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1,3-Bis(Trifluoromethyl)-5-Bromobenzene

1,3-Bis(Trifluoromethyl)-5-Bromobenzene

Hongda Chemical

    Specifications

    HS Code

    919420

    Chemical Formula C8H3BrF6
    Molecular Weight 317.005
    Appearance Solid (Typical)
    Boiling Point Data may vary, around 170 - 180 °C
    Melting Point Data may vary, around 20 - 30 °C
    Density Data may vary, around 1.8 - 1.9 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane
    Vapor Pressure Low
    Flash Point Data may vary, around 60 - 70 °C

    As an accredited 1,3-Bis(Trifluoromethyl)-5-Bromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1,3 - bis(trifluoromethyl)-5 - bromobenzene in a sealed chemical - grade bottle.
    Storage 1,3 - bis(trifluoromethyl)-5 - bromobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly closed container, preferably made of corrosion - resistant material. This helps prevent decomposition, leakage, and potential chemical reactions that could pose safety risks.
    Shipping 1,3 - bis(trifluoromethyl)-5 - bromobenzene is a chemical. Shipping requires proper packaging in accordance with hazardous material regulations, ensuring containment and protection during transit to prevent any leakage or damage.
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    1,3-Bis(Trifluoromethyl)-5-Bromobenzene 1,3-Bis(Trifluoromethyl)-5-Bromobenzene
    General Information
    Historical Development
    1,3-Bis (trifluoromethyl) -5-bromobenzene is also an organic compound. Looking at the process of its creation, it is one of the characteristics of the evolution of real chemistry. At the beginning, various sages worked tirelessly in the field of chemistry, expecting to synthesize new compounds.
    In the past, the art of organic synthesis was not as complete as it is today, and everyone worked hard to find a way to synthesize this compound. After repeated tests, the reaction mechanism was analyzed, the material ratio and reaction conditions were studied. Beginning with simple equipment and limited knowledge, it was explored one after another.
    With the passage of time, the theory of chemistry became more and more clear, and the technology became more and more exquisite. The method of synthesis gradually improved from clumsy, and the yield and purity also gradually improved. The synthesis and evolution of this compound is like a long river, witnessing the continuous exploration of chemical research, contributing to the grand cause of chemistry, and laying the foundation for subsequent scientific research and application. It can be described as one of the coordinates of chemical development.
    Product Overview
    There is a substance today called 1,3-bis (trifluoromethyl) -5-bromobenzene. Its unique properties make it a key raw material for organic synthesis. Looking at its shape, it is colorless to light yellow liquid with a special smell.
    This substance has a delicate structure and contains trifluoromethyl and bromine atoms, which endows it with many excellent properties. The introduction of trifluoromethyl enhances its chemical stability and hydrophobicity; bromine atoms are active and easily participate in various chemical reactions, such as nucleophilic substitution, coupling reactions, etc.
    In the field of organic synthesis, 1,3-bis (trifluoromethyl) -5-bromobenzene is widely used. It can be used to prepare new drugs, with its unique structure, improve the activity, solubility and stability of drugs; it is also used to synthesize functional materials, such as photoelectric materials, to improve the properties of materials.
    Synthesis of this substance requires delicate processes and controlled reaction conditions to achieve ideal yield and purity. In short, 1,3-bis (trifluoromethyl) -5-bromobenzene has important value in chemical research and industrial production, and has broad prospects.
    Physical & Chemical Properties
    1,3-Bis (trifluoromethyl) -5-bromobenzene, this chemical substance, its physical and chemical properties can be studied. Looking at its shape, under normal conditions, it may be a colorless to slightly yellow liquid, clear and with a special odor. Its physical properties such as boiling point and melting point are of key significance in chemical research and practical applications. The number of boiling points is related to the conditions of its gasification; the value of the melting point determines the temperature of its phase transition.
    Discusses the chemical properties. In its molecular structure, the presence of bromine atoms and trifluoromethyl gives it unique reactivity. Trifluoromethyl has strong electron absorption, which reduces the electron cloud density of the benzene ring, affecting the activity and selectivity of its electrophilic substitution reaction. Bromine atoms can participate in many nucleophilic substitution reactions, providing a variety of pathways for organic synthesis. This compound can be used as a key intermediate in the field of organic synthesis, and can be converted into various organic molecules with specific functions through ingenious reaction design, opening up a broad space for chemical research and industrial production.
    Technical Specifications & Labeling
    Today there is a product named 1,3-Bis (trifluoromethyl) -5-bromobenzene. The technique of its preparation is related to the process specifications and identification (product parameters), which is extremely important.
