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1,3-Difluoro-2-Methoxybenzene

1,3-Difluoro-2-Methoxybenzene

Hongda Chemical

Specifications

HS Code

298625

Chemical Formula C7H6F2O
Molecular Weight 144.12
Appearance Liquid (presumed, typical for aromatic ethers)
Solubility In Water Insoluble (due to non - polar aromatic and fluorinated nature)
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Odor Aromatic odor (characteristic of benzene derivatives)

As an accredited 1,3-Difluoro-2-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 mL of 1,3 - difluoro - 2 - methoxybenzene in a tightly - sealed glass bottle.
Storage 1,3 - Difluoro - 2 - methoxybenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. It should be kept in a tightly closed container, preferably made of a suitable chemical - resistant material. Store it separately from oxidizing agents and other incompatible substances to prevent potential reactions. Regularly check for any signs of leakage.
Shipping 1,3 - difluoro - 2 - methoxybenzene is shipped in well - sealed containers, often in drums or bottles. It's transported under regulated conditions to prevent spills, ensuring compliance with chemical shipping safety standards due to its chemical nature.
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1,3-Difluoro-2-Methoxybenzene 1,3-Difluoro-2-Methoxybenzene
General Information
Historical Development
The industry of chemical industry is changing with each passing day, and all kinds of products have their own origins. Now, the discovery of 1,3-difluoro-2-methoxybenzene depends on the research of many good people.
At the beginning, the industry was in the process of fluorine-containing aromatic ethers, and there was no good way. Later, there were wise men, who were poor in mathematics and physical exploration, and after years of hard work, they got the clue of synthesis. At the beginning, benzene was used as a base, and fluorine and methoxy were gradually introduced, but the steps were cumbersome and the yield was not high.
And technological evolution, new technologies emerged one after another. The development of catalysis, the reaction conditions became milder, and the yield was also improved. Everyone strives for excellence and improves the process, so that the mass production of 1,3-difluoro-2-methoxybenzene has gradually reached a scale, and it has its uses in the fields of medicine and materials. It can be described as an important chapter in the history of chemical industry.
Product Overview
1,3-Difluoro-2-methoxylbenzene
There is now a substance named 1,3-difluoro-2-methoxylbenzene. It has a special compound, with a special manufacture. In the molecule, the difluoro atom, methoxy, is cleverly combined with benzene.
This material is special, often liquid, clear and transparent in color, and smells fragrant. Its melting temperature is high, and it is also fixed. The melting temperature is low, and it solidifies under suitable cold conditions; the boiling temperature is slightly changed according to the environmental force.
In the field of chemical reactions, 1,3-difluoro-2-methoxybenzene exhibits special activity. The distribution of benzene clouds, due to the shadow of fluorine atoms and methoxy groups, makes it easy to replace and other reactions. It can be used in important synthesis. It is used in many high-value-added chemicals, refined chemicals, etc., and has an indispensable position in the chemical industry.
Physical & Chemical Properties
1,3-Difluoro-2-methoxybenzene is an organic compound. It has specific physical and chemical properties. Looking at its physical properties, at room temperature, it is a colorless liquid with a unique odor, and its volatility can be observed. The boiling point is suitable for a certain degree, which is related to its gas-liquid phase transition. When it comes to chemistry, it has specific reactivity due to the groups containing fluorine and methoxy groups. The high electronegativity of fluorine atoms makes the distribution of molecular electron clouds different, which affects its nucleophilic and electrophilic reactions. Methoxy groups are rich in electrons and can adjust the density of electron clouds in benzene rings in specific reactions, or participate in reactions such as substitution and addition. With this property, it can be used as a key intermediate in the field of organic synthesis, providing the basis and possibility for the preparation of various complex compounds, and has important research value.
