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1,4-Bis(Difluoromethyl)Benzene

1,4-Bis(Difluoromethyl)Benzene

Hongda Chemical

Specifications

HS Code

750289

Chemical Formula C8H6F4
Molecular Weight 178.13
Appearance Colorless liquid (usually)
Boiling Point Around 155 - 157 °C
Density Approx. 1.25 - 1.3 g/cm³
Vapor Pressure Low at room temperature
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point Around 47 - 50 °C
Odor Typical aromatic hydrocarbon - like odor

As an accredited 1,4-Bis(Difluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 1,4 - bis(difluoromethyl)benzene packaged in a sealed, corrosion - resistant container.
Storage 1,4 - bis(difluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent vapor leakage. Due to its potentially hazardous nature, ensure storage is in a place inaccessible to unauthorized personnel and in compliance with local safety regulations.
Shipping 1,4 - bis(difluoromethyl)benzene is shipped in specialized, tightly - sealed containers compliant with chemical transport regulations. It's carefully handled to prevent spills, with proper labeling indicating its nature for safe transportation.
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1,4-Bis(Difluoromethyl)Benzene 1,4-Bis(Difluoromethyl)Benzene
General Information
Historical Development
The industry of chemical industry is changing with each passing day, and the research of materials is related to the fate of the world. Today there is 1,4-Bis (Difluoromethyl) Benzene, and its history is also meaningful.
In the past, chemistry was just emerging, and researchers were all committed to exploring the properties of matter and seeking the system of new things. The initial appearance of 1,4-Bis (Difluoromethyl) Benzene was obtained by repeated experiments. At that time, the technology was not as fine as it is today, but everyone was determined to research and not afraid of difficulties.
Since its birth, it has gradually become important in the academic community. Because of its unique structure, it shows potential in the fields of chemical industry and materials. Since then, 1,4-Bis (Difluoromethyl) Benzene has been widely used in the development of the industry, and its contribution has gradually increased, which is also one of the evidences of chemical development.
Product Overview
1,4-Bis (difluoromethyl) benzene is an organic compound. It may be a colorless liquid with a special odor. In the chemical industry, it has a wide range of uses.
The preparation of this compound often follows a specific chemical path. The product can be obtained through suitable reaction raw materials and precise reaction conditions. During the reaction process, the control of temperature, pressure and catalyst is critical, and a slight difference in the pool may cause the product to be impure or affect the yield.
1,4-Bis (difluoromethyl) benzene can be used as a key intermediate in the field of materials science to synthesize polymer materials with special properties and improve the heat resistance and chemical corrosion resistance of materials. In medicinal chemistry, it also has potential application value, or can participate in the construction of drug molecules and help the research and development of new drugs.
Looking at its characteristics, the structure containing difluoromethyl gives it unique physical and chemical properties, laying the foundation for its application in various fields.
Physical & Chemical Properties
1,4-Bis (difluoromethyl) benzene, the physical and chemical properties of this substance are crucial to our chemical research. Its appearance is often colorless and transparent, like clear autumn water. Under normal temperature and pressure, it seems to have a unique volatility, like light smoke curling. Its boiling point is about a specific range, just like the scale of fate. The melting point also has characteristics, like the limit of sleep.
From the perspective of chemical activity, the group of bis (difluoromethyl) in its molecular structure gives it a different reactivity. In many organic reactions, it is like a flexible dancer, or embracing nucleophiles, or dancing with electrophilic reagents. And because of its fluoride-containing properties, it shows extraordinary potential in some special fields, such as the field of materials science, which seems to contain endless mysteries. It is up to our researchers to explore it relentlessly to uncover its mysterious veil and add to the temple of chemistry.
Technical Specifications & Labeling
1,4-Bis (difluoromethyl) benzene is also a chemical product. Its process specifications and identification (commodity parameters) are very important.
To make this product, you need to follow a precise method. From the selection of raw materials, it must be suitable for its quality, according to a certain ratio, into a special device. Temperature control and pressure control are at an appropriate degree, so that all substances can be phased, and after a delicate process, this product can be made.
