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1,2-Difluoro-3-Nitrobenzene

1,2-Difluoro-3-Nitrobenzene

Hongda Chemical

Specifications

HS Code

748377

Chemical Formula C6H3F2NO2
Molar Mass 159.09 g/mol
Appearance Liquid (usually)
Color Colorless to light yellow
Boiling Point 197 - 198 °C
Melting Point 12 - 14 °C
Density 1.472 g/cm³
Solubility In Water Insoluble
Flash Point 82 °C
Vapor Pressure Low (at room temperature)
Odor Characteristic aromatic odor

As an accredited 1,2-Difluoro-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 1,2 - difluoro - 3 - nitrobenzene packaged in a sealed, corrosion - resistant bottle.
Storage 1,2 - difluoro - 3 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is potentially flammable. Keep it in a tightly closed container, preferably made of corrosion - resistant materials due to its chemical nature. Store it separately from oxidizing agents and reducing agents to prevent hazardous reactions.
Shipping 1,2 - difluoro - 3 - nitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It is transported under proper temperature control, following strict hazardous chemical shipping regulations to ensure safety during transit.
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1,2-Difluoro-3-Nitrobenzene 1,2-Difluoro-3-Nitrobenzene
General Information
Historical Development
The chemical industry is changing with each passing day, and there are many substances. There are 1,2-difluoro-3-nitrobenzene, which also has a unique process in the chemical industry. In the past, chemical research began to flourish, exploring the properties and production methods of various substances, and this compound gradually entered the field of vision. In the early days, due to technical limitations, synthesis was difficult and output was limited. However, with the passage of time and the advance of science and technology, many chemists worked hard to study their new synthesis methods. Through unremitting efforts, the synthesis skills became increasingly exquisite, and the output also increased. From its initial rarity to its increasing popularity in the chemical industry, 1,2-difluoro-3-nitrobenzene has witnessed the process of chemical development, just like a drop in the long river, but it shines with unique brilliance, leaving an indelible mark on the evolution of chemical history.
Product Overview
1,2-Difluoro-3-nitrobenzene is an organic compound. It is a colorless to light yellow liquid with a special odor. This substance has a wide range of uses in the field of organic synthesis.
Its preparation method is often obtained by a specific reaction path. Through a series of reaction steps such as halogenation and nitrification, the reaction conditions such as temperature, pressure, and catalyst use can be carefully controlled to achieve the purpose of preparation.
In the chemical industry, 1,2-difluoro-3-nitrobenzene is an important intermediate. It can be used to create a variety of drugs, pesticides, and functional materials. Due to its fluorine-containing and nitro-containing special functional groups, this compound is endowed with unique chemical activity and physical properties, which helps to derive many products with special properties. It makes a significant contribution to the development of modern chemical industry.
Physical & Chemical Properties
1,2-Difluoro-3-nitrobenzene is an organic compound. Its physical properties, at room temperature, are colorless liquids with a special odor. Its boiling point is between several degrees Celsius. Due to the exact value, it is often measured experimentally and varies slightly with environmental conditions. Its density is heavier than water, placed in water, and sinks at the bottom.
In terms of its chemical properties, the presence of fluorine atoms and nitro groups on the benzene ring gives it a unique reactivity. Nitro is a strong electron-absorbing group, which decreases the electron cloud density of the benzene ring, making it difficult for electrophilic substitution reactions to occur, but nucleophilic substitution reactions are easier to proceed. Although fluorine atoms have strong electronegativity, they can participate in various chemical reactions under specific conditions, such as exchange reactions with nucleophiles. This compound is often an important intermediate in the field of organic synthesis. With its special physicochemical properties, it can prepare many organic materials with specific functions.
Technical Specifications & Labeling
Today there is a product called 1,2-difluoro-3-nitrobenzene. In our chemical research, process specifications and identification (product parameters) are the key.
This 1,2-difluoro-3-nitrobenzene, the process specifications need to be precisely controlled. The choice of raw materials must be pure, and the ratio must be compatible. If various reactants meet, they should be based on a specific number to make the reaction smooth. In the reaction environment, the temperature and pressure must not be ignored, and they must be stable in a suitable area to obtain good results.
As for the identification (product parameters), the appearance and color should be carefully observed, and the smell should also be the main point. Its purity, geometry, and impurity content all need to be clear. Such data are truthfully marked as evidence for identification, so that everyone can see the nature of the product at a glance, and it can be used properly in the chemical industry.
Preparation Method
The preparation method of 1,2-difluoro-3-nitrobenzene is related to the production of raw materials, reverse steps and catalytic processes. The raw materials are very important, and a specific starting material needs to be obtained, and it can only be achieved by multi-step refinement and reverse steps.
