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1,2-Difluoro-4-Methoxybenzene

1,2-Difluoro-4-Methoxybenzene

Hongda Chemical

Specifications

HS Code

156031

Chemical Formula C7H6F2O
Molecular Weight 144.12
Appearance Colorless liquid
Boiling Point 171 - 173 °C
Melting Point N/A
Density 1.196 g/mL at 25 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Vapor Pressure N/A
Flash Point 60 °C

As an accredited 1,2-Difluoro-4-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1,2 - difluoro - 4 - methoxybenzene in 500g glass bottle with secure seal.
Storage 1,2 - difluoro - 4 - methoxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances to avoid potential reactions. Follow proper safety regulations for chemical storage.
Shipping 1,2 - Difluoro - 4 - methoxybenzene is shipped in properly sealed containers. Compliance with chemical transportation regulations is ensured. Special care is taken to prevent leakage during transit due to its chemical nature.
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1,2-Difluoro-4-Methoxybenzene 1,2-Difluoro-4-Methoxybenzene
General Information
Historical Development
1,2-Difluoro-4-methoxybenzene is also a product of chemistry. Its origin really depends on the research of Zhu Xian. In the past, the way of chemistry was not as clear as it is today, and the public searched for the traces of this substance in the vast unknown.
At the beginning, only a little bit of its properties were known, and then through the work of successive generations, the techniques were gradually refined, and they were able to make it. After years of poverty, or in simple rooms, or in humble places, I worked tirelessly to study, and to achieve perfection.
After years of change, the method of preparation has been continuously refined. From the crude at the beginning, it has gradually become excellent today. What was difficult in the past has now become easy to do. This is all the unremitting work of predecessors, so that 1,2-difluoro-4-methoxybenzene can see the light of day, shining brightly in the field of chemistry, laying the foundation for future generations.
Product Overview
There is now a product named 1,2-difluoro-4-methoxybenzene. It is an organic compound that is like a colorless liquid with a special odor. The preparation of this substance requires multiple fine processes.
First take the appropriate raw materials and use specific reaction conditions to make it chemically react. During the reaction, temperature, pressure and other factors need to be precisely controlled. If there is a slight difference, the purity and yield of the product will be affected. After several steps of reaction, the crude product is obtained, which needs to be purified.
The method of purification, either by distillation or by extraction, depends on the specific situation. After purification, pure 1,2-difluoro-4-methoxybenzene can be obtained. It is widely used in the chemical industry. Or as an intermediate for the synthesis of other fine chemicals, it is also indispensable in the preparation of medicine and pesticides, and can provide key support for the development of related industries.
Physical & Chemical Properties
1,2-Difluoro-4-methoxybenzene, this physical property is related to chemical research. Its physical properties, at room temperature as a colorless liquid, taste slightly different, volatile. The boiling point is about hundreds and tens of degrees, the density is slightly smaller than water, insoluble in water, but easily soluble in organic solvents, such as alcohols, ethers and the like.
When it comes to chemical properties, fluorine and methoxy groups on the phenyl ring give it unique activity. Fluorine atoms are highly electronegative, causing the electron cloud density of the phenyl ring to change, which affects the activity of electrophilic substitution reactions. Methoxy group is the power supply radical, which can increase the density of the electron cloud of the phenyl ring and the para-position, which is favorable for the attack of electrophilic reagents. Under suitable conditions, it can undergo electrophilic substitution reactions such as halogenation, nitrification, and sulfonation, and has a wide range of uses in the field of organic synthesis. It can be used as an intermediate in the synthesis of fine chemicals such as medicine and pesticides, which is of great significance to chemical research and industrial production.
Technical Specifications & Labeling
Today there is a product named 1,2-difluoro-4-methoxybenzene. The preparation of its technique is related to technical specifications and identification (product parameters), which is of paramount importance.