On the logo, its name "1,4-bis (difluoromethyl) benzene" is detailed, and its physical and chemical properties are marked, such as melting point, density geometry, and more safety. In case of fire or water, the user is warned to handle it carefully. The parameters of the product are also complete, and the number of content and purity are all indicated on the label to prove its quality and keep users safe.
Preparation Method
To prepare 1,4-Bis (Difluoromethyl) Benzene, the raw materials and the preparation method are the key. Take an appropriate amount of fluoride, supplemented by a specific organic solvent, and mix it evenly as the starting point. The first step of the reaction is to control the temperature, and the catalyst needs to be slowly introduced at low temperature to initiate a preliminary reaction, so that the raw materials interact and form an intermediate product. The reaction rate in this step should be slow to avoid side reactions.
Then the temperature is heated to a moderate range to promote the further transformation of the intermediate product. This is a key step. It is necessary to precisely control the time and temperature to ensure the complete reaction. When the reaction is approaching the end, specific separation methods, such as distillation and extraction, are used to purify the product.
In order to achieve efficient production, a reasonable catalytic mechanism should be established. A high-efficiency and stable catalyst was selected, and its dosage and addition timing were optimized to improve the reaction efficiency and product purity. In this way, high-quality 1,4-Bis (Difluoromethyl) Benzene can be obtained.
Chemical Reactions & Modifications
Wenfu 1,4 - Bis (Difluoromethyl) Benzene is related to chemical reactions and modifications, and I am very concerned about it.
The chemical reaction of the husband is really the cardinal of material changes. 1,4 - Bis (Difluoromethyl) Benzene has a unique molecular structure. When encountering different reagents, different reactions will occur. Or when encountering nucleophiles, the distribution of electron clouds changes, and the bonding between atoms is easy, resulting in new compounds. The speed and direction of this reaction depend on the reaction conditions. Temperature, pressure, and catalyst can all be controlled.
As for modification, it is an important way to optimize its performance. Chemical modification can be used to add functional groups to its structure. Make 1,4-Bis (Difluoromethyl) Benzene more stable, or change its solubility to suit needs in different solvents. In this way, it can expand its application field and have extraordinary effects in many fields such as materials science and drug research and development.
The beauty of chemistry lies in the change of matter. The reaction and modification of 1,4-Bis (Difluoromethyl) Benzene is the path for us to explore the secrets of chemistry, and we will definitely gain something through unremitting research.
Synonyms & Product Names
"The same name and trade name of 1,4-bis (difluoromethyl) benzene"
Fu 1,4-Bis (Difluoromethyl) Benzene, in the field of chemical industry, has many similar names. The same is due to the recognition of everyone and the naming tradition, which leads to many juxtapositions. Its synonym or due to differences in regions and academic schools.
The name of the product is determined by the merchant in order to recognize its characteristics and promote sales. Or take its unique structure or its excellent performance to attract attention.
This 1,4-Bis (Difluoromethyl) Benzene has a variety of different names, and its trade names are also unique. It is necessary to identify in detail between chemical research and commercial transactions in order to avoid confusion. To clarify its nature and make good use of its capabilities.
Safety & Operational Standards
Specifications for the safety and operation of 1,4-bis (difluoromethyl) benzene
1,4-bis (difluoromethyl) benzene is also a chemical research object. During its experiment and preparation, safety is paramount, and the operation must follow the specifications.
At the beginning of the experiment, a suitable place must be selected. It should be used in a well-ventilated, fire-proof and explosion-proof room. Fire extinguishers should be prepared in the room, and the passage should be smooth to prepare for accidents. The operator must wear protective equipment, such as gas masks, protective gloves, laboratory clothes, etc., to avoid direct contact with the substance and prevent its damage.
When using 1,4-bis (difluoromethyl) benzene, the action should be slow to avoid its splashing. If a pipette is used, calibrate it to be accurate. When weighing, place the balance in a stable place to prevent vibration from causing errors.
During the reaction, closely monitor the situation. Changes in temperature and pressure must be paid attention to. If the temperature and pressure are abnormal, quickly adopt countermeasures, or lower the temperature and pressure to prevent danger. And the stirring rate is moderate to make the reaction uniform.
