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1,3-Difluoro-5-Iodobenzene

1,3-Difluoro-5-Iodobenzene

Hongda Chemical

Specifications

HS Code

306955

Chemical Formula C6H3F2I
Molar Mass 254.009 g/mol
Appearance A colorless to light yellow liquid
Boiling Point 193 - 194 °C
Melting Point N/A
Density 2.079 g/mL at 25 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Flash Point 79.8 °C
Refractive Index 1.5935 (20 °C)

As an accredited 1,3-Difluoro-5-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1,3 - difluoro - 5 - iodobenzene packaged in a sealed, chemical - resistant bottle.
Storage 1,3 - difluoro - 5 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly - sealed container, preferably made of a material resistant to chemical corrosion, like glass or some types of plastics. Avoid storing it near oxidizing agents. This storage method helps prevent decomposition, leakage, and potential fire or explosion hazards.
Shipping 1,3 - difluoro - 5 - iodobenzene is shipped in sealed, corrosion - resistant containers. Special care is taken to prevent leakage during transit, following strict chemical transportation regulations to ensure safety.
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1,3-Difluoro-5-Iodobenzene 1,3-Difluoro-5-Iodobenzene
General Information
Historical Development
1,3-Difluoro-5-iodobenzene is also a chemical product. Looking back to the past, this product was made at the beginning, and it really relied on the research of the sages. At the beginning, it only existed between the ideas of the dukes, and then after repeated trials, it took shape.
In the past, the sages of chemistry, in the subtle laboratory, ignited the fire of wisdom, and explored the way of its synthesis with exquisite methods. Or because the raw materials are difficult to find, or because the techniques are not refined, the road of synthesis is full of thorns. However, the dukes are persevering, and after months and years of hard work, this product has finally become more and more complete.
Since its birth, in the field of chemistry, it has gradually shown its extraordinary appearance. It is either the basis for new agents or the synthesis of other substances, and the wider the use and deeper the influence, it is actually a brilliant pearl on the road to chemical development.
Product Overview
1,3-Difluoro-5-iodobenzene is also an organic compound. Its shape may be colorless to light yellow liquid, with special chemical properties. This compound contains fluorine, iodine and other elements. The electronegativity of fluorine is strong, which makes the molecular electron cloud distribution specific, while the iodine atom is larger, which affects the molecular spatial structure and reactivity.
In the field of organic synthesis, 1,3-difluoro-5-iodobenzene has a wide range of uses. It can be used as a key intermediate to construct a variety of complex organic molecules through halogenation reactions, coupling reactions, etc. Its fluorine-containing properties can improve the stability and biological activity of the product. And because of the high activity of iodine atoms, it can guide specific position reactions and help precise synthesis. However, the synthesis process requires fine control of the reaction conditions to ensure the purity and yield of the product.
Physical & Chemical Properties
1,3-Difluoro-5-iodobenzene is also an organic compound. Its physical and chemical properties are related to research in many fields. This substance has unique physical properties. At room temperature, it may be liquid, colored or nearly colorless and transparent, with a certain volatility and a specific smell. Its physical constants such as boiling point and melting point are crucial in chemical synthesis, separation and purification.
From the perspective of chemical properties, the atoms of fluorine and iodine in 1,3-difluoro-5-iodobenzene give it active chemical activity. Fluorine atoms have strong electronegativity, which changes the distribution of molecular electron clouds and affects their reactivity. Iodine atoms can participate in many reactions such as nucleophilic substitution, providing a key reaction check point for organic synthesis. Under different reaction conditions, it can react with a variety of reagents to generate various derivatives, which has great application potential in drug development, materials science and other fields.
Technical Specifications & Labeling
Today there is a product named 1,3-difluoro-5-iodobenzene. Its process specification and identification (product parameters) are the key.
In terms of process specifications, it needs to be synthesized in a precise way. First take an appropriate amount of fluorine-containing reagent and benzene-containing substrate, put it in a special utensil, control the temperature moderately, and supplement it with a catalytic agent to make it fully react. When reacting, observe the change of its color and odor, and adjust the conditions in a timely manner to ensure a smooth reaction.
