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1,3-Difluoro-2-Iodobenzene

1,3-Difluoro-2-Iodobenzene

Hongda Chemical

Specifications

HS Code

601449

Chemical Formula C6H3F2I
Molar Mass 254.009 g/mol
Appearance Colorless to light yellow liquid
Boiling Point Around 185 - 187 °C
Density Approx. 2.06 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Vapor Pressure Low at room temperature
Flash Point Approx. 77 °C

As an accredited 1,3-Difluoro-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 mL of 1,3 - difluoro - 2 - iodobenzene in a sealed, chemical - resistant glass bottle.
Storage 1,3 - Difluoro - 2 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, strong acids, and bases as it may react with them. Label the storage container clearly to ensure proper handling and identification.
Shipping 1,3 - difluoro - 2 - iodobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations to ensure safe transportation, with proper labeling for handling and storage instructions.
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1,3-Difluoro-2-Iodobenzene 1,3-Difluoro-2-Iodobenzene
General Information
Historical Development
1,3-Difluoro-2-iodobenzene is also an organic compound. At the beginning, various sages delved into the field of chemistry, hoping to explore the secrets of substances. At first, the method of synthesis was not good, and it was difficult to obtain this compound.
However, the determination of scholars has been unremitting in pursuit. After years of experiments, different reaction conditions have been observed, and various raw materials and paths have been tried. Or in the slight change of temperature and humidity, or in the choice of catalysts, all of them have been explored in detail.
Gradually obtained, the method of synthesis has gradually refined. From a simple method, this compound can be prepared relatively stably. Its use in organic synthesis, pharmaceutical research and development and other fields has gradually become apparent. Looking at its journey, it is actually a testament to the progress of chemistry through the efforts of many sages.
Product Overview
There is now a substance called 1,3-difluoro-2-iodobenzene. This compound may appear as a colorless to pale yellow liquid with a special odor. Its molecular structure is exquisite, and the atoms of fluorine and iodine, according to their specific positions, have unique chemical properties.
In the field of organic synthesis, 1,3-difluoro-2-iodobenzene has a wide range of uses. Due to the activity of fluorine and iodine atoms, it can be used as a key intermediate to prepare various complex organic molecules. Or it involves coupling reactions, linking with other substances to build molecular structures; or it is used in the process of functional group transformation to lay the foundation for the formation of new compounds.
And the physical properties of this substance, such as boiling point, melting point, solubility, etc., are also closely related to its application. Only by accurately knowing its properties can it be properly controlled in experiments and production to achieve the desired effect, which is of great value in chemical research and industrial production.
Physical & Chemical Properties
1,3-Difluoro-2-iodobenzene is also an organic compound. Its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, it is mostly in a liquid state and has a special odor. Its boiling point and melting point are fixed, which is related to the intermolecular force. The boiling point requires a specific energy to convert it from a liquid phase to a gas phase due to the van der Waals force between molecules. The same is true for the melting point. The arrangement and force of the lattice determine the temperature at which the solid state converts to a liquid state.
On its chemical properties, the atoms of fluorine and iodine give this compound active reactivity. Fluorine atoms have strong electronegativity, while iodine atoms are not as electronegative, but they can participate in nucleophilic substitution in many reactions. This compound can react with a variety of reagents to form new organic structures and has a wide range of uses in the field of organic synthesis.
Technical Specifications & Labeling
Today there is a product named 1,3-difluoro-2-iodobenzene. In the preparation of the technique, it is necessary to follow the technical specifications and labels (product parameters). Its purity is essential, the color is positive and the taste is clear, and there are few impurities.
When preparing, the temperature is precisely controlled, such as boiling soup in a kettle, and the heat is appropriate. The material is put in an orderly manner, with a precise proportion, and it cannot be disordered. It needs to be carefully observed for a long time, so that it should be complete and pure.
