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1,3-Difluoro-5-Nitrobenzene

1,3-Difluoro-5-Nitrobenzene

Hongda Chemical

Specifications

HS Code

692712

Chemical Formula C6H3F2NO2
Molar Mass 159.09 g/mol
Appearance Solid
Color White to off - white
Melting Point 52 - 54 °C
Boiling Point 207 - 208 °C
Density 1.512 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, acetone
Purity Typically high - purity grades available, e.g., 98%+

As an accredited 1,3-Difluoro-5-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1,3 - difluoro - 5 - nitrobenzene packaged in 500 - gram bottles.
Storage 1,3 - Difluoro - 5 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It should be stored in a tightly - sealed container, preferably made of corrosion - resistant materials due to its chemical nature. Keep it separate from oxidizing agents and reducing agents to prevent potential chemical reactions.
Shipping 1,3 - difluoro - 5 - nitrobenzene is a chemical. Shipping should be in well - sealed containers, compliant with hazardous chemical regulations. It may require proper labeling, secure packaging to prevent leakage during transportation.
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1,3-Difluoro-5-Nitrobenzene 1,3-Difluoro-5-Nitrobenzene
General Information
Historical Development
"The History of 1,3-Difluoro-5-nitrobenzene"
The husband of 1,3-difluoro-5-nitrobenzene is also an important product of chemistry. Tracing back to its origin, at the beginning, the academic community did not delve deeply into fluorine-containing nitroaromatic hydrocarbons, and such substances were mostly hidden in the unknown.
Catch up to modern times, chemical masters have devoted themselves to exploring various reaction mechanisms. When the art of organic synthesis was gradually refined, 1,3-difluoro-5-nitrobenzene began to emerge. Chemists, with their ingenuity, used fluorination, nitrification and other methods to gradually unearth it from the micro.
The method of its preparation only existed in theoretical research at first, and after countless trials and errors, it was feasible. Since then, 1,3-difluoro-5-nitrobenzene has gradually shown its extraordinary ability in many fields such as medicine and materials, opening a new chapter, and paving a new way for chemical research and industrial application.
Product Overview
There is a chemical substance named 1,3-difluoro-5-nitrobenzene. It is a chemical substance with unique properties. The appearance of this substance may be in a specific state, or in a crystalline state, or as a powder, and the color is also characterized. It has unique properties in the field of chemistry.
1,3-difluoro-5-nitrobenzene can be an important raw material for organic synthesis. It can participate in various reactions, such as nucleophilic substitution reactions. With its fluorine and nitro properties, other groups are introduced to form new compounds.
Furthermore, its physical properties are also exquisite. Melting point and boiling point are its characteristics, which are related to its morphology and behavior under different conditions. Solubility varies among various solvents, and the choice of separation, purification and reaction medium is essential.
Viewing this 1,3-difluoro-5-nitrobenzene, although a micro-chemical, is indispensable in the process of chemical research and industrial practice. Exploring its properties and uses will benefit the development of chemistry.
Physical & Chemical Properties
1,3-Difluoro-5-nitrobenzene is also an organic compound. It has unique physical and chemical properties. Looking at its physical properties, at room temperature, it is a colorless to light yellow liquid with a specific odor. Its boiling point is worth noting, about a certain degree, which is related to the difficulty of its gasification. As for the density, it is also an inherent value, which is related to its state when mixed with other substances.
On its chemical properties, due to the presence of fluorine and nitro functional groups, the activity is apparent. Nitro has strong electron absorption, which reduces the density of electron clouds in the benzene ring, making it difficult to cause electrophilic substitution reactions, while nucleophilic substitution is easy. Although fluorine atoms are small, they affect molecular polarity and stability. Therefore, 1,3-difluoro-5-nitrobenzene is widely used in organic synthesis and other fields, and can be used as an intermediate to produce a variety of fine chemicals, which is important for chemical research and industrial production.
Technical Specifications & Labeling
There is now a product named 1,3-difluoro-5-nitrobenzene. In the preparation method, it is necessary to follow the precise process regulations. Prepare the materials first, and put them in the utensils in an appropriate amount in sequence. Control the temperature to an appropriate extent, observe the state of its reaction, and do not make mistakes.
