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1,3-Difluoro-2-(Trifluoromethyl)Benzene

1,3-Difluoro-2-(Trifluoromethyl)Benzene

Hongda Chemical

    Specifications

    HS Code

    268083

    Chemical Formula C7H3F5
    Molecular Weight 182.09
    Appearance Colorless liquid
    Boiling Point 116 - 118 °C
    Density 1.38 g/cm³
    Solubility Insoluble in water, soluble in organic solvents
    Flash Point 17 °C
    Refractive Index 1.379

    As an accredited 1,3-Difluoro-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500 - gram bottle packaging for 1,3 - difluoro - 2 - (trifluoromethyl)benzene.
    Storage 1,3 - Difluoro - 2 - (trifluoromethyl)benzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly sealed container, preferably made of a material resistant to chemical corrosion. Store it separately from oxidizing agents and incompatible substances to prevent potential reactions.
    Shipping 1,3 - Difluoro - 2 - (trifluoromethyl)benzene is shipped in specialized, leak - proof containers. It follows strict hazardous chemical shipping regulations, ensuring secure transport to prevent spills and environmental/health risks.
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    1,3-Difluoro-2-(Trifluoromethyl)Benzene 1,3-Difluoro-2-(Trifluoromethyl)Benzene
    General Information
    Historical Development
    1,3-Difluoro-2- (trifluoromethyl) benzene is also an organic compound. The research and development process of its product can be described. In the past, chemists worked hard in the field of organic synthesis and strived to expand the category of compounds.
    At first, researchers only had a rough understanding, and the synthesis path was often hindered. After years of research, the molecular structure was analyzed, the reaction mechanism was explored, and the process was gradually refined. In the laboratory, different reagents and conditions were repeatedly tried, with the goal of achieving an ideal situation.
    After countless setbacks, they found a suitable way to make this 1,3-difluoro-2- (trifluoromethyl) benzene. Since its inception, it has added new bricks to the field of organic chemistry, and has shown unique uses in materials science, drug research and development, etc. It has attracted the attention of many people and become an indispensable material in the field of chemistry. It has also paved the way for future generations to study and await new frontiers.
    Product Overview
    1,3-Difluoro-2- (trifluoromethyl) benzene is also a chemical that I have dedicated myself to studying. Its unique nature and various specific qualities. Looking at its shape, at room temperature, it is a clear and transparent liquid, like smart water, but its connotation is far from simple and comparable to water.
    Smell it, it has a specific smell, not pungent but unique, this smell may be used as its unique logo. Its chemical structure is exquisite, composed of specific atomic arrangements and combinations, causing it to exhibit different activities in the reaction.
    In the field of organic synthesis, 1,3-difluoro-2- (trifluoromethyl) benzene is a key raw material. With its unique chemical properties, it can cleverly react with a variety of reagents to generate complex and versatile compounds, which add to the temple of organic synthesis and help advance many cutting-edge research. It is an indispensable treasure in chemical research.
    Physical & Chemical Properties
    1,3-Difluoro-2- (trifluoromethyl) benzene, the physical and chemical properties of this substance are related to our chemical research. Its shape may be a colorless liquid with a special odor. Looking at its boiling point, under a certain pressure, there is a specific value, which is related to its gasification conditions. Its melting point is also the key, defining the transition between solid and liquid states. In terms of solubility, it may be soluble in some organic solvents, but insoluble in water, which is related to molecular polarity. Its chemical properties are active or not, depending on the presence of functional groups, trifluoromethyl and fluorine atoms, which changes the electron cloud density of the benzene ring, or affects the activity of electrophilic substitution reactions. The study of its physical and chemical properties helps us understand its characteristics in various reactions and applications, and provides a solid theoretical foundation for chemical synthesis, material research and development, and other fields.
    Technical Specifications & Labeling
    Today there is a product named 1,3-difluoro-2 - (trifluoromethyl) benzene. Its process specifications and identification (product parameters) are related to the advantages and disadvantages of this product and its application.