First take the amount of an aryl compound, this radical. Mix fluorine-containing fluoride in a specific ratio, in a dense and high-density reactor, and control it to a certain precision. At this step, fluorine atoms can be introduced. After the reverse is determined, the temperature is slightly reduced, and the nitrogenation is added, and the specific temperature is raised again. The nitro is cleverly connected to complete the purification.
The catalytic preparation cannot be ignored. The use of high-efficiency gold compounds and catalysts can greatly improve the performance of the reaction rate. After each reaction step is completed, the extraction, refining and other steps are lifted to obtain a high degree of 1,2-difluoro-3-nitrobenzene. This method requires a grid to control the quality of each product in order to ensure the quality of the product.
Chemical Reactions & Modifications
Recently, we have studied the chemical and anti-modification of 1,2-difluoro-3-nitrobenzene, and we have gained some experience. This compound is unique, and there is no way to investigate it.
Its reverse path often follows a specific method. Due to the nuclear substitution and the activity of fluorine atoms, it can be replaced by multiple nuclei. However, it is difficult to control the high-quality components.
As for the modification, different bases are introduced to improve its properties. The introduction of multiple and donor sub-groups can slightly improve its sub-cloud density and optical properties. This is all obtained, and further research is still needed, hoping that more breakthroughs can be made in the application of this compound and explore new frontiers.
Synonyms & Product Names
1,2-Difluoro-3-nitrobenzene, the essence of chemical. Among all the same substances, it has unique characteristics. Although its name is the same, it is also known by all who know it.
The same name of this substance is either named by its nature or by its structure. Or according to the system, or according to the use, each has its own name. Although the names are different but the quality is the same, they all refer to this thing.
As for the business names, they are also different. The business names are different according to their aspirations and wishes. However, the origin is this 1,2-difluoro-3-nitrobenzene. In the chemical industry, it has a wide range of uses and is important for all workers. It is also well known in the industry with its same name and trade name, and cannot be ignored.
Safety & Operational Standards
Safety and Handling Specifications for 1,2-Difluoro-3-nitrobenzene
Fu 1,2-difluoro-3-nitrobenzene is an important substance in chemical research. When it is researched and used, safety and handling standards are of paramount importance.
This substance is dangerous to a certain extent. From the perspective of physical properties, its properties are unique, odor is different from normal, and under specific conditions, it may be volatile. Chemically, it is active and sensitive, and may react violently when exposed to certain substances.
In terms of safety, store it first. Keep it in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its flammability, fire prevention is a priority. It should be stored separately from oxidants, reducing agents, etc., and must not be mixed to prevent accidental chemical reactions.
When operating, all norms must be strictly observed. Experimenters need to wear professional protective equipment, such as protective clothing, protective gloves and goggles, to prevent contact and splash damage. Operate in a fume hood to disperse possible harmful gases and ensure the safety of the experimental environment. During operation, the action should be steady and slow to avoid violent vibration and collision to prevent danger.
If a leak unfortunately occurs, do not panic. When evacuating the leaking contaminated area quickly to a safe area, isolate and strictly restrict access. Emergency responders must wear self-contained positive pressure breathing apparatus, wear anti-virus clothing, and cut off the leakage source as much as possible. In the case of small leaks, it can be absorbed by sand, vermiculite or other inert materials. For large leaks, it is necessary to build embankments or dig holes to contain them, cover them with foam, reduce steam disasters, and then properly dispose of them.
In short, in the research and use of 1,2-difluoro-3-nitrobenzene, safety and operating standards are the cornerstones of ensuring personnel safety and smooth experiments, and must not be neglected.
Application Area
1,2-Difluoro-3-nitrobenzene is also a chemical substance. Its application field is very critical. In the field of pharmaceutical synthesis, it can be used as an important intermediate to help create special drugs, cure various diseases, and save people's suffering. In the context of material research and development, it is also very useful, which can optimize material properties and make materials more suitable for specific needs, such as enhancing its stability, heat resistance, etc.
In the past, the discovery and application of various chemical substances have promoted the progress of the world. 1,2-Difluoro-3-nitrobenzene is no exception. Its application in different fields, such as pearls, has added luster to the development of various industries. We should deeply study its nature and make good use of its ability to promote the progress of science and technology and people's livelihood, so that this material blooms more brilliantly in the application field and benefits all people in the world.
Research & Development
1,2-Difluoro-3-nitrobenzene is something I have been studying very carefully. When I first came into this, I found that its properties are very different, and it often takes on a different state in various chemical reactions.
I have carefully observed the structure of its molecules, the strength of its bonds, and the distribution of its electron clouds. After repeated experiments, I have observed the rate of its reaction with other substances and the characteristics of its products. Every new acquisition is carefully recorded.
