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1,4-Bis(Trifluoromethyl)Benzene

1,4-Bis(Trifluoromethyl)Benzene

Hongda Chemical

Specifications

HS Code

599108

Chemical Formula C8H4F6
Molar Mass 214.11 g/mol
Appearance Colorless liquid
Odor Characteristic
Density 1.39 g/cm³
Boiling Point 125 - 127 °C
Melting Point -35 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble
Vapor Pressure At 20 °C: 2.7 hPa
Flash Point 26 °C
Refractive Index 1.365

As an accredited 1,4-Bis(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1,4 - bis(trifluoromethyl)benzene in 500 - mL glass bottle for chemical use.
Storage 1,4 - bis(trifluoromethyl)benzene should be stored in a cool, well - ventilated area, away from heat sources and ignition points as it is flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. Ensure proper labeling for easy identification and safety.
Shipping 1,4 - bis(trifluoromethyl)benzene is shipped in specialized, well - sealed containers. These are designed to prevent leakage, ensuring safe transport due to its chemical nature. Shipment follows strict hazardous materials regulations.
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1,4-Bis(Trifluoromethyl)Benzene 1,4-Bis(Trifluoromethyl)Benzene
General Information
Historical Development
The development of 1,4-bis (trifluoromethyl) benzene can also be traced. In the past, the field of chemistry was explored endlessly. At the beginning, people studied the way of organic synthesis to obtain this special compound. At that time, the conditions were not complete as they are today, but the wise men made unremitting efforts. After several attempts, various reactions were used as a way, or improved steps, or easier raw materials. After a long time of work, breakthroughs were gradually made. From the beginning, it only existed in the imagination, and it was able to be prepared in small quantities in the laboratory later, which was a big improvement. Then, with the rise of science and technology, the equipment was refined, and the preparation method was also optimized, and the yield gradually increased and the purity was better. Therefore, 1,4-bis (trifluoromethyl) benzene has gradually become a valuable material for the chemical industry and has emerged in many fields, opening up its unique development chapter.
Product Overview
1,4-Bis (trifluoromethyl) benzene is an organic compound. It is a colorless liquid with a special odor. The melting point of this substance is quite low, and the boiling point is not very high. It is stable at room temperature and pressure.
Its structure is unique, and two or three fluoromethyl groups are symmetrically listed in the opposite position of the benzene ring. This structure endows it with specific rationalization. Because it contains many fluorine atoms, it has good chemical stability and thermal stability. And it has good hydrophobicity and is soluble in many organic solvents.
In the industrial field, 1,4-bis (trifluoromethyl) benzene is widely used. It is often used as a raw material for the synthesis of special polymer materials, which helps to improve the weather resistance and chemical corrosion resistance of materials. It is also used in the preparation of pharmaceutical intermediates, making great contributions to the creation of new drugs, or emerging in the field of electronic chemicals, contributing to the development of related industries.
Physical & Chemical Properties
1,4-Bis (trifluoromethyl) benzene, an organic compound. It has unique physicochemical properties. Looking at its physical properties, at room temperature, it is a colorless liquid with a special odor. Its boiling point is moderate, and it can be vaporized under a certain temperature and pressure. Its density is lighter than water, insoluble in water, but easily soluble in organic solvents. This property makes it use organic solvents as a medium to perform various reactions.
On its chemical properties, due to the presence of trifluoromethyl, it has strong electron absorption, resulting in a decrease in the electron cloud density of the benzene ring. Therefore, in the electrophilic substitution reaction, the activity of benzene is lower than that of benzene, but its special structure allows it to undergo halogenation, nitrification and other reactions under specific reaction conditions, and the regioselectivity is unique. It can obtain different products according to different reaction conditions, and has important application value in the field of organic synthesis.
Technical Specifications & Labeling
For 1,4-bis (trifluoromethyl) benzene, the process specifications and identification (commodity parameters) are the key. This substance, like a colorless liquid, has a specific taste. The preparation method depends on the delicate process. The choice of raw materials must be carefully selected, and the proportion balance must be accurate. The reaction temperature should not be slightly different, or controlled in a specific range, in order to make the reaction smooth.