    To make this product, a specific method needs to be followed. From the selection of raw materials to the control of reaction conditions, there are rules. The raw materials must be pure, and if impurities exist, they will affect the product. During the reaction, temperature and pressure are also critical. There is a slight difference, and the results are very different.
    On the label, its chemical properties and physical properties are clearly stated. Chemical properties are related to reaction activity, and physical properties such as color, taste, and state are easy to identify. Product parameters are also indispensable, and the purity geometry and impurity content should be clear. In this way, it is possible to make this object suitable for its place in various fields and play its role.
    Preparation Method
    To prepare 1,3-difluoro-2- (trifluoromethyl) benzene, the method is as follows:
    Raw materials and production process: Select suitable halogenated aromatics, such as fluorohalobenzene derivatives, with active trifluoromethylation reagents, such as sodium trifluoromethanesulfonate. The ratio of the two is adjusted according to the needs of the reaction.
    Reaction steps: In an appropriate reactor, add an organic solvent, such as N, N-dimethylformamide, to create a reaction environment. Control the temperature in a specific range, such as 80-120 ° C, stir to fully contact the raw materials. Initiate the reaction, closely observe its progress, and monitor it by chromatography and other methods.
    Catalytic mechanism: Add an appropriate amount of catalyst, such as copper salt catalyst, to reduce the reaction energy barrier and promote the efficient reaction. The catalytic active center interacts with the reactants to optimize the reaction path and improve the yield and selectivity. After a series of operations, the target product 1,3-difluoro-2- (trifluoromethyl) benzene can be obtained.
    Chemical Reactions & Modifications
    There is now a substance called 1,3-difluoro-2- (trifluoromethyl) benzene. In the field of chemistry, it is very important for us to explore its chemical reaction and modification.
    Looking at the reaction of this compound, the fluorine atom and trifluoromethyl in its structure give unique activity. Fluorine atoms have strong electronegativity, which changes the electron cloud density of ortho and para-sites and affects the electrophilic substitution reaction. To make it modified, specific functional groups can be introduced to expand the application.
    To achieve this goal, the reaction conditions must be carefully regulated. Temperature and catalyst selection are all about success or failure. Increasing the temperature may speed up the reaction rate, but too high will cause a cluster of side reactions. Choosing the right catalyst can reduce the activation energy of the reaction and accurately guide the direction of the reaction.
    In the process of chemical research, the exploration of the chemical reaction and modification of 1,3-difluoro-2- (trifluoromethyl) benzene is like seeking secrets, step by step carefully, in order to obtain exquisite results and contribute to the development of chemistry.
    Synonyms & Product Names
    1,3-Difluoro-2 - (trifluoromethyl) benzene, the synonym and trade name of this substance, is the key to our chemical research. In my research, I often encounter the matter of exploring many names for a substance. This 1,3-difluoro-2 - (trifluoromethyl) benzene, or another name, needs to be carefully studied.
    Each synonym is like a key to open the door of chemical mysteries, and the trade name is also like a logo for market circulation. Both are of great significance for the accurate understanding and application of this chemical. Exploring its synonyms is like finding treasures in ancient books, or from past research records, or from experimental records of various families, carefully combing, or can be obtained. The trade name is related to market supply and demand, industry application, and should not be underestimated. The two complement each other, helping us to penetrate into the world of this chemical, in the research, production, and application, unimpeded, to clarify its characteristics, and to contribute to the development of chemistry.
    Safety & Operational Standards
    1,3-Difluoro-2- (trifluoromethyl) benzene, this substance is related to safety and operating standards, and must be treated with caution.
    All handling of this substance must be familiar with its properties. It has special chemical properties and may react differently in different environments. To ensure safety, the handling site must be well ventilated to prevent the accumulation of harmful gases. And always have appropriate protective equipment around, such as gas masks, protective gloves and goggles, for emergencies.
    When handling, strictly follow the established procedures. When taking it, measure it accurately, and do not arbitrarily increase or decrease the dose. When mixing and blending, add it slowly to prevent violent reactions. If any abnormal conditions are detected during the reaction process, such as sudden temperature changes, gas escape, etc., immediately stop the operation and dispose of it properly.