Now looking at its application in the field of synthesis, it has great potential. Or it can be used as a key intermediate to produce a variety of high-value-added products. Although the road ahead is long, I firmly believe that through unremitting research, it will be able to expand its application, promote its wide spread in various fields of chemical industry, add new color to the academic and industry, and lead it to move forward steadily to reach new territory.
Toxicity Research
Those who study poisons in modern times focus on the toxicology of 1,2-difluoro-3-nitrobenzene. This substance is strong and potentially harmful. Try to study it in various ways to observe its impact on living things. Take white mice as an experiment, feeding food containing this substance. Not long after, white mice are more uncomfortable, slow to move, sharp loss of diet, and dull hair. And its organs also have abnormal changes, liver and kidney functions are damaged. And plant test, planted in the soil containing this substance, growth is sluggish, and leaves gradually wilt. It can be seen that 1,2-difluoro-3-nitrobenzene is very toxic, and it is harmful to animals and plants. When studying its toxicology, be careful to prevent harm to all living beings.
Future Prospects
In today's world, 1,2-difluoro-3-nitrobenzene is unique and has a wide range of uses. Our scientific researchers are full of hope for its future development.
In the chemical industry, 1,2-difluoro-3-nitrobenzene may be the cornerstone of new materials. With the advancement of science and technology, the demand for materials is changing day by day, and it may be able to enter the ranks of high-end materials through exquisite synthesis paths, adding to the electronics and aerospace industries.
In the process of pharmaceutical research and development, there are also infinite possibilities. After fine modification, or into a specific drug precursor, it will help to overcome difficult diseases. And under the trend of green synthesis, the development of efficient and low-cost production methods should be a priority in the future. Optimize the process, reduce pollution and reduce emissions, so that production and the environment coexist harmoniously.
Furthermore, expand the method of detection and analysis, accurately grasp its properties and reactions, in order to make better use of it. We should study diligently to make 1,2-difluoro-3-nitrobenzene shine in the future and benefit the world.
Where to Buy 1,2-Difluoro-3-Nitrobenzene in China?
As a trusted 1,2-Difluoro-3-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1,2-Difluoro-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1,2-difluoro-3-nitrobenzene?
1,2-Diethyl-3-cyanopyridine has a wide range of main uses. In the field of medicine, it is often a key intermediate for the synthesis of many drugs with important curative effects. For example, in the preparation of some antibacterial drugs, it is used as a basic raw material to participate in the construction of the core chemical structure of the drug, and through its unique chemical properties, gives the drug antibacterial activity.
In the field of pesticides, 1,2-diethyl-3-cyanopyridine also plays an important role. It can be used as an important component in the synthesis of high-efficiency pesticides, which can enhance the killing power and pertinence of pesticides to pests, improve the effect of pesticides, protect crops from pest infestation, and ensure a bumper agricultural harvest.
In addition, in the field of materials science, it can be used to synthesize organic materials with specific properties. Due to its molecular structure properties, it can impart unique optical, electrical and other properties to materials, and is applied to the research and development and preparation of new materials such as organic Light Emitting Diode (OLED), which promotes the progress and innovation of materials science.
In summary, 1,2-diethyl-3-cyanopyridine has important uses in many fields such as medicine, pesticides and materials science, and is of great significance to the development of related industries.
What are the physical properties of 1,2-difluoro-3-nitrobenzene?
1% 2C2-diene-3-cyanopyridine, this substance is an organic compound with special physical and chemical properties. Its properties are colorless to pale yellow liquid at room temperature, with a special odor.
On solubility, it is soluble in common organic solvents such as ethanol and ether, but has limited solubility in water. This is because its molecular structure contains lipophilic groups, which makes it poorly hydrophilic, and it dissolves well in organic solvents due to similar miscibility principles.
Boiling point and melting point are important physical properties. The boiling point is in a specific temperature range, reflecting the strength of intermolecular forces. The intermolecular forces of this compound include van der Waals force and dipole-dipole force, so that its boiling point maintains a certain value. The melting point is also determined by the molecular arrangement and interaction, and it is converted from a solid state to a liquid state at a specific temperature.
In terms of chemical properties, the carbon-containing carbon double bond and the cyanyl group make it highly reactive. The carbon-carbon double bond can undergo addition reactions, such as addition with halogens and hydrogen halides, to construct new carbon-carbon bonds or introduce other functional groups. The cyanyl group can be hydrolyzed to form carboxyl groups, or converted into amino groups by reduction reaction, thereby preparing a variety of organic compounds, which are widely used in the field of organic synthesis.
In addition, the conjugated structure of 1% 2C2-diene-3-cyanopyridine gives it certain optical properties, or can absorb specific wavelengths of light, which has potential application value in the field of photochemistry. Due to its unique physicochemical properties, it has attracted attention in many fields such as medicine and materials science, and has developed important raw materials for organic synthesis and new materials.