To make this product, you need to follow a precise method. The selection of raw materials, when it suits its quality and proportions, must be accurate. When reacting, the temperature and duration must be strictly monitored. Control the temperature in a moderate range, and be punctual to comply with its regulations, in order to ensure a smooth reaction and obtain a pure product.
Its identification (product parameters) cannot be ignored either. Color, taste, purity, etc., are all the keys to judgment. When the color is pure and positive, the taste should match its nature, and the purity must reach the standard number. In this way, only qualified products can be used for various purposes to meet the needs of all parties. Technical specifications and identification (product parameters), the two complement each other, and it is difficult to become a good product without one.
Preparation Method
To prepare 1,2-difluoro-4-methoxybenzene, the method is as follows:
Prepare raw materials, select fluoride and methoxybenzene-containing benzene as groups. Perform a specific chemical process, the first step is the reaction step. Place an appropriate amount of raw materials in a special container in sequence, control temperature, pressure and reaction. In this process, the proportion of raw materials is precisely allocated to ensure that the reaction is better.
The second is the catalytic mechanism, adding a high-efficiency catalyst to speed up the reaction and yield. The choice of catalyst is related to success or failure, and it needs to have high activity and selectivity.
After this reaction, the product is initially formed, but it contains impurities. In the follow-up, high purity 1,2-difluoro-4-methoxybenzene can be obtained by purification to remove impurities and store sperm. The preparation method, raw materials and processes, reaction steps and catalytic mechanism are all key, and one ring is interlocked to make this good product.
Chemical Reactions & Modifications
The reaction and modification of 1,2-difluoro-4-methoxybenzene are very important in the chemical environment. The reaction of this compound is very different, and it has been explored in the past. The initial reaction was carried out by the conventional method, but the yield was not good, and the side effects were frequent.
Looking at the way of its modification, I tried various strategies. There was a change in temperature control, but it did not meet expectations. Later, it was easy to catalyze, but the activity was insufficient. So I thought of a new way and introduced ligands, which worked wonders. The selectivity of the reaction greatly increased, and the yield also increased significantly.
From this point of view, the reaction and modification of transformation require careful consideration and repeated attempts in order to clear the clouds and see the sun and achieve a good environment. The research of 1,2-difluoro-4-methoxybenzene can be used as a reference for other things.
Synonyms & Product Names
1,2-Difluoro-4-methoxybenzene, this substance is also known as fluoroanisole. Although its name is different, it refers to the same substance. I have been studying chemistry for many years, and I am well aware of the properties of this substance. Fluoroanisole is very important in the field of organic synthesis. It has unique chemical activity and can be a key raw material for many synthetic reactions. Looking at ancient books, although there is no detailed description of it, it is inferred from today's chemical knowledge that the position of fluorine and methoxy in its structure affects its reactivity. Fluorine atoms have strong electronegativity, while methoxy groups have the ability to supply electrons. The synergy between the two makes this compound appear in different states in many reactions. In the preparation of synthetic flavors and pharmaceutical intermediates, this substance is often relied on. Its alias is also well known in the industry, due to industry exchanges and research. People call it 1,2-difluoro-4-methoxybenzene or fluorinated anisole in different situations during experiments and production. Although the names are different, they are actually the same.
Safety & Operational Standards
1,2-Difluoro-4-methoxybenzene is also a chemical product. In the way of our generation's chemical research, its safety and operating standards are really the most important and cannot be ignored.
Looking at this 1,2-difluoro-4-methoxybenzene, its characteristics are specific. For safety, store it first. When looking for a cool, dry and well-ventilated place, avoid being close to fire and heat sources, and cover it with the risk of explosion. And it must be kept away from oxidants, strong alkalis and other substances to prevent chemical changes and accidents.
During operation, protective gear is indispensable. The operator must wear appropriate protective clothing, goggles and protective gloves to prevent it from touching the skin, entering the eyes, and damaging the body. Do it in the ventilation cabinet, so that the escaping gas can be dispatched in time, so as not to cause the concentration in the air to be too high and endanger the human body.
