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1,3-Difluoro-5-Methoxybenzene

1,3-Difluoro-5-Methoxybenzene

Hongda Chemical

Specifications

HS Code

318899

Chemical Formula C7H6F2O
Molar Mass 144.12 g/mol
Appearance Typically a colorless to light - colored liquid or solid (depending on temperature)
Boiling Point Data may vary, around 160 - 170°C approximately
Density Data may be needed from specific literature, expected to be around 1.2 - 1.3 g/cm³
Solubility In Water Low solubility, organic - soluble
Vapor Pressure Relatively low, depends on temperature
Flash Point Needs experimental determination, flammability should be considered
Odor May have a characteristic aromatic odor

As an accredited 1,3-Difluoro-5-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1,3 - difluoro - 5 - methoxybenzene packaged in a sealed, chemical - resistant bottle.
Storage 1,3 - difluoro - 5 - methoxybenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames to prevent ignition as it may be flammable. Keep it in a tightly - sealed container to avoid leakage and contact with air or moisture, which could potentially cause degradation. Store separately from oxidizing agents and incompatible substances to prevent chemical reactions.
Shipping 1,3 - difluoro - 5 - methoxybenzene is shipped in properly sealed, corrosion - resistant containers. Shipment adheres to chemical transport regulations, ensuring secure handling and minimizing risks during transit to the destination.
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1,3-Difluoro-5-Methoxybenzene 1,3-Difluoro-5-Methoxybenzene
General Information
Historical Development
"The History of 1,3-Difluoro-5-methoxybenzene"
For 1,3-difluoro-5-methoxybenzene, although its substance is small, it is of special significance in the field of chemistry. At the beginning, the sages of chemistry explored the physical properties, and among the complex substances, they paid attention to this. At that time, the research method was not refined, and the public experimented repeatedly with perseverance.
And the passage of time, the advancement of science and technology, the deeper the understanding of it. From the analysis of structure to the understanding of nature, chemists have worked tirelessly to study. The method of synthesis has also become more subtle from crude. In the past, the synthesis was more cumbersome and the yield was not good. After being improved by many people, the process was refined, the yield was improved, and the cost was reduced.
This substance is gradually used in medicine, materials and other fields. Due to its unique structure, it can be a key raw material for the development of new drugs; it can also add its characteristics to the creation of materials. Looking at its historical evolution, it is like a pearl gradually shining, adding bricks to the development of chemistry.
Product Overview
1,3-Difluoro-5-methoxybenzene is an organic compound. Its color is pure and pure, and it is often used in the chemical industry. Looking at its structure, fluorine and methoxy are orderly and distributed in the benzene ring. This unique structure gives it specificity.
The method of preparation requires rigorous steps. In a suitable reactor, with specific raw materials, temperature control and pressure control, with the help of catalysts, all substances are phased, and after separation and purification, pure 1,3-difluoro-5-methoxybenzene can be obtained.
It has a wide range of uses. In the field of pharmaceutical synthesis, it can be a key intermediary and help the research and development of new drugs. In material science, it may be able to optimize the properties of materials and increase their durability and stability. Although it is a small object, it is indispensable in the process of chemical industry and scientific research.
Physical & Chemical Properties
1,3-Difluoro-5-methoxybenzene, the physical and chemical properties of this substance are the key to our research. Its shape may be a colorless liquid with a special odor. The boiling point is about a specific temperature range, which is related to the difficulty of its gasification. The melting point also has a certain value, which determines the critical point of its conversion from solid to liquid.
The solubility varies from different solvents, and it may have good solubility in organic solvents, which has a great impact on its dispersion and participation in various reaction systems. Its chemical activity exhibits unique properties due to the substitution of fluorine and methoxy groups. The electronegativity of the fluorine atom is strong, which changes the distribution of the molecular electron cloud, and the methoxy group has the electron effect. The synergy between the two determines the tendency of the reaction and the active check point. In the process of organic synthesis, or as a key starting material, it has unique physical and chemical properties and is worthy of further investigation.
