, etc., and mixes well with organic reagents.
Chemically, the benzene ring is stable, but the substitution of fluorine and methoxy groups makes it have specific reactivity. Fluorine atoms have high electronegativity and can participate in nucleophilic substitution reactions; methoxy donators increase the electron cloud density of benzene ring ortho-para, and are prone to electrophilic substitution reactions, which have broad application prospects in the field of organic synthesis.
Technical Specifications & Labeling
Today, there is a product called 1,4-difluoro-2-methoxybenzene, which is quite important in the field of chemical industry. Its process specifications and identification (product parameters) are the focus of our research.
In terms of its process specifications, starting from the selection of raw materials, it is necessary to be pure and free of impurities, and to meet the standards. During the reaction process, the temperature and pressure must be precisely controlled, with no difference. If the kettle is combined, the materials are fed in sequence, and the stirring speed is moderate to ensure that the reaction is sufficient.
As for the identification (product parameters), the appearance and color should be clearly observed, and the shape and color are all key. The standard of purity must reach high quality, and the impurity content must be strictly controlled. Physical parameters, such as the point of melting and boiling, also need to be determined in detail. In this way, only the best products can be obtained, and they can be used without hindrance and live up to the work of research.
Preparation Method
To prepare 1,4-difluoro-2-methoxybenzene, the method is as follows:
Raw materials and production process: Take an appropriate amount of 2-methoxy-4-nitrophenol as the starting material, which is easy to obtain. Use anhydrous potassium carbonate as an acid binding agent, in a suitable organic solvent, and mix it well with fluorinating reagents such as potassium fluoride.
Reaction steps: Heat up to a certain temperature, keep the reaction system stable, and make it fully react. During this period, the reaction process needs to be closely monitored, and the degree of reaction should be monitored by means of thin-layer chromatography. When the reaction is as expected, cool the reaction liquid.
Purification mechanism: The reaction product is extracted with organic solvent, the organic phase is dried with anhydrous sodium sulfate, and the solvent is removed by reduced pressure distillation. Further purification by column chromatography can obtain pure 1,4-difluoro-2-methoxybenzene. The product obtained by this method has good purity and can meet the needs of many applications.
Chemical Reactions & Modifications
In modern times, chemical refinement has deepened in the study of various compounds. Today there is 1,4-difluoro-2-methoxylbenzene, and its chemical reaction and modification are the focus of our investigation.
If you want to understand its reaction, you must investigate its structure in detail. In this substance, the position of fluorine and methoxy group has a great impact on its chemical properties. Fluoride has strong electronegativity, which can change the electron cloud density of the benzene ring, causing the position of electrophilic substitution reaction to be different. Methoxy group has the property of electron supplier, which also affects the reaction path.
As for modification, new groups may be introduced to change its physical and chemical properties. If an appropriate reagent is used to replace the fluorine atom with a nucleophilic substitution, a new derivative can be obtained, or its stability can be increased, or its solubility can be changed. Or other functional groups can be added to the benzene ring to adjust its activity and make it used for a special purpose. It is promising in the fields of medicine and materials. This is what we chemists should do in depth to research and use for the world.
Synonyms & Product Names
1,4-Difluoro-2-methoxylbenzene is also a chemical substance. There are many opinions on its synonymous name. Or "2-methoxy-1,4-difluorobenzene", the meaning is the same and the order is different, but the names of the products are also different.
The names of the products sold in the market are also different. There are those who are known for their characteristics, or "high-efficiency fluoromethoxylbenzene reagent", to show their effectiveness in experiments; there are also uses, such as "1,4-difluoro-2-methoxylbenzene for fine chemicals", indicating its suitability in the chemical industry.
We are students of chemistry. To explore this thing, we need to study all the names in detail before we can obtain it. Knowing its synonymous name and the name of its commodity, we can make correct use of this chemical tool when we study and apply it.
Safety & Operational Standards
1,4-Difluoro-2-methoxybenzene, this chemical substance, is related to safety and operating standards, and is of paramount importance.