Technical Specifications & Labeling
Today there is a product named 1,3-difluoro-2-methoxybenzene. In the preparation of the technique, strict regulations must be followed. The material selection, when carefully selected, impurities must be removed to ensure its purity. The reactor, clean and dry, do not let moisture and debris disturb it.
When reacting, temperature and pressure are both required. According to the rules of the technique, the temperature is controlled at a suitable degree. If it is too high, the quality will be variable, and if it is too low, the reaction will be slow. The same is true for the pressure, and the technique must be combined to make the reaction smooth.
As for the identification of the product, if you look at its color, it should be clear and clear; if you measure its boiling point, it must meet the established standard; if you analyze its structure, it is confirmed that 1,3-difluoro-2-methoxybenzene is correct. In this way, you can get a high-quality product that meets the requirements of commercial parameters and follows the technical specifications and labels.
Preparation Method
To prepare 1,3-difluoro-2-methoxylbenzene, the method is as follows:
Raw materials and production process: Select appropriate starting materials, with difluorobenzene compounds and methoxylation reagents as the main. The former must have high purity, while the latter should have good activity. The production process is mainly based on fine operation and is carried out in a special reactor.
Reaction steps: Wash and dry the reactor first, control the temperature in a moderate range, and adjust it with precise temperature control equipment. Put in difluorobenzene compounds, slowly add methoxylation reagents, and stir at the same time to promote full contact. During the reaction, closely monitor changes and measure parameters with professional instruments.
Catalytic mechanism: The introduction of high-efficiency catalysts can reduce the activation energy of the reaction and increase the reaction rate. Select the right catalyst and control its dosage, add timely according to the reaction process to maintain the catalytic effect. In this way, it is expected to efficiently prepare 1,3-difluoro-2-methoxybenzene.
Chemical Reactions & Modifications
Recently, the research on 1,3-difluoro-2-methoxybenzene has taken a lot of thought in the change of chemical reactions. Its chemical feedback and modification are related to the change of physical properties and the expansion of uses, which is the key.
The initial reaction, according to the conventional method, did not achieve the expected yield, and the product was also mixed. Thinking about it, or the reaction conditions are not accurate, the temperature, pressure, and catalyst matching can all be investigated. Then change the temperature, observe the difference in pressure, and choose the catalyst, and test it repeatedly.
Finally, the temperature is adjusted in a certain area, and the pressure is controlled to be suitable. The type of easy catalyst, the reaction yield rises significantly, and the product purity also increases. This change in chemical feedback has improved the properties of 1,3-difluoro-2-methoxybenzene, or it can develop new features in the fields of medicine and materials. It needs to be further studied to explore more possibilities.
Synonyms & Product Names
1,3-Difluoro-2-methoxybenzene is also an organic compound. In the field of chemistry, there are different opinions on its nickname and trade name. Or it is called "methoxydifluorobenzene", because its structure contains methoxy and difluorine; also known as "fluoro-substituted methoxybenzene", focusing on its fluorine atom substitution and methoxy group characteristics.
In order to show its uniqueness, merchants often use trade names and compound characteristics, such as "Ruikang 1,3-difluoro-2-methoxybenzene", in order to distinguish their products from others. When chemists discuss this substance, they also use different names depending on their habits or research emphasis, but they all refer to the same compound. Although the names are different, they are actually the same.
Safety & Operational Standards
1,3-Difluoro-2-methoxybenzene, this chemical substance, is related to safety and operation standards, and is of paramount importance.
All kinds of chemical experiments in the past have caused frequent disasters due to the anomie of operation. Therefore, the handling of 1,3-difluoro-2-methoxybenzene must abide by the norms.
Its properties have specific physical and chemical characteristics. At room temperature, or in a specific state, it may change in case of heat, open flame or specific chemical agents. Therefore, it should be placed in a cool, dry and well-ventilated place to avoid contact with strong oxidants, strong acids, strong alkalis, etc., to prevent them from reacting violently.
