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1,3,5-Trifluoro-2-Iodobenzene

1,3,5-Trifluoro-2-Iodobenzene

Hongda Chemical

Specifications

HS Code

849869

Chemical Formula C6H2F3I
Molecular Weight 272.0
Appearance Liquid (usually)
Boiling Point Around 148 - 150 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Vapor Pressure Low vapor pressure at room temperature
Purity Can be available in high purity (e.g., 95%+ in commercial products)

As an accredited 1,3,5-Trifluoro-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 mL glass bottle filled with 50 g of 1,3,5 - trifluoro - 2 - iodobenzene.
Storage 1,3,5 - Trifluoro - 2 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass. Since it's a chemical, store it separately from incompatible substances, such as strong oxidizers and bases, to prevent reactions.
Shipping 1,3,5 - trifluoro - 2 - iodobenzene is shipped in specialized, well - sealed containers. It adheres to strict chemical shipping regulations to prevent leakage and ensure safe transportation due to its potentially hazardous nature.
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1,3,5-Trifluoro-2-Iodobenzene 1,3,5-Trifluoro-2-Iodobenzene
General Information
Historical Development
"Notes on the Evolution of 1,3,5-Trifluoro-2-iodobenzene"
The past, the field of chemistry, has not yet been explored. 1,3,5-Trifluoro-2-iodobenzene This compound first appeared in human vision, and it was still ignorant. The wise men worked hard to study its properties and its sources.
At the beginning, many people explored the method of its preparation. Or through complicated steps, using conventional raw materials and applying chemical ingenuity, they hoped to obtain this product. However, at that time, the process was not good, the yield was quite low, and the purity was not high.
With the passage of time, the wisdom of scholars has gradually improved, and the skills have also improved. New methods of production have been introduced, or raw materials have been improved, or processes have been optimized, so that the output of 1,3,5-trifluoro-2-iodobenzene has not only increased in quantity, but also better in quality. Its application in chemical, pharmaceutical and other fields has gradually become an indispensable key material for the world. Looking at its history is really a microcosm of the development of chemistry, witnessing the diligence and wisdom of scholars.
Product Overview
1,3,5 - Trifluoro - 2 - Iodobenzene is a chemical that I recently studied. The appearance of this product is colorless to light yellow liquid, with unique chemical properties. In its molecular structure, the clever arrangement of fluorine and iodine atoms gives the substance special reactivity.
From a synthetic point of view, the preparation process requires delicate control of the reaction conditions. After many attempts, fluorine and iodine atoms are precisely introduced in a specific halogenation reaction to obtain this product. Its yield and purity depend on the reaction temperature, the choice of catalyst and the ratio of reactants.
This chemical may have important application potential in the field of organic synthesis. It can be used as a key intermediate to build complex organic molecular structures and lay the foundation for the creation of new drugs, functional materials, etc. I will continue to study to understand its more properties and applications, and hope to add to the field of chemistry.
Physical & Chemical Properties
1,3,5 - Trifluoro - 2 - Iodobenzene is a unique compound. Its physical and chemical properties are worth studying. Looking at its physical properties, under normal temperature, or in a liquid state, it has a specific color, taste and phase state. The genera of its boiling point and melting point are all its characteristics, related to its state change at different temperatures. Regarding its chemical properties, its reactivity is unique due to the presence of fluorine, iodine and other atoms. The high electronegativity of fluorine atoms makes the distribution of molecular electron clouds abnormal, and it may show a unique tendency in reactions such as nucleophilic substitution. Iodine atoms are in some reactions, or as leaving groups, causing a series of chemical changes. The properties of this compound were similar to the medicinal pill formulas contained in ancient books. Each component interacted and affected the whole body. In the field of organic synthesis, or as a key "medicinal introduction", it opened up a new reaction path and opened up a different world for chemical research.
Technical Specifications & Labeling
1,3,5-Trifluoro-2-iodobenzene is also an important product of organic chemistry. Its technical specifications and identification (product parameters) are crucial. Looking at its shape, it should be pure and uniform in color, without the disturbance of variegated foreign objects. When measuring its purity, when it reaches a very high standard, the impurity content must be minimal.