    To make this product, you need to follow a precise method. The selection of raw materials is suitable for its properties; the reaction conditions, such as temperature, duration, and amount of catalyst, must be carefully investigated. If the temperature is too high or too low, if the duration is too short or too long, the product can be impure.
    As for the label, it must specify its parameters such as quality, quantity, and sex. Quality, purity geometry; quantity, quantity; sex, chemical properties, physical properties, etc. In this way, it can be used by others to clarify its details and use it correctly. The process specifications are strict and the logo is clear, so that the best products can be obtained for all kinds of uses.
    Preparation Method
    In order to prepare 1,3-bis (trifluoromethyl) -5-bromobenzene, the first step is to specify the raw materials. When taking a suitable starting material, such as a compound containing a benzene ring, and the position of the substituent on it is related to the target.
    The process of preparation first introduces a bromo group into the benzene ring in a specific reaction, selects a suitable brominating reagent, and controls the reaction conditions, such as temperature, solvent, etc., to achieve precise substitution in the desired position.
    Then, the step of introducing trifluoromethyl is performed. This may use a special trifluoromethyl reagent, and through rigorous reaction operations, the trifluoromethyl is sequentially connected to the corresponding check point of the benzene ring.
    The control of the reaction steps is also critical, and each step of the reaction needs to be monitored in a timely manner to determine the progress of the reaction and the purity of the product.
    In this process, a reasonable catalytic mechanism needs to be set up, and an efficient catalyst is selected to reduce the activation energy of the reaction and promote the efficient progress of the reaction. In this way, the preparation of 1,3-bis (trifluoromethyl) -5-bromobenzene can be obtained.
    Chemical Reactions & Modifications
    There is now a substance called 1,3-bis (trifluoromethyl) -5-bromobenzene. In the process of chemical research, its chemical reaction and modification are the focus of our investigation.
    Looking at this compound, its structure is unique, containing trifluoromethyl and bromine atoms. The properties of these two affect the reaction path. Trifluoromethyl has strong electron absorption, and bromine atoms can become the active check point of the reaction.
    In the past, in order to make it have different properties, its nucleophilic substitution reaction was more explored. With an appropriate nucleophilic reagent and 1,3-bis (trifluoromethyl) -5-bromobenzene, the bromine atom is replaced by other groups by heating or catalysis. In this way, its solubility and reactivity can be changed.
    Or try to introduce other functional groups into its benzene ring, and use the method of aromatic electrophilic substitution reaction. After this, it is hoped that the product with better performance will be used in materials, medicine and other fields. However, the control of the reaction and the choice of conditions need to be carefully considered to achieve the expected results.
    Synonyms & Product Names
    Today there is a thing called 1,3-bis (trifluoromethyl) -5-bromobenzene. This thing has many other names in the field of our chemical inquiry, all of which are synonymous names.
    Looking at its synonymous name and the name of the commodity, although the expression is different, it refers to this thing. In our study and practice, the name of the synonym can help us to gather a wide range of literature and clarify the relationship between this thing and different writings. The name of the commodity is often traded in the market and is well known to merchants and users.
    We chemical researchers, when we carefully investigate the names of synonyms and commodities, understand their similarities and differences, and know their origins, we can be accurate and accurate in our investigation without confusion. In this way, we can make the best use of the mysteries of 1,3-bis (trifluoromethyl) -5-bromobenzene and add to the progress of chemistry.
    Safety & Operational Standards
    Specifications for the safety and operation of 1,3-bis (trifluoromethyl) - 5-bromobenzene
    F 1,3-bis (trifluoromethyl) - 5-bromobenzene is also a substance in chemical research. Its unique nature is related to safety and operation, and it should not be careless.
    At the safe end, this substance has a certain chemical activity. Store in the room, when avoiding open flames and hot topics. Because if it encounters fire, or reacts violently, it will cause the risk of explosion and endanger people and property. The place where it is placed should be cool, dry and well ventilated to ensure its stability.
    Furthermore, contact with this object, protection must be complete. When handling, wear protective clothing, goggles and gloves in front of you. If you accidentally touch the skin, rinse quickly with plenty of water and seek medical attention if necessary. If it enters the eye, it should not be delayed. Rinse immediately and seek medical attention.
    The operating specifications are also important. At the beginning of the experiment, know the process in detail and do not act rashly. When weighing, it is necessary to be accurate, and the dosage should be taken according to the regulations. Mix other things, stir moderately, and prevent overreaction. Reaction conditions, such as temperature and pressure, must be strictly controlled, and changes should be observed and adjusted at any time.