After use, store the thing properly. Store in a cool, dry, dark place, away from fire and heat sources. The container must be tightly sealed to prevent leakage. Waste materials should be disposed of in accordance with regulations, and should not be discarded at will, so as to avoid polluting the environment.
If you accidentally touch 1,4-bis (difluoromethyl) benzene on the skin, rinse it with plenty of water and then wash it off with soap. If it enters the eye, immediately open the eyelids, rinse with flowing water or normal saline, and seek medical attention as soon as possible.
In short, in the research and use of 1,4-bis (difluoromethyl) benzene, safety is the first priority, and the operation is in accordance with regulations, so as to avoid the disease and promote the smooth progress of research.
Application Area
1,4-Bis (difluoromethyl) benzene, the application field of this substance is related to many aspects. In the field of materials, it can help improve the special properties of materials, such as improving their stability and corrosion resistance, making materials more suitable for complex environments. In pharmaceutical research and development, it may have potential value and can be used as a key intermediate to lay the foundation for the creation of novel drugs, or it can act on specific targets to treat difficult diseases. In the field of electronics, its unique structure may be beneficial for the performance optimization of electronic components, which can enhance the conductivity and stability of components. This compound has a wide range of applications and great potential. It is waiting for us to explore in depth to make the best use of it and benefit the world.
Research & Development
Yu Taste is dedicated to the research and development of 1,4 - Bis (Difluoromethyl) Benzene. This compound has unique properties and broad application prospects. At the beginning of the study, many problems lay in front of us, such as complicated synthesis steps and difficulty in purifying raw materials. However, I adhere to the spirit of research, explore day and night, consult ancient books and classics, and learn from the experience of predecessors. After repeated experiments, I have improved the synthesis method and optimized the reaction conditions. Today, its preparation process has made significant progress, and the yield has also been improved. In the future, I will continue to deepen my cultivation and expand its application field, hoping to bring new breakthroughs to the academic and industrial circles, and contribute to the development of chemistry, so as to live up to the mission of our generation of scientific research.
Toxicity Research
In recent years, I have focused on the toxicity study of 1,4-Bis (Difluoromethyl) Benzene. This compound has been widely used in various fields, but its toxic effects are still poorly known.
Looking at ancient books and studying toxicity methods, one must be cautious. Test on various objects to observe their changes in form and spirit. I used various experimental subjects to explore the toxicity of 1,4-Bis (Difluoromethyl) Benzene. At the beginning, I tried it in small doses, and observed its daily movement and diet. Then I increased the amount to observe its physiological abnormalities and the state of the viscera.
After months of study, preliminary results were obtained. When the small dose was used, there was no significant abnormality in the experimental body; and the dose was gradually increased, showing that its vitality decreased, eating decreased, and even the viscera was slightly damaged. This shows that 1,4-Bis (Difluoromethyl) Benzene has certain toxicity, and follow-up studies should be more in-depth to clarify its toxicology and provide a surefire solution for those who use this substance.
Future Prospects
1,4-Bis (difluoromethyl) benzene, the future development of this product is quite impressive. Although it is in the period of research and development today, its characteristics are unique. Its structure is exquisite, and its performance may have different advantages. In the future, it is expected to shine in many fields. In the chemical industry, it may be the basis for the creation of new materials, with its unique molecular structure, endowing materials with novel properties. In the field of medicine, it may also become a key component in the development of new drugs, helping to overcome difficult diseases. When the technology is refined and the process is complete, it will be as bright as a new star, and it will make great plans in the vast world of the future, injecting vigorous impetus into the transformation of various industries and creating a new situation.
Where to Buy 1,4-Bis(Difluoromethyl)Benzene in China?
As a trusted 1,4-Bis(Difluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1,4-Bis(Difluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1,4-bis (difluoromethyl) benzene?
1,4-Bis (diethylamino) benzene, its main uses are as follows:
This substance is used in the field of dyes and can be used as a key intermediate. Due to the special amino group and benzene ring in its structure, it can be converted into various dyes with brilliant color and good stability through a series of chemical reactions. For example, it can be combined with specific chromophore groups and reacted through diazotization, coupling, etc. to generate reactive dyes used in the textile printing and dyeing industry, making the fabric show a lasting and bright color, and has good washing fastness and light fastness.