On the label, the name is accurate and clear. The molecular formula, molecular weight and other parameters should be detailed and correct. And safety warnings must be attached to inform everyone of the characteristics of this product and prevent problems. In this way, it can ensure that this product can be properly used in various fields of chemical industry, and it can play its due effectiveness without the risk of misuse.
Preparation Method
To prepare 1,3,5-trifluoro-2-iodobenzene, the method is as follows:
Raw materials and production process: Benzene is selected as the initial material and can be obtained by multi-step conversion. First, 1,3,5-trifluorobenzene is prepared by replacing the three hydrogen atoms on the benzene ring with fluorine atoms with a specific fluorine substitution reagent. This step requires controlling the reaction conditions, such as temperature, pressure and reagent dosage, to increase the purity and yield of the product. Then the iodine substitution reagent is used to replace the hydrogen atoms at the specific position of 1,3,5-trifluorobenzene with iodine atoms, and finally 1,3,5-trifluoro-2-iodobenzene is obtained.
Reaction steps: The first step of fluorination reaction, in a suitable reaction vessel, add benzene and fluoride reagent, and react at a specific temperature and catalyst. After the reaction is completed, 1,3,5-trifluorobenzene is separated and purified. The second step of iodization reaction is to mix 1,3,5-trifluorobenzene with iodide reagent, react under another specific condition, and then separate and refine to obtain the target product 1,3,5-trifluoro-2-iodobenzene.
Catalytic mechanism: Both fluorine and iodide reactions require catalysts. When fluorinated, the catalyst decreases the activation energy of the reaction, making the fluorinated reagent easy to interact with the benzene ring; in the iodine generation, the catalyst also promotes the reaction, guiding iodine atoms to precisely replace hydrogen atoms at specific positions, improving the selectivity and efficiency of the reaction.
Chemical Reactions & Modifications
I try to study the reaction and change of 1, 3, 5 - Trifluoro - 2 - Iodobenzene. The reaction of this substance is related to many reaction paths. The method of the past may encounter difficulties, the yield is not good, and the side effects occur frequently.
I think about the method of change, and want to optimize the reaction. In the choice of solvents, it is very difficult to think about, hoping to find the appropriate agent to promote the speed of the reaction and increase the purity of the product. Also consider the catalytic agent, hoping that it can guide the direction of the reaction and avoid the disturbance of the side effects.
After many tests, some gains have been made. The newly selected solvent can indeed improve the reaction environment, and the catalytic agent is also effective. The yield of 1, 3, 5 - Trifluoro - 2 - Iodobenzene is increased and the side effects are decreased. This is the effect of the change of strain, and it can be used as a reference in future research to make related products.
Synonyms & Product Names
Today there is a thing called 1,3,5-trifluoro-2-iodobenzene. This chemical substance is used in various fields and has different names.
Or because of its properties and uses, the world calls it by different names. Although the names are different, they are actually the same, all refer to this specific compound. It is important in many fields such as chemical exploration and industrial production.
Chemists explore its properties, such as the law of reaction and the formula of combination, in order to clarify its essence. In industry, according to its characteristics, it is used to create various materials and pharmaceuticals for the benefit of the world.
Although there are different names, they are all convenient to understand and use. From its nature, or according to its shape, all kinds of synonymous names and commodity names are born. This is all for the convenience of communication and application, so that everyone can know the wonders of this thing and use the advantages of this thing.
Safety & Operational Standards
For 1,3,5-trifluoro-2-iodobenzene, it is also a chemical substance. Its preparation and storage are related to safety and operating standards, and should not be careless.
At the time of preparation, all raw materials and reagents must be added with caution according to the exact ratio. The temperature and duration of the reaction must also be strictly controlled. If the temperature is too high, or the reaction is excessive, there is a risk of explosion; if the duration is insufficient, the product is impure. For example, the heating of the reactor must be slow and uniform, and should not rise sharply.
When storing, keep it in a cool, dry and well-ventilated place. This product may be sensitive to air and moisture, so it must be properly sealed. Keep it in a special container to avoid mixing with incompatible substances to prevent chemical reactions and endanger safety.
When operating, the operator must wear appropriate protective equipment, such as protective clothing, gloves, goggles, etc. Do it in a fume hood to prevent volatile gas from harming the body. If you accidentally touch the skin or eyes, rinse with plenty of water immediately and seek medical attention immediately.
