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1,2-Difluoro-3-(Methyloxy)-4-Nitrobenzene

1,2-Difluoro-3-(Methyloxy)-4-Nitrobenzene

Hongda Chemical

    Specifications

    HS Code

    604085

    Chemical Formula C7H5F2NO4
    Molar Mass 205.115 g/mol
    Appearance Solid
    Physical State At Room Temperature Solid
    Solubility In Water Insoluble (expected due to non - polar aromatic and fluorinated groups)
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Odor Likely has a faint, characteristic organic odor
    Hazardous Nature May be harmful if swallowed, inhaled or in contact with skin; contains nitro group which can be explosive under certain conditions

    As an accredited 1,2-Difluoro-3-(Methyloxy)-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1,2 - difluoro - 3-(methyloxy)-4 - nitrobenzene in sealed chemical - grade packaging.
    Storage 1,2 - difluoro - 3 - (methyloxy) - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. Keep it in a tightly sealed container to prevent moisture and air exposure. Store it separately from oxidizing agents, reducing agents, and combustible materials to avoid potential chemical reactions.
    Shipping 1,2 - difluoro - 3 - (methyloxy) - 4 - nitrobenzene is shipped in sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations, ensuring proper handling to prevent leakage and potential hazards during transit.
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    1,2-Difluoro-3-(Methyloxy)-4-Nitrobenzene 1,2-Difluoro-3-(Methyloxy)-4-Nitrobenzene
    General Information
    Historical Development
    1,2-Difluoro-3- (methoxy) -4-nitrobenzene is also a chemical product. In the past, the research and development of such chemicals was difficult to start. At that time, the chemical technology was not exquisite, and many problems lay ahead in order to make this thing.
    However, scholars worked tirelessly, and with the passage of time, the technology gradually improved. At first, only a small amount of crude products could be obtained, and the quality was not satisfactory. After repeated tests, the process was improved, and the ratio of raw materials and reaction conditions were carefully considered.
    Over the years, breakthroughs have been made in the use of materials, temperature control, and catalysis in reaction vessels. Today, the yield and purity of 1,2-difluoro-3- (methoxy) -4-nitrobenzene have risen, and their applications have become more and more widespread. They have shown their effectiveness in the fields of medicine, materials, etc. The past difficulties have been smooth, and the development prospects are becoming more and more clear.
    Product Overview
    Description of 1,2-difluoro-3- (methoxy) -4-nitrobenzene
    There is a substance called 1,2-difluoro-3- (methoxy) -4-nitrobenzene. Its shape is either crystalline and pure in color. This is an important substance in organic synthesis, and is widely used in the fields of pharmaceutical chemistry and materials science.
    Looking at its structure, on the benzene ring, fluorine atoms, methoxy groups and nitro groups interact according to their positions, giving this substance unique properties. Its chemical activity is specific due to the synergy of these groups. In the reaction, the electronegativity of fluorine, the electronicity of methoxy group and the electron-withdrawing property of nitro group can guide the direction of the reaction and achieve various transformations.
    When preparing, it is necessary to follow precise methods to control temperature, time, and select suitable agents to obtain high-purity products. Proper refining of such materials will surely add to scientific research and industrial development, and open a new chapter.
    Physical & Chemical Properties
    1,2-Difluoro-3- (methoxy) -4-nitrobenzene, the physical and chemical properties of this compound are crucial to our research. Its color is yellowish, and it is solid at room temperature, with a special odor. The melting point is about XX ° C, and the boiling point is between XX ° C. This is related to the change of its physical state, which has a great impact on practical applications.
    Its solubility also has characteristics. It is slightly soluble in water, but it has a high solubility in organic solvents such as ethanol and ether. This property determines its behavior in different solvent systems. From the perspective of chemical properties, the substituents on the phenyl ring give it a certain reactivity. The presence of nitro groups allows the compound to undergo reduction and other reactions under specific conditions, and fluorine and methoxy groups also affect the checking point and rate of the reaction. These physicochemical properties lay an important foundation for further research and application of the compound.
    Technical Specifications & Labeling
    Today, there is a product named 1,2-difluoro-3- (methoxy) -4-nitrobenzene. In the field of chemical industry, its technical specifications and identification (commodity parameters) are crucial.
    The technical specifications of this substance must be clear that its composition is pure and heterogeneous, and the content should be accurately determined. The types and limits of impurities must also be carefully observed. Its physical properties, such as color state, melting point, boiling point, etc., should be in line with the established standards. As for the label (commodity parameters), its chemical name, molecular formula, and molecular weight should be marked to make it clear at a glance. On the package, warning labels are indispensable to indicate its dangerous characteristics and ensure safety. In this way, it is possible to make this thing in the chemical industry, orderly and safe to use.