When it comes to labeling (product parameters), this product has a colorless to slightly yellow appearance, a specific melting boiling point, and is accurate to a small number. Its purity is extremely high, and impurities must be controlled at extremely small levels. On the packaging, the chemical name, molecular formula, and warning words should be written in clear words to inform people of the characteristics and protection of this product, so as to meet the requirements of process specifications and identification (product parameters).
Preparation Method
The method of preparing 1,3-difluoro-5-iodobenzene involves raw materials, production processes, reaction steps and catalytic mechanisms. First, an appropriate amount of fluorobenzene is taken as the starting material, supplemented by specific halogenated reagents, such as iodide, in a suitable reaction vessel, and the temperature is precisely controlled, about a specific temperature range, so that it can fully react. This reaction requires the help of a specific catalyst to accelerate the reaction process and increase its yield. After the reaction is completed, a series of separation and purification methods, such as extraction, distillation and other steps, are used to remove impurities to obtain a pure 1,3-difluoro-5-iodobenzene product. The entire production process requires fine regulation of all aspects to ensure that the reaction is carried out in sequence and efficiently, from raw material input to finished product output, all steps are closely interlocked in order to obtain high-quality products.
Chemical Reactions & Modifications
I am committed to the chemical research of 1,3-Difluoro-5-Iodobenzene, and I know that the reaction and modification of this compound are very important.
Its chemical reaction, at the beginning, mostly follows the conventional path, but if you want to break through, you must find another way. In previous experiments, common reagents were used to promote its reaction, but although it was effective, the yield and purity were not ideal. I thought about changing the reaction conditions, adjusting the temperature and pressure, and selecting a specific catalyst, hoping that it can change differently.
As for the modification, it has also undergone many attempts. Add different groups to its molecular structure, hoping to change its physical and chemical properties. Such as introducing some active groups to make it easier to participate in specific reactions, or to change its solubility and stability.
Every attempt is like exploring the secrets. Although there are setbacks, in the path of chemistry, I will pursue unremitting pursuit, hoping to eventually achieve significant progress in the reaction and modification of 1,3 - Difluoro - 5 - Iodobenzene, adding new color to the field of chemistry.
Synonyms & Product Names
There is a recent thing named 1,3-difluoro-5-iodobenzene, which is quite useful in chemical substances. This name is also based on its structure. However, there are many similarities and differences in terms of titles in the world.
Or there are other names called for their properties and uses. If it is fluorine-containing and iodine-containing, and connected to the benzene ring, it is also called fluoroiodobenzene. Because of its special characteristics. And market transactions, business is convenient, or create the name of a different commodity, hoping to attract attention and easy to recite. Although the names are different, they all refer to this 1,3-difluoro-5-iodobenzene. Those of us who are scholars need to be clear about all kinds of names before we can make mistakes in order to understand the things of chemistry and make good use of this material.
Safety & Operational Standards
For 1,3-difluoro-5-iodobenzene, it is also important for chemical substances. In the room, its safe operation is of paramount importance and should not be ignored.
Where this material is connected, it must first be properly protected. Wear corrosion-resistant gloves on your hands to avoid the connection of the skin. If the skin is accidentally contaminated, quickly wash it with a lot of water and seek treatment. The eyes should be equipped with anti-chemical eyes to prevent it from entering the eyes. If there is such a problem, immediately wash it with physiological water, and it will be urgent.
The operation is good, and it is best to place it in the row. Because of its certain resistance, it is easy to cause harmful accumulation and endanger the person. If there is a source of ignition or smoke, this material may be flammable, and it may be dangerous in case of open flame or high temperature.
If it is not stored, it should be placed in a room where it is dry and well connected. Store in equal parts of oxidized and raw materials, and must not be mixed to prevent damage. There are suitable materials to contain leaks.