Furthermore, if it involves the transfer and measurement of 1,2-difluoro-4-methoxybenzene, the action should be slow and stable to prevent it from spilling. The equipment used must be clean and suitable to maintain the accuracy of the experiment. In case of leakage, quickly cut off the fire source, isolate the scene, and evacuate everyone. A small amount of leakage can be adsorbed by inert substances such as sand and vermiculite; a large amount of leakage needs to be blocked by a dike, collected carefully, and disposed of according to regulations.
Also, if you accidentally come into contact with the human body and touch the skin, rinse quickly with a large amount of water, followed by soap; those who enter the eyes, rinse immediately with flowing water or normal saline, and seek medical treatment. If you inhale its gas, leave the scene quickly, go to a place with fresh air, give artificial respiration if necessary, and seek medical first aid.
All these are the rules for the safety and operation of 1,2-difluoro-4-methoxybenzene. Those who study chemistry in our generation should follow them carefully to ensure that everything goes smoothly and avoid disasters.
Application Area
1,2-Difluoro-4-methoxybenzene, this compound has its uses in many fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help create new drugs with special curative effects. Through exquisite chemical synthesis, it can be integrated into a specific molecular structure, which may give drugs better biological activity and targeting.
In the field of materials science, it also has extraordinary potential. Or it can be used as a raw material to prepare functional materials with excellent performance. After special processing, it may be able to produce materials with unique optical and electrical properties, suitable for cutting-edge fields such as optoelectronic devices.
Furthermore, in the fine chemical industry, 1,2-difluoro-4-methoxybenzene can be used to synthesize high-end fragrances, dyes and other fine chemicals. After precise blending and reaction, high-quality and distinctive products can be created to meet the diverse needs of the market. Its application field is wide and the prospect is quite promising.
Research & Development
There is now a product named 1,2-difluoro-4-methoxybenzene. We are chemical researchers, and we have dedicated ourselves to its research and development.
This product has unique properties, its structure is exquisite, and it contains fluorine and methoxy groups, which affect its physical and chemical properties. In the reaction, it often shows special activity and can be a key raw material for organic synthesis.
Our generation has repeatedly experimented to explore the best preparation method. From the selection of raw materials, to the regulation of reaction conditions, temperature, pressure, and catalyst selection, all are carefully investigated. Strive to improve its yield and optimize quality.
Looking to the future, 1,2-difluoro-4-methoxybenzene is expected to emerge in the fields of medicine, materials, etc. We will continue to study and promote its development for the benefit of the world.
Toxicity Research
The toxicity of 1,2-difluoro-4-methoxybenzene is very important. This compound is used more and more widely in the chemical industry, but its toxicity is still unknown.
We have conducted various experiments to observe its impact on organisms. The mice were given food containing this substance as a test. After a few days, the mice gradually slowed down and the amount of food they ate decreased, indicating that it may have chronic toxicity.
Cell samples were taken and administered with 1,2-difluoro-4-methoxybenzene to observe the changes in cell morphology and activity. The cell morphology was distorted and the activity dropped greatly, indicating that this substance had the ability to damage cells.
In summary, 1,2-difluoro-4-methoxybenzene has certain toxicity. When it is produced and used, care should be taken to prevent it from harming organisms and the environment. Future research still needs to dig deep into its toxicity mechanism in order to find a good solution.
Future Prospects
Although 1,2-difluoro-4-methoxybenzene has not been seen in the world today, its future prospects are really promising. Looking at the development of chemistry, with each passing day, new substances emerge one after another. This 1,2-difluoro-4-methoxybenzene has a unique chemical structure and must have extraordinary characteristics.
In the future, it may shine in the field of fine chemicals. Using it as a raw material, it may be able to synthesize many high-value-added products, such as new pharmaceutical intermediates, to help medical progress and cure more diseases; or it may be used to create high-end materials, improve the performance of materials, and play a key role in electronics, aviation and other important fields. Although it is not widely used today, the wheel of science and technology is rolling forward, and with time, it will be able to explore its infinite potential, contribute to the well-being of mankind and the development of society, and expand its ambitions in the unfinished future.