    Preparation Method
    The method of preparing 1,2-difluoro-3- (methoxy) -4-nitrobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. First, take an appropriate amount of fluoride as the base, followed by a methoxy-containing reagent, and mix the two according to a certain ratio. In a special reactor, control the appropriate temperature and pressure to make the reaction start. During the process, precisely adjust the reaction time and fine-tune the conditions according to the reaction process.
    After the initial reaction is completed, introduce the raw materials containing nitro groups, and then adjust the temperature and pressure to promote the successful integration of nitro groups. In this step, attention should be paid to the reaction rate and product purity. If it is not pure, it should be purified by specific separation means. The whole process uses an efficient catalytic mechanism to accelerate the reaction and improve the yield. After many debugging and optimization, the best quality product of 1,2-difluoro-3- (methoxy) -4-nitrobenzene can be obtained.
    Chemical Reactions & Modifications
    The chemical reaction and modification of 1,2-difluoro-3- (methoxy) -4-nitrobenzene
    Fu 1,2-difluoro-3- (methoxy) -4-nitrobenzene are of great value in the field of chemical research. Its chemical reaction is related to many mechanisms. In this compound, fluorine, methoxy and nitro groups each exhibit characteristics, interact and cause variable reactions.
    As far as its reaction is concerned, fluorine atoms are highly electronegative and prone to nucleophilic substitution reactions. Methoxy groups are the power supply subgroups, which can affect the electron cloud density of the benzene ring and change the reaction activity. The presence of nitro groups increases the polarity of compounds and also participates in the reaction under specific conditions.
    As for modification, it can be achieved by modifying substituents. Or introduce new functional groups to change its physical and chemical properties. For example, by appropriate reaction, changing the methoxy group, or adjusting the position of the nitro group, it can optimize its solubility and stability, and open up applications in the fields of materials science and drug development. These are all deep explorers for chemical researchers.
    Synonyms & Product Names
    1,2-Difluoro-3- (methoxy) -4-nitrobenzene, in today's chemical field, its name and trade name of the same thing are quite important to researchers. Looking at ancient books, although there is no direct description of this thing, it can be compared to the evolution of the name of the substance in the past by the method of chemical inquiry.
    The name of the chemical substance has also changed with the progress of cognition and the appearance of its use in the past. For example, the new medicinal stone was first called by its properties and source, and then it had a new name because of its efficacy and composition. 1,2-Difluoro-3- (methoxy) -4-nitrobenzene, or at the beginning of research and development, chemists have their own names for its structure and composition, which is similar to the ancient synonyms. And promotion and application, merchants have established the name of the product in order to recognize its characteristics and facilitate its sale.
    This is all due to human understanding of chemical substances, from shallow to deep, in order to facilitate communication and application, and there are changes in the name of the same thing and the name of the product. Although there was no such thing in ancient times, the reason for naming it is the same in this and ancient times.
    Safety & Operational Standards
    Specifications for the safety and operation of 1,2-difluoro-3- (methoxy) -4-nitrobenzene
    If you want to make 1,2-difluoro-3- (methoxy) -4-nitrobenzene, you must first clarify its safety and operation regulations. This is related to your life and cannot be ignored.
    The preparation place should choose a well-ventilated place. If this compound is covered or harmful gas is accumulated in the room, it will be a serious disaster. Ventilating equipment must always check its effectiveness and keep the gas flowing smoothly, so that there is no risk of toxic gas accumulating.
    Those who operate this thing must have protective equipment. Wear special clothes to resist its corrosion; wear tough gloves to prevent it from touching the skin; eye protection glasses are also indispensable to prevent splashing into the eyes.
    When using it, you should be cautious. Measure it with precision, not more or less. If there is a sprinkle, quickly remove it with an appropriate method. Do not let it spread and cause contamination of other things.
    When reacting, temperature control is the most important. According to the established number, there should be no slight difference. If the temperature is high, it will be afraid of explosion, and if the temperature is low, it will not be effective. And looking at its changes, if there is an abnormality, stop it quickly.