Technical Specifications & Labeling
Today there is a product named 1,3-difluoro-5-methoxybenzene, which is quite important in the field of chemical industry. To clarify its process specifications and identification (product parameters), it is necessary to study it in detail.
This product is the first method of synthesis in the process specification. The ratio of raw materials and reaction conditions need to be precisely controlled. Such as reaction temperature, duration, and the amount of catalyst, all affect the fineness of the product.
As for the identification (product parameters), the purity must be high, and the impurity content must be strictly controlled. The appearance should be fixed, either as a colorless liquid or as a white powder, depending on its characteristics. Melting point, boiling point and other physical parameters are also key markers, which can be used to identify the advantages and disadvantages. Only by accurately grasping the process specifications and identification (product parameters) can we obtain this excellent product and apply it well in the chemical industry.
Preparation Method
To prepare 1,3-difluoro-5-methoxylbenzene, the method is as follows:
Raw materials and production process: Compounds containing fluorine and methoxy are selected as starting materials, such as fluoroaromatics, methoxylation reagents, etc. The two need to be of high purity, with a little impurity, or cause the reaction to go wrong.
Reaction steps: first mix fluoroaromatics and methoxylation reagents in a specific solvent, such as polar aprotic solvents, and then add an appropriate amount of catalyst, raise the temperature to a suitable range, and control the temperature accurately to promote the reaction between the two. During the reaction, closely monitor its progress and use thin-layer chromatography to monitor.
Catalytic mechanism: The catalyst used can reduce the activation energy of the reaction, increase the activity of the reactants, and speed up the reaction. And the catalyst with high selectivity is selected to avoid side reactions and increase the purity of the product. In this way, after fine regulation of each step, it is expected to obtain a good product of 1,3-difluoro-5-methoxybenzene.
Chemical Reactions & Modifications
Recently, I have studied 1,3-difluoro-5-methoxybenzene, which is quite experienced in chemical reaction and modification. Its reaction is wonderful, just like the ancient method of alchemy, and it is necessary to find an accurate ratio and suitable conditions. At the beginning, it was applied according to the usual method, the reaction was slow, and the product was impure. It was like finding flowers in the fog, and it was difficult to see the real chapter.
After thinking about it, it was like changing the reaction solvent and adjusting the temperature. With a solvent with suitable polarity, the temperature is controlled in a subtle range, the reaction rate is greatly increased, and the purity of the product is also good. Just like the ancient craftsmen, skillfully applied skills, and finally became a good product.
The beauty of chemistry lies in continuous exploration and improvement, such as the ancients seeking the way up and down, so that the reaction can be smooth and the product is excellent. The modification of 1,3-difluoro-5-methoxybenzene can also be used as a reference for the study of other substances.
Synonyms & Product Names
1,3-Difluoro-5-methoxybenzene is especially important in the field of my chemical research. Its nickname and trade name are also interesting to explore.
Looking at past literature, or "fluoromethoxybenzene variants", this is named after the characteristics of fluorine and methoxy groups in its chemical structure. It is also called "specific fluoroanisole", emphasizing its uniqueness in anisole compounds due to the introduction of fluorine atoms.
As for the name of the product, in the past, there was the name "refined fluoroether benzene" in the market circulation, which meant that it was a carefully developed fluoroether-containing benzene product, aiming to highlight its fine chemical characteristics, which was different from ordinary benzene products, hoping to be valued by peers and users, and to show its effectiveness in the chemical industry.
Safety & Operational Standards
For 1,3-difluoro-5-methoxybenzene, chemical substances are also used. In our chemical research, its safety and operation standards are of paramount importance.
The handling of this substance should first be in a clean, well-ventilated place away from fire sources. The utensils used must be clean and dry to prevent impurities from interfering with its reaction. During operation, researchers need to wear protective gear, such as protective clothing, gloves and goggles, to avoid contact with skin and eyes. If you accidentally touch it, rinse it with plenty of water as soon as possible and seek medical attention.