Watching this substance, in the laboratory environment, all safety matters should be kept in mind. Its properties must be investigated in detail. It may have a certain chemical activity, be slightly careless, or cause accidents. Therefore, before taking it, you must be familiar with its physical properties, and understand that it will react with different substances before you can be safe.
When operating, standard behavior is indispensable. First protection, wear appropriate protective equipment, such as gloves, goggles, etc., to prevent its harm to the body and eyes. When taking it, the method should be stable and accurate, and the amount should be taken according to the quantity, so as not to overdose or spill. The method of storage also has regulations. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent it from changing due to improper environment.
Furthermore, after use, the disposal of its waste must also follow the norms. Do not dispose of it at will, so as not to pollute the environment and leave harm to people. When properly disposed of according to a specific process, it is harmless.
In short, the safety and operating standards of 1,4-difluoro-2-methoxylbenzene are something that experimental workers should never forget. Only by following this standard can we ensure the smoothness of the experiment and protect the safety of ourselves and the environment.
Application Area
1,4-Difluoro-2-methoxybenzene has a wide range of application fields. In the field of medicinal chemistry, it can be used as a key intermediate to help create new drugs and cure various diseases. With its special chemical structure, it can cooperate with specific targets in the body and play a pharmacological effect.
In the field of materials science, it also has wonderful uses. It can participate in the synthesis of special polymer materials, endowing materials with unique properties, such as enhancing their stability and changing optical properties, etc., which is quite valuable in the manufacture of electronic devices and optical instruments.
Furthermore, in the fragrance industry, or by virtue of its special smell and chemical activity, it can prepare a unique fragrance, increase the level and uniqueness of the fragrance, and satisfy the needs of the world's sense of smell. Therefore, 1,4-difluoro-2-methoxybenzene is of great significance in many application fields, and it is a chemical substance that cannot be ignored.
Research & Development
Today, there is a product named 1,4-difluoro-2-methoxybenzene, which is gradually emerging in our field of chemical research. We focused on exploring its characteristics, and after repeated experiments, we investigated its physical and chemical properties in detail.
Its structure is unique, and the position of fluorine and methoxy groups affects many properties. This substance often appears in a specific state in the reaction, providing an opportunity for the synthesis of new compounds.
After long-term research, our team has explored ways to optimize the synthesis, improve the yield and purity. And consider its stability in different environments, hoping to expand its application.
Over time, 1,4-difluoro-2-methoxybenzene or in the fields of medicine, materials, etc., will shine and promote the progress and development of the industry. This is what we scientific researchers hope for.
Toxicity Research
The industry of chemical industry is related to people's livelihood, but the study of poisons is crucial. Today, based on the theory of 1,4-difluoro-2-methoxybenzene, its toxicity is studied in detail.
Guanfu 1,4-difluoro-2-methoxybenzene, which occasionally appears in the chemical process. To initially observe its properties, or not to find any specificity, but to delve into the study of toxicity, one should not underestimate it. After various experiments, it can be known that if it enters the body, it may disturb the order of physiology.
Try to test it in animals, and if you ingest this agent, you may experience discomfort, such as slow movement and reduced appetite. In severe cases, the function is damaged, and the organs may be damaged by it. Although it is not highly toxic or the like, it is exposed to it for a long time, and hidden dangers.
Therefore, when chemical workers use this substance, they must be cautious and prepare comprehensive protection measures. They should not ignore the investigation of toxicity.
Future Prospects
In today's world, 1,4-difluoro-2-methoxybenzene has unique properties and a wide range of uses. Although the world has made small achievements in its research, the future prospects are limitless.
My generation expects that it may become a key raw material in the development of medicine. With its unique structure, it may help to create new medicines and solve the suffering of the world's diseases. And in the field of materials science, it is also expected to shine. With exquisite blending and processing, new materials with excellent performance may be produced, which can be used in aerospace, electronics and other important places to promote the rapid progress of science and technology.
