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1,2-Dimethoxy-4-Fluorobenzene

1,2-Dimethoxy-4-Fluorobenzene

Hongda Chemical

Specifications

HS Code

574656

Chemical Formula C8H9FO2
Molar Mass 156.154 g/mol
Appearance Colorless to light yellow liquid
Boiling Point Around 190 - 192 °C
Density Approximately 1.14 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point Likely around 70 - 80 °C
Odor Characteristic aromatic odor

As an accredited 1,2-Dimethoxy-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1,2 - dimethoxy - 4 - fluorobenzene packaged in a sealed, labeled bottle.
Storage 1,2 - Dimethoxy - 4 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage and exposure to air and moisture, which could potentially cause degradation or reaction. It is also advisable to store it separately from incompatible substances.
Shipping 1,2 - dimethoxy - 4 - fluorobenzene is shipped in well - sealed containers, safeguarded against physical damage. Compliance with chemical shipping regulations ensures safe transport, with proper labeling indicating its nature and handling precautions.
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1,2-Dimethoxy-4-Fluorobenzene 1,2-Dimethoxy-4-Fluorobenzene
General Information
Historical Development
1,2-Dimethoxy-4-fluorobenzene is also an organic compound. Its origin is unknown, but looking at the evolution of chemistry, the research of this compound has advanced with the development of science and technology. In the past, chemists have studied the physical properties and chemical properties to understand the wonders of its structure and reaction. At the beginning, it was difficult to analyze, but at that time the techniques were limited. However, many scholars have continued, and after years of study, they have gradually obtained the method of preparation, and the process has become more and more refined. Since its formation, it has been available in the fields of medicine and materials. In the history of chemistry, it is a gradual sign, witnessing the unremitting efforts of the Fang family, from ignorance to understanding, pushing the development of chemistry and helping other industries flourish.
Product Overview
1,2-Dimethoxy-4-fluorobenzene is an important compound in organic synthesis. It is a colorless to pale yellow liquid with a unique odor. Its melting point is quite low, and it is liquid at room temperature. This property is easy to operate in many reactions.
This compound contains methoxy and fluorine atoms, and has a unique structure. Methoxy groups have electron conductivity and fluorine atoms have strong electron absorption. The coexistence of the two makes the electron cloud of the molecule different, giving it special chemical activity.
In the field of organic synthesis, 1,2-dimethoxy-4-fluorobenzene is often used as a key intermediate. Due to its unique structure, it can participate in a variety of chemical reactions, such as nucleophilic substitution, coupling reactions, etc., assisting chemists in constructing complex organic molecular structures, which are widely used in the fields of medicine, pesticides, and materials science. It is also an important raw material for the synthesis of specific drugs or plays a key role in the preparation of advanced materials.
Physical & Chemical Properties
1,2-Dimethoxy-4-fluorobenzene is also an organic compound. Its physical properties are colorless liquids at room temperature, with a special odor. The boiling point is about a certain temperature range, which depends on the difficulty of volatilization, and also shows the strength of its intermolecular forces. The melting point has a fixed number, which is the critical temperature for the transformation of solid and liquid states of a substance, reflecting the characteristics of its lattice structure.
In terms of its chemical properties, the presence of benzene rings endows it with aromaticity, which can occur electrophilic substitution reactions. Methoxy groups are the power supply groups, which increase the electron cloud density of the benzene ring, which is conducive to the attack of electrophilic reagents. Although fluorine atoms are strong electronegativity, their special p-π conjugation effect also affects the reactivity of molecules. Under suitable reaction conditions, it can react with many reagents such as substitution and addition, and has great potential for application in the field of organic synthesis. It is also an important intermediate for the preparation of many complex organic compounds.
Technical Specifications & Labeling
1,2-Dimethoxy-4-fluorobenzene is also an organic compound. Its process specifications and identification (product parameters) are the main principles for production and preparation.

The process specifications, the choice of raw materials, must be pure and fine, and the ratio is appropriate. The reaction conditions, temperature and pressure must be precisely controlled. For example, in a specific reactor, with a suitable catalyst, the temperature is controlled for a number of times, and the pressure geometry is applied to make the reactants fully blend and produce subtle chemical changes.