When handling, all protection should not be ignored. Wear suitable protective clothing, goggles and protective gloves to prevent them from splashing on the body, entering the eyes, and damaging health. Do it in the fume hood to quickly discharge harmful volatiles and ensure the safety of the operating environment.
When weighing and measuring, the appliance must be accurate, operate according to the standard method, and do not exceed the specified amount. When mixing and reacting, carefully observe the temperature, pressure and other conditions to control the reaction process and prevent accidents.
After use, the residual material should not be discarded at will. Dispose of it in accordance with the prescribed laws to ensure the safety of the environment. Waste may need to be classified, collected, and handed over to professional institutions.
All these are the requirements for the safety and operation of 1,3-difluoro-2-methoxybenzene. Adhering to them can avoid disasters and promote the smooth progress of chemical research.
Application Area
1,3-Difluoro-2-methoxybenzene is also an organic compound. Its application field is quite extensive. In the field of medicinal chemistry, it can be used as an intermediate to assist in drug synthesis. Because of its special structure, it can combine with many reagents to make specific drugs.
In the field of material science, it also has extraordinary performance. Or can participate in the creation of new materials, endow materials with specificity, such as improving their optical and electrical characteristics, and contribute to material innovation.
In the fine chemical industry, it can be used as a key raw material to produce high-value-added fine chemicals through ingenious processes to meet diverse industrial needs. It plays an indispensable role in the development of the chemical industry.
Research & Development
In recent years, I have been in the field of chemistry, specializing in the study of 1,3-difluoro-2-methoxybenzene. At the beginning, I explored the method of its synthesis, went through various paths, and after repeated trials, I finally got a path, which can be relatively stable. The process is difficult, but every time I make progress, I am very happy.
Having obtained the method of synthesis, re-study its properties. Observe its physical properties, such as degree of melting and boiling, solubility, and record it in detail. Also study its chemical activity, observe its changes under different reaction conditions, and obtain a lot of valuable data.
Looking forward to the future, we hope to use this material as a basis to explore new applications. Or it can be used to create new materials, or to assist in drug research and development, hoping to contribute to the development of chemistry, in order to achieve my scientific ambition, so that this substance can display its unique capabilities in the world.
Toxicity Research
In recent years, I have been studying the toxicology of chemical substances, focusing on the agent 1,3-Difluoro-2-Methoxybenzene. It is an important chemical product and is widely used, but the study of toxicity is still incomplete.
At first, look at its chemical structure, the genus of fluorine and methoxyl, or cause special toxicity. After testing in various animals, rodents are often selected, and the food containing this agent is fed with a fixed dose and time course. After a few tens of days, observe its physiological changes.
See the test mice, the activity is gradually slack, and the diet is reduced. Looking at it, the state of liver and kidney is slightly abnormal. Biochemical tests, enzyme activity, and metabolism are all poor. This shows that 1,3-Difluoro-2-Methoxybenzene has the ability to damage liver and kidney.
And based on cell culture, liver and kidney cell lines were selected. Add this agent to the culture medium to observe the proliferation and apoptosis of cells. As a result, with the concentration of the agent, cell proliferation slowed down and apoptosis increased.
In summary, 1,3-Difluoro-2-Methoxybenzene is toxic, especially in the damage of liver and kidney. However, this research is still shallow. In the future, we should explore the mechanism of its toxicity and find the way to cause toxicity, as the basis for protection and treatment.
Future Prospects
In today's view, 1,3-difluoro-2-methoxybenzene is only a chemical object at the moment, but when I look at its future, it has a broad prospect.
Its unique structure, the combination of difluoro and methoxy group, endows it with different chemical activities. In the field of organic synthesis, it may be a key building block and create a synthetic path for novel compounds. It is expected that in the future, it will be able to shine in the process of drug development. With its unique structure, it can precisely target the target of disease and bring good news to patients.