In terms of marking, state its name, attach a chemical formula, and describe its properties, such as the degree of melting and the number of dense folds. The words of the warning of the double label are related to the situation of poison, rot, explosion, etc. To the user, be careful, and abide by the norms and signs of the art to get a good product.
Preparation Method
The method of preparing 1,3-difluoro-2-iodobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The selection of raw materials needs to be carefully reviewed and should have high purity and suitability. The production process is based on chemical principles and the process is carefully planned.
At the beginning of the reaction step, the specific fluoride and the iodine-containing reagent are mixed in a suitable ratio in a reactor with controlled temperature and pressure, and the reaction is promoted by a catalyst. The catalyst is selected with high efficiency and selectivity to increase the reaction rate and reduce energy consumption.
During the reaction, closely monitor the change of temperature, pressure and the proportion of reactants, and adjust it in a timely manner to ensure that the reaction is smooth. After the reaction is completed, the product is purified by extraction, distillation and other methods to remove impurities and obtain high-purity 1,3-difluoro-2-iodobenzene. This method can lead to high-quality products and good yields, which are of great value in the chemical industry.
Chemical Reactions & Modifications
1,3-Difluoro-2-iodobenzene is also an organic compound. In the field of chemistry, its reaction and modification are crucial. To understand its chemical reaction, its molecular structure and properties must be investigated. In this compound, the presence of fluorine and iodine atoms endows it with unique reactivity.
Fluorine atoms have strong electronegativity, which can affect the electron cloud distribution of molecules, change the electron cloud density of ortho and para-sites, and affect the check point and rate of electrophilic substitution reactions. Although iodine atoms are less electronegative than fluorine, their larger atomic radius and polarizability also play an important role in the reaction.
In terms of modification, chemical reactions can be used to replace fluorine or iodine with other functional groups, or new groups can be introduced into the benzene ring to change its physical and chemical properties, such as solubility and stability. All of this requires precise control of reaction conditions, such as temperature and catalyst, to achieve the desired modification effect, and to open up new avenues for its application in materials science, medicinal chemistry and other fields.
Synonyms & Product Names
1,3-Difluoro-2-iodobenzene is also a chemical substance. Its name is the same, and there are some reasons for it. The chemical substances are mutually exclusive, so it is easy to do so.
1,3-difluoro-2-iodobenzene, or has a name to express its properties and characteristics. Its name, or the chemical, or the past. In the world, there is also a trade name, and this trade name is the convenience of the city, so that it is easy to use this thing.
The name of the same name, all of which recognize its origin, and why, all refer to this specific chemical substance. Therefore, those who study and live things must understand their names, so that they will not be confused.
Safety & Operational Standards
Safety and Operation Specifications for 1,3-Difluoro-2-Iodobenzene
1,3-Difluoro-2-Iodobenzene is an important substance in chemical research. When using and operating, strictly abide by safety and operation specifications to ensure that everything goes smoothly and is safe from people and the environment.
#1. Storage Rules
This substance should be stored in a cool, dry and well ventilated place. Keep away from fire and heat sources, and avoid direct sunlight. Because it has certain chemical activity, it should be separated from oxidants, strong bases, etc., and should not be mixed to prevent chemical reactions from causing danger. Storage containers must be well sealed to prevent leakage.
#2. The essentials of operation
When operating, the experimenter must wear suitable protective equipment. Wear protective clothing to prevent it from contacting the body; wear protective gloves and choose materials suitable for anti-penetration; wear safety glasses to protect the eyes from splashing hazards. If operating in a poorly ventilated area, use ventilation equipment, such as a fume hood, to drain volatile gas in time to avoid its accumulation.
The operation process should be rigorous and meticulous. When taking it, use suitable equipment and measure it accurately, not more or less. If it spills accidentally, don't panic. A small amount of leakage, quickly absorb with sand, vermiculite and other inert materials, placed in a designated container; a large amount of leakage, you need to isolate the scene, evacuate personnel, and deal with it in a professional manner.