As for the quality evaluation, looking at its color, it should be pure and correct, and there should be no noise. Measure its degree, melting point and boiling point are all in compliance. Check its quality, the amount of impurities must be extremely small.
The method of process regulation and tasting of this product is related to its use and should not be ignored. The craftsman needs to be careful before he can get a good product to meet all needs.
Preparation Method
The preparation of 1,3-difluoro-5-nitrobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The selection of raw materials requires careful selection of those with specific purity and characteristics to ensure the quality of the product. The production process should follow a rigorous process, from raw material pretreatment to the regulation of the reaction process, all need to be precisely controlled.
Reaction step, the first step of mixing raw materials, must be uniform, so that the components are fully in contact. Then the temperature rises to initiate the reaction, during which the temperature and pressure must be adjusted according to specific laws to promote the reaction in a favorable direction.
The catalytic mechanism is key, and the appropriate catalyst can greatly improve the reaction rate and yield. It is expected that 1,3-difluoro-5-nitrobenzene can be efficiently prepared by selecting high-efficiency catalysts, studying their interaction with reactants, and optimizing catalytic conditions, which will provide high-quality raw materials for applications in related fields.
Chemical Reactions & Modifications
Taste the wonders of chemical industry, the changes are endless, and the properties of the substance can be changed to suit the needs. Today, there is 1,3-difluoro-5-nitrobenzene, which is in the process of chemical synthesis, and its reaction and modification are related to the prosperity of all industries.
Looking at its chemical response, it is often a nucleophilic substitution substrate. The fluorine atom has unique activity, and the nitro group also has an impact. However, the initial state may have harsh reaction conditions and the yield is not ideal.
Therefore, the method of modification is sought to optimize the reaction path. After various experiments, or the introduction of specific groups to adjust the distribution of electron clouds and change their activity; or easier reaction media, temperature, catalyst, so that the reaction is smooth. In this way, the reaction can be mild, the yield can be improved, and it can be used in a good environment. It adds bricks and tiles to the chemical industry and exhibits the miraculous power of chemistry.
Synonyms & Product Names
1,3-Difluoro-5-nitrobenzene is one of the chemical substances. Its synonyms and trade names are of great significance in both academia and industry.
A synonym is a different word referring to the same substance. In the field of chemistry, many substances have different names due to different discovery processes and research perspectives. 1,3-difluoro-5-nitrobenzene, or because of its structural characteristics and synthesis paths, is also called another name, which is a synonym category.
As for the trade name, it is the name established by the merchant for product promotion and market differentiation. If 1,3-difluoro-5-nitrobenzene is put into commercial application, merchants will give it a unique trade name according to its characteristics, uses, and target audience, in recognition of its characteristics, so that consumers can identify and choose it.
From this perspective, the synonyms and trade names of 1,3-difluoro-5-nitrobenzene are just like the two sides of the chemical and commercial world, reflecting its diverse roles and values.
Safety & Operational Standards
Safety and Operation Specifications of 1,3-Difluoro-5-nitrobenzene
For 1,3-difluoro-5-nitrobenzene, it is also a common compound in chemical preparation. Its reactivity is related to the safety and operation standards of the experimenter, and it cannot be ignored.
On the safe side, this substance is dangerous. Its odor is pungent, if inadvertently inhaled, it can cause respiratory discomfort, cough, chest tightness in light cases, or damage to the lungs in severe cases. And it also irritates the skin and eyes. When touched, the skin is red, swollen, painful, painful, tears flow into the eyes, and even damage the eyesight. Therefore, when operating, protective equipment is indispensable. It is necessary to wear protective clothing, which is dense and tough, and can resist the contamination of this substance; wear anti-goggles, which are clear and firm, and can protect your eyes in case; wear a gas mask, which can filter the poison accurately and ensure the safety of your breathing.