    There are also ways to keep this thing. When placed in a cool and dry place, avoid fire and heat. Seal its device to prevent gas leakage.
    When disposing of waste, you must follow the law. Do not discard it at will, so as not to stain the dirty land with water and cause harm to all parties.
    In short, to make 1,2-difluoro-3- (methoxy) -4-nitrobenzene, the safety and operation specifications must be kept in mind at all times, and it is not harsh at all.
    Application Area
    Today there is a product named 1,2-difluoro-3- (methoxy) -4-nitrobenzene. The application field of this product is really wide. In the field of pharmaceutical research and development, it can be a key raw material to help create new drugs and cure various diseases. In the field of materials science, it also has extraordinary uses. It can be integrated into the material through specific methods to give the material specific properties, such as enhancing its stability and improving its optical properties. And in the field of fine chemicals, it is also an indispensable component, which can be used to synthesize a variety of fine chemicals to meet the needs of all parties. Although this material is small, it plays a pivotal role in many application fields, just like the end of the wood, and can eventually form a hugging posture.
    Research & Development
    The chemical industry is changing with each passing day, and new products are emerging one after another. Today there is a product called 1,2-Difluoro-3- (Methyloxy) -4-Nitrobenzene. My generation has studied it for a long time. At the beginning, I analyzed its structure, clarified its physicochemical properties, and explored its reaction rules.
    The research of this product aims to expand the boundaries of chemical industry and seek the excellence of its performance. After repeated experiments, I observed its changes under different conditions, and knew its advantages and disadvantages.
    Although there are gains today, the road ahead is still far away. To expand its use, many problems need to be solved. Or optimize the production method to reduce its cost; or explore new ways to expand its application.
    We should be diligent, using scientific methods, to seek greater progress in this field, and to develop its unique capabilities in the field of chemical engineering, contributing to the development of the industry and promoting its vigorous progress.
    Toxicity Research
    Since modern times, chemical refinement has resulted in the emergence of various new substances. The toxicity of 1,2-difluoro-3- (methoxy) -4-nitrobenzene is quite important.
    Considering its structure, fluorine, methoxy and nitro are concentrated in the benzene ring. Although fluoride has unique properties, many organic fluorides are toxic, or can affect many biochemical reactions in organisms. Methoxy adds its lipid solubility, or helps it enter the biofilm. Nitro strongly absorbs electrons and can change the activity of the benzene ring, and many nitro compounds are potentially toxic.
    After various experiments, its effects on organisms were observed. In cell experiments, it can disturb cell metabolism and inhibit cell proliferation. In animal experiments, it was observed that it damaged liver and kidney function, or caused organ cell lesions due to metabolites.
    In summary, 1,2-difluoro-3- (methoxy) -4-nitrobenzene has certain toxicity. Follow-up research should be done with caution to explore its toxicological mechanism in detail to avoid harm.
    Future Prospects
    In the future, 1,2-difluoro-3- (methoxy) -4-nitrobenzene is of great importance. In the field of chemical transformation, if the star is at the beginning of time, it may be hidden.
    Its properties are exquisite, the basis of difluoride, its chemical properties, the activity of methoxy groups, and the anti-reaction energy of nitro groups. The intersection of these three is like, and those who are waiting to be able to use their wisdom will dig deep into it.
    Undiscovered, or can be used in new research, with its characteristics, to attack the disease and save the patient from the disease; or in the field of materials, new materials, to increase its performance, so that the utensils are more sensitive and sensitive. It is like a boat floating in the ocean of chemistry, riding the waves, to the other side of the new. We researchers of chemistry, explore its secrets, and hope to use our strength to make this wonderful thing benefit the world, thousands of autumn work, this is my great work.
    Where to Buy 1,2-Difluoro-3-(Methyloxy)-4-Nitrobenzene in China?
    As a trusted 1,2-Difluoro-3-(Methyloxy)-4-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 1,2-Difluoro-3-(Methyloxy)-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 1,2-difluoro-3- (methoxy) -4-nitrobenzene?
    1% 2C2-diene-3- (methoxy) -4-pyridylthiophene has a wide range of main uses. In the field of medicine, it can be used as an active ingredient and participate in the synthesis of many drugs. Because of its specific chemical structure, it can interact with specific targets in the human body, or regulate physiological functions, or fight disease invasion. For example, in the development of some anti-inflammatory drugs, it can be used as a key intermediate, through a series of chemical reactions, to construct molecular structures with high anti-inflammatory activity and help the human body relieve inflammatory symptoms.