Furthermore, with the improvement of analytical technology, the insight into its nature will become deeper. At that time, more novel application methods will be developed, bringing many unexpected changes to the world. This is a great prospect for the future, and we should study it diligently to make it come true as soon as possible.
Where to Buy 1,4-Difluoro-2-Methoxybenzene in China?
As a trusted 1,4-Difluoro-2-Methoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1,4-Difluoro-2-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1,4-difluoro-2-methoxybenzene?
1,4-Diethyl ether-2-methoxybenzene, which was in the era of Tiangongkai, has not been accurately recorded and described. However, in today's chemical knowledge and industrial application, its use is quite extensive.
First, in the field of organic synthesis, 1,4-diethyl ether-2-methoxybenzene is often used as an important intermediate. Due to its special chemical structure, it can be converted into many high-value organic compounds through various chemical reactions. For example, it can be substituted and added with other reagents through specific reaction paths to prepare drugs, fragrances and fine chemicals with special functions.
Second, in the field of materials science, it also has certain applications. Or it can participate in the synthesis process of polymer materials, by polymerizing with other monomers, giving the material unique properties, such as improving the solubility, flexibility or thermal stability of the material, and then meeting the special needs of different fields for material properties.
Third, in some special chemical reaction systems, 1,4-diethyl ether-2-methoxybenzene can be used as a solvent. Because it has suitable solubility and stability, it can dissolve a variety of organic compounds, and it does not easily react with the reactants or products under the reaction conditions, which helps to smooth the reaction and improve the efficiency and selectivity of the reaction.
Although this is not mentioned in Tiangong Kaiwu, the chemical industry is developing rapidly today. With its unique chemical properties, 1,4-diethyl ether-2-methoxybenzene plays an indispensable role in many fields such as organic synthesis, materials science and chemical technology, and promotes the continuous progress of modern industry and science and technology.
What are the physical properties of 1,4-difluoro-2-methoxybenzene?
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This substance is often a colorless and transparent liquid with a special odor. Its density is smaller than that of water, so it can float on the water surface. In terms of boiling point, due to the characteristics of intermolecular forces, its boiling point is relatively low, and it is more volatile at room temperature and pressure, which makes it easy to diffuse in air.
In terms of solubility, 1%2C4-%E4%BA%8C%E6%B0%9F-2-%E7%94%B2%E6%B0%A7%E5%9F%BA%E8%8B%AF%E7%9A%84%E6%9C%89%E6%95%88%E6%80%A7%E5%92%8C%E9%80%89%E6%8B%A9%E6%80%A7%E4%B8%8E%E5%85%B6%E7%BB%93%E6%9E%84%E7%9B%B8%E5%85%B3. In organic solvents, such as ethanol, ether, etc., it often has good solubility, because its molecular structure and organic solvent molecules can form an appropriate interaction force, which is conducive to the occurrence of the dissolution process. However, its solubility in water is not good, because the ability to form hydrogen bonds between the molecules of this substance and the water molecules is weak, and the molecular polarity is quite different from that of the water molecules, making it difficult for the two to dissolve.
In addition, the conductivity of this substance is also worthy of attention. Because it is an organic compound, there are no free-moving ions in the molecule, so it does not have electrical conductivity in both solid and liquid states, and is a typical non-electrolyte. These physical properties of this substance have an important impact on its application and treatment methods in many fields such as organic synthesis and chemical production.
What are the synthesis methods of 1,4-difluoro-2-methoxybenzene?
1% 2C4-diene-2-methoxybenzene. The synthesis method of this compound is related to the delicate skills of organic chemistry. I am here today with the ancient and elegant words for you.
First, the coupling reaction between halogenated aromatics and alkenylboronic acids can be obtained. Halogenated aromatics, such as benzene derivatives containing halogenated atoms, and alkenylboronic acids can be coupled with the help of palladium catalysts and in the environment of bases. Palladium catalysts such as tetra (triphenylphosphine) palladium can activate the carbon-halide bond of halogenated aromatics, and bases such as potassium carbonate can adjust the pH of the reaction system and promote the formation of negative ions of alkenyl boronic acid. The combination of the two forms a carbon-carbon bond, and gradually builds the skeleton of the target molecule, and then obtains 1% 2C4-diene-2-methoxybenzene.
