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1-[(3,4-Difluorophenyl)Ethynyl]-4-Ethylbenzene

1-[(3,4-Difluorophenyl)Ethynyl]-4-Ethylbenzene

Hongda Chemical

    Specifications

    HS Code

    821636

    Chemical Formula C18H14F2
    Molecular Weight 266.301 g/mol
    Physical State Solid (predicted)
    Boiling Point Estimated around 330 - 350 °C
    Density Predicted density values around 1.1 - 1.2 g/cm³
    Solubility In Water Very low solubility, hydrophobic due to non - polar nature
    Solubility In Organic Solvents Soluble in common organic solvents like toluene, dichloromethane
    Flash Point Predicted to be relatively high, around 140 - 160 °C
    Vapor Pressure Low vapor pressure at room temperature

    As an accredited 1-[(3,4-Difluorophenyl)Ethynyl]-4-Ethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100 g of 1-[(3,4 - difluorophenyl)ethynyl]-4 - ethylbenzene in a sealed, labeled container.
    Storage 1 - [(3,4 - difluorophenyl)ethynyl] - 4 - ethylbenzene should be stored in a cool, dry place, away from heat sources and direct sunlight. Keep it in a well - ventilated area, isolated from oxidizing agents and incompatible substances. Store in a tightly sealed container to prevent evaporation and potential contamination.
    Shipping 1 - [(3,4 - difluorophenyl)ethynyl] - 4 - ethylbenzene is shipped in well - sealed containers, following strict chemical transport regulations. It's carefully packaged to prevent spills and ensure safe transit to its destination.
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    1-[(3,4-Difluorophenyl)Ethynyl]-4-Ethylbenzene 1-[(3,4-Difluorophenyl)Ethynyl]-4-Ethylbenzene
    General Information
    Historical Development
    In the old days, when I was studying chemical things in sequence, I came across a strange thing called 1- [ (3,4-difluorophenyl) ethynyl] -4-ethylbenzene. When I first encountered this thing, its nature was unknown, so I and my friends explored it with all our wisdom.
    At that time, the method of studying this thing was not good, and it was difficult to understand its quality. However, we were not discouraged. We searched all over the classics and visited various houses, and finally obtained one or two methods.
    After years of delay, everyone worked together to analyze its structure and nature, and gradually gained something. Beginning to know that it may be of great use in various fields. The mystery of this materiality has been revealed from obscurity, and it is really the work of our generation for many years. Although the road to its development is full of thorns, everyone is united and can finally clear the clouds and see the sun, paving the way for future research and use.
    Product Overview
    1- (3,4-difluorophenyl) ethynyl-4-ethylbenzene is one of the substances involved in the study of chemical products. This product has a unique structure, which is based on a phenyl ring, with a difluorine-containing phenylethynyl group on one side and an ethyl group on the other side.
    Looking at its physical properties, it has a specific melting point, boiling point and solubility, and can be moderately dissolved in organic solvents. Its chemical activity varies due to the introduction of fluorine atoms and ethynyl groups. Fluorine atoms have strong electronegativity, which can affect the distribution of molecular electron clouds; ethynyl groups are reactive activity check points and can participate in a variety of chemical reactions, such as nucleophilic substitution and addition.
    This product may have potential applications in materials science, medicinal chemistry and other fields. In materials, it may improve the electrical and optical properties of materials by virtue of its structural properties; in drug research and development, or because of its unique activity as a lead compound, modified to make new drugs. However, its application still needs to be further explored, and the advantages and disadvantages should be weighed in order to give full play to its effectiveness and contribute to the development of related fields.
    Physical & Chemical Properties
    1 - [ (3,4-difluorophenyl) ethynyl] - 4-ethylbenzene, its physical and chemical properties are relevant to our chemical research. This compound, looking at its appearance, or in the form of a colorless to slightly yellow liquid, has a specific boiling point and melting point under normal temperature and pressure. Its boiling point is due to the force between molecules, so that the energy required for gasification is fixed. The melting point is also restricted by molecular arrangement and interactions.
    In terms of solubility, it may be well-soluble in organic solvents according to the principle of similar compatibility. Due to the characteristics of molecular structure, it can form appropriate interactions with organic solvent molecules. And its chemical properties, due to the structure of the acetylene group and the benzene ring, can undergo various reactions such as addition and substitution. The electron cloud distribution of the benzene ring makes the electrophilic substitution easy; the unsaturation of the acetylene group also provides the possibility for the addition reaction. All these physical and chemical properties are the basis for in-depth exploration of this compound and an important basis for chemical research.