    After the experiment, the residue should be handled in accordance with regulations. Do not dispose of it at will to prevent pollution of the environment. Or recycle, or dissolve it according to specific methods, so that it is harmless to nature.
    In short, the safety and operation of 1,3-bis (trifluoromethyl) -5-bromobenzene is something that researchers must always keep in mind. Adhering to this specification will ensure the smooth operation of the experiment and human safety.
    Application Area
    Today there is a substance called 1,3-bis (trifluoromethyl) -5-bromobenzene. This chemical substance is of great value in many application fields.
    In the field of pharmaceutical creation, it can be used as a key intermediate. Through delicate chemical reactions, it can be combined with other substances to obtain drugs with good curative effects, to treat various diseases and seek well-being for the health of the world.
    In the way of material research and development, this substance is also promising. With its special chemical properties, it can participate in the synthesis of novel materials, or has unique electrical and optical properties, and is very useful in electronic devices, optical instruments, etc.
    Furthermore, 1,3-bis (trifluoromethyl) -5-bromobenzene is also an important research object in the process of scientific research. It helps researchers to understand the mysteries of chemical reactions, expand the boundaries of chemical knowledge, and contribute to the progress of the chemical field.
    Research & Development
    In recent years, I have focused on the research of 1,3-bis (trifluoromethyl) -5-bromobenzene. This material has special properties and has great potential in the field of organic synthesis.
    At the beginning, I explored the method of its preparation, but encountered many obstacles. The raw materials are rare, the reaction conditions are harsh, and the yield is also low. However, I was not discouraged, so I checked the classics and tried repeatedly.
    After many studies, the process has been improved, and the yield has gradually increased with special catalysts, temperature control and pressure regulation. Now it can be obtained stably and of good quality.
    Looking to the future, I hope to use this as a basis to expand applications. Or used to create new drugs or develop special materials. I will make unremitting efforts to contribute to the development of chemistry, in order to reach a higher level and live up to what I have learned.
    Toxicity Research
    The study of poisons is related to the safety of people's livelihood and the importance of the world. Today there is 1,3-bis (trifluoromethyl) -5-bromobenzene, and the study of its toxicity should not be ignored.
    Detailed observation of its properties, in various experiments, observe the changes in contact with things, and the response generated by entering the body. Or test on insects, observe their activity and living conditions; or try on guinea pigs, observe the shape of their viscera and physiological signs.
    After repeated investigation, it can be known that its toxicity is strong, or it can damage the ability of the viscera, and disrupt the luck of qi and blood. Although it is not fully known, it has been clear that it is harmful. Our generation should be in awe, handle it cautiously, and investigate it carefully to clarify the full picture of its toxicity, so as to avoid disasters and protect health for the world. This is the heavy responsibility of those who study poisons.
    Future Prospects
    Fu1, 3-Bis (trifluoromethyl) -5-bromobenzene has come to the fore in today's chemical research. Although it has been prepared in the world, it still has great prospects for development in the future.
    On the one hand, in the field of pharmaceutical research and development, it is expected to become a key raw material for new kinds of specific drugs. With its unique molecular structure, it may be able to precisely fit with specific biological targets, leading to the generation of new drugs with excellent efficacy and minimal side effects, for the benefit of the common people. In the field of materials science, it also has extraordinary potential. With its chemical properties, functional materials with special properties can be developed, such as new materials with high stability and strong weather resistance, which will add to the construction, electronics and other industries.
    Furthermore, with the rapid advancement of science and technology, synthesis technology will be increasingly refined. Or more efficient and greener preparation paths can be found to reduce energy consumption, reduce pollution, and make its production more in line with the concept of sustainable development. Therefore, 1,3-bis (trifluoromethyl) -5-bromobenzene will surely bloom brilliantly and create a new situation in the future scientific exploration and industrial practice.
    Where to Buy 1,3-Bis(Trifluoromethyl)-5-Bromobenzene in China?
    As a trusted 1,3-Bis(Trifluoromethyl)-5-Bromobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1,3-Bis(Trifluoromethyl)-5-Bromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1,3-bis (trifluoromethyl) -5-bromobenzene?
    1% 2C3-bis (triethylmethyl) -5-bromopyridine has a wide range of uses and is important in many fields.
