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What is the use of 1, 3 - Benzenedicarbonitrile, 4 - Fluoro -
1% 2C3-benzodimethonitrile, 4-fluoro- (ie 4-fluoro-1,3-benzodimethonitrile) This substance has a wide range of uses. In the field of medicinal chemistry, it can be used as a key intermediate to help create new drugs. With its unique chemical structure, it can participate in many reactions, thereby synthesizing compounds with specific pharmacological activities, opening up new paths for pharmaceutical research and development.
In the field of materials science, 4-fluoro-1,3-benzodimethonitrile can be used to prepare high-performance polymer materials. Its addition can effectively improve the thermal stability, mechanical properties and chemical stability of polymers. For example, the introduction of this substance in the synthesis of special engineering plastics can significantly improve the performance of the material in harsh environments such as high temperature and chemical corrosion, and then it is widely used in aerospace, electronics and other fields that require extremely high material properties.
In organic synthetic chemistry, it is often used as a starting material or a reaction intermediate, participating in the construction of complex organic molecular structures. Because of its nitrile and fluorine atoms, it can be derived through various chemical reactions, such as the hydrolysis of nitrile groups to form carboxyl groups, or the reaction of nucleophilic substitution with other reagents, thereby preparing a wide variety of organic compounds, greatly enriching the "raw material library" of organic synthesis, and promoting the development and innovation of organic synthetic chemistry.
What are the physical properties of 1, 3 - Benzenedicarbonitrile, 4 - Fluoro -
1% 2C3 + -phthalonitrile, 4-fluoride, that is, 4-fluoro-1,3-phthalonitrile, this material has many physical properties. Its appearance is often white to light yellow crystalline powder, which is easy to observe and handle.
The melting point is between 124 ° C and 128 ° C. As an important characteristic of a substance, the melting point is of great significance in the identification and purification process. In this temperature range, the substance changes from solid to liquid state, and its purity can be determined. The higher the purity, the narrower the melting point range.
The boiling point of the substance is about 346.5 ° C, and it will change from liquid to gas at high temperature. The boiling point of this substance is influenced by the intermolecular force. The higher boiling point of this substance indicates that the intermolecular force is strong.
From the perspective of solubility, it is difficult to dissolve in water. Water is a common solvent, and it is difficult to dissolve in water, reflecting the weak interaction between the substance and water molecules. However, it is soluble in some organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF). This property is crucial in the field of organic synthesis and separation, and researchers can choose suitable solvents to carry out reactions or separation operations.
The density of 4-fluoro-1,3-benzodimethylnitrile is about 1.32 g/cm ³. Density, as an inherent property of the substance, needs to be considered in the planning of product storage and transportation.
In addition, the substance has good stability and is not easy to react with common substances such as oxygen and moisture in the air at room temperature and pressure, which provides convenience for its storage and use. However, under specific conditions, such as high temperature and strong acid-base environment, its chemical properties will become active and corresponding chemical reactions will occur.
What are the chemical properties of 1,3 - Benzenedicarbonitrile, 4 - Fluoro -
The chemical properties of this compound are as follows:
In terms of physical properties, it is usually in the solid form. Due to the cyanide group and fluorine atom, the intermolecular force presents a specific situation. Cyanide (-CN) has strong polarity and can enhance the intermolecular dipole-dipole interaction, so its melting point, boiling point or higher than compounds with similar structures but no such polar groups. Although fluorine atoms are small, they also contribute to molecular polarity due to their large electronegativity, or affect their solubility in different solvents. Generally speaking, due to its polar groups, it may have a certain solubility in polar solvents such as alcohols and ketones.
Chemically, the cyanyl group has high activity. Hydrolysis can occur, and under acidic or basic conditions, the cyanyl group can be gradually converted into a carboxyl group (-COOH). Hydrolyzed in acidic media, Mr. Amide (-CONH ²) is formed, and then hydrolyzed into carboxylic acids; under alkaline conditions, the hydrolysis process may be faster. Cyanyl groups can also participate in nucleophilic addition reactions, and many nucleophilic reagents such as alcohols and amines can react with them to form new compounds containing nitrogen or oxygen, thereby expanding the molecular structure and deriving a variety of organic synthesis products.
Furthermore, although the fluorine atoms on the benzene ring are relatively stable, they can also participate in the reaction under certain conditions. Due to its high electronegativity, the electron cloud density of the benzene ring can be reduced, which affects the electrophilic substitution reaction activity and check point selectivity on the benzene ring. When the electrophilic substitution reaction is carried out, the electron cloud density of the adjacent and para-position of the fluorine atom is relatively high, and the electrophilic reagents may be more inclined to attack this position. At the same time, the fluorine atom can affect the overall chemical behavior and molecular accumulation mode of the compound by forming weak interactions with other atoms or groups, such as fluorine bonds, which may have potential application value in the field of supramolecular chemistry.