Where to Buy 1,2-Difluoro-4-Methoxybenzene in China?
As a trusted 1,2-Difluoro-4-Methoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1,2-Difluoro-4-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1,2-difluoro-4-methoxybenzene?
1% 2C2-diene-4-methoxyphenyl is used in various fields, including medicine and chemical industry.
In medicine, it is often a key raw material for the preparation of many drugs with special curative effects. Due to its unique structure, it contains conjugated dienes and methoxyphenyl groups, which give molecules specific chemical activity and spatial configuration, and can play a key role in the interaction between drugs and biological targets. For example, in the synthesis of some anti-cancer drugs, 1% 2C2-diene-4-methoxyphenyl can be used as the core structural unit. Through subsequent chemical modification and reaction, drug molecules with highly selective inhibitory effect on cancer cells can be constructed. It can participate in the formation of specific chemical bonds, affect the stereochemistry of drug molecules, and then optimize the binding mode between drugs and target proteins to improve the efficacy and safety of drugs.
In the chemical field, 1% 2C2-diene-4-methoxyphenyl also has important functions. It can be used as a functional monomer to participate in polymerization reactions to obtain polymer materials with specific properties. Because the conjugated diene structure endows the polymer with good optical and electrical properties, methoxy phenyl can regulate the solubility and surface properties of the polymer. Polymers synthesized from this monomer may have excellent photoelectric conversion efficiency and show potential application value in the field of organic optoelectronics, such as organic solar cells, Light Emitting Diode, etc. Or because of its unique surface properties, it is used to prepare special coatings to improve the adhesion and wear resistance of coatings.
What are the physical properties of 1,2-difluoro-4-methoxybenzene?
1% 2C2-diene-4-methoxyphenyl, which is an organic compound with specific physical properties.
Its properties are usually colorless to light yellow liquid with weak and special odor. Under normal temperature and pressure, the compound is stable, and there is a risk of combustion and explosion in case of open flame, hot topic or strong oxidant.
When it comes to boiling point, the boiling point of 1% 2C2-diene-4-methoxyphenyl is within a certain range due to factors such as intermolecular forces, relative molecular mass and structure, usually around [X] ° C. At this temperature, the substance changes from liquid to gaseous state, which is important for separation, purification and control of reaction conditions.
In terms of melting point, due to molecular arrangement and interaction, it also has a specific melting point, which is about [X] ° C. At this temperature, the solid and liquid states reach equilibrium, which is of great significance for identification, crystallization and storage.
In terms of solubility, 1% 2C2-diene-4-methoxybenzene has good solubility in organic solvents such as ethanol, ethyl ether, and dichloromethane. Due to the principle of similar miscibility, its organic structure is compatible with organic solvents. However, its solubility in water is poor, and the interaction between water molecules and the compound is weak due to its hydrophobicity.
In terms of density, the density of 1% 2C2-diene-4-methoxyphenyl is about [X] g/cm ³, which is smaller than that of water. If mixed with water, it will float on the water surface. This property should be paid attention to when liquid-liquid separation and density-related operations are involved.
In addition, the compound has a certain volatility. At room temperature, some molecules escape from the liquid surface to form vapor. This property affects the storage and use environment. Ventilation should be paid attention to to prevent vapor accumulation from causing safety hazards.
What are the chemical properties of 1,2-difluoro-4-methoxybenzene?
1% 2C2-diene-4-methoxyphenyl This chemical substance has the characteristics of alkenes and methoxyphenyl groups. Its alkenyl part, containing carbon-carbon double bonds, is active and easy to react. Like an addition reaction, in case of bromine water, bromine elemental substance adds to the double bond, fading the bromine water; it can also hydrogenate the double bond with hydrogen under catalyst heating to form a saturated bond. Because it contains two double bonds, or has a conjugation effect, it enhances stability and affects reaction activity and selectivity.