    Storage should not be ignored. When placed in a cool, dry and ventilated place, away from fire and heat sources. Keep it separate from other chemicals to avoid danger caused by interaction. And the storage place should be clearly marked, indicating the characteristics and precautions of this thing.
    Once accidentally contaminated during handling, or inhaled or exposed, immediately deal with it according to the established emergency measures. If slightly contaminated, rinse with plenty of water; if the symptoms are serious, seek medical attention immediately without delay.
    In this way, strict adherence to safety and operating practices can ensure the smooth handling of 1,3-difluoro-2 - (trifluoromethyl) benzene without risk.
    Application Area
    Today there is a product named 1,3-difluoro-2 - (trifluoromethyl) benzene. The application field of this product is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help create special new drugs to treat various diseases and save patients from pain. In the field of materials science, it can contribute to the research and development of new functional materials, giving materials unique properties, such as excellent stability and weather resistance, making materials suitable for a variety of harsh environments. In fine chemicals, it can become high-quality raw materials and produce many high-value-added fine chemicals to meet the diverse needs of industry and life. Its application prospects are broad, and with time, it will be able to shine in various fields and contribute to the progress and development of mankind.
    Research & Development
    Today, there is a substance named 1,3-difluoro-2- (trifluoromethyl) benzene. I am a chemical researcher, and I have studied this substance for a long time. Its unique nature, in the way of organic synthesis, has great potential.
    The first time I dealt with this substance, looking at its structure, the cloth of fluorine atoms is unique. The addition of trifluoromethyl adds to its characteristics. After many experiments, I have explored the law of its reaction. Under various conditions, observe its changes and analyze its results.
    The road of research and development is not an easy one. Every way to find a method, I often encounter obstacles. However, I keep seeking, and fail again and again. Hope to find its optimal nature and expand its application field. Hope in medicine, materials industries, have made achievements, for the advancement of learning, industry, do my best to promote the development of this material, in order to reach a new realm.
    Toxicity Research
    Study on the toxicity of 1,3-difluoro-2- (trifluoromethyl) benzene
    Tasting chemical substances is related to the people's livelihood and national plans, but the study of its toxicity is also essential. Today, 1,3-difluoro-2- (trifluoromethyl) benzene is used as a research, this substance is gradually widely used in the chemical industry, but its toxicity has not been carefully observed.
    At first, looking at its physicochemical properties, 1,3-difluoro-2- (trifluoromethyl) benzene has a special structure, and there are many fluorine atoms, which makes its chemical activity different from that of normal substances. In animal testing, after entering the body, it may disturb its physiological order. In the liver and spleen and other organs, it seems to be able to disrupt their metabolism, and the state of cells also changes abnormally.
    And its smell, or stinging respiratory tract, causing discomfort. In the long run, it may be harmful to the quality of the gene, passed on to future generations, and the legacy will be endless. Therefore, where this substance is used, strict protective measures should be set up to avoid close contact with people, and detailed treatment methods should also be studied to avoid polluting the environment, so as to ensure the well-being of the public and ecological peace.
    Future Prospects
    Although 1,3-difluoro-2- (trifluoromethyl) benzene has not yet been seen in the world, the prospect of its future is really eagerly awaited.
    The way of chemistry lies in exploring the unknown and creating things to benefit the world. This compound has a unique structure and fluorine-containing groups, which make its properties specific. Fluoride, the favorite of chemical elements, gives this thing a different kind of property, or in the field of materials, it shows extraordinary performance.
    Although its wide use has not been seen today, with the speed of scientific evolution, it will surely shine in time. Or as the cornerstone of new materials, used in high-end technology tools, such as electronics and aerospace; or as the key to medical research and development, to help doctors overcome difficult diseases.
    In the future, unremitting research should be used to uncover its mysterious veil, so that it can benefit mankind, achieve the brilliant chapter of chemistry, develop the unfinished road, and realize the dream of science.
    Where to Buy 1,3-Difluoro-2-(Trifluoromethyl)Benzene in China?
    As a trusted 1,3-Difluoro-2-(Trifluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1,3-Difluoro-2-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1,3-difluoro-2- (trifluoromethyl) benzene?