In summary, 1,3-phenyldimethylnitrile, 4-fluorine-cause contain cyanyl and fluorine atoms, which have unique physical and chemical properties and have important research significance and application potential in many fields such as organic synthesis and materials science.
What is the synthesis method of 1,3 - Benzenedicarbonitrile, 4 - Fluoro -
The synthesis of 1% 2C3-phenyldimethylnitrile and 4-fluorine is related to the delicacy of chemical technology. This synthesis method is based on chemical principles and existing experience.
First of all, the choice of raw materials is crucial. To obtain this compound, select the relevant raw materials containing benzene ring, cyano group and fluorine atom. The benzene ring can provide the backbone for the synthesis, and the cyano group and fluorine atom are the key substituents. Suitable halogenated benzene compounds are commonly selected. Due to the suitable activity of the halogen atom, the cyano group and fluorine atom can be introduced through subsequent reactions.
Second, the method of cyano group introduction. Nucleophilic substitution reaction with halogenated benzene is often carried out with cyanide reagents, such as potassium cyanide (KCN) or sodium cyanide (NaCN), under suitable reaction conditions. This process requires careful control of the reaction temperature, solvent and reaction time. If the temperature is too high, it is easy to cause side reactions to occur; if the temperature is too low, the reaction rate will be slow. Commonly used solvents include dimethyl sulfoxide (DMSO) or N, N-dimethylformamide (DMF), which can promote the smooth progress of the reaction due to its good solubility to raw materials and reagents.
Furthermore, the introduction of fluorine atoms. Nucleophilic fluorination reagents, such as potassium fluoride (KF), can be used. This step also requires attention to the reaction conditions, especially the selectivity of the fluorine atom introduction Through the analysis of the localization effect of the substituents on the benzene ring, the appropriate reaction path can be selected to ensure the accurate introduction of fluorine atoms into the target position.
Separation and purification are also important in the whole synthesis process. After the reaction, the product is often mixed with impurities such as unreacted raw materials and by-products. According to the differences in the physical and chemical properties of the product and the impurity, methods such as distillation, recrystallization, column chromatography, etc. can be used for separation and purification to obtain high-purity 1% 2C3-benzodimethylnitrile, 4-fluorine products. In this way, the effective synthesis of this compound can be obtained.
1,3 - Benzenedicarbonitrile, 4 - Fluoro - in which areas
1%2C3+-+Benzenedicarbonitrile%2C+4+-+Fluoro is 4-fluoro-1,3-phenyldimethylnitrile, which is widely used and has applications in many fields.
First, in the field of materials science, it can be used as a key raw material for the synthesis of high-performance polymers. Due to its unique chemical structure, it can endow polymers with excellent thermal stability, chemical stability and mechanical properties. By polymerizing with other monomers, engineering plastics, fiber materials, etc. can be prepared with excellent performance, which are widely used in aerospace, automotive manufacturing and other industries that require strict material properties. For example, in aerospace, such high-performance polymers can be used to manufacture internal structural components of aircraft, reducing weight while ensuring structural strength.
Second, in the field of organic synthesis, it is an important intermediate. With the activity of benzene ring with cyano and fluorine atoms, many organic compounds can be derived through various chemical reactions. It can participate in nucleophilic substitution, addition and other reactions, providing the possibility for the synthesis of organic molecules with specific functions, such as the preparation of new drug molecules, pesticide active ingredients and functional dyes. Taking drug synthesis as an example, it can be used as a starting material to construct molecular structures with unique pharmacological activities through multi-step reactions.
Third, in the field of electronics, the materials it participates in the synthesis can be used to make electronic devices. Such as some organic semiconductor materials, the molecular structures constructed by 4-fluoro-1,3-benzodimethanonitrile can have good charge transport properties, which is expected to be applied to organic Light Emitting Diode (OLED), organic field effect transistor (OFET) and other devices, and promote the development of electronic devices to be flexible and wearable.
Fourth, in the study of new catalysts, 4-fluoro-1,3-benzodimethanonitrile can be used as a ligand to complex with metal ions to form a metal complex catalyst with unique catalytic activity. Such catalysts exhibit high selectivity and catalytic efficiency in organic synthesis reactions, which can promote reactions that are difficult to achieve by traditional methods, providing a new way for the development of organic synthesis chemistry.