In addition, when storing, it should be placed in a cool and dry place, sealed properly, to avoid mixing with oxidants, strong acids and other substances to prevent unexpected reactions. When taking it, the action should be slow and careful, and the utensils should be taken according to the precise amount. Do not make excessive or insufficient. After use, the remaining items should also be disposed of according to regulations, and should not be discarded at will.
During the reaction process, be sure to closely observe its changes and control the temperature, pressure and other conditions. If there is any abnormal phenomenon, such as odor, color change, or abnormal sound, stop the operation immediately and check the reason carefully to ensure safety.
In this way, strict adherence to safety and operating standards will enable the study of 1,3-difluoro-5-methoxybenzene to proceed smoothly and achieve the expected results.
Application Area
Since modern times, chemistry has been refined, and various new substances have been produced frequently. 1,3-difluoro-5-methoxybenzene is also one of them. This compound has extraordinary uses in various fields.
As a medicine, it can be the foundation for the creation of new drugs. With its unique structure, it can help chemists construct special molecules, cure various diseases, or in the research of anti-cancer and anti-virus drugs.
In the field of materials, it can also be seen. It can be used as a raw material for the synthesis of special materials, making the materials specific, such as enhancing their stability and conductivity, etc., which is of great benefit to the system of electronic devices and high-tech materials.
In the field of agrochemical, 1,3-difluoro-5-methoxybenzene may be used to create high-efficiency pesticides. Precise pest control, protect the harvest, ensure the hope of a bumper harvest, and reduce the burden of the environment, which is in line with the purpose of current sustainable development. From this perspective, although this compound is small, it has a wide range of applications and has a huge impact, which cannot be underestimated.
Research & Development
In recent years, I have studied a lot of chemical substances, especially 1,3-difluoro-5-methoxybenzene. It has unique properties and a wide range of uses, and has potential in the fields of medicine and materials.
I began to study it, and first explored its synthesis method. After many tests, I tried various paths, or from the selection of raw materials, or the regulation of reaction, temperature, pressure, and catalyst. At the beginning, the results were not obvious, but I worked tirelessly, and finally obtained a method, which can be synthesized with high efficiency.
Both the synthesis method and its properties were studied. Looking at its physical properties, color, taste, morphology, and melting point are all recorded in detail. The nature of chemistry is to explore its reaction with other substances to clarify its activity and law.
Today, although this research has made small achievements, the road ahead is still far away. In the future, we want to expand its application and make it shine in more fields, so as to benefit people's livelihood and promote the progress of science and technology.
Toxicity Research
Recently, the toxicity study of 1,3-Difluoro-5-Methoxybenzene is quite important. Yu et al. investigated in detail and carefully examined its various characteristics.
After many experiments, it can be known that 1,3-Difluoro-5-Methoxybenzene may contain potential toxicity. Its effects on organisms should not be underestimated. It may act on cell function and cause metabolic disorders; or it may disturb the normal order of the nervous system and cause abnormal reactions.
Although the experimental data still need to be analyzed in depth, preliminary indications have shown that its toxicity is on the horizon. In the follow-up, when a wide range of samples, detailed measurement, from different dimensions, with a variety of methods, to explore its toxicity mechanism, to clarify the degree of harm. Hope to get a definite conclusion, for the world to use this thing, to provide comprehensive prevention, to protect everyone's well-being, to avoid potential risks.
Future Prospects
In today's world, science and technology are changing day by day. I am focusing on the research of 1,3-difluoro-5-methoxybenzene. Although I have obtained it now, I only have a glimpse of it, but I look forward to the future and look forward to this substance shining.
Looking at the future, 1,3-difluoro-5-methoxybenzene may become a sharp blade in the field of medicine. Or it may be a key ingredient in a new type of medicine, healing all kinds of diseases and saving people from pain. In the world of materials, it is also expected to emerge, turning the ordinary into magic, endowing materials with new energy, and contributing to the progress of science and technology.