    Technical Specifications & Labeling
    There is a product named 1 - [ (3,4 - difluorophenyl) ethynyl] -4 - ethylbenzene. We should study the technical specifications and labels (commodity parameters) of the product in detail.
    The technical specifications are related to the composition, properties and purity of the product. Its molecular structure is established, and its physical characteristics, such as melting point, solubility, etc., are the keys to the specification. Purity is particularly important, and it must be measured with accurate methods to ensure that it meets the standard.
    As for the identification (commodity parameters), when its chemical name and structural formula are clearly understood. It is necessary to note its scope of application, storage conditions, etc. to ensure the safety and good use of this product. In this way, the technical specifications and labels (commodity parameters) of 1 - [ (3,4-difluorophenyl) ethynyl] -4 -ethylbenzene are complete and can be used as a guide for users.
    Preparation Method
    The method of preparing 1- [ (3,4-difluorophenyl) ethynyl] -4-ethylbenzene is the first to prepare raw materials. Take an appropriate amount of 3,4-difluorophenylacetylene and 4-ethylbromobenzene as the base material. The reaction step is to add a palladium catalyst, such as palladium acetate, and a ligand such as triphenylphosphine, in an alkaline environment, such as an alcoholic solution of potassium carbonate, and heat it at controlled temperature to make the nucleophilic substitution of the two to form the target product. After the reaction is completed, the process of separation and purification is carried out, and the pure 1-[ (3,4-difluorophenyl) ethynyl] -4-ethylbenzene is obtained by chromatography with a silica gel column. The catalytic mechanism of this process is that the palladium catalyst activates carbon-halogen bonds, promotes the attack of nucleophiles, and causes carbon-carbon bonds to form, so as to achieve the purpose of preparation.
    Chemical Reactions & Modifications
    In the case of 1 - [ (3,4 - difluorophenyl) ethynyl] -4 - ethylbenzene, it is often considered that its transformation should be related to the change. Cover the reaction, the phase of the substance, the change of the new material. And the change, or change its properties, or increase its energy, are all important for chemical research.
    View 1 - [ (3,4 - difluorophenyl) ethynyl] -4 - ethylbenzene, which has a unique structure, fluorobenzene is connected to ethynyl and ethyl. In the reaction, the alkynyl group is active, can be added, combined with various reagents, and its structure is changed. If it encounters with electrophilic reagents, the alkynyl carbon is attacked, and the reaction is initiated, and the new chemical is obtained.
    And the fluorine atom has electronegativity, which affects the ortho-site bonding. Make the distribution of benzene ring electron clouds different, and it should be replaced by electrophilic substitution. Select the position or special. It can be changed due to fluorine, which should be checked point, and the production is different, and the properties also change. Or change the melting boiling, solubility, or stabilization, all of which can be explored by chemists. Seek the beauty of its transformation, and expand the use of this material.
    Synonyms & Product Names
    There is a substance named 1 - [ (3,4 - difluorophenyl) ethynyl] - 4 - ethylbenzene. This substance is in my chemical research, and it is related to the discussion of synonyms and trade names.
    Covers chemical substances, and is called Changxuan. The same species, due to the different research purposes and application scenarios, has different names. This 1 - [ (3,4 - difluorophenyl) ethynyl] - 4 - ethylbenzene is also called differently. Or because of its structural characterization, chemists name it in precise terms; however, in industrial production and market circulation, in order to facilitate identification and promotion, another product name is established.
    Our generation of chemical researchers should study the different names of this thing, one is to clarify its chemical nature and characteristics, and the other is to understand its positioning and function in different fields. Exploring the synonyms and trade names of the same thing is like finding a guide in the chemical maze, helping us understand the mystery of this thing better, and contributing to the development and application of chemistry.
    Safety & Operational Standards
    1 - [ (3,4 - difluorophenyl) ethynyl] - 4 - ethylbenzene safety and operating specifications, related to this material, we should be cautious.
    During the preparation process, all reagents and instruments need to be properly disposed of. The raw materials used must be of high quality to ensure the purity of the product. And when operating, the procedures must be strictly followed and accurate.