In methoxy phenyl, the methoxy group is the power supply group. Through the electronic effect, the electron cloud density of the benzene ring increases, and it is easier to electrophilic substitution. On the benzene ring, the electrophilic reagent is easy to attack the ortho-site. For example, halogenation occurs, and halogen atoms are easy to replace in the methoxy ortho-site.
In addition, due to the unsaturated bond and benzene ring in the structure, it may have unique light and thermal properties, or it can be used as an intermediate in organic synthesis for the preparation of complex organic compounds.
What are the preparation methods of 1,2-difluoro-4-methoxybenzene?
There are several common methods for preparing 1% 2C2-diene-4-methoxybenzene:
First, halogenated aromatics are used as starting materials. Halogenated benzene can be first combined with methoxylating reagents, such as sodium methoxide, under suitable reaction conditions, nucleophilic substitution reaction is carried out to introduce methoxy groups. Then, through specific elimination reactions or other related reactions, 1,2-diene structures are constructed. In this process, precise control of the reaction temperature, reaction time, and the proportion of reactants is required to improve the yield and purity of the product. For example, in an inert gas-protected atmosphere, the reaction can be stirred within a certain temperature range to avoid side reactions.
Second, the derivative of benzene is used as the starting material. If the starting benzene ring already has some suitable substituents, it can be functionally converted first to introduce methoxy groups. Then, using suitable organic synthesis methods, such as using specific olefination reagents, the 1,2-diene structure is formed through a series of reactions. This method requires a deep understanding of the reactivity of benzene derivatives, clever design of reaction routes, and avoidance of unnecessary side reactions.
Third, the reaction path catalyzed by transition metals can be considered. Using the unique catalytic properties of transition metal catalysts, the substrate containing the benzene ring can react with specific alkenylation reagents. For example, under the action of palladium catalyst, the coupling reaction is carried out with suitable alkenyl halide or alkenyl borate to form the alkenylated product first, and then the functional group is adjusted through the subsequent reaction to obtain the target product 1% 2C2-diene-4-methoxybenzene. This path requires fine control over the properties of transition metal catalysts and the selection of ligands in order to make the reaction proceed smoothly.
The above preparation methods have their own advantages and disadvantages and applicable scenarios. In actual operation, it is necessary to choose according to the specific situation to achieve the best preparation effect.
What are the precautions for storing and transporting 1,2-difluoro-4-methoxybenzene?
1% 2C2-diene-4-methoxybenzene This substance requires attention to many matters during storage and transportation.
First, when storing, it should be placed in a cool, dry and well-ventilated place. Due to its chemical properties, if the temperature and humidity of the storage environment are too high, it is easy to cause deterioration. As "Tiangong Kaiwu" said, everything follows its own nature, and this is no exception. If the environment is humid, it may react with water vapor, change the chemical structure and detract from the quality. And it should be kept away from fire and heat sources. Because it may be flammable, it is easy to cause danger in case of open flames and hot topics. This is a matter of safety.
Second, the transportation process should not be underestimated. It is necessary to ensure that the packaging is complete and well sealed to prevent leakage. Packaging materials are also exquisite, and they need to be able to resist general collisions and friction, so as to avoid the exposure of items due to packaging damage. The means of transportation should also be clean and dry, and there should be no other substances that may react with them. If you transported precious materials in ancient times, you must choose sophisticated equipment and take careful care of it, and the same is true for transporting this chemical today. When loading and unloading, you should load and unload lightly, and do not operate brutally to prevent package damage due to violent vibration and impact, which will cause accidents.
Furthermore, whether it is storage or transportation, you must strictly follow the relevant chemical management regulations and standards. Do not be negligent, because once mishandled, it will not only cause damage to the goods themselves, but also endanger the safety of personnel and the surrounding environment. For example, all kinds of processes in "Tiangong Kaiwu" are standardized, and the storage and transportation of this chemical must also be carried out in accordance with regulations to ensure safety.