Second, the reaction of aldose or ketone with alkenyl Grignard reagents is also a good strategy. Aldose or ketone, with active carbonyl, alkenyl Grignard reagents, such as alkenyl magnesium halide, have strong nucleophilic bonds. When the two meet, the carbon anion of the alkenyl Grignard reagent attacks the carbonyl carbon to form an alkoxide intermediate. After hydrolysis, an alcohol containing alkenyl groups can be obtained. If the alcohol is then properly eliminated to remove the hydroxy group and the hydrogen on the adjacent carbon, the carbon-carbon double bond can be generated, and then the methoxylation step can be performed to obtain the target product.
Third, benzene is used as the starting material, and the methoxy group is first introduced through the alkylation reaction. Benzene and halomethane are catalyzed by Lewis acid such as aluminum trichloride to obtain methoxybenzene. After the halogenation reaction, a halogen atom is introduced at a specific position in the benzene ring. Then through the coupling reaction of metal catalysis, such as with alkenyl halide, under the action of suitable catalyst and base, the diene structure is formed, and the final product is 1% 2C4-diene-2-methoxybenzene.
These methods have their own advantages and disadvantages. The control of reaction conditions, the ease of availability of raw materials, the purity and yield of the product are all the keys to consider. In the process of organic synthesis, if you are traveling on a hidden path, you need to choose carefully in order to reach the other side of the target.
What should be paid attention to when storing and transporting 1,4-difluoro-2-methoxybenzene?
1% 2C4-diethyl-2-methoxybenzene, this is an organic compound. During storage and transportation, many key matters need to be paid attention to.
The first priority is safety. Because of its flammability, toxicity and other hazardous properties. When storing, it should be placed in a cool and ventilated warehouse, away from fire and heat sources to prevent fire or explosion. The temperature of the warehouse should not be too high, and it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. It is dangerous due to violent chemical reactions with each other.
Times and packaging. The packaging for transportation and storage must be tight and sealed to prevent leakage. Packaging materials should have good corrosion resistance and pressure resistance, which can effectively protect the compound from external factors. If the package is damaged and the compound leaks, it will not only pollute the environment, but also pose a threat to human health.
The other is the label. On the storage container and the transportation vehicle, the name of the compound, the dangerous nature and the corresponding warning label should be clearly marked. In this way, the staff can see at a glance, follow the correct safety procedures when operating, and avoid the dangers caused by unknowing.
In addition, during transportation, ensure that the transportation vehicle is in good condition, shock-proof, moisture-proof and sun-proof. Avoid package damage caused by violent vibration, and also prevent the deterioration of the compound or dangerous reactions caused by moisture and sun exposure.
When storing and transporting 1% 2C4-diethyl-2-methoxybenzene, it is necessary to adhere to safety regulations and pay attention to details to ensure the safety of personnel and the environment.
What are the safety risks associated with 1,4-difluoro-2-methoxybenzene?
1% 2C4-diene-2-methoxybenzene, which is related to the safety risk and has the risk of explosion. Its vapor and air can form an explosive mixture. In case of open flame and high heat energy, it can ignite and explode, and react violently with oxidants. Furthermore, it is also harmful to the human body. Inhalation, ingestion or absorption through the skin may damage health. Its vapor or fog has irritating effects on the eyes, mucosa and upper respiratory tract, and also irritates the skin. Long-term exposure, or sensitizing effects, and even adverse effects on the hematopoietic system and nervous system. And because of its volatility, it can spread in the environment, or cause pollution to the atmosphere, water and soil, affecting the ecological balance. Pollution of water sources can endanger aquatic organisms, and dispersion in the atmosphere will affect air quality. Therefore, when using, storing, and transporting this chemical, it is necessary to operate in strict accordance with safety regulations and take appropriate protective measures to ensure safety.