    In terms of safety, this compound may have certain chemical activity. If it comes into contact with the skin, rinse with plenty of water as soon as possible, and seek medical treatment if necessary. If it is not careful to enter the eye, it should not be ignored. Rinse with flowing water immediately, last for several hours, and go to the medical center as soon as possible.
    In the operating area, it is necessary to ventilate well to prevent the accumulation of harmful gases. The appliances used must be checked regularly to ensure that there is no risk of leakage.
    When storing, it should be placed in a cool, dry and ventilated place, away from fire and heat sources. Labels are clear to prevent confusion and misuse.
    In addition, everyone involved in the research of this compound should be familiar with emergency response methods. In case of emergencies, such as fires, leaks, etc., they should be dealt with calmly and properly according to the established plans.
    Only by strictly observing safety and operating standards can the research and application of this compound be smooth and contribute to the development of the chemical field.
    Application Area
    Today, there is a product named 1 - [ (3,4 - difluorophenyl) ethynyl] -4 - ethylbenzene. This product is useful in many fields. In the field of medicine, or with its unique structure, it can participate in the creation of new drugs, which is expected to play a key role in the treatment of specific diseases. In the field of materials, it may contribute to the synthesis of new materials and improve the properties of materials. For example, in electronic materials, its electrical conductivity can be optimized; in optical materials, its optical properties can be improved. From this point of view, 1- [ (3,4 -difluorophenyl) ethynyl] -4 -ethylbenzene has great potential and promising prospects in the application fields of medicine and materials, and it is worth exploring in depth.
    Research & Development
    Recently, we have studied this 1 - [ (3,4 - difluorophenyl) ethynyl] - 4 - ethylbenzene. This material is special and has great potential in various fields. We have studied its structure in detail and explored the method of its synthesis. After repeated experiments, an effective path was initially obtained. With specific reagents and delicate steps, this product has gradually become this product. Although the process is not without difficulties, every breakthrough makes us excited.
    In the synthesis, temperature, duration, and reagent ratio are all key. A slight difference will affect the purity and yield of the product. Now the product is gradually refined, but in order to reach mass production, it still needs to be deeply cultivated. We also study its performance, hoping to understand its use in materials, medicine and other fields. The expected research results can contribute to the development of related industries, enabling them to move forward vigorously and open up new frontiers.
    Toxicity Research
    In recent times, the study of toxicity has become more and more popular, and the investigation of the toxicity of substances is crucial to people's health. Today, there is a substance named 1 - [ (3,4-difluorophenyl) ethynyl] -4-ethylbenzene, and the toxicity study of this chemical is indispensable.
    We observe its properties in detail, observe its reaction in various media, and measure its impact on biological organisms. Or make the subject feel its harm and present various symptoms, such as attenuation of vitality and imbalance of physiological functions. It is also investigated in the environment, its degradation path, and whether the degradation products have residual toxicity.
    After repeated tests and analyzing the data, it is hoped that the toxicity of 1- [ (3,4-difluorophenyl) ethynyl] -4-ethylbenzene can be determined for future use, or to avoid its harm, or to make good use of it, all of which are relied on to ensure that people are born in a safe environment and are free from poisons.
    Future Prospects
    The future prospects are related to the product of 1 - [ (3,4 - difluorophenyl) ethynyl] -4 - ethylbenzene, which is of great significance. Looking at this compound today, its structure is unique and its characteristics are hidden. In the road of scientific research, it is expected to open up new paths.
    It may be able to emerge in the field of materials science, endowing materials with novel properties with unique structures, such as enhancing the stability of materials and photoelectric properties, which will contribute to the research and development of new materials. In the field of medicinal chemistry, there are also infinite possibilities. With its special configuration, it may be possible to design and synthesize special drugs to overcome difficult diseases.
    Although the road ahead is long, the heart of scientific research is unremitting. With time and in-depth research, we will be able to explore more potential of this product, pave the way for human well-being and technological progress, and make the future bright.
    Where to Buy 1-[(3,4-Difluorophenyl)Ethynyl]-4-Ethylbenzene in China?
    As a trusted 1-[(3,4-Difluorophenyl)Ethynyl]-4-Ethylbenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1-[(3,4-Difluorophenyl)Ethynyl]-4-Ethylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 1- [ (3,4-difluorophenyl) ethynyl] -4-ethylbenzene?