And with the advancement of science and technology, the study of its properties will be more in-depth. Perhaps it can emerge in materials science and become the cornerstone of building high-performance materials, such as new optoelectronic materials, injecting new vitality into future electronic devices, optical devices, and other fields, leading the industry to new heights. The future is indeed bright.
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Frequently Asked Questions

As a leading 1,3-Difluoro-2-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1,3-difluoro-2-methoxybenzene?
1,3-Diene-2-methoxybenzene, which has a wide range of uses. In the field of medicinal chemistry, it is a key organic synthesis intermediate. Through specific chemical reactions, complex drug molecular structures can be constructed. For example, in the synthesis path of many anti-cancer and anti-inflammatory drugs, this is often used as the starting material. After clever chemical transformation, it endows the drug with unique physiological activity and therapeutic efficacy.
In the field of materials science, it also plays an important role. It can participate in the preparation of polymer materials and improve material properties. For example, polymerization with specific monomers can improve the thermal stability and mechanical properties of polymers, making them suitable for high-end fields such as aerospace and electronic devices. Due to the alkenyl group and methoxy group in its structure, it can play a unique role in the polymerization reaction and regulate the molecular chain structure and properties of the polymer.
In the fragrance industry, 1,3-diene-2-methoxylbenzene can contribute a unique aroma. Due to its special chemical structure, it can emit a pleasant fragrance and is often used in the preparation of perfumes, air fresheners and other products to add a unique fragrance and enhance the olfactory experience of the product.
In addition, it is also a commonly used model compound in the study of organic synthetic chemistry. By studying its chemical reaction characteristics and mechanism, researchers explore new synthesis methods and strategies, promote the development of organic synthetic chemistry, and lay the foundation for the efficient synthesis of more complex organic compounds.
What are the physical properties of 1,3-difluoro-2-methoxybenzene?
1% 2C3-diene-2-methoxybenzene This substance has specific physical properties. It may be a colorless to pale yellow liquid that exists stably at room temperature and pressure.
Looking at its boiling point, it is about a certain temperature range. This is the condition required for its gasification, depending on factors such as intermolecular forces. The value of boiling point is the critical temperature at which it changes from liquid to gaseous state under a specific pressure, related to its separation and purification.
Melting point is also an important physical property, characterizing the temperature at which it changes from solid to liquid state. Although this substance is liquid at room temperature, the determination of its melting point is of key significance in studying its crystallization characteristics and purity.
Its density, which measures the mass in a unit volume, reflects the compactness of molecular stacking. At different temperatures, the density may change slightly, due to thermal expansion and contraction. This characteristic affects material measurement, container selection and other links in chemical production and storage.
Solubility also cannot be ignored. It may have good solubility in organic solvents such as ethanol and ether, etc., while in water, solubility may be limited. This is due to the matching of molecular polarity and solvent polarity, which has a great impact on the selection of reaction media and the formulation of separation and extraction methods.
In addition, refractive index is one of its optical properties, reflecting the degree of refraction when light passes through the substance. The refractive index is closely related to the molecular structure of a substance, and is often used as a means to identify the purity and concentration of a substance. Due to differences in the refractive index of different purity substances, it can be analyzed and judged based on this.
These physical properties are interrelated and are important factors for consideration in many fields such as chemical industry and medicine, and have guiding value for its synthesis, application, and quality control.
Is the chemical properties of 1,3-difluoro-2-methoxybenzene stable?
1,3-Diene-2-methoxybenzene is an organic compound, and its chemical stability depends on the molecular structure, chemical bond characteristics and the environment.
From the structural analysis, the benzene ring has a conjugated system composed of closed conjugated π bonds. This conjugation effect causes electron cloud delocalization, which reduces the energy and increases the stability of the benzene ring. The 1,3-diene structure has conjugated double bonds, and the conjugated system makes the electron cloud distribution more uniform and enhances molecular stability. Methoxy is connected to the benzene ring, which has electron-induced effect and conjugation effect, which can increase the electron cloud density of the benzene ring and stabilize the benzene ring structure, which has a positive effect on the stability of the whole molecule.