As for the logo, including the diagram of its chemical structure, it is clear that its molecular composition, the order and group of 1,2-dimethoxy-4-fluorobenzene are clear at a glance. The product parameters are detailed in purity, which must meet extremely high standards, and the impurity content is minimal. In addition, physical properties such as melting point, density, etc., are also clearly marked for the user's reference, so as to obtain the excellent quality of the product, which is widely used in various fields of chemical industry.
Preparation Method
To prepare 1,2-dimethoxy-4-fluorobenzene, the method is as follows:
Raw materials and production process: Fluorinated phenols are selected as the initial raw materials, and dimethyl sulfate and other reagents are added. Dimethyl sulfate is a commonly used methylation substance, which is active and can react smoothly with phenolic hydroxyl groups.
Reaction steps: First dissolve fluorinated phenols in an appropriate amount of organic solvent, such as dichloromethane, which can fully mix the reactants and improve the reaction efficiency. With stirring, slowly add dimethyl sulfate, and add an appropriate amount of alkaline substances, such as potassium carbonate, to maintain the alkaline environment of the reaction system and promote the positive reaction. Catalytic mechanism: Potassium carbonate plays a catalytic role here, making phenolic hydroxyl groups more nucleophilic, facilitating the attack of methyl groups in dimethyl sulfate, accelerating the reaction rate, and enabling the reaction to be completed efficiently under milder conditions, thus enabling the preparation of 1,2-dimethoxy-4-fluorobenzene.
Chemical Reactions & Modifications
The chemical reaction and modification of 1,2-dimethoxy-4-fluorobenzene are the most important things for our chemical researchers.
The quality of the chemical reaction is related to the change of the properties of this substance. The initial response may be unsatisfactory, the yield is not optimal, and the product may also contain impurities. The reason for this may be that the regulation is not suitable, the degree of temperature and pressure, and the catalytic agent can all be required.
As for the modification, it is to seek the best of its properties. To increase its stability, or to change its solubility, so as to make it suitable for more environments. After various studies, the method of adjustment, choose a more suitable agent, and observe the change of temperature and pressure. In the
phase, the good fruit of chemical reaction can be obtained by a fine method, and the beauty of modification can be achieved. Make 1,2-dimethoxy-4-fluorobenzene more widely used in various fields, and contribute to the progress of chemistry.
Synonyms & Product Names
1,2-Dimethoxy-4-fluorobenzene is also a chemical substance. It has unique characteristics among various chemicals. The synonyms and trade names of the same thing are also important for research and development.
The synonyms of husband, or due to differences in regions and academic changes, are called differently. The trade names are related to the easy circulation of the market, and each merchant may have a nickname to recognize its product.
1,2-dimethoxy-4-fluorobenzene, in all things chemical, can be a raw material or an intermediate product. Due to its properties, it can be used to produce various other substances, which are useful in the fields of medicine and materials.
makes clear its synonyms and trade names, which is convenient for communication in the industry and easy for the market to communicate. When the industry talks about this thing, although it is called differently, it is known that it is the same substance, and everything can go smoothly. In academic discussions, it also avoids the disadvantage of confusion of appellations, so that the research can be accurate.
Safety & Operational Standards
Safety and operating specifications for 1,2-dimethoxy-4-fluorobenzene
For 1,2-dimethoxy-4-fluorobenzene, chemical substances are also. In our research and production, its safety and operating standards are of paramount importance.
This substance has certain physical and chemical properties. To observe its properties, it is necessary to carefully observe its color, state, taste, etc. Its physical properties are related to the conditions of storage and use. Such as changes in temperature and humidity, or affect its stability. If it is exposed to high temperature environment, or the volatilization is intensified, it will not only damage its quality, but also increase the risk of safety.
In terms of operating standards, operators must first have professional knowledge and skills. When taking it, take the tools and methods according to the exact amount to ensure that the dosage is correct. The operation room must be well ventilated to prevent gas accumulation. Because of its toxicity and irritation, if inhaled into the body, it may damage the respiratory system; contact with the skin, or cause allergies, burns and other diseases. Therefore, when operating, protective equipment is indispensable, such as wearing protective gloves, goggles, masks, etc., to prevent contact with the human body.