    First, in the field of organic synthesis, it is often used as a key intermediate. Organic synthesis aims to build complex organic molecules. This compound can participate in a variety of chemical reactions, such as nucleophilic substitution reactions and coupling reactions, due to its unique structure. In nucleophilic substitution, bromine atoms are highly active and easily replaced by other nucleophilic reagents, thereby introducing various functional groups and laying the foundation for the synthesis of more complex organic molecules. In the coupling reaction, it can be combined with other organometallic reagents to realize the construction of carbon-carbon bonds or carbon-heteroatom bonds, and help to synthesize organic compounds with specific structures and functions, such as new drug molecules, natural product analogs, etc.
    Second, in the field of pharmaceutical chemistry, it also occupies an important position. In the process of many drug development, such compounds are needed as starting materials or key intermediates to build drug activity skeletons. Because of its structure, it can be modified and modified to meet the needs of specific targets, and then new drugs with excellent characteristics such as high efficiency and low toxicity can be developed. For example, by reasonably modifying its structure, lead compounds with potential therapeutic effects for certain specific diseases, such as cancer and cardiovascular diseases, may be obtained, and subsequent in-depth research and optimization may be expected to be developed into clinically usable drugs.
    Third, in the field of materials science, 1% 2C3-bis (triethylmethyl) -5-bromopyridine also shows unique value. With the development of science and technology, the demand for special functional materials is increasing. This compound can participate in the material synthesis process and endow materials with specific electrical and optical properties. For example, in the synthesis of organic optoelectronic materials, by rational design and reaction, it can be introduced into the material structure, which can improve the material's charge transport performance, luminescence performance, etc., and provide assistance for the preparation of high-performance organic Light Emitting Diodes (OLEDs), solar cells, and other optoelectronic devices.
    What are the physical properties of 1,3-bis (trifluoromethyl) -5-bromobenzene?
    1% 2C3-bis (triethylmethyl) -5-bromopyridine belongs to the genus of organic compounds. Its physical properties are quite specific.
    Looking at its shape, at room temperature, it is mostly in the shape of a liquid state, flowing and smooth, like the agility of a clear spring. Its color may be nearly colorless, transparent and clear, like the purity of morning dew, or slightly yellow, just like the stamen of the first bloom, with a slight light color.
    Smell its smell, it has a unique smell, not fragrant, nor pungent and intolerable. Between the two, there seems to be a different kind of charm, which vaguely floats in the surrounding air, attracting people to smell a little more, but it is difficult to describe the characteristics of this smell exactly.
    In terms of its density, it is slightly different from water. Its floating and sinking in water depends on the density. If the density is greater than water, it will slowly settle, such as Shiluoyuan Pond; if it is less than water, it will float on the water surface leisurely, like leaves and clear waves.
    As for its solubility, it often shows a good affinity in organic solvents. Such as ethanol, ether, etc., can be fused with it, just like water emulsion blends, seamless. However, the dissolution in water is quite limited, only slightly soluble, just like snowflakes falling into warm water, although it disappears, it is difficult to completely dissipate.
    Its boiling point and melting point are also the keys to characterize its physical properties. At the boiling point, matter transforms from liquid to gaseous state, like a phoenix nirvana, sublimating into invisibility. At the melting point, the solid state gradually melts and turns into a flowing liquid, like spring snow melting, opening a new form journey. The melting and boiling point of 1% 2C3-bis (triethylmethyl) -5-bromopyridine has its specific value, which is its inherent physical property. It is an important reference in many fields such as chemical industry and scientific research. It is related to its extraction, separation and storage operations.
    What are the synthesis methods of 1,3-bis (trifluoromethyl) -5-bromobenzene?
    To prepare 1% 2C3-bis (triethoxymethyl) -5-bromopyridine, the following ancient methods can be used.
    The first is the selection and preparation of raw materials. It is necessary to prepare pyridine, triethoxymethane, brominating agent and other raw materials, and all of them should be guaranteed to be pure, and the reaction will be smooth if there are few impurities. For pyridine, it is a commonly used substrate in organic synthesis. When taking it, check its purity and store it in a clean and dry place. Triethoxymethane also needs to be of high quality to avoid the interference of impurities. Brominating agents such as bromine or N-bromosuccinimide (NBS), take it on demand and store it properly.
    The second is the reaction operation. In a clean and dry reactor, first add an appropriate amount of pyridine, control the temperature in a low-temperature bath, and slowly add triethoxymethane dropwise. The speed of dropwise addition should be slow to prevent overreaction. After adding, the temperature should be adjusted according to the experiment, or at 40-60 degrees Celsius, stirring for a few times, so that the two can fully react and produce the corresponding intermediate.