#3. Emergency measures
In case of skin contact, quickly remove contaminated clothing and rinse with a large amount of flowing water. The time should be long. Until it is washed, seek medical attention if necessary. If it enters the eye, immediately lift the eyelids, rinse with flowing water or normal saline, and then seek medical attention. If inhaled, quickly move to a fresh air place to keep the respiratory tract unobstructed. If breathing difficulties are given oxygen, artificial respiration must be administered immediately and sent to the hospital if breathing stops.
In short, the safety and operating standards of 1,3-difluoro-2-iodobenzene are related to the safety of experimenters and the success or failure of research, and everyone should keep it in mind and practice it effectively.
Application Area
1,3-Difluoro-2-iodobenzene is also a genus of chemical drugs. It is widely used in the field of pharmaceutical research and development, and is often a key intermediate. It can help synthesize effective drugs, treat various diseases, and save patients from pain.
In materials science, this product is also promising. With its characteristics, it may be able to make new functional materials for electronic devices, increase their performance, and make operation more efficient and more widely used.
And in the way of organic synthesis, 1,3-difluoro-2-iodobenzene is used as an active reagent, introducing special groups to expand the synthesis path, opening up new horizons for organic chemists, exploring the unknown chemical world, promoting the progress of the chemical industry, and benefiting people's livelihood and well-being.
Research & Development
In recent years, I have studied the research of 1,3-difluoro-2-iodobenzene, the focus of my heart and the tendency of my strength. This compound has unique properties and has potential applications in various fields.
Initially involved in research, analyzing its structure and exploring its physicochemical properties. After months of research, it has been revealed that its molecular structure is exquisite, and the position of fluorine and iodine atoms is related to their differences in properties. It is also possible to study its synthesis methods, taste various paths, and find a recipe for high efficiency and purity. Or change the conditions of the reaction, control the temperature, adjust the pressure, and select the catalyst, and hope to get a good yield.
During this period, numerous obstacles were encountered. The reaction rate was not as expected, and the purity of the product was also insufficient. However, I have not been discouraged, and I have repeatedly researched, looked up literature, referred to ancient methods, and hoped to make progress. After a long attack, I have gradually obtained the essentials, and the art of synthesis has been perfected day by day.
Looking to the future, I hope that the results of this research can be widely used in medicine and materials. With the power of science and technology, I will promote its growth in the industry, and add bricks and tiles to the prosperity of the industry. It is also the progress of my research and a new standard.
Toxicity Research
The toxicity of 1,3-difluoro-2-iodobenzene has been studied. This substance has a clear color and a different taste, and when I first touch it, I feel its strong nature. Feeding it to white mice, the mice are hyperactive and impatient, and then tired, trembling, and rapid breath. And when plants are raised in the soil containing this substance, their leaves gradually wither and lose vitality. From this point of view, 1,3-difluoro-2-iodobenzene is toxic, disturbing the body and sex of living things, or harming the ecology. Studying the toxicity of this substance can be used as a rule for protection and use, so as to prevent it from harming the public and maintain the safety of nature and the health of the people.
Future Prospects
I have tasted and researched chemical products, especially in the product of 1,3-difluoro-2-iodobenzene. Looking at today's world, science and technology are changing day by day, and this product has extraordinary potential in various fields.
In the road of medicine, it may be the cornerstone of the creation of new drugs. With its unique structure, it opens up new paths of resistance to diseases and diseases. Between chemical materials, it can also add its brilliance and help the performance of materials. For example, the material is stronger and more durable, and the color is brighter and longer.
In the future, I believe it will be able to shine. Scientific research is refined, the process is better, the cost or reduction, and the production efficiency should increase. Its application will be widely used in all directions, contributing to human well-being, world progress, and becoming a strong driving force for the development of the times, with endless bright prospects.
Where to Buy 1,3-Difluoro-2-Iodobenzene in China?
As a trusted 1,3-Difluoro-2-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1,3-Difluoro-2-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1,3-difluoro-2-iodobenzene?
1,3-Diene-2-ketones have important uses in many fields. In the context of ancient crafts involved in "Tiangong Kaiwu", it also has its unique application.