In terms of identification, its name is written on the packaging, and the molecular formula and molecular weight are also clearly marked. Warning words, eye-catching to inform risks, such as flammability, irritation, etc., all need to be detailed. Commodity parameters cover the purity geometry and the amount of impurities, which are all related to its quality. In this way, it can be used in a variety of applications, safe and efficient.
Preparation Method
To prepare 1,4-bis (trifluoromethyl) benzene, the method is as follows:
Prepare raw materials, with fluoride as the starting material. After the reaction, a multi-step reaction is carried out. First, the fluorine-containing halogen is mixed with a specific reagent in an appropriate proportion, in a sealed container, heated at a moderate temperature, to promote the initial reaction and generate an intermediate product.
Then, the obtained intermediate product is transferred to a new container, and the catalyst is added to adjust the reaction conditions to make it transform. This catalytic mechanism uses the catalyst activity check point to reduce the reaction energy barrier and accelerate the reaction process.
The production process pays attention to the precision of the reaction steps. After each step of the reaction, the product needs to be carefully separated and purified to prevent the accumulation of impurities. Strictly controlled temperature, pressure and reaction time to ensure the purity and yield of the product. After these methods, the product of 1,4-bis (trifluoromethyl) benzene can be obtained.
Chemical Reactions & Modifications
1,4-Bis (trifluoromethyl) benzene is also an organic compound. In the field of chemical research, its reaction and modification are quite important to scholars.
Looking at its reaction, it can go through various paths. If it encounters nucleophilic reagents, or it undergoes a substitution change. Because trifluoromethyl has strong electron-absorbing properties, it causes the electron cloud density of the benzene ring to change, and the activity is also different.
As for modification, the method of introducing functional groups can be used. To increase its solubility, or a hydrophilic group can be added; to change its reactivity, other groups can be placed on the benzene ring to adjust the electron cloud distribution.
Chemists often explore the optimal reaction conditions to obtain high-purity products, and seek efficient and environmentally friendly reactions. Looking forward to the future, the knowledge of the reaction and modification of this compound will be more profound, so as to help expand various applications and develop its talents in materials, medicine and other industries.
Synonyms & Product Names
1,4-Bis (trifluoromethyl) benzene, with its unique physical properties, is widely used in the field of chemical industry. Its aliases and trade names are also numerous, all related to its characteristics and the scope of use.
In the research of science, the name is indeed crucial. 1,4-Bis (trifluoromethyl) benzene, or those with different names for its structure, also have different names for different uses. Merchants sell it, or according to the needs of the market and the characteristics of its functions, it is named under the name of the product.
Various synonyms and trade names, although different, actually refer to the same. For researchers, it is clear that they are the same, and they can be used to avoid errors in experimentation and production. And with different names, it also reflects the diverse uses of this product in the industry, whether it is related to pharmaceutical synthesis or material creation, all of which rely on its characteristics to develop their capabilities.
Safety & Operational Standards
1,4-Bis (trifluoromethyl) benzene, this substance is related to safety and operating standards, and must be treated with caution.
The chemical substance of Guanfu, 1,4-bis (trifluoromethyl) benzene, has different properties. Its shape may be a colorless liquid, volatile, and has a unique odor. However, this substance should not be ignored in a safe environment.
First words Store in a cool, dry and well ventilated place. Avoid open fires and hot topics to prevent the danger of explosion. It should be stored in a sealed container to avoid excessive contact with air, which will cause its properties to change.
As for the operation, be sure to prepare protective equipment. Operators wear protective clothing, protective gloves, and goggles are also indispensable to prevent them from touching the skin, entering the eyes, and damaging the body. Work in the fume hood to make the volatile gas escape in time to avoid gathering in the room and harming the body.
If you accidentally touch it and get it on the skin, rinse it with plenty of water quickly, and then wash it with soap. If it enters the eyes, rinse it with running water immediately and seek medical attention.
Furthermore, this substance is also subject to regulations when it is discarded. It should not be discarded at will. It should be properly handled according to the method of chemical waste disposal to protect the environment.
In short, the safety and operating standards of 1,4-bis (trifluoromethyl) benzene are the most important in chemical research, production, and other links.