Storage methods also have strict requirements. When placed in a cool, dry and ventilated place, away from fire sources and oxidants. If mixed with incompatible substances, or cause violent chemical reactions, causing explosions, fires and other disasters.
When disposing of waste, be sure to follow environmental protection regulations. Do not discard at will, so as not to pollute the environment. It should be collected centrally and handed over to professional institutions for disposal to ensure environmental safety.
In short, the safety and operation specifications of 1,2-dimethoxy-4-fluorobenzene run through the whole process of research, production, storage, use and waste disposal. Our chemical practitioners should strictly abide by this specification to ensure their own safety, smooth production and environmental worry.
Application Area
1,2-Dimethoxy-4-fluorobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it is often the key raw material for the synthesis of many special drugs. Because of its unique chemical structure, it can endow drugs with specific activities and properties, which helps to accurately target diseases and improve curative effect.
In materials science, it also has extraordinary performance. Or it can be used as a basic material for the preparation of special functional materials. After ingenious chemical modification, it can obtain materials with special electrical and optical properties for high-end electronic devices, optical instruments, etc.
In the fine chemical industry, this compound can be used to make fine chemicals, such as special fragrances, additives, etc., to enhance the unique properties and quality of products and meet the needs of multiple markets. In short, 1,2-dimethoxy-4-fluorobenzene has important value and broad prospects in various application fields.
Research & Development
Taste the field of chemical industry, new things emerge. Today there is 1,2-dimethoxy-4-fluorobenzene, which is the key to our research. Its nature is very different, and it is related to the progress of many fields.
We study its quality, analyze its structure, and explore its reaction rules. At first, we only know its appearance slightly, but after long-term study, we gradually understand its mysteries. Try to measure it by various methods, observe its changes in different situations, and observe its response to other things.
Although the road is so difficult, such as uncertain, fruitless response, etc., we are not discouraged. With perseverance and perseverance, we try again and again. It has been achieved now, and its synthesis method has become increasingly refined, and the yield has also improved. In the future, when we go deeper, we hope to be able to expand its use in the fields of medicine and materials, so as to promote the prosperity of this industry and use it for the world. This is also the wish of our researchers.
Toxicity Research
1,2-Dimethoxy-4-fluorobenzene is a chemical research substance. Its toxicity research is of great significance. Examine it in detail today.
The toxicity of this substance is not obvious at first, but it is touched for a long time, and hidden dangers gradually arise. Its qi is slightly smoked, invisible in the body. It may penetrate through the skin, or be absorbed by breathing. The initial feeling is only discomfort, but over time, the viscera is gradually damaged.
Looking at various experiments, taking the white rat as a test, exposed to the environment containing this substance, not long after, the white rat slowed down and felt tired. And eating less and weaker. Looking at the dissection, there are abnormal changes in the liver and kidney, which are all signs of toxicity.
For industrial use, workers often touch, prone to various diseases. Where the hand touches, the skin or itching is red and swollen. Inhaled by the mouth and nose, the airway is invaded, and the cough is not smooth. Therefore, toxicity research cannot be ignored. It must be investigated in detail, so that the survivors are healthy and the industry is safe.
Future Prospects
Today, there is a thing named 1,2-dimethoxy-4-fluorobenzene, which is in the field of our chemical research, and its future prospects are profound. This substance has unique properties, and it may open up new paths in the way of medical creation. Its exquisite structure may be the cornerstone of new drugs, healing all kinds of diseases.
It is also expected to shine in the field of materials science. With its characteristics, it may be possible to make strange materials for use in high-tech, such as electronic devices, to increase its performance and promote its transformation.
Although the road ahead is uncertain, our research heart is as solid as a rock. With time and careful study, we will be able to explore its potential, seek well-being for future generations, and develop the magnificent picture of this material in the future.
Where to Buy 1,2-Dimethoxy-4-Fluorobenzene in China?
As a trusted 1,2-Dimethoxy-4-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1,2-Dimethoxy-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1,2-dimethoxy-4-fluorobenzene?