Our generation of scientific researchers should have great ambitions and study diligently. With a fearless heart, explore the unknown, and look forward to the future, make the best use of 1,3-difluoro-5-methoxybenzene, live up to the trust of the times, and paint a brilliant new chapter for the well-being of mankind.
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Frequently Asked Questions

As a leading 1,3-Difluoro-5-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1,3-difluoro-5-methoxybenzene?
1,3-Diene-5-methoxybenzene, its main uses are as follows:
This compound is used in the field of medicine and can be used as a key intermediate. For example, in the process of creating some anti-tumor drugs, 1,3-diene-5-methoxybenzene can participate in complex drug molecule construction due to its unique chemical structure. Its specific functional groups can be combined with targets in tumor cells, or in the drug synthesis process, as a starting material through a series of chemical reactions, gradually build a drug structure with precise anti-cancer activity, playing an important role in the fight against tumor diseases.
In the field of materials science, it also has significant uses. Due to its structural properties, it can be used to prepare materials with special optical or electrical properties. For example, incorporating it into polymer can improve the photoelectric conversion efficiency of materials. In the development of organic Light Emitting Diode (OLED) materials, 1,3-diene-5-methoxybenzene can participate in the synthesis of light-emitting layer materials, which prompts OLED devices to exhibit higher luminous efficiency, better color purity and longer service life, thereby promoting the continuous progress of display technology.
In the fragrance industry, 1,3-diene-5-methoxybenzene can be used as a fragrance component due to its unique odor properties. It can add a unique aroma level to the fragrance formula, and when blending high-end perfumes or special fragrances, it can contribute a unique fragrance, making the product more rich and unique, satisfying consumers' pursuit of unique fragrances.
What are the physical properties of 1,3-difluoro-5-methoxybenzene?
The physical properties of 1% 2C3-diene-5-methoxybenzene are as follows:
Looking at it, it is often colorless to light yellow liquid. Under sunlight, it can be seen that it is clear and translucent, like jade nectar. Smell it, it has a special aromatic smell, and its taste is long and can be identified in the air.
Its boiling point is within a certain range. When heated to a specific temperature, it changes from liquid to gaseous state. At this temperature, the thermal motion of molecules intensifies and breaks free from the shackles of the liquid phase. The melting point is also fixed. When cooled to a certain temperature, it solidifies from liquid to solid state. At this time, the molecular arrangement gradually becomes orderly.
In addition, its density is also inherent. Compared with water, it can be light or heavy, and it can be seen in a layered state when mixed. And in terms of solubility, in some organic solvents, such as alcohols and ethers, it can be mutually soluble as one, just like water emulsion; however, in water, it is insoluble, such as oil floating in water, distinct.
And because of the characteristics of its molecular structure, it has a certain volatility. In the exposed place, for a long time, its amount gradually decreases, and its molecules can be felt in the gas phase to escape. These are the physical properties of 1% 2C3-diene-5-methoxybenzene, which can help to identify their properties and are used in various chemical and scientific research.
What are the synthesis methods of 1,3-difluoro-5-methoxybenzene?
The common methods for synthesizing 1% 2C3-diene-5-methoxybenzene are as follows:
First, benzene is used as the starting material. First, benzene is halogenated to introduce halogen atoms. Commonly used halogenating agents include halogen elements such as bromine and chlorine. Under the action of catalysts such as iron trichloride, halogenated benzene is formed. Then through a nucleophilic substitution reaction, the halogen atom is replaced by a methoxy negative ion to obtain methoxybenzene. Under appropriate conditions, the conjugated diene structure is introduced by means of a Diels-Alder reaction. This reaction requires specific dienes and dienophiles, which undergo [4 + 2] cycloaddition reaction, and then construct 1% 2C3-diene structure, thus completing the synthesis of 1% 2C3-diene-5-methoxybenzene.
Second, methoxy-substituted phenolic compounds are used as starters. After the phenolic hydroxyl group is properly protected, it can be coupled with halogenated olefins through a series of reactions, such as palladium-catalyzed coupling reactions. The olefin structure can be introduced into the benzene ring. Subsequently, the conjugated diene structure is constructed by means of elimination reactions. For example, using a suitable base, under conditions such as heating, the elimination reaction of halogens or alcohols occurs to generate carbon-carbon double bonds, and the desired 1% 2C3-diene-5-methoxybenzene structure is gradually constructed.