Application Area
1,4-Bis (trifluoromethyl) benzene is also a chemical substance. Its application field is quite wide. In the field of medicine, it can be used as a key intermediate for the synthesis of many special drugs, to help the process of pharmaceutical research and development, and to help heal diseases. In the field of materials science, it can be used to prepare materials with special properties, such as materials with good weather resistance and strong chemical stability, which are widely used in aerospace, high-end equipment manufacturing and other industries to make equipment more durable and stable. In the field of fine chemicals, it is an important raw material for the synthesis of various high-end fine chemicals, such as special fragrances, high-performance coatings, etc., adding color to life and industry. With its unique chemical structure, this substance plays a key role in various application fields and promotes the development and progress of various industries.
Research & Development
In recent times, the art of chemistry has become more and more refined, and it has been explored in detail in various substances. Today, 1,4 - Bis (Trifluoromethyl) Benzene is a substance that our generation has been studying for many years.
Beginning, analyzing its structure, distinguishing its characteristics, and observing its changes in different environments. At the beginning, progress was difficult, and many difficulties lay ahead. However, we worked tirelessly, experimenting repeatedly, and using different methods to explore the boundaries of its properties.
After a long period of research, we gradually understood its reaction mechanism, and we also gained results in synthesis. After improving the process, the purity and yield of the product were improved. This achievement was not achieved overnight. It was the result of the team's hard work day and night, repeated scrutiny, and defiance of failure.
Looking forward to the future, we hope to expand its application field based on this, and play its role in many aspects such as material science and pharmaceutical research and development.
Toxicity Research
The observation of taste and smell of physical properties is of great importance to people's livelihood. Today, the study of the toxicity of 1,4-Bis (Trifluoromethyl) Benzene should not be ignored.
This substance, although it has a unique chemical conformation, contains fluorinated groups, or the risk of toxicity. According to the ancient theory, the nature of a substance often originates in its essence. The presence of fluorine atoms in this substance makes its chemical activity different from that of ordinary species.
Or there are clouds, which are difficult to self-degrade in the environment. If they accumulate but do not disperse, it will harm the ecology. If they enter the body of an organism, they may disrupt its physiological order. In the tiny cells, or damage the integrity of its membranes, and disrupt its metabolic path. And looking at the signs of the experiments, every time the tested organism shows an abnormal state, the growth is sluggish, and the reproduction is blocked.
is to study its toxicity and understand its harm, so as to obtain a strategy to avoid harm and benefit, protect the safety of the people, and protect the balance of nature.
Future Prospects
The author of 1,4 - Bis (Trifluoromethyl) Benzene is also a chemical product. I am a chemical researcher, and I hope that it will be developed in the future.
This compound has special properties, and the introduction of fluorine atoms gives it special properties. Not yet, in the field of materials, or it can be the cornerstone of new functional materials. With its specific properties, or it can be used in weathering and corrosion-resistant materials.
And it can also be used in physicochemical engineering. Or to assist in the research of specific effects, to develop specific diseases, and to develop excellent effects.
Furthermore, in the catalytic reaction, its special properties, or new catalytic pathways can be developed to improve the efficiency of reaction. Therefore, 1,4-Bis (Trifluoromethyl) Benzene has not yet been developed, such as the early rise of the dynasty, the future is not good, and the possibility of filling the limitations is waiting for me to explore it in depth in order to uncover it and make it beneficial to the world.
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Frequently Asked Questions

As a leading 1,4-Bis(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1,4-bis (trifluoromethyl) benzene?
1,4-Bis (triethoxysilyl) benzene is used in a variety of applications. Its main uses are probably as follows:
First, in the field of material modification, the function is quite good. This substance can interact with the surface of various matrix materials by means of siloxane groups, so that the surface properties of the material can be improved. If added to the organic polymer, it can strengthen the interfacial bonding force between the polymer and inorganic substances, and improve the mechanical properties and heat resistance of the composite material. Just like the method of mortise and tenon, the two fit seamlessly, sharing external forces and resisting thermal changes.
Second, it is also a key thing when preparing hybrid materials. Due to the hydrolysis and polycondensation of siloxane groups, they can react with metal salts or metal alkoxides to form organic-inorganic hybrid materials. This hybrid material has the advantages of both organic and inorganic substances, or has good optical properties, electrical properties, or high chemical stability. It is like a skilled craftsman combining the strengths of different materials to create a new product with wonders.