Operating specifications, it is particularly important. When using it, it should be in the fume hood. If there is good ventilation, harmful gases will quickly disperse and will not gather in the room. And the action should be slow to avoid its splashing. The measuring device must be clean and accurate, so as not to mix impurities and cause deviations in the reaction. The storage place should be cool, dry and well ventilated, away from fire and heat sources. This substance is dangerous when heated or exposed to open flames.
Furthermore, after the experiment, the residue should not be discarded at will. When in accordance with regulations, properly dispose of it. Or neutralize, or decompose, to ensure that it is harmless, in line with the principles of environmental protection.
In short, in the operation of 1,3-difluoro-5-nitrobenzene, safety is the first priority, and norms are the most important. Experimenters only need to be cautious and strictly abide by the guidelines to ensure the smooth experiment and their own safety.
Application Area
1,3-Difluoro-5-nitrobenzene, this chemical has a wide range of uses. In the field of medicine, it can be used as a key intermediate. After ingenious synthesis and transformation, it can lay the foundation for the research and development of new antibacterial drugs and help humans resist the infestation of pathogens. In the field of materials science, it can participate in the creation of special materials. After specific reactions, it endows the materials with unique electrical and optical properties and is applied to advanced electronic devices. In pesticide research, it also has important value. Using it as a starting material and carefully designed reaction paths can synthesize high-efficiency and low-toxicity pesticides, which can help agriculture harvest and protect crops from thriving. It can be said to be versatile and play a key role in various fields, promoting the development and progress of various industries.
Research & Development
In the field of chemical industry, the research of new substances is particularly important. Today there is 1,3-difluoro-5-nitrobenzene, and I have been studying it for a long time.
At the beginning, I wanted to get pure quality, but the method was difficult to find. All kinds of attempts, or poor raw materials, or refined techniques, have not yielded good results. But I have not given up, thinking day and night, consulting ancient books and today's works, visiting various houses.
After getting inspiration, fine-tuning the steps, easier raw materials, and skillfully controlling the heat. After many trials, I finally got a good product. And its nature is stable, can meet many needs.
Since then, the research on 1,3-difluoro-5-nitrobenzene has been slightly successful. However, I know that scientific research is endless, and I should continue to be diligent. I hope to make further progress in the future, and do my best for the prosperity of chemical industry.
Toxicity Research
The nature of toxins studied by those close to it, especially 1,3-difluoro-5-nitrobenzene. This substance is also useful in the field of chemical industry, but the study of toxicity cannot be ignored.
Examine its properties in detail, and it can be caused by entering the body or through respiration and skin. The hair of poison also damages the viscera, and messes up qi and blood. Looking at all the experiments, when fed to white mice, the amount is slightly exceeded, showing that they are sluggish, their food and drink are wasted, and even die.
Investigating its toxicology, the cover is due to the genus of fluorine and nitro in its structure, which is disturbing to the biochemical process. Fluoride is very active and easy to combine with other substances; nitro can also induce biochemical changes, causing cell damage and functional decline.
Therefore, the study of toxicity of this substance is essential for protection. Workers should be strict in their regulations, careful in their operations, and do not allow poison to invade the body. It is also a long-term plan for the chemical industry.
Future Prospects
1,3-Difluoro-5-nitrobenzene is also a chemical substance. Its future prospects are what we are all thinking about. Today, this compound is unique and has a wide range of possible uses.
It has not been developed yet, or can be used for refined synthesis. The fluoro-nitro group in it can lead to a variety of chemical reactions, and can provide new research and development with exquisite starting materials. Physicochemical fields, or as a result, new breakthroughs can be made to save many patients.
Or in the material science. With clever modification, it may be possible to obtain functional materials with excellent performance, such as special materials or optical materials, used in sub-devices and optical devices, and promote the progress of science and technology.
Therefore, 1,3-difluoro-5-nitrobenzene has not yet been able to achieve its capabilities, but it has not yet been developed. Just like the dawn, it has limited hope and must be completed in the chemical and phase fields.
Where to Buy 1,3-Difluoro-5-Nitrobenzene in China?
As a trusted 1,3-Difluoro-5-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1,3-Difluoro-5-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1,3-difluoro-5-nitrobenzene?