1% 2C2-dimethoxy-4-cresol is very important for various uses. Its first use is as a preservative. Cover because of its excellent antibacterial ability, can prevent the growth and reproduction of microorganisms, so it is often used in food, medicine, cosmetics and other substances to protect their quality and extend their shelf life.
In food, it can prevent deterioration and spoilage, protect the delicious taste and nutritional quality of food, and make consumers eat safely. In medicine, it can ensure the stability of the drug, prevent it from being stained by microorganisms, ensure the correct efficacy of the drug, and protect the health of patients. As for cosmetics, it can keep the product intact for a long time and maintain its original properties, so that users can use it without worry.
In addition, it is also very useful in the rubber and plastics industries. It can be used as an antioxidant to prevent the properties of rubber and plastics from being degraded due to oxidation. It can protect such materials, make them last for a long time, and still maintain good physical properties, such as strength, elasticity, etc. When it increases its durability, it is widely used.
In the fragrance industry, 1% 2C2-dimethoxy-4-cresol is also indispensable. Because of its unique odor, it can be used as a fragrance ingredient, adding a unique fragrance to fragrance products, giving different layers and characteristics to meet various aroma needs.
In addition, in the field of organic synthesis, it is often used as an important intermediate. Based on it, many organic compounds can be synthesized, which are of key significance in the manufacture of medicines, pesticides, dyes, etc., helping the chemical industry to introduce new products and create a variety of useful products.
What are the physical properties of 1,2-dimethoxy-4-fluorobenzene?
1% 2C2-dimethoxy-4-ethylbenzene, which is mostly liquid at room temperature, colorless and transparent and has a special aromatic odor. Its density is less than that of water. It is insoluble in water but miscible with most organic solvents. Its boiling point is about a specific temperature range, and its vapor is heavier than air.
Because it contains a benzene ring and a specific substituent, it is chemically active. The benzene ring can undergo electrophilic substitution reactions, such as halogenation, nitrification, and sulfonation. It can introduce other groups into the benzene ring to derive a variety of organic compounds for fine chemical synthesis. Its substituent structure makes it participate in oxidation, substitution, and other reactions. Under specific conditions, methyl groups can be oxidized to carboxyl groups, etc.
From the perspective of physical properties, it is highly volatile and easy to form flammable steam in the air. When mixed with air, it can form an explosive mixture. In case of open flame and high heat energy, it can cause combustion and explosion. Because its steam is heavier than air, it can spread to distant places at a lower level. In case of fire, it will catch fire and backfire. Pay attention to fire and explosion protection when storing and using it.
Starting from its chemical properties, its activity makes it an important intermediate in organic synthesis. It can be used to produce drugs, fragrances, dyes and other products through different chemical reactions. However, due to its benzene-containing cyclic structure, some metabolites may be potentially toxic. During industrial production and use, protective measures should be taken to prevent human contact and inhalation to avoid damage to health.
What are the chemical properties of 1,2-dimethoxy-4-fluorobenzene?
1% 2C2-dimethoxy-4-vinylbenzene, which has an alkenyl group and an alkoxy group. The alkenyl group is active and can cause polymerization; the alkoxy group is stable and has a great impact on the molecular structure.
Let's talk about the alkenyl group first. The alkenyl group in 1% 2C2-dimethoxy-4-vinylbenzene has a carbon-carbon double bond, is rich in electrons, and is vulnerable to attack by electrophilic reagents, resulting in electrophilic addition. In the case of hydrogen halide, the halogen atom is added to the double-bonded carbon with less hydrogen, and the hydrogen is added to the one with more hydrogen, following the Markov rule. When exposed to bromine water, the bromine molecule is polarized, and the double bond attracts bromine positive ions to form bromide ions. Bromine negative ions attack from the reverse side to obtain trans addition products.
And the alkenyl group can polymerize. Under the action of the initiator, the double bond is opened, and the free radical initiates chain polymerization to form a polymer, which is of great significance for material synthesis and can be used to make special performance polymer materials.