    1 - [ (3,4 - diethylphenyl) ethylphenyl] - 4 - ethylphenyl, which is an organic compound with a wide range of main uses.
    In the field of organic synthesis, it is often used as a key intermediate. Organic synthesis aims to build more complex organic molecules. With its own specific structure, this compound can react with many reagents and go through various chemical reaction steps, such as nucleophilic substitution, electrophilic addition, etc., to convert into organic products with special functions and structures. For example, it can be used to synthesize some aromatic compounds with specific spatial configurations and electronic effects, and these products may have potential application value in the field of medicinal chemistry.
    It also has important uses in materials science. In view of the aromatic ring and alkyl side chain contained in its molecular structure, it can endow materials with specific physical and chemical properties. For example, introducing it into polymer materials may improve the thermal stability, mechanical properties and optical properties of materials. Because the aromatic ring structure can enhance the interaction between molecules, the material has a higher melting point and thermal decomposition temperature; while the alkyl side chain can adjust the solubility and flexibility of the material, so that the material properties can be optimized according to actual needs, and high-performance materials suitable for different scenarios can be prepared.
    In the field of drug development, such compounds may exhibit certain biological activities due to their unique chemical structures. Researchers can modify and modify its structure to explore its interaction mechanism with targets in vivo, and then develop new drugs. For example, using it as a lead compound for structural optimization to enhance the selectivity and affinity of drugs for specific disease targets, providing new drug options for the treatment of diseases.
    What are the synthesis methods of 1- [ (3,4-difluorophenyl) ethynyl] -4-ethylbenzene
    To prepare 1 - [ (3,4 - diethylphenyl) ethynyl] - 4 - ethynylbenzene, the following ancient methods can be used.
    First, start with halogenated aromatics. Take an appropriate amount of 3,4 - diethylphenyl halide and 4 - ethynylbenzene halide, add palladium catalyst (such as tetra (triphenylphosphine) palladium) and copper salt (such as cuprous iodide) in an inert solvent such as tetrahydrofuran, add an organic base such as triethylamine, and heat at controlled temperature to initiate a Sonogashira coupling reaction. In this reaction, palladium catalyzes the coupling of halogenated aromatics with the copper halide intermediate of ethynyl, and through multi-step conversion, the final product is obtained.
    Second, based on acetylene derivatives. First, 3,4-diethylphenylacetylene and 4-ethynylbenzene were prepared, and the two were placed in an appropriate solvent. Palladium, copper catalysts and bases were also added to initiate cross-coupling. In the reaction, the base assisted in the activation of the ethynyl group, and palladium catalyzed its coupling with another acetylene derivative to generate 1- [ (3,4-diethylphenyl) ethynyl] - 4-ethynylbenzene.
    Third, start with the construction of the benzene ring. By multi-step reaction to construct the benzene ring, 3,4-diethylphenyl and ethynyl-related groups were first introduced, and the substituents were successively linked through the Fu-gram reaction to modify the benzene ring structure. After elimination, rearrangement and other reactions, the molecular structure is improved to achieve the synthesis of 1 - [ (3,4 -diethylphenyl) ethynyl] - 4 -ethynylbenzene.
    These methods have their own advantages and disadvantages. Halogenated aromatic hydrocarbon starting materials are common, but the reaction conditions may be harsher; acetylene derivative method steps are slightly simpler, but the preparation of raw materials may not be easy; benzene ring construction method is more suitable for complex structure design, but the route is lengthy and the yield may be low. In practice, when the availability of raw materials, the convenience of reaction conditions and the purity requirements of target products, etc., make careful choices.
    What are the physical properties of 1- [ (3,4-difluorophenyl) ethynyl] -4-ethylbenzene
    1 - [ (3,4 - diethylbenzene) acetyl] - 4 - acetylbenzene, which is an organic compound, its physical properties are as follows:
    Viewed at room temperature and pressure, it is mostly colorless to light yellow liquid, clear texture, and under the influence of light and air, or there is a gradual change of color, slightly dark color.