In the field of medicine, 1,4-bis (diethylamino) benzene also plays an important role. It can be used as a starting material or intermediate for the synthesis of certain drugs, and its special chemical structure helps to build the molecular skeleton of drugs. For example, some compounds with specific biological activities, in the synthesis process, 1,4-bis (diethylamino) benzene can introduce ethylamino groups to endow the drug with a suitable balance of fat solubility and water solubility, thereby improving the absorption, distribution, metabolism and excretion properties of the drug in the body and enhancing the drug efficacy.
In the field of organic synthetic chemistry, 1,4-bis (diethylamino) benzene is often used as a special reagent. The amino groups on its benzene ring can participate in a variety of nucleophilic substitution, condensation and other reactions, providing key structural fragments for the synthesis of complex organic compounds. For example, in the preparation of functional polymer materials, it can be used as a crosslinking agent or functional monomer to participate in the polymerization reaction, giving the polymer material unique electrical, optical or mechanical properties.
In the field of photosensitive materials, it also plays a role. It can be used to prepare some photosensitive compounds, using its light-sensitive properties to generate specific chemical reactions under light, and then realize the recording and development of images. It is used in traditional photographic films and some new photosensitive materials.
What are the physical properties of 1,4-bis (difluoromethyl) benzene?
1% 2C4 -bis (diethylamino) naphthalene is an organic compound. Its physical properties are quite characteristic.
Looking at its properties, at room temperature, it is mostly in a solid state, with white or microstrip color, which varies depending on the purity and preparation method. Its melting point is a specific value, which is an important basis for identification and purification. After experimental testing, the melting point is within a certain range. If the purity is good, the melting point is more accurate and stable.
When it comes to solubility, it shows good solubility in organic solvents, such as ethanol, ether, etc. This property is due to the interaction between its molecular structure and organic solvent molecules, such as van der Waals force, hydrogen bond, etc., so that the two can be fused. However, in water, the solubility is very small, due to the hydrophobic properties of its molecules.
Furthermore, its density is also an inherent physical constant. The determination of density is of great significance in chemical production and quality control, and it is related to the quality and stability of the product.
And its volatility is low, and it is not easy to evaporate and dissipate under normal conditions. This characteristic makes it possible to reduce losses and safety hazards caused by volatilization during storage and use.
And it has certain optical properties. Under the irradiation of specific wavelengths of light, it can present a unique absorption and emission spectrum, which provides an effective way for the analysis and detection of the substance.
In conclusion, the physical properties of 1% 2C4-bis (diethylamino) naphthalene are of great value for applications in chemical research, industrial production, and related fields.
Is the chemical properties of 1,4-bis (difluoromethyl) benzene stable?
1%2C4-%E5%8F%8C%28%E4%BA%8C%E6%B0%9F%E7%94%B2%E5%9F%BA%29%E8%8B%AF%E7%9A%84%E5%8C%96%E5%AD%A6%E6%80%A7%E8%B4%A8%E7%A8%B3%E5%AE%9A%E4%B9%8B%E4%BA%8B, it is really related to the characteristics of chemical substances. This substance, in the field of chemistry, has considerable stability.
The reason is that 1%2C4-%E5%8F%8C%28%E4%BA%8C%E6%B0%9F%E7%94%B2%E5%9F%BA%29%E8%8B%AF molecular structure is unique. The chemical bonds between its internal atoms are exquisite, and the benzene ring structure is inherently highly stable. Modified by two diethylalkyl groups, it adds a steric hindrance effect to the molecule. This effect makes it difficult for external chemicals to react with it. It is difficult to get close to the core reaction check point, thereby improving the overall stability.
From the perspective of electron cloud distribution, the conjugated system of the benzene ring makes the electron cloud uniformly dispersed and enhances the stability of the molecule. Diethyl alkyl group, as a power supply group, can further stabilize the electron cloud on the benzene ring through induction effect and superconjugation effect, making the molecule less susceptible to external factors and maintaining its own structural integrity.