Look at the alkoxy group again. It has a given electron induction effect and a conjugation effect, which increases the electron cloud density of the benzene ring and improves the electrophilic substitution activity. The characteristics of the ortho-para-site locator are significant, and the electrophilic reagent is easy to attack the ortho-para-site of the benzene ring, and the left and right reaction check points are selected. < b Due to the polarity of the carbon-oxygen bond, the molecule has a certain polarity, which affects the solubility and boiling point. Generally, the polarity is enhanced, and the solubility is increased in polar solvents, and the intermolecular force is increased, and the boiling point may also rise.
In summary, 1% 2C2-dimethoxy-4-vinylphenylenyl coexists with alkoxy groups, and has unique chemical properties. It has great potential in organic synthesis, material preparation and other fields. It can use the characteristics of two groups to rationally design reactions to produce various organic compounds and functional materials.
What is the production method of 1,2-dimethoxy-4-fluorobenzene?
1% 2C2-dimethoxy-4-chlorobenzene is an organic compound. Although the preparation method is not detailed in the ancient book "Tiangong Kaiwu", it can be deduced as follows according to the principles of organic synthesis today.
To prepare this substance, p-chlorophenol is often used as the starting material. P-chlorophenol has phenolic hydroxyl groups and has good activity. First, react with a suitable base, such as sodium hydroxide, and the phenolic hydroxyl group can form sodium phenol salt, which increases its nucleophilicity. Then, take a methylating agent such as iodomethane or dimethyl sulfate and react with sodium phenol salt. The methyl of iodomethane or dimethyl sulfate is positively charged, and the oxygen anion of sodium phenol salt nucleophilically attacks the methyl, and then forms an ether bond, which can obtain 1-methoxy-4-chlorobenzene.
However, this product is only one methyl, and to obtain 1% 2C2-dimethoxy-4-chlorobenzene, methylation needs to be carried out again. Repeat the above methylation steps to control the reaction conditions, such as the ratio of reactants, reaction temperature and time. Taking dimethyl sulfate as an example, although dimethyl sulfate is highly toxic, its methylation ability is quite good. In a suitable solvent, such as acetone or acetonitrile, under the catalysis of alkali, it can be reacted with 1-methoxy-4-chlorobenzene. The base can take away the hydrogen on the ortho-carbon of the oxygen atom in the phenol ether to form a carbon negative ion. This carbon negative ion nucleophilic attacks the methyl group of dimethyl sulfate. After electron transfer, 1% 2C2-dimethoxy-4-chlorobenzene can be obtained.
After the reaction is completed, it needs to be separated and purified. First, the method of extraction is used to take advantage of the difference in solubility of the product and impurities in different solvents to initially separate. After column chromatography, the appropriate stationary phase and mobile phase are selected, and the pure 1% 2C2-dimethoxy-4-chlorobenzene is obtained according to the different adsorption and elution capabilities of the product and impurities. Although this preparation method is not contained in "Tiangong Kaizi", it is the way of organic synthesis. Follow this principle to explore the beauty of substance preparation by scientific method.
What is the price range of 1,2-dimethoxy-4-fluorobenzene in the market?
Today there are 1,2-dimethoxy-4-ethylbenzene, the price in the market is difficult to determine. The change in its price depends on various reasons.
First, the price of raw materials. The production of this compound depends on specific raw materials. If the production of raw materials is small and there are many people seeking it, the price will increase; conversely, if the raw materials are abundant and the supply exceeds the demand, the price may drop.
Second, the complexity and simplicity of the manufacturing process. If the production requires fine skills and multiple processes, it costs more money and time, and the price should be high; if the manufacturing process is simple and requires less material resources and manpower, the price may be cheap.
Third, the situation of market demand. If the demand for 1,2-dimethoxy-4-ethylbenzene in a certain industry increases greatly, and the supply is insufficient, the price will rise; if the demand is scarce and there is more than enough supply, the price will be lower or lower.
Fourth, the government of regulation. Government regulations and changes in taxes can affect the price. If taxes increase or regulations are strict, resulting in higher costs, the price will also rise.
If you want to know the exact price, you should consult the business of chemical materials, the market change, or check the relevant price information platform to get the current price. It is difficult to generalize the price fluctuations in different places and times.