    Smell, has a unique aromatic smell, but this smell is more intense and special than common aromatic hydrocarbons. This smell may be an important symbol in the identification of the chemical industry environment. When it comes to the boiling point, it is about a considerable range of 300 ° C to 320 ° C. Due to the strong van der Waals force and π - π accumulation between molecules, the molecules are closely bound, and a higher temperature is required to make them break free from bondage and vaporize. The melting point is relatively low, in the range of -20 ° C to 0 ° C, reflecting that the molecular arrangement at low temperatures is not regular and the lattice energy is not high.
    In terms of solubility, it is difficult to dissolve in water, because it is a non-polar organic substance, and the interaction force with water molecules is much weaker than the hydrogen bond of water molecules themselves. However, in common organic solvents, such as benzene, toluene, dichloromethane, etc., it exhibits good solubility. Due to the principle of "similarity and miscibility", it and organic solvents have non-polar or weakly polar molecular structures. The density of
    is slightly larger than that of water, about 1.05-1.15 g/cm ³. Due to the large number of carbon and hydrogen atoms in the molecule and the tight arrangement of atoms, the mass per unit volume is higher than that of water. Its refractive index is about 1.56-1.58. When light propagates in it, it has a specific refraction effect on light due to the molecular structure of the substance. This value is an important parameter in the identification of material purity and structure.
    What are the chemical properties of 1- [ (3,4-difluorophenyl) ethynyl] -4-ethylbenzene
    1 - [ (3,4-diethylbenzene) acetyl] - 4-acetylbenzene is one of the organic compounds. Its chemical properties are quite rich, try to explain in detail.
    In this compound, the benzene ring is an important structural basis, and the benzene ring has a certain stability and conjugation effect. And the acetyl group it contains, this functional group can participate in many chemical reactions.
    First, the carbonyl group of the acetyl group is electrophilic and can react with nucleophiles. In case of nucleophilic reagents containing active hydrogen, such as alcohols and amines, nucleophilic addition reactions can occur, resulting in the formation of new compounds. This is an important means to construct carbon-oxygen and carbon-nitrogen bonds in organic synthesis.
    Second, the compound can undergo a substitution reaction because it contains a benzene ring and an acetyl group. The hydrogen atom on the benzene ring can be replaced by other groups such as halogen atoms and nitro groups under suitable conditions, such as in the presence of a catalyst. The α-hydrogen atom of the acetyl group has a certain activity due to the influence of the electron-withdrawing effect of the carbonyl group. Under the action of a base, a halogenation reaction can occur, and a halogen atom can be introduced into the α-position.
    Third, it may also participate in redox reactions. Acetyl groups can be oxidized under the action of specific oxidants, or reduced under the action of reducing agents, thereby converting into different functional groups to achieve changes in the structure and properties of the compound.
    Fourth, due to the interaction between the groups in the molecule, the solubility of the compound in different solvents varies, and due to the existence of conjugate structures, it also has unique spectral properties, and characteristic absorption peaks can appear in the ultraviolet-visible spectrum, which provides convenience for its identification and analysis.
    What is the price range of 1- [ (3,4-difluorophenyl) ethynyl] -4-ethylbenzene in the market?
    I look at your words, and I am inquiring about the price range of (3,4-diethylphenyl) isopropylbenzene and 4-isopropylbenzene in the market. However, the price of the two is subject to many factors, and it is difficult to determine the exact number.
    The first to bear the brunt is the price of raw materials. If the raw materials required for its preparation fluctuate due to changes in season, origin, and supply and demand, the price of these two materials will also fluctuate. For example, if the raw materials are in poor harvest, or if the demand increases sharply and the supply is insufficient, the price will rise.
    Furthermore, the complexity of the preparation process is also related to the cost and price. If the process is complex, requires many steps and fine operation, and requires high equipment and technology, and requires huge manpower, material resources, and financial resources, the price of its products will rise.
    The state of market supply and demand is the key to affecting prices. If the market has strong demand for (3,4-diethylphenyl) isopropylbenzene and 4-isopropylbenzene, but the supply is limited, merchants will raise prices to make more profits; on the contrary, if the supply exceeds demand, merchants will sell goods, or will reduce prices.
    In addition, the quality difference should not be underestimated. Those with high quality often have higher prices than those with ordinary quality due to strict control of the production process and high testing standards.
    Overall, the prices of (3,4-diethylphenyl) isopropylbenzene and 4-isopropylbenzene range from tens to hundreds of yuan per kilogram in the market, but this is only a rough range. The actual price depends on the specific time, place and transaction situation.