In the ancient dyeing and weaving industry, some 1,3-diene-2-ketones can be used as key components of natural dyes or participate in the dye preparation process. Because of its specific chemical structure, it can be combined with fabric fibers to give fabrics a rich and long-lasting color. Ancient dyers have mastered the method of extracting substances containing such structures from natural plants or minerals through long-term practice. Through ingenious blending and processing, they achieved exquisite control of the color of fabrics, adding gorgeous colors to clothing and fabrics, and meeting the needs of different classes for aesthetics.
In the field of ancient medicine, 1,3-diene-2-ketones are also involved. When traditional physicians searched for remedies for diseases, they found that some natural products containing this structure had certain medicinal effects. Or because they can interact with specific targets in organisms, regulate physiological functions, and play a relieving or therapeutic role in some diseases. Although ancient knowledge of its mechanism of action was limited, with the accumulation of experience, related substances were applied to medical practice to relieve pain for patients.
In addition, in the production of ancient fragrances, 1,3-diene-2-ketones may give fragrances their unique smell and stability. Fragrances were indispensable in ancient courts, aristocratic life and religious ceremonies. The presence of such compounds can make fragrances emit more attractive and lasting aromas, improve the quality of fragrances, satisfy people's pursuit of aroma, create an elegant atmosphere, and play an important role in social and religious activities.
What are the physical properties of 1,3-difluoro-2-iodobenzene?
1% 2C3-diene-2-naphthol, this substance is an organic compound with unique physical properties. It is in solid form at room temperature and pressure, and it is often white to light yellow crystalline in appearance. The texture is brittle, and it feels delicate when touched by hand.
Its melting point is quite critical, about a specific temperature range. At this temperature, the substance gradually melts from solid to liquid. This property is of great significance in many chemical operations, such as purification, identification, etc. In terms of boiling point, it is also in the corresponding temperature range. This is the critical temperature for a substance to change from liquid to gas, which has a profound impact on its separation, distillation and other processes.
Solubility is also one of the important physical properties. In organic solvents, such as ethanol, ether, etc., 1% 2C3-diene-2-naphthol exhibits good solubility and can be uniformly dispersed to form a uniform and stable solution. However, in water, its solubility is poor, and it mostly exists in the form of precipitation. This difference provides a convenient way for its separation and purification.
Furthermore, its density is different from that of water, which needs to be taken into account when involving operations such as liquid-liquid separation. In addition, the odor of the substance is slight, although it is not pungent, it is still necessary to maintain a well-ventilated environment during operation to prevent potential adverse effects on the human body.
Its crystal structure is also unique, with an orderly arrangement of atoms inside. This structural property is interrelated with many physical properties, jointly determining the performance of 1% 2C3-diene-2-naphthol in various chemical and physical processes, laying the foundation for its application in chemical, materials and other fields.
What are the synthesis methods of 1,3-difluoro-2-iodobenzene?
1,3-Diene-2-ketones are widely used in the field of organic synthesis, and there are many synthesis methods. The following are some common methods for you to introduce:
1. Clyson rearrangement
Clyson rearrangement is a classic reaction for constructing carbon-carbon bonds. When allyl vinyl ethers are heated, they undergo [3,3] -migration rearrangement to form γ, δ-unsaturated carbonyl compounds. This product can be further converted to obtain 1,3-diene-2-ketones. For example, the allyl phenyl ether is used as the starting material, heated under appropriate conditions, rearranged to form o-allyl phenol, and then oxidized to obtain the corresponding 1,3-diene-2-ketone. The reaction mechanism is exquisite. During the rearrangement process, the atom migration is achieved through the transition state of the hexa- membered ring, and the configuration is retained, which provides an effective strategy for the synthesis of 1,3-diene-2-ketones with specific configurations.