Although 1,3-diene-5-carboxylbenzene did not directly mention this specific compound in "Tiangong Kaiwu", its possible uses can be deduced from the perspective of ancient technology and chemical cognition.
In traditional dyeing and weaving processes, compounds containing such structures may be used as intermediates of natural dyes. Ancient dyers knew well that pigments were extracted from various plants and minerals for fabric dyeing. If 1,3-diene-5-carboxylbenzene exists in some plant components, its special structure may be converted into bright and stable dyes through chemical reactions, adding color to silk, hemp and other fabrics to meet the needs of the ancients for diverse clothing colors.
In the field of ancient medicine, it may also have potential uses. Ancient healers often used natural substances as medicine, which were processed and combined to exert therapeutic effects. 1,3-diene-5-carboxylbenzene may have a regulatory effect on some diseases of the human body due to structural characteristics. For example, some compounds containing carboxyl groups and unsaturated bonds have anti-inflammatory and antibacterial activities. The ancients may have found their medicinal value in practice and explored it. After proper treatment, it can be used to treat sores, swelling, trauma and other diseases.
Furthermore, in the traditional fragrance making process, it may be used as one of the ingredients of fragrances. Ancient nobles and literati were quite particular about incense, and fragrances needed to have unique aroma and stability. If 1,3-diene-5-carboxybenzene has a special smell, it can be blended into incense to add a different flavor to incense, incense pills, etc., and create an elegant and pleasant atmosphere.
What are the physical properties of 1,3-difluoro-5-nitrobenzene?
1% 2C3-diethyl-5-carboxypyridine, this physical property is as follows:
Its properties, under normal conditions, or white to slightly yellow crystalline powder, the appearance is fine, the quality is pure, the color is uniform, no variegation and foreign matter, or under light There may be a weak luster.
The melting point is quite critical, about [X] ℃, this value is an important indicator in the identification and purification of substances. Heating to this temperature, the substance begins to melt from solid to liquid, and the melting process is relatively smooth, without sharp changes. In terms of solubility, the solubility in water is limited and slightly soluble. There may be a small amount of dispersion in water and it is difficult to form a homogeneous solution. In organic solvents such as ethanol and acetone, the solubility is quite good, and it can be rapidly dispersed and dissolved to form a clear and transparent solution. This property is of great significance in its extraction, separation and solvent selection for chemical reactions.
Stability also needs attention. In normal temperature and humidity environments, the properties are relatively stable and can be stored for a long time without significant deterioration. In case of strong acids, strong bases, or in high temperature, high humidity, and strong oxidation environments, the chemical structure may change, resulting in changes in properties.
Volatility is weak, and it is difficult to volatilize into the air at room temperature. Therefore, in conventional storage and use scenarios, there is no need to worry about loss due to volatilization or environmental problems.
In addition, the substance has certain chemical activity and can participate in a variety of chemical reactions under specific conditions, such as esterification, substitution, etc., which is why it is widely used in the field of organic synthesis.
The above physical properties are expected to help you in the research and application of this substance.
What are the chemical properties of 1,3-difluoro-5-nitrobenzene?
The chemical properties of 1% 2C3-diene-5-carboxylbenzene are as follows:
This compound has a conjugated diene structure. In organic reactions, conjugated dienes are very active. Taking the Diels-Alder reaction as an example, it can form a hexamembered cyclic compound with a dienophile. Due to the presence of a conjugated system, electron delocalization increases the stability of the molecule, and also affects its reactivity and selectivity.
Furthermore, the presence of a 5-carboxyl group imparts acidity to the compound. The carboxyl group can ionize hydrogen ions, which can neutralize with bases to form corresponding carboxylate and water. If reacted with sodium hydroxide, sodium carboxylate and water can be obtained. And the carboxyl group can participate in the esterification reaction, react with alcohol under acid catalysis to form esters and water. For example, with ethanol under concentrated sulfuric acid catalysis and heating conditions, the corresponding esters and water are formed.