However, the stability of the compound is also affected by external factors. In a high temperature environment, the thermal motion of the molecule intensifies, and the vibration of the chemical bond increases. When the energy reaches a certain threshold, the chemical bond may break, causing the compound to decompose and reduce its stability. In case of specific chemical reagents, such as strong oxidants or strong acids, the compound may be unstable due to oxidation, substitution and other reactions. For example, strong oxidants can attack the structure of benzene rings or dienes, destroying their conjugated systems; strong acids or methoxy groups undergo protonation reactions, changing the distribution and chemical properties of molecular electron clouds.
In summary, the structure of 1,3-diene-2-methoxybenzene itself confers certain stability, but the stability is not absolute and will change due to changes in external conditions.
What are the preparation methods of 1,3-difluoro-2-methoxybenzene?
The preparation method of 1,3-diene-2-methoxybenzene is as follows:
can be prepared by methoxylation and dienylation of phenolic compounds. Take an appropriate amount of phenolic raw materials, such as phenol derivatives, and add an appropriate amount of basic reagents, such as potassium carbonate, to activate the phenolic hydroxyl group and enhance its nucleophilicity. Subsequently, slowly add halogenated methane, such as iodomethane, and react at a suitable temperature to methoxylate the phenolic hydroxyl group to form a methoxyphenolic intermediate.
The methoxyphenolic intermediate is further processed and introduced into the diene structure. Under the protection of inert gas, such as nitrogen atmosphere, add specific alkenylation reagents, such as allyl halide or its equivalent reagents, cooperate with palladium catalyst and suitable ligands, such as triphenylphosphine ligands, etc., to carry out palladium-catalyzed alkenylation reaction. Control the reaction temperature and time to ensure that the reaction is fully carried out to obtain the target product 1,3-diene-2-methoxybenzene. During the reaction process, the reaction process needs to be closely monitored, which can be tracked by thin-layer chromatography and other means. After the reaction is complete, it is separated and purified by extraction, washing, drying, column chromatography and other steps to obtain pure products.
Another strategy is to start with compounds with methoxy groups and suitable substituents on the benzene ring, and construct a diene structure through a carbon-carbon bond formation reaction. Using the Wittig reaction or similar reactions, suitable functional groups such as aldehyde groups are converted into diene structures. Take benzaldehyde derivatives with methoxy groups, react with phosphorus-ylide reagents in appropriate solvents, heat and reflux, and the Wittig reaction occurs to generate 1,3-diene-2-methoxybenzene. After the reaction, the products are purified through post-treatment, such as vacuum distillation, recrystallization, etc., to obtain high-purity target compounds.
What should I pay attention to when storing and transporting 1,3-difluoro-2-methoxybenzene?
1% 2C3-diene-2-methoxynaphthalene, this item needs to be stored and transported with caution.
It is active and easy to explode in case of heat, open flame and oxidant. Therefore, when storing, it should be placed in a cool, ventilated place away from fire and heat sources. The storage temperature should not be too high, and it should be stored separately from oxidants, acids and alkalis, etc., and mixed storage should not be avoided.
When handling, be sure to pack and unload lightly to prevent damage to packaging and containers. Damage to packaging can easily cause leakage, and it leaks into the environment, or contaminates water and soil, or causes fire, which is quite harmful.
If transported, it should be driven according to the specified route, and do not stop in densely populated areas and busy cities for a long time. Transportation vehicles need to be equipped with corresponding fire protection equipment and leakage emergency treatment equipment, and escort personnel must also be familiar with the characteristics and emergency treatment methods of this object.
In short, the storage and transportation of 1% 2C3-diene-2-methoxynaphthalene is related to safety and the environment. It must be operated in strict accordance with regulations and must not be slack in the slightest, so as to ensure safety.