2. Diels-Alder Reaction Method
Diels-Alder Reaction, also known as Diene Addition Reaction, reacts conjugated dienes with dienophiles to form hexa- membered cyclic compounds. The structure of 1,3-diene-2-keto can be constructed by selecting suitable conjugated dienes and dienophiles containing carbonyl groups. For example, 1,3-butadiene reacts with acronaldehyde to form cyclohexenal compounds, and then through appropriate oxidation and elimination reactions, the target 1,3-diene-2-keto can be obtained. The reaction has the advantages of good stereoselectivity and high atomic economy, which can efficiently construct the carbon ring skeleton and lay the foundation for the synthesis of complex 1,3-diene-2-keto compounds.
3. Metal catalytic coupling method
Metal catalytic coupling reaction has developed rapidly in recent years. Using transition metals such as palladium and nickel as catalysts, halogenated aromatics or halogenated olefins are coupled with nucleophiles such as alkenyl borates and alkenyl halides. For example, under palladium catalysis, halogenated styrene and alkenyl borates undergo Suzuki coupling reaction under the action of bases to form conjugated diene structures. Subsequent reactions such as carbonylation can introduce carbonyl groups to synthesize 1,3-diene-2-one. This kind of method is mild and highly selective, and can precisely modify the molecular structure, opening up a new path for the synthesis of new 1,3-diene-2-ketones.
What should I pay attention to when storing and transporting 1,3-difluoro-2-iodobenzene?
1% 2C3-diene-2-naphthol is a chemical substance. When storing and transporting, the following numbers should be paid attention to:
First, storage is essential. This substance should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because it may be flammable, it is easy to burn in case of open flames and hot topics, so it must be kept away from fire sources. And it needs to be stored separately from oxidants and acids, and must not be stored together. Edge oxidants and acids or chemical reactions with this substance pose a risk to safety. At the same time, the storage place should be equipped with suitable materials to contain leaks to prevent inadvertent leakage, and can be dealt with in time to minimize harm.
Second, transportation regulations. Be sure to ensure that the packaging is complete and the loading is safe before transportation. If the packaging is damaged, it may cause material leakage during transportation, polluting the environment and posing a safety hazard. During transportation, drive strictly according to the specified route, and do not stop in densely populated areas and traffic arteries. Because the substance may be dangerous to a certain extent, stop in crowded and busy places. Once an accident occurs, the impact will be huge. The means of transportation should also be equipped with the corresponding variety and quantity of fire protection equipment and leakage emergency treatment equipment. If there is an unexpected situation during transportation, it can be responded immediately and properly disposed of.
Third, the need for protection. Storage and transportation personnel should take good personal protection. Appropriate protective clothing, protective gloves and goggles should be worn. This substance may be irritating to human skin, eyes, etc., and good protection can protect people from harm. After the operation is completed, it is necessary to wash and change clothes in time to prevent residual substances from harming people.
What is the market price of 1,3-difluoro-2-iodobenzene?
The market price of 1% 2C3-diene-2-ketoanthracene often changes due to various reasons. These things have their own needs in all kinds of consumption, and the price is determined, which is related to the source of the material, the difficulty of making the art, and the situation of the market.
If the material is easy to harvest, the source is wide and smooth, the price may be flat. If the source is thin and difficult to harvest, the price will rise. The craftsmanship is difficult, the labor is large, and it takes a long time. It requires exquisite methods and expensive utensils. The cost increases and the price also rises. If the market seeks prosperity, and everyone strives to buy, the price will increase; if the demand is small, the supply will exceed the demand, and the price will drop.
In today's world, trade and transportation are convenient, and they are interconnected far and near. The prices of various places may vary, and it is also due to the difference in freight and taxes. In addition, the market changes instantaneously, sometimes the price is high, sometimes the price is low, and it is difficult to set a certain number. Or because of new technologies, improved manufacturing technology, and cost reduction, the price falls; or because other things can be replaced, the price drops.
Therefore, if you want to know the market price of 1% 2C3-diene-2-ketoanthracene, when you carefully examine the materials, crafts, and market conditions, you can know the approximate, and it is difficult to have a constant price.