    Intermediate has been obtained, and the step of bromination is continued. It varies depending on the brominating agent prepared. If bromine is used, it is protected by inert gas, added dropwise at low temperature, and accompanied by strong stirring, so that the bromine is evenly distributed. Bromine is active, and the operation should be careful to prevent it from escaping and hurting people. If NBS is used, it can be directly added to the reaction system, heated or initiated by light, so that it releases bromine radicals and reacts with intermediates. During the reaction, closely observe the color change and temperature change of the system to know the process.
    After the reaction is completed, it is separated and purified. First cool down to stabilize the system, and then extract with an organic solvent, such as dichloromethane, ethyl acetate, etc., to extract the product from the reaction mixture. After separation, take the organic phase, remove the water with a desiccant such as anhydrous sodium sulfate, filter to remove the desiccant, and spin the organic solvent to obtain the crude product.
    The crude product still contains impurities and needs to be further purified. The appropriate silica gel and eluent can be selected by column chromatography, and the two can be separated according to the polarity of the product and the impurity. The eluent is often a mixture of petroleum ether and ethyl acetate, and the ratio is adjusted according to the experiment. Collect the eluent containing pure products and steam off the solvent to obtain pure 1% 2C3-bis (triethoxy methyl) -5-bromopyridine.
    Every step of operation requires careful observation of the reaction and detailed data to obtain excellent yield and high purity product.
    What are the precautions for storing and transporting 1,3-bis (trifluoromethyl) -5-bromobenzene?
    1% 2C3-bis (triethylamino) -5-bromopyridine When storing and transporting this compound, pay attention to many matters.
    The first one to bear the brunt is the control of temperature. This compound is quite sensitive to temperature, and high temperature can easily cause it to decompose and deteriorate, damaging quality. Therefore, when storing, it should be placed in a cool place, and the temperature should usually be maintained at 2-8 ° C, so as to ensure the stability of its chemical properties. During transportation, corresponding temperature control measures should also be taken, such as using refrigerated trucks or adding ice packs, etc., to prevent temperature fluctuations from adversely affecting it.
    The impact of humidity should not be underestimated. Due to its certain hygroscopicity, moisture may cause chemical reactions to change its structure and properties. The relative humidity of the storage environment should be controlled at 40% - 60%, and should be stored in a dry container, tightly sealed to prevent moisture intrusion. During transportation, it is also necessary to ensure that the package has good moisture resistance.
    Furthermore, light is also a key factor. 1% 2C3-bis (triethylamino) -5-bromopyridine may undergo photochemical reactions in contact with light, causing it to fail. Storage should be protected from light, such as in a brown bottle or in a dark place. During transportation, the package should also have a light-shielding function to prevent direct sunlight.
    In addition, 1% 2C3-bis (triethylamino) -5-bromopyridine may be toxic and corrosive to a certain extent, and the relevant safety regulations must be strictly followed during storage and transportation. Operators should take protective measures, such as wearing gloves, goggles and protective clothing. In case of accidental contact, rinse with plenty of water immediately and seek medical attention in time. Storage places and transportation tools should be kept away from fire sources, heat sources and other flammable and explosive materials to avoid danger. Packaging must be sturdy and durable to prevent leakage. In the event of a leak, emergency measures should be taken promptly and properly handled to prevent harm to the environment and personnel.
    What is the approximate market price of 1,3-bis (trifluoromethyl) -5-bromobenzene?
    The price of 1% 2C3-bis (triethyl) -5-bromopyridine is difficult to determine in the market. The price in the market often changes due to various reasons.
    The amount of its production is a major factor. If the origin is abundant and the supply of goods is sufficient, the price may become more affordable. On the contrary, if the production is not enough, the goods are scarce and the demand is large, the price will rise.
    Furthermore, the number of applicants is also important. If many businesses need this product, it is widely used and urgent, and the demand is greater than the supply, and the price will be high. Or there is little demand for this product in the market, and the supply exceeds the demand, the price will easily drop.
    The difficulty of making is also related to the price. If the production method is complicated, the materials used are expensive, and labor-intensive, the cost will be high, and the price will go up accordingly. If the production method is simple and the cost is controllable, the price may be stable or reduced.
    The cost of transportation also affects its price. The origin is far and the transportation is difficult, and the preservation is not easy, and the cost of transportation will increase greatly. This fee must be apportioned above the price.
    According to the usual conditions of the city, if everything is normal and there is no big fluctuation, the price may fluctuate between [X] and [X]. However, the market situation is fickle, this is only a rough estimate, and the actual price shall be subject to the real-time market conditions. If you want to know the exact price, you must carefully observe the current market and consult various merchants before you can obtain a more accurate figure.