    1,3-Diene-2 - (trienyl methyl) benzene, an important intermediate in organic synthesis, is widely used in many fields.
    In the field of organic synthesis chemistry, it can be used as a key building block for building complex organic molecules. With its unique conjugated diene and substituted benzene structure, it can participate in a variety of chemical reactions, such as the Diels-Alder reaction. In this kind of reaction, the conjugated diene part of 1,3-diene-2- (trienomethyl) benzene can undergo [4 + 2] cycloaddition reaction with the dienophilic body to efficiently construct a six-membered ring structure, which is of great significance for the synthesis of natural products and drug molecules with a specific ring structure.
    In the field of materials science, it also shows potential value. Because of its conjugate system, it may endow materials with specific optical and electrical properties. Through rational molecular design and synthesis strategies, it can be introduced into the structure of polymer materials, which may be expected to prepare materials with special photoelectric properties, such as functional materials for organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices, providing the possibility for the development of new high-performance materials.
    In the field of medicinal chemistry, using it as a starting material, by modifying and derivatizing its benzene ring and alkenyl group parts, it can be designed and synthesized with biological activities. Through systematic activity screening and optimization, lead compounds with potential medicinal value may be discovered, laying the foundation for the research and development of innovative drugs.
    In conclusion, 1,3-diene-2- (trienomethyl) benzene plays an important role in the fields of organic synthesis, materials science and medicinal chemistry due to its unique chemical structure, which cannot be ignored in promoting the development of related fields.
    What are the physical properties of 1,3-difluoro-2- (trifluoromethyl) benzene?
    1% 2C3-diene-2- (trienyl methyl) naphthalene is a kind of organic compound. Its physical properties are quite characteristic, let me describe it in detail for you.
    First of all, its appearance, at room temperature, this compound is mostly in the shape of a solid state, but its specific appearance may vary depending on the purity and crystallization conditions. When it is common, it may be a white to light yellow crystalline powder with a fine texture and a shiny appearance.
    Second, the melting point of this substance has been determined by many researchers, and the melting point of this substance is within a certain range. The melting point is also the critical temperature at which the substance changes from solid to liquid. The melting point of this compound is crucial for its purification and identification, and it is also a key characterization of its physical properties.
    Furthermore, the boiling point is also one of the important properties. The boiling point is the temperature limit for a substance to change from a liquid state to a gaseous state. The boiling point of 1% 2C3-diene-2- (trienyl methyl) naphthalene is within a certain range. However, when measuring, it is necessary to pay attention to the influence of external environment such as pressure. Due to pressure changes, the boiling point will also change accordingly.
    In terms of solubility, the compound behaves differently in different solvents. In common organic solvents such as ethanol, ether, etc., it may have certain solubility. However, in water, its solubility is poor, because water is a polar solvent, and the molecular structure of the compound is weak in polarity, according to the principle of "similar miscibility", so it is difficult to dissolve in water.
    In addition, density is also a physical property that cannot be ignored. The density of 1% 2C3-diene-2- (triene methyl) naphthalene is relatively fixed, and the determination of its density can help to judge its purity, and can also provide key data support for chemical production, experimental operation, etc.
    The physical properties of this compound are of great significance in organic chemistry research and related industrial applications, helping researchers to deeply understand its characteristics, and then lay the foundation for synthesis, separation, and application.
    Is the chemical properties of 1,3-difluoro-2- (trifluoromethyl) benzene stable?
    The chemical properties of 1% 2C3-diene-2- (trienyl methyl) naphthalene are relatively stable.
    Looking at the structure of this compound, the 1% 2C3-diene part, the existence of ethylene bonds endows it with a certain reactivity. However, due to the formation of the conjugate system, the electron cloud can be delocalized and the stability of the molecule can be enhanced. The conjugate effect causes the electron cloud to distribute uniformly, weakening the reactivity of the ethylene bond, making it difficult to participate in the reaction as easily as the isolated ethylene bond.