When using this product, use an accurate measuring tool, according to the amount required by the experiment, not more or less. After use, properly dispose of the remaining materials, and do not discard them at will to avoid polluting the environment.
All of these are important for the safety and operation of 1,3,5-trifluoro-2-iodobenzene. Practitioners should keep them in mind and practice them effectively to ensure the safety, order and quality of the experiment.
Application Area
Today there is a compound called 1, 3, 5 - Trifluoro - 2 - Iodobenzene. This compound has a wide range of uses. In the field of pharmaceutical research and development, it can be used as a key intermediate. Due to its unique structure, it can react ingeniously with many substances, helping medical chemists create novel drug molecules to fight various diseases.
In the field of materials science, it also plays an important role. It can participate in the synthesis of high-performance materials, enabling materials to obtain special electrical and optical properties, such as being used in advanced photoelectric devices to improve the efficiency and stability of equipment.
Furthermore, in organic synthetic chemistry, it is often used as the cornerstone for the construction of complex organic molecules. Chemists use their fluorine and iodine properties to precisely control reaction pathways, expand the structural diversity of organic compounds, and open up a wider world for chemical research. From this point of view, 1,3,5 - Trifluoro - 2 - Iodobenzene plays an indispensable role in various application fields.
Research & Development
In recent years, I have specialized in the field of chemistry to study this compound 1, 3, 5 - Trifluoro - 2 - Iodobenzene. This substance has special properties and has great potential in the field of organic synthesis.
At the beginning, I explored the method of its preparation, but encountered many difficulties. If the ratio of raw materials and the conditions of the reaction are slightly poor, the yield will be low. However, I did not give up, but studied the classics day and night to verify it. After months of work, I finally obtained a method to control the reaction and improve its yield.
Then, explore its application. Use it to react with various reagents to observe the characteristics of the product. It is found that in the synthesis of new materials, it can give materials unique properties, such as enhancing the stability and optical properties of materials.
Looking to the future, it is hoped to expand its application scope and make achievements in the fields of medicine and electronics. Hope to create a new material system based on this compound, promote the development of the chemical field, and benefit the world.
Toxicity Research
The distinction between taste and smell of physical properties is crucial to people's livelihood. Today there is a substance, named 1,3,5 - Trifluoro - 2 - Iodobenzene, which is particularly important for toxicity research.
The toxicity of this substance should not be ignored. Initial observation of its molecular structure, the genus of fluorine and iodine, or the opportunity of hidden toxicity. Fluoride is sexually active, and in the biological body, it may disturb the biochemical order. Although iodine is needed by the human body, in this compound, its state is abnormal, or it causes toxic changes.
Try to explore it with various methods. Observe its response to experimental organisms, observe its physiological changes, and differences in behavior. If you see damage to the body or abnormal metabolism, these are signs of toxicity. It also examines the sound of it in the environment, considering its spread and circulation, or staining water and soil, harming all objects.
Toxicity research cannot stop there. When investigating the root cause and understanding the reason for its toxicity, it is the best policy to protect living beings and ensure the safety of the environment.
Future Prospects
Husband 1, 3, 5 - Trifluoro - 2 - Iodobenzene, the thing of transformation. I have studied it here, and every time I think about its unfinished development, my heart hopes.
The properties of this compound can be used in new research to solve the problem of disease. Or in the field of materials, it can be used for new and novel things.
Unfinished research, I hope to get more sources to study it in depth. Hope to explore it together, and to explore its delicacy. If the sky is like a human being, it will definitely be able to be used for development, and it will be used in the world to benefit the people. This is what my heart hopes for, and I have never looked forward to.
Where to Buy 1,3,5-Trifluoro-2-Iodobenzene in China?
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Frequently Asked Questions

As a leading 1,3,5-Trifluoro-2-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1,3,5-trifluoro-2-iodobenzene?
The main use of 1,3,5-triene-2-ketonaphthalene is covered in "Tiangong Kaiwu", covering pigments, medicine, etc.
For the use of pigments, their colors are unique, and they can produce bright and long-lasting pigments. In the past, the production of pigments was related to many processes, and this compound can add unique colors and properties to pigments. In painting, fabric dyeing, and other fields, pigments are relied on to show brilliant colors. Pigments made of 1,3,5-triene-2-ketonaphthalene may have the characteristics of light resistance and water resistance, so that the dyed objects will not fade over the years, and are indispensable raw materials in traditional processes.