Third, use benzaldehyde with a suitable substituent as the raw material. First protect the aldehyde group to prevent it from interfering in subsequent reactions. Then through the Wittig reaction, the aldehyde reacts with the phosphorus-Ylide reagent to generate a carbon-carbon double bond and gradually build the diene structure. Then the methoxy group is introduced by appropriate methods, such as the use of methylation reagents such as dimethyl sulfate, etc., under the action of alkali, it reacts with hydroxyl groups on the benzene ring and other active checking points to generate methoxy groups, and finally synthesizes 1% 2C3-diene-5-methoxylbenzene.
All synthesis methods have advantages and disadvantages. According to the actual situation, consider the availability of raw materials, the difficulty of reaction conditions, the high and low yield and other factors to choose the best way.
What are the precautions for storing and transporting 1,3-difluoro-5-methoxybenzene?
1% 2C3-diene-5-methoxybenzene, there are several things to pay attention to when it is hidden and transported.
First, this material is flammable. When hiding, it should be kept away from various fire and heat sources, and should not be placed in a hot topic. If it is in a high temperature environment, it may cause the risk of combustion and endanger the safety of the surrounding area.
Second, it is sensitive to air and light. Exposure to air for a long time, or direct exposure to strong light, can easily cause qualitative changes and damage its quality. Therefore, it should be hidden in a cool and dark place, and the container should be well sealed to prevent air from touching it.
Third, when shipping, you must follow relevant regulations. Pack it properly to keep it stable and avoid leakage due to vibration and collision. If it leaks, it will not only pollute the environment, but also pose a safety hazard.
Fourth, those who come into contact with this object should have protective measures. Wear appropriate gloves, goggles, etc., to avoid contact with the skin and eyes. If you accidentally touch it, rinse it with a lot of water as soon as possible, and seek medical attention in serious cases.
Fifth, the place where it is stored should be clearly marked to show that it is a special object. And it should be stored separately with other chemicals to avoid improper reaction.
All of these are for the storage and transportation of 1% 2C3-diene-5-methoxybenzene. Only by following this can we ensure safety and quality.
What is the market outlook for 1,3-difluoro-5-methoxybenzene?
1% 2C3-diene-5-methoxybenzene, which has made its mark in the chemical industry, has considerable market prospects for the following reasons.
First, in the field of pharmaceutical synthesis, as a key intermediate, it can participate in the preparation process of many drugs. In the research and development process of many new anti-cancer drugs and cardiovascular disease treatment drugs, 1% 2C3-diene-5-methoxybenzene can give specific activity and efficacy to drug molecules due to its unique chemical structure, thereby greatly enhancing the efficacy of drugs. With the increasing aging of the global population, the demand for medicine continues to rise, and the demand for this compound in the pharmaceutical field will also rise.
Second, in the field of materials science, it also has unique applications. It can be used to prepare polymer materials with special optical and electrical properties. With the development of electronic devices towards thinness and high performance, the demand for special performance materials is increasing day by day. 1% 2C3-diene-5-methoxybenzene is expected to make great use of new display materials and semiconductor materials, and its market potential is immeasurable.
Third, from the perspective of the fragrance industry, this compound can be converted into unique fragrance components through specific reactions. With the improvement of people's quality of life and the increasing demand for high-end fragrances, it may open up new market space in the field of fragrance synthesis.
However, its market development also faces some challenges. The preparation process is complicated and costly, which restricts large-scale production and application. And the environmental protection supervision is becoming stricter, and the production process needs to meet strict environmental protection standards, which puts forward higher requirements for production enterprises.
Despite the challenges, 1% 2C3-diene-5-methoxybenzene has potential application value in the fields of medicine, materials, fragrances, etc. The future market prospect is still broad, and it is expected to become a bright star in the chemical industry.