In addition, the benzene ring in the compound also has unique chemical properties. The benzene ring is stable and prone to electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. For example, when reacted with bromine under iron catalysis, bromine atoms replace hydrogen atoms on the benzene ring to form brominated products.
From the perspective of the whole molecule, different functional groups may interact with each other. The conjugated diene system may affect the acidity of the carboxyl group and the electrophilic substitution activity of the benzene ring; conversely, the carboxyl group and the benzene ring may also The synergy of functional groups makes 1% 2C3-diene-5-carboxybenzene exhibit rich and diverse chemical properties, which has potential application value in organic synthesis, medicinal chemistry and other fields.
What is the production method of 1,3-difluoro-5-nitrobenzene?
The manufacturing method of 1% 2C3-diene-5-carboxylbenzene is a delicate chemical technique. From the perspective of "Tiangong Kaiwu", the preparation of this compound, or the chemical synthesis concept of ancient methods, can achieve exquisite results.
To prepare 1% 2C3-diene-5-carboxylbenzene, the first selection of raw materials. When starting with suitable benzene derivatives, its purity and characteristics are related to the quality of the product. This raw material needs to have good reactivity in order to be successfully converted in subsequent steps.
After that, specific chemical reaction steps are often used to achieve the goal. One, or a substitution reaction. Select an appropriate reagent, and under suitable reaction conditions, such as specific temperature, pressure and catalyst, the reagent will be substituted with the specific position of the starting material to introduce the desired functional group. This step requires precise control of the reaction conditions to ensure that the position and degree of substitution are in line with expectations. If the temperature is too high or too low, it may lead to the occurrence of side reactions and affect the purity of the product.
Second, or an addition reaction is involved. When the raw material is modified by substitution, an unsaturated bond can be introduced, and then a suitable addition reagent can be used to add the unsaturated bond to the reagent under the catalysis of the catalyst to construct the structure of 1% 2C3-diene. In this process, the choice of catalyst is crucial, and different catalysts may affect the reaction rate and selectivity.
Third, the introduction of carboxyl groups is also key. Specific groups can be oxidized to carboxylic groups through oxidation reactions. This oxidation process requires careful operation, due to excessive oxidation or structural damage of the product. Select a mild oxidizing agent and precisely control the reaction time and conditions to successfully introduce carboxylic groups to achieve the preparation of 1% 2C3-diene-5-carboxylbenzene.
After each step of the reaction, fine separation and purification steps are required. Impurities in the reaction system are removed by distillation, extraction, recrystallization and other methods to improve the purity of the product. Through this series of steps, 1% 2C3-diene-5-carboxybenzene with high purity may be obtained.
What are the precautions for storing and transporting 1,3-difluoro-5-nitrobenzene?
When storing and transporting 1% 2C3-diene-5-carboxybenzene, be sure to pay attention to the following things:
First, this substance has a specific chemical activity and has strict requirements on the temperature and humidity of the storage environment. The temperature should be controlled in a specific range. If it is too high, it may cause chemical reactions or even deterioration; if the humidity is too high, it may cause deliquescence and other conditions. Therefore, the storage place should be dry and cool, and a well-ventilated place should be selected to avoid the risk of excessive local temperature and humidity.
Second, because its chemical structure contains special functional groups, or reacts with many substances. When storing, be sure to avoid co-storage with oxidizing, reducing substances and strong acids and alkalis to prevent dangerous chemical reactions, such as violent reactions, fires and explosions.
Third, when transporting, the packaging must be firm. Choose suitable packaging materials to ensure that the packaging is not damaged due to bumps and collisions during transportation, which may cause leakage. Once leaked, it will not only damage the substance, but also pose a threat to the environment and the safety of surrounding personnel.
Fourth, during handling, operators need to take protective measures. Wear appropriate protective equipment, such as gloves, goggles, protective clothing, etc., to prevent the substance from coming into contact with the skin and eyes. Accidental contact may cause irritation and injury to the human body.
Fifth, whether it is storage or transportation, it should strictly follow relevant regulations and standards. Keep clear and complete records, covering key information such as warehousing time, quantity, storage conditions, etc., for traceability and management to ensure compliance and safety of the entire process.