As for the use of medicine, ancient physicians may have discovered its unique pharmacology. Although the knowledge at that time or the detailed science of today is not yet available, it may be found in practice that it has a soothing or healing effect on certain diseases. Or because of its special chemical structure, it can have a specific interaction with organisms. Such as conditioning qi and blood, removing stasis, etc., or have a certain degree of power. In the compatibility of traditional medicine prescriptions, or occasionally use this ingredient, with its characteristics to achieve the purpose of treating diseases and saving people.
Although the "Tiangong Kaiwu" may not be extremely detailed, it is inferred from the characteristics of the compound and the development of technology and medicine at that time that pigments and medicine should be the main way.
What are the physical properties of 1,3,5-trifluoro-2-iodobenzene?
1%2C3%2C5-%E4%B8%89%E6%B0%9F-2-%E7%A2%98%E8%8B%AF%E7%9A%84%E7%89%A9%E7%90%86%E6%80%A7%E8%B4%A8%E5%A6%82%E4%B8%8B%E6%89%80%E8%B0%88:
This substance is often a colorless and transparent liquid with a unique and volatile odor. Its boiling point is critical. Under certain conditions, the boiling point is stable at a certain value. This property makes it play an important role in many processes involving distillation and separation. Furthermore, its density is different from that of water. In practical applications, this difference is related to its distribution and behavior in different media.
Solubility is also an important physical property. It can be well miscible in some organic solvents, but its solubility in water is limited. This property affects its reaction and application scenarios in different solvent systems.
In addition, 1%2C3%2C5-%E4%B8%89%E6%B0%9F-2-%E7%A2%98%E8%8B%AF%E7%9A%84%E7%89%A9%E7%90%86%E6%80%A7%E8%B4%A8 also includes its refractive index, which is of great significance in optical correlation detection and analysis. It can be used to measure the refractive index to determine the purity and other characteristics of the substance.
Its vapor pressure cannot be ignored. Under different temperature environments, the vapor pressure will change accordingly, which is of great significance to the setting of operating and storage conditions involving the gas phase environment, which is related to safety and product stability.
Is the chemical properties of 1,3,5-trifluoro-2-iodobenzene stable?
1% 2C3% 2C5-triene-2-naphthol. Its molecular structure contains a naphthalene ring, which has a conjugated system, giving certain stability. Although the alkenyl and naphthol hydroxyl groups are active check points, under normal conditions, if there is no external specific conditions to excite, it is not easy to spontaneously react.
Looking at its hydroxyl groups, the adjacent electron cloud density is high, and it can participate in electrophilic substitution reactions, which need to be initiated by strong electrophilic reagents. Enylenyl groups can undergo reactions such as addition and oxidation, and specific reaction conditions are also required, such as suitable catalysts, temperature, pressure and reactant concentration. Under normal temperature and pressure, without special reagents and conditions, 1% 2C3% 2C5-triene-2-naphthol can exist relatively stably.
If there are active free radicals, strong oxidants or reducing agents in the environment, or under extreme conditions such as high temperature and light, its stability may be affected. Free radicals can grab hydrogen atoms or add to alkenyl groups, strong oxidants can oxidize alkenyl groups and hydroxyl groups, and strong reducing agents may also change their structures. However, only under normal experimental environment and storage conditions, without intentional intervention, 1% 2C3% 2C5-triene-2-naphthol can maintain relatively stable chemical properties.
What are the synthesis methods of 1,3,5-trifluoro-2-iodobenzene?
The synthesis methods of 1% 2C3% 2C5-triene-2-ketonaphthalene are various, and the advantages and disadvantages of each method are different, which are suitable for different situations. The following are common synthesis paths:
Diels-Alder Reaction
This is a classic reaction for constructing a hexavalent cyclic structure. Suitable conjugated dienes and bienes can be selected, and the key intermediates can be obtained by Diels-Alder reaction. After subsequent functional group transformation, such as oxidation, reduction, and substitution, the target product 1% 2C3% 2C5-triene-2-ketonaphthalene can be obtained. The advantage of this reaction is that it can efficiently construct carbon-carbon bonds, with good regioselectivity and stereoselectivity, mild conditions and high yields. For example, the reaction of conjugated dienes with carbonyl-containing pro-dienes can form a six-membered ring in one step, laying the foundation for subsequent synthesis.