If there is an unfortunate leakage, the first thing is to quickly remove the contaminated person to a safe place, and the line is separated, and access is restricted. Cut the source of ignition, and the emergency manager should wear a self-straightened breathing apparatus and chemical protection clothing. Do not connect leaks to combustible materials. Small leaks should be absorbed by sand, vermiculite or other inert materials. Large amounts of leakage, embankment or pit containment, pump transfer to tank or collector, recycling or storage.
Therefore, the safe operation of 1,3-difluoro-5-iodobenzene is a must for room workers, so as to ensure personal safety.
Application Area
Today, there is a product named 1,3-difluoro-5-iodobenzene, which is widely used in the field of chemical industry. In the development of medicine, it can be used as a key raw material to help doctors make special drugs and treat various diseases in the world. In the field of materials science, this substance can contribute to the development of new materials, making them unique, such as better conductivity and heat resistance.
In the process of organic synthesis, 1,3-difluoro-5-iodobenzene is an important building block. Chemists use it to build complex molecular structures and expand the variety of organic compounds. It is of exceptional value in the fields of scientific research and industry, promoting the progress of various technologies and benefiting the world.
Research & Development
In recent years, Yu dedicated himself to the research of 1,3-difluoro-5-iodobenzene. This compound has great potential in the field of organic synthesis, but its preparation and application still need to be explored.
Yu Chu was involved in this research, carefully consulted the classics, and carefully examined the methods of predecessors. There are many shortcomings. So he decided to find a new way, tried and tried again, and finally obtained a method that can produce this product with high efficiency. The method focuses on the precise control of reaction conditions, the appropriate balance of raw material proportions, and is in line with the concept of green chemistry.
Looking at this achievement now, although there are gains, the road ahead is still far away. In the future, we should further study its application, expand its path in drug research and development, materials science, and other fields, and strive to push this research to a new level, hoping to contribute to the academic community and industry, so as to promote the long-term development of this compound and make it beneficial to the world.
Toxicity Research
Today, there is a substance called 1,3-difluoro-5-iodobenzene, which is very important to our chemical research. Our generation takes toxicity research as a priority to investigate the characteristics of this substance in detail.
After many studies, it has been found that 1,3-difluoro-5-iodobenzene has certain toxicity. In its molecular structure, the atoms of fluorine and iodine make its chemical activity different. When it comes into contact with organisms, it can penetrate through the skin or be ingested by respiration, which then interferes with the normal biochemical reactions in the organism.
Looking at its impact on cells, it can cause cell metabolic disorders, hinder the activity of key enzymes, and even endanger cell survival. And in animal experiments, it has also been seen to have adverse effects on organ function. Although this substance is useful in the field of chemical synthesis, its toxicity should not be underestimated. We should handle it with caution. When developing and applying it, we must weigh the pros and cons. We must not ignore its potential harm to preserve the well-being of the survivors and the tranquility of the environment.
Future Prospects
In today's world, science and technology are changing day by day, and the industry of chemistry is also booming. For our chemical researchers, 1,3 - Difluoro - 5 - Iodobenzene has an unlimited future prospect.
Looking at its properties, it is unique and exquisite, providing novel possibilities for many chemical reactions. Based on it, it can explore new paths in material science, or create new materials with extraordinary properties, which can be used in electronic and optical fields, such as the light of tomorrow.
It also has potential for great use in drug development. With time, through meticulous research, or according to its characteristics, we can produce new drugs with outstanding curative effects and solve the pain of the world. This is our ambition.
Although there may be thorns in the road ahead, we will keep our research heart and move forward with determination. I am convinced that in the years to come, 1,3 - Difluoro - 5 - Iodobenzene will surely shine, add brilliance to the chemical industry, add glory to human well-being, open a new chapter, and lead us to a more splendid future.
Where to Buy 1,3-Difluoro-5-Iodobenzene in China?
As a trusted 1,3-Difluoro-5-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1,3-Difluoro-5-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1,3-difluoro-5-iodobenzene?
1,3-Diene-5-alkyne is a class of compounds with special structures in organic chemistry, which has important uses in many fields.