Third, it also plays an important role in the field of self-assembly and template synthesis. Its regular molecular structure can be used as a template to guide the orderly arrangement of other molecules or nanoparticles, and then prepare materials with special morphologies and structures. As if invisible, it delineates the trajectories of molecules and particles, so that they are arranged in sequence to form a delicate structure.
Fourth, in the coatings and adhesives industry, 1,4-bis (triethoxysilyl) benzene can enhance the adhesion between coatings and substrates, improve the weather resistance and wear resistance of coatings; in adhesives, it can enhance the bonding strength and make the bonding more firm and lasting. Just like a good adhesive, it closely connects things and lasts for a long time.
What are the physical properties of 1,4-bis (trifluoromethyl) benzene?
1,4-Bis (triethylamino) benzene is an organic compound. Its physical properties have many characteristics, as detailed below:
Under normal temperature and pressure, it is mostly colorless to light yellow liquid, with a clear appearance and a certain fluidity. This is a visually observable characteristic.
As for the smell, it often emits a special aromatic smell, but this smell is not popular because it can be pungent and uncomfortable at a specific concentration, forming a unique sensory experience on the sense of smell.
When it comes to solubility, 1,4-bis (triethylamino) benzene exhibits good solubility in organic solvents. Such as common ethanol, ether, acetone and other organic solvents can be mutually soluble with it. This property is derived from the interaction force between its molecular structure and the molecules of the organic solvent, so that the two can blend with each other. However, its solubility in water is very small, because its molecular polarity is quite different from that of water molecules, so it is difficult to dissolve in water.
Melting point and boiling point are also important physical properties. Its melting point is relatively low, about -20 ° C, which means that the substance exists stably in liquid form at room temperature. In terms of boiling point, it is usually in a higher temperature range, roughly around 300 ° C. A higher boiling point indicates that the intermolecular force is strong, and more energy is required to transform it from liquid to gas.
The density of 1,4-bis (triethylamino) benzene is also considerable. Compared with water, the density of 1,4-bis (triethylamino) benzene is slightly higher than that of water, about 0.98g/cm3. This characteristic causes it to sink in the bottom when mixed with water, which is a key consideration in substance separation and mixing experiments.
In addition, 1,4-bis (triethylamino) benzene still has a certain degree of volatility. Although the volatility is not extremely strong, it will gradually evaporate when left in an open environment for a long time. Its vapor density is higher than that of air, so the vapor is easy to accumulate at low levels, which may cause certain safety hazards in poorly ventilated environments.
What are the chemical properties of 1,4-bis (trifluoromethyl) benzene?
1% 2C4 -bis (triethylamino) benzene is an organic compound. Its chemical properties are particularly interesting, and I will explain them in detail for you.
In this compound, the benzene ring is its basic structure, which is as stable as a rock, giving it a certain stability. The bi (triethylamino) group connected to the 1,4 position of the benzene ring has a great influence on its properties.
From the perspective of physical properties, 1% 2C4 -bis (triethylamino) benzene has a specific melting boiling point. Due to the characteristics of intermolecular forces, its melting boiling point depends on the molecular structure and interactions. And its solubility is also shown. In organic solvents, due to the principle of similar miscibility, or equivalent solubility, in water, the solubility is negligible due to polar differences.
As for the chemical properties, the first one to bear the brunt is its alkalinity. The nitrogen atom in the triethylamino group has a lone pair of electrons and can accept protons, so the compound is alkaline. This alkalinity can play a key role in many chemical reactions, such as neutralization with acids, which can generate corresponding salts.
In addition, the presence of benzene rings also gives it aromatic-related reactivity. Although the benzene ring is stable, under appropriate conditions, electrophilic substitution reactions can occur. For example, in the case of halogenating agents, nitrifiers, etc., hydrogen atoms on the benzene ring may be substituted to form derivatives such as halogens and nitro compounds. And the hindrance effect of bis (triethylamino) may affect the positional selectivity of electrophilic substitution reactions.