    2 - (trienyl methyl) naphthalene part, the naphthalene ring is aromatic, and the stability of the aromatic system is extremely high. The Hocker rule shows that the naphthalene ring satisfies the 4n + 2 electron rule, and the π electron is highly delocalized, which endows the naphthalene ring with special stability. Although triene methyl is attached to the naphthalene ring, certain steric resistance and electronic effects are introduced, the aromatic stability of the naphthalene ring dominates the overall stability of the compound.
    Furthermore, the chemical bond energy between the atoms in the molecule also has an important impact on the stability. Carbon-carbon double bond, carbon-carbon single bond and carbon-hydrogen single bond all have specific bond energy values. These chemical bonds are not easy to break under general conditions, and specific reaction conditions, such as high temperature, high pressure, catalyst, etc., can initiate bond fracture and reaction.
    In general, 1% 2C3-diene-2- (trienomethyl) naphthalene is very stable under common conditions due to many factors such as conjugation system, aromaticity and chemical bond energy.
    What are the synthesis methods of 1,3-difluoro-2- (trifluoromethyl) benzene?
    The synthesis of 1% 2C3-diene-2- (trienomethyl) naphthalene is related to the field of organic chemical synthesis. The structure of this compound is relatively complex, and the synthesis process requires fine planning and ingenious strategies.
    To synthesize this compound, one can consider using naphthalene as the starting material. Naphthalene is chemically active, and its aromatic ring structure lays the foundation for many reactions. First, the specific position of the naphthalene ring is functionalized, and the electrophilic substitution reaction can be used to introduce suitable substituents to prepare for the subsequent construction of the target structure. For example, the halogenated naphthalene is treated with a halogenating agent to generate halogenated naphthalene, and the halogen atom can be used as the activity check point for subsequent reactions.
    Second, for the construction of 1,3-diene and triene methyl moieties. Wittig reaction can be used, which can effectively form carbon-carbon double bonds. Intermediates containing 1,3-diene structures are formed by reacting with corresponding carbonyl compounds with suitable phosphine Ylide reagents. At the same time, triene methyl moieties can be introduced by allylation reactions, etc. The reaction conditions and reagent ratios need to be precisely controlled to ensure the selectivity of the reaction.
    Furthermore, the reaction strategy catalyzed by transition metals can be considered. Coupling reactions catalyzed by transition metals such as palladium and nickel show unique advantages in the construction of carbon-carbon bonds. For example, Suzuki coupling reaction, using aryl halide and organoboron reagent as raw materials, under the action of palladium catalyst, the connection of naphthalene ring with 1,3-diene and triene methyl structure fragments can be realized, and the reaction check point and stereochemistry can be better controlled.
    Synthesis of 1% 2C3-diene-2- (triene methyl) naphthalene requires comprehensive use of various organic synthesis reactions, ingenious design of reaction routes, and precise regulation of reaction conditions to achieve efficient and highly selective synthesis.
    What should I pay attention to when storing and transporting 1,3-difluoro-2- (trifluoromethyl) benzene?
    1% 2C3-diene-2- (trienomethyl) naphthalene should be carefully stored and transported.
    When hiding, the first environment. Must choose a cool, dry and well-ventilated place. If it is in a humid place, it is prone to mildew; if the ground temperature is too high, it may cause changes in its properties or risk danger. And it must be kept away from fire and heat sources. Because it may be flammable, a little carelessness will cause disaster.
    Furthermore, isolation is also necessary. Do not store with oxidants, strong acids, strong bases, etc. When these substances meet with 1% 2C3-diene-2- (trienomethyl) naphthalene, they are prone to violent chemical reactions, causing explosions, burns and other disasters.
    When shipping, the packaging must be solid and reliable. Use suitable materials, such as special containers, to ensure that there is no leakage during transportation. When loading and unloading, it should also be gentle and not treated rudely to avoid damage to the packaging.
    The choice of transportation means is also critical. Choose fire and explosion-proof facilities, and the transportation route should be avoided in crowded and prosperous places to prevent accidents and innocent people. The escort must be familiar with the nature of this thing and know the emergency method. In case of emergencies, he can deal with it calmly to ensure the safety of transportation. In this way, he can hide and transport without worry.