In the field of organic synthesis, 1,3-diene-5-alkyne is a key synthesizer. Because it has both conjugated dienes and alkynyl groups in its molecules, it has unique chemical activity. Through various chemical reactions, such as cyclization, cyclic compounds with diverse structures can be constructed. For example, through the Diels-Alder reaction, the conjugated diene part can undergo [4 + 2] cycloaddition with the dienophilic body to form a six-membered cyclic structure. This reaction condition is mild and highly selective, providing an effective path for the synthesis of complex cyclic compounds; alkynyl groups can participate in Sonogashira coupling reactions, etc., and couple with halogenated aromatics or halogenated olefins to realize the construction of carbon-carbon bonds, thereby expanding the molecular skeleton and synthesizing organic compounds with specific structures and functions. It is of great significance in the field of total synthesis of natural products and drug synthesis.
In the field of materials science, 1,3-diene-5-alkyne has also emerged. The conjugated structure endows it with unique optical and electrical properties. Introducing it into the main chain or side chain of polymer materials can prepare materials with special optoelectronic properties. The conjugated structure can promote the delocalization of intra-molecular electrons, so that the material exhibits good fluorescence properties, which can be applied to Light Emitting Diode (LED), fluorescence sensors and other fields; its electrical properties also make it promising to become an organic semiconductor material for the fabrication of electronic devices such as organic field effect transistors, providing a new direction for the development of new functional materials.
In summary, 1,3-diene-5-alkyne plays an indispensable role in the fields of organic synthesis and materials science with its unique structure, providing an important material basis and research direction for the development of related fields.
What are the physical properties of 1,3-difluoro-5-iodobenzene?
The physical properties of 1% 2C3-diene-5-chlorobenzene are as follows:
This substance is either liquid at room temperature, with a specific color, or colorless and transparent, or slightly yellowish luster. Its shape is like water and slightly heavy in quality. It is smooth and has no stagnation.
Smell it, it has a special smell. This smell is pungent and strong, and it feels uncomfortable when it enters the nose. If it is in a closed compartment, this smell is especially severe and nauseating. The boiling point of
is quite considerable, and a higher temperature is required to turn it from liquid to gaseous. If placed in an open container, heat it with fire, and wait until a certain heat, the bubbles will surge, and then boil, turning into curling steam. The melting point is relatively low. In an ordinary low temperature environment, it may remain liquid. However, in a cold and cold environment, when the temperature drops to a specific degree, it will solidify into a solid state, and the appearance may be crystal clear. It is hard and brittle to touch.
The density is greater than that of water. If an equal amount of water and 1% 2C3-diene-5-chlorobenzene are taken and placed in the same container, it can be seen that it is submerged under water, with clear boundaries, such as the clarity of a verdure.
In terms of solubility, it is difficult to dissolve in water, and the two meet. If oil floats on water, it is difficult to blend. After stirring, it will quickly stratify. However, in organic solvents, such as ethanol and ether, it can be well miscible and can be uniformly dispersed to form a clear solution.
In addition, its refractive index also has characteristics. When light passes through 1% 2C3-diene-5-chlorobenzene, the degree of bending of the light path is different from that of common substances. With this property, it may play a unique role in optical related experiments or industrial production.
What are the synthesis methods of 1,3-difluoro-5-iodobenzene?
The synthesis method of 1% 2C3-diene-5-alkynyleheptane can be started from the following aspects:
First, use suitable halogenated hydrocarbons as starting materials. Alkenyl halogenated hydrocarbons containing appropriate halogen atoms can be selected to react with alkynyl halogenated hydrocarbons, using metal-organic reagents such as Grignard reagents or organolithium reagents. For example, first prepare an alkenyl-containing Grignard reagent and make it undergo a nucleophilic substitution reaction with alkynyl halogenated hydrocarbons, so that carbon-carbon bonds can be formed and the carbon skeleton of the target molecule can be gradually built. When reacting, attention should be paid to the control of reaction conditions, such as reaction temperature and solvent selection. A suitable low temperature environment can avoid the occurrence of side reactions, while ether solvents, such as ether or tetrahydrofuran, have good solubility and stability to metal-organic reagents, which helps the reaction to proceed smoothly.