At the same time, 1% 2C4 -bis (triethylamino) benzene nitrogen atoms may participate in coordination reactions. Because of its lone pair electrons, it can form coordination bonds with metal ions, and then construct coordination compounds, which may have potential applications in catalysis, materials science and other fields.
Furthermore, the chemical stability of the compound is also affected by environmental factors. Under extreme conditions such as high temperature, strong acid, and strong base, its structure may be changed, and reactions such as decomposition and rearrangement may occur. Therefore, when storing and using it, it is necessary to pay attention to appropriate conditions to ensure the stability of its chemical properties.
What are the preparation methods of 1,4-bis (trifluoromethyl) benzene?
For 1% 2C4-bis (triethoxysilyl) benzene, there are several ways to prepare it.
One method is to react with 1% 2C4-dibromobenzene and triethoxysilyl lithium reagent for nucleophilic substitution. First take an appropriate amount of 1% 2C4-dibromobenzene, place it in a dry reaction bottle, use anhydrous ethyl ether as a solvent, cool it to low temperature, and slowly add triethoxysilyl lithium reagent dropwise. Add it dropwise, raise it to room temperature, and stir for a while. After the reaction is completed, 1% 2C4-bis (triethoxysilyl) benzene can be obtained through separation and purification steps. This method requires attention to the anhydrous operation of the reagent to prevent side reactions.
The second method uses 1% 2C4-phthalic acid as the starting material. First, 1% 2C4-phthalic acid and ethanol are esterified under the catalysis of concentrated sulfuric acid to obtain 1% 2C4-diethyl phthalate. Then, 1% 2C4-diethyl phthalate and triethoxysilane are reduced and coupled in the presence of a metal catalyst to obtain the target product. In this process, the esterification reaction needs to control the temperature and the ratio of acid to alcohol, and the reduction coupling reaction has strict requirements on the activity and dosage of the catalyst.
The third method reacts with 1% 2C4-dichlorobenzene with a silanizing reagent. 1% 2C4-dichlorobenzene, a silanizing reagent and an appropriate amount of alkali are co-placed in a suitable solvent to heat the reflux reaction. After the reaction is completed, the product is purified by extraction, distillation and other operations. This method is relatively simple to operate, but the control of the reaction conditions also needs to be precise to ensure the purity and yield of the product.
Preparation of 1% 2C4-bis (triethoxysilyl) benzene All methods have their own advantages and disadvantages, and should be used according to the actual needs and conditions.
What are the precautions for using 1,4-bis (trifluoromethyl) benzene?
1% 2C4 -bis (triethoxysilyl) benzene, when using it, there are several ends that should be paid attention to.
First, this material has chemical activity, when using it, avoid contact with water, acid, alkali and other substances that can promote its reaction. Water can cause hydrolysis and condensation of siloxane groups. If the operating environment humidity is high, or the material contains moisture, it may make the product performance easier, so it should be stored in a dry environment, and the material needs to be tested for its water content.
Second, its volatility should not be underestimated, and it is important to operate in a well-ventilated place. If it is in a closed and poorly ventilated place, its volatile gas accumulates, which will damage the health of the operator and increase the risk of ignition and explosion. When there is a complete ventilation device in the operation room to keep the air flowing smoothly and the harmful gases are dispersed in time.
Third, when compatible with other substances, the compatibility of the two must be checked in detail. Different organic and inorganic substances are mixed with it, or chemical reactions occur, or the stability of the system is lost. Such as some metal salts or catalysts, or their reaction paths are changed, which affects the structure and performance of the product. Therefore, before mixing, it is recommended to test its compatibility with a small amount.
Fourth, storage conditions are also critical. It should be stored in a cool, dry and dark place, protected from high temperature and strong light. High temperature can promote its self-polymerization or accelerate reactions such as hydrolysis, and strong light may also lead to photochemical reactions, resulting in quality deterioration. Storage containers should be corrosion-resistant, such as glass, specific plastic materials, to prevent the container from reacting with materials.
Fifth, protective measures are indispensable during operation. Appropriate protective clothing, gloves and goggles are required to avoid contact with the skin and eyes. In case of inadvertent contact, rinse with plenty of water immediately and seek medical treatment if necessary.