Is the chemical properties of 1,2-difluoro-3-nitrobenzene stable?
1% 2C2-diethyl-3-cyanopyridine This compound has relatively stable chemical properties. Because of its structure, cyano (-CN) has a strong electron-absorbing ability, which can make the electron cloud distribution of the molecule relatively stable, and it is not easy to react easily disturbed by external factors. At the same time, the pyridine ring is aromatic, and the π electron cloud forms a closed conjugate system, which endows the pyridine ring with high stability, making it less prone to reactions such as ring opening and other destructive structures. In addition, the connection of two ethyl groups to the pyridine ring increases the steric resistance of the molecule to a certain extent, making it difficult for other reagents to approach the active check point, further enhancing the stability of the molecule.
However, this stability is not absolute. Under certain conditions, such as high temperature, strong acid-base environment or the presence of specific catalysts, the compound will also react. For example, under strong basic conditions, the cyanyl group may undergo hydrolysis and be converted into other functional groups such as carboxyl or amide groups; when high temperature and there is a suitable catalyst, the substituents on the pyridine ring may undergo reactions such as rearrangement. However, in general, under normal temperature, pH and general chemical environment, 1% 2C2-diethyl-3-cyanopyridine can maintain relatively stable chemical properties.
What are the synthesis methods of 1,2-difluoro-3-nitrobenzene?
The synthesis methods of 1% 2C2-diene-3-cyanobenzene generally include the following:
First, benzene is used as the starting material. The benzene is first halogenated to introduce halogen atoms, such as halogen with halogen under the action of catalyst to form halobenzene. Then, through cyanide substitution reaction, the halogen atom is replaced with cyanide to obtain cyanobenzene. Then, through a specific alkenylation reaction, under suitable reaction conditions and the action of reagents, the 1,2-diene structure is introduced into the benzene ring. During this process, the alkenylation reaction requires fine regulation of the reaction conditions, such as temperature, solvent and catalyst type, to ensure that the position and configuration of the double bond are accurate.
Second, start from the compounds containing alkenyl groups. If there are suitable feedstocks with alkenyl groups that are easy to carry out subsequent reactions, the alkenyl groups can be protected first to prevent unnecessary changes in the double bonds in the subsequent reactions. Subsequently, the cyanyl group is introduced through reactions such as nucleophilic substitution, and then the alkenyl group is restored through the deprotection step, and the alkenyl group is appropriately modified to construct the 1,2-diene structure. This path requires careful selection of the protecting group, which not only ensures the stability of the protecting group in the subsequent reaction, but also can be successfully removed under appropriate conditions.
Third, the coupling reaction catalyzed by transition metals. Select suitable halogenated aromatics, alkenyl halides and cyanyl sources, and construct target molecules through multi-step coupling reaction under the action of transition metal catalysts such as palladium and nickel. The key to this method lies in the selection of catalysts and the optimization of reaction conditions. Different transition metal catalysts have different activities and selectivity. Reaction temperature, type of base and ligand and other factors will also significantly affect the reaction yield and selectivity. It is necessary to carefully explore each reaction condition to achieve efficient synthesis of 1% 2C2-diene-3-cyanobenzene.
What are the precautions for storing and transporting 1,2-difluoro-3-nitrobenzene?
1% 2C2-diene-3-cyanobenzene is a special chemical substance. In the process of storage and transportation, there are many things to pay attention to.
Bear the brunt, the storage place must be dry and cool. This substance is afraid of moisture and heat, humid or high temperature environment, which can easily cause it to deteriorate or cause chemical reactions. Therefore, it is crucial to choose a place with good ventilation and constant temperature in an appropriate range. If placed in a humid place, water vapor can easily interact with it, or change its chemical structure; if placed in a high temperature place, it may cause its volatilization to accelerate, and even risk combustion and explosion.
Furthermore, when transporting, the packaging must be strict. Special containers are required to ensure their tightness to prevent leakage. Because of its certain chemical activity, once it leaks or reacts with surrounding substances, it will endanger the environment and the safety of transporters. And during transportation, bumps and collisions should be avoided to avoid damage to the container and cause the material to flow out.
Repeat, storage and transportation should be away from fire sources and oxidants. When this substance encounters an open flame or a strong oxidant, or reacts sharply, it will ignite a raging fire, or even explode, causing a disaster. Therefore, in the relevant areas, fireworks are strictly prohibited, and the oxidants should also be placed separately to prevent the possibility of contact between the two.
In addition, the operation and management personnel must be professionally trained. Familiar with the characteristics of the substance, storage and transportation specifications, can act. In this way, in the event of an accident, it can be handled quickly and correctly to minimize losses and hazards.