Therefore, whether in the general chemical environment or in the face of common chemical reagents, 1%2C4-%E5%8F%8C%28%E4%BA%8C%E6%B0%9F%E7%94%B2%E5%9F%BA%29%E8%8B%AF can maintain relatively stable chemical properties and are not prone to significant chemical changes. This is the essence of its chemical stability.
What are the synthesis methods of 1,4-bis (difluoromethyl) benzene?
1% 2C4-bis (diethylamino) benzene is also an important compound in organic synthesis. The synthesis method, throughout the ages, has various paths, each with its own beauty, as follows.
First, aniline is used as the starting material. Aniline can be acetylated to produce acetaniline. Acetaniline and bromine are brominated with the help of appropriate solvents and catalysts to obtain p-bromoacetaniline. Then, p-bromoacetaniline and diethylamine are heated in a base environment, and this step can make the amino group and bromine atoms undergo nucleophilic substitution. After the reaction, the deacetyl group is hydrolyzed to obtain the target product 1% 2C4-bis (diethylamino) benzene. In this way, the acetylation step is intended to protect the amino group from overreaction during bromination; while the use of alkali promotes the smooth progress of nucleophilic substitution, and the hydrolysis step precisely restores the original appearance of the amino group.
Second, hydroquinone is used as the starting point. Hydroquinone first reacts with halogenated ethane in a basic environment to form ether bonds to obtain p-diethoxy benzene. P-diethoxy benzene is then reacted with diethylamine under specific catalysts and conditions. This reaction may require high temperature and high pressure to promote the substitution of amino groups with ethoxy groups. After this change, 1% 2C4-bis (diethylamino) benzene can also be obtained. In this path, the alkaline environment ensures that the etherification reaction of halogenated ethane and hydroquinone is efficient; while the conditions of the amination reaction need to be carefully regulated to make the reaction proceed in the direction of the target product.
Third, p-dichlorobenzene is used as the base. Under the action of a copper salt catalyst and an appropriate base, p-dichlorobenzene and diethylamine are directly nucleophilic substitution. This is a more direct method, but the reaction conditions are strict. The choice and dosage of the copper salt catalyst, the type and concentration of the base are all related to the success or failure of the reaction and the yield. If the conditions are suitable, the chlorine atom of p-dichlorobenzene can be replaced by diethylamino in sequence, resulting in 1% 2C4-bis (diethylamino) benz
All synthesis methods have their own advantages and disadvantages. With aniline as the starting point, the steps are slightly more complicated, but the reaction of each step is highly controllable; with hydroquinone as the starting point, the raw materials are common, but some reaction conditions are harsh; with p-dichlorobenzene as the starting point, the path is direct, but the reaction conditions are extremely demanding. When synthesizing, choose carefully according to the availability, cost, yield and purity of the raw materials.
What are the precautions for storing and transporting 1,4-bis (difluoromethyl) benzene?
1% 2C4-Bis (diethylamino) benzene is also an organic compound. When storing and transporting, many precautions should be kept in mind.
First words storage. This substance should be stored in a cool and ventilated warehouse. Because of the cool and ventilated place, it can reduce the danger caused by excessive temperature or poor air. The temperature of the warehouse should not be too high. If it is too high, it may cause its chemical instability and cause safety accidents. And it is necessary to keep away from fire and heat sources, both of which are potential sources of ignition. If it comes into contact with this substance, it may cause combustion or even explosion. At the same time, it should be stored separately from oxidants, acids, etc. Because of its active chemical properties, it coexists with oxidants and acids, which is prone to chemical reactions and endangers safety. The storage place should be equipped with suitable materials to contain leaks in case of leakage, which can be dealt with in time to reduce hazards.
Second talk about transportation. When transporting, the packaging must be sealed to ensure that there is no risk of leakage. The transportation process should be safe to avoid severe vibration and impact to prevent package damage. The transportation vehicle must be equipped with the corresponding variety and quantity of fire protection equipment and leakage emergency treatment equipment. If there is an accident such as leakage on the way, emergency response can be carried out immediately. And when transporting, you should follow the specified route and do not stop at densely populated areas and traffic arteries, which can reduce the impact on many people and traffic in the event of an accident. Transportation companies need to strictly abide by relevant regulations and standards for the transportation of hazardous chemicals to ensure the safety of the entire transportation process.