Second, with the help of partial hydrogenation of alkynes. Alkynes containing appropriate substituents can be synthesized first, and then the alkynes can be partially hydrogenated to alkenes using specific catalysts and reaction conditions. For example, using a Lindlar catalyst, this catalyst is made of palladium attached to calcium carbonate and partially poisoned with lead acetate. In the presence of hydrogen, alkynes can be selectively converted to cis-olefins, thereby constructing the alkenyl structure in the target molecule. The key to this method is the control of the amount of catalyst and the reaction time to prevent excessive hydrogenation to form alkanes.
Third, the cyclization reaction of alkenyne is used, and then the ring opening operation is carried out. Some alkenyne compounds can undergo intramolecular cyclization reactions under specific conditions to form cyclic intermediates. Subsequently, the cyclic intermediates are opened by appropriate reagents and reaction conditions to obtain the target product. For example, under the catalysis of transition metal catalysts such as copper or palladium, alkenyne can undergo cyclization reactions, and then nucleophiles or oxidants can be used to open the ring. This process requires precise regulation of reaction conditions to ensure the selectivity and yield of cyclization and ring opening steps.
What should be paid attention to when storing and transporting 1,3-difluoro-5-iodobenzene?
When storing and transporting 1% 2C3-diene-5-naphthalene, the following numbers should be paid attention to:
First, temperature control. This compound is quite sensitive to temperature, and high temperature can easily cause its decomposition reaction or increase its volatilization rate, which in turn affects its quality and stability. Therefore, the storage temperature should be maintained in a low temperature and cool place, generally 2-8 ° C. During transportation, cold chain equipment should also be used to prevent the temperature from getting too high.
Second, isolate the air. The substance is prone to oxidation reaction with oxygen in the air, thereby changing its chemical structure and properties. When storing, a container with good sealing performance should be selected, such as a glass bottle and sealed with a rubber plug, or a container made of metal and tightly sealed. During transportation, also ensure that the package is well sealed, and can be filled with an appropriate amount of inert gas such as nitrogen to create an oxygen-free environment.
Third, avoid light. Light can cause photochemical reactions of this compound, causing it to deteriorate. The storage area should be shaded from light. It can be stored in a brown bottle, or stored in a dark room without light exposure. During transportation, use a light-shielding packaging material to protect it from direct sunlight.
Fourth, be careful of collision and friction. This substance has a certain sensitivity, and strong collision or friction may cause it to react dangerously. When storing, it should be placed in a stable and not susceptible to vibration. During transportation, fix it properly to avoid collision and friction with each other.
Fifth, keep away from fire sources and oxidants. 1% 2C3-diene-5-alkynaphthalene naphthalene is flammable and easy to react violently with oxidants, causing combustion and even explosion. When storing and transporting, be sure to keep a safe distance from fire sources and oxidants. Fireworks are strictly prohibited in the working area, and corresponding fire protection facilities are equipped.
What is the market price of 1,3-difluoro-5-iodobenzene?
The market price of 1% 2C3-diene-5-chlorobenzene varies with time, place, and supply and demand. In a changing market, the price is not constant and often fluctuates according to various reasons.
If the supply is abundant and there are few buyers, the price may decline. If there are many covers but people do not want them, the seller wants to sell quickly, so it must be tempting at a low price. On the contrary, if the supply is scarce and there are many buyers, the price will often rise. Everyone wants it, and the seller will raise the price because of it.
The competition in the market is also the reason for the change in price. If there are many people in the same industry, they will all sell this kind, competing for profits for customers, or reducing the price to sell. However, if this product is unique and there is no competition, the seller may have the right to set the price, and the price may be higher.
Furthermore, changes in the current situation and regulations of the government can affect the price. In case of war, natural disasters, and the road of production and sales is blocked, the price will rise. If the government increases taxes here, the cost will increase, and the price will follow.
To know the exact market price of 1% 2C3-diene-5-chlorobenzene, when you carefully observe the current market situation, consult merchants, brokers, or market observation data, you can get a more accurate price.