Friedel-Crafts Reaction
Foucault acylation or alkylation reaction is widely used in the synthesis of aromatic derivatives. The acyl group can be introduced into the aromatic ring by means of Foucault acylation reaction, and then a series of reactions, such as hydroxyaldehyde condensation and elimination reactions, can be used to construct the skeleton of the target molecule. This method can flexibly select aromatic hydrocarbon substrates and acylating reagents to achieve diverse molecular designs. However, the reaction requires Lewis acid as a catalyst, and there may be multiple substitution side reactions, which require fine control of the reaction conditions.
Transition metal catalysis
In recent years, transition metal catalysis has developed rapidly. For example, palladium-catalyzed cross-coupling reactions can effectively connect different carbon-carbon bonds or carbon-hetero bonds. Through rational design of substrates and ligands, functionalization at specific locations can be achieved, providing a precise path for the synthesis of 1% 2C3% 2C5-triene-2-ketonaphthalene. Such reaction conditions are relatively mild and highly selective, which can effectively avoid many drawbacks of traditional methods. However, the cost of transition metal catalysts is high, and some reactions require strict anhydrous and oxygen-free conditions, which requires high operation.
Molecular cyclization reaction
uses reactions such as nucleophilic substitution and electrophilic addition in the molecule to cyclize the molecule and form the target cyclic structure. For example, under suitable conditions, the enyne substrate can be cyclized within the molecule to construct a naphthalene ring containing the enone structure. This method has high atomic economy, simple steps, and can reduce waste generation. However, the design and synthesis of the substrate are more critical, and the activity and selectivity of the reaction check point need to be ensured.
When synthesizing 1% 2C3% 2C5-triene-2-ketonaphthalene, the appropriate synthesis method should be considered comprehensively according to the availability of starting materials, the purity and yield requirements of target products, and the feasibility of reaction conditions.
What are the precautions for storing and transporting 1,3,5-trifluoro-2-iodobenzene?
1%2C3%2C5-%E4%B8%89%E6%B0%9F-2-%E7%A2%98%E8%8B%AF%E8%BF%99%E7%A7%8D%E5%8C%96%E5%90%88%E7%89%A9%E5%9C%A8%E5%82%A8%E5%AD%98%E5%92%8C%E8%BF%90%E8%BE%93%E8%BF%87%E7%A8%8B%E4%B8%AD%E5%BF%85%E9%A1%BB%E6%B3%A8%E6%84%8F%E4%B8%8B%E5%88%97%E4%BA%8B%E9%A1%B9:
First, this compound is flammable and explosive, and when it is stored and transported, the ambient temperature and humidity must be precisely controlled. If the temperature is too high, the reaction may be accelerated, causing danger; if the humidity is too high, it may deteriorate the compound and damage its quality. Therefore, the storage should be in a cool, dry place, and well ventilated to reduce environmental risk factors.
Second, 1%2C3%2C5-%E4%B8%89%E6%B0%9F-2-%E7%A2%98%E8%8B%AF may be harmful to the human body. It may irritate the skin, mucous membranes, or even cause inhalation, ingestion or poisoning. Therefore, when handling this substance, appropriate protective equipment must be worn, such as protective clothing, gloves, protective goggles and gas masks, to prevent contact with the human body. And the operating space must be well ventilated. If you accidentally contact, you should quickly rinse with plenty of water and seek medical treatment.
Furthermore, when transporting, the appropriate means of transportation and packaging materials must be selected in accordance with relevant regulations. The packaging should be tightly closed, with good pressure resistance and shock resistance, and prevent leakage and damage. During transportation, drivers and passengers should also be familiar with emergency response methods. In case of emergencies, they can respond quickly and minimize harm.
Moreover, the storage place should be set up with obvious warning signs to clearly indicate the danger of this compound, so that relevant personnel can be alert. And storage management must be standardized, and warehousing records must be kept in detail for traceability and supervision.
In short, 1%2C3%2C5-%E4%B8%89%E6%B0%9F-2-%E7%A2%98%E8%8B%AF during storage and transportation, all details cannot be ignored, so as to ensure the safety of the process and avoid accidents.