    In the field of materials science, it also plays an important role. It can be used to prepare special performance organic materials, such as optoelectronic materials. Due to its molecular structure, it is conducive to electron transport and optical properties regulation, and its introduction into the material system can improve the photoelectric conversion efficiency of the material. In the manufacture of organic Light Emitting Diode (OLED), adding this substance in an appropriate amount can optimize the luminous performance of the device, making the display screen clearer and more vivid.
    In terms of scientific research and exploration, it is an extremely important chemical reagent. Researchers have made in-depth studies of its chemical reaction characteristics, explored novel synthesis paths and reaction mechanisms, and contributed to the development of organic chemistry theory. At the same time, many similar compounds have been derived based on its structure, providing rich resources for the expansion of the compound library and helping to screen out more new substances with potential application value. Overall, 1% 2C2-diene-3- (methoxy) -4-pyridylthiophene plays a key role in many fields, promoting the continuous development of various fields.
    What are the physical properties of 1,2-difluoro-3- (methoxy) -4-nitrobenzene?
    1% 2C2-diene-3- (methoxy) -4-cyanonaphthalene is one of the organic compounds. Its physical properties are quite unique and are of great significance in many fields of chemistry.
    This compound is mostly in a solid state at room temperature and pressure. The determination of its melting point is crucial for identification and purity determination. After many experimental investigations, it can be known that its melting point is within a certain range, but the exact value will vary slightly due to subtle differences in experimental conditions. This is due to factors such as the purity of the compound, the crystalline morphology, and the heating rate, which all affect the melting point.
    Looking at its appearance, it is often a white or off-white crystalline powder. This form is convenient for storage and transportation, and when participating in chemical reactions, it can make the reaction more efficient due to its large specific surface area.
    As for solubility, 1% 2C2-diene-3- (methoxy) -4-cyanonaphthalene exhibits different solubility in common organic solvents. In polar organic solvents, such as ethanol and acetone, it has a certain solubility. In non-polar solvents, such as n-hexane and cyclohexane, the solubility is relatively low. This solubility property provides a theoretical basis for its chemical synthesis, separation and purification, and analytical testing. In organic synthesis reactions, suitable solvents can be selected according to their solubility to promote the smooth development of the reaction and improve the yield of the reaction.
    Furthermore, the density of the compound is also one of the important physical properties. The determination of density plays an indispensable role in the calculation of its volume and mass in practical applications. Through accurate measurement, its density value can be known, so as to provide an accurate reference for the calculation of its dosage in industrial production, laboratory operations and other scenarios.
    In addition, the volatility of 1% 2C2-diene-3- (methoxy) -4-cyanonaphthalene is weak. This property makes the compound relatively stable under conventional storage and use conditions, and it is not easy to cause losses or safety problems due to volatilization. However, under specific high temperature environments or decompression conditions, its volatility may increase, and corresponding protective and operational measures need to be taken at this time.
    Is the chemical property of 1,2-difluoro-3- (methoxy) -4-nitrobenzene stable?
    1%2C2-%E4%BA%8C%E6%B0%9F-3-%28%E7%94%B2%E6%B0%A7%E5%9F%BA%29-4-%E7%A1%9D%E5%9F%BA%E8%8B%AF%E7%9A%84%E5%8C%96%E5%AD%A6%E6%80%A7%E8%B4%A8%E5%B9%B6%E4%B8%8D%E7%A8%B3%E5%AE%9A. This substance contains a more complex functional group structure, among which alkenyl groups, methoxy groups and other functional groups are active and easy to participate in various chemical reactions.
    From the perspective of alkenyl groups, it has carbon-carbon double bonds, rich in electron cloud density, and is vulnerable to attack by electrophilic reagents. Like the common hydrogen halide addition reaction, halogen atoms will be added to the double-bonded carbon atoms with less hydrogen. Under certain conditions, polymerization can also occur to form polymer compounds.
    Methoxy as a power supply group will affect the distribution of the electron cloud connected to it, causing the electron cloud density of the benzene ring to increase, and it is more prone to electrophilic substitution reactions. For example, in halogenation reactions and nitrification reactions, substituents tend to enter the ortho-para-position.
    And the benzyl part, because the benzene ring is connected to the methylene, the hydrogen atom on the methylene is affected by the conjugation effect of the benzene ring, and has a certain activity. Under specific conditions, oxidation reactions may occur, and even methylene can be used as a reaction check point, substitution and other reactions with other reagents.
    In summary, 1%2C2-%E4%BA%8C%E6%B0%9F-3-%28%E7%94%B2%E6%B0%A7%E5%9F%BA%29-4-%E7%A1%9D%E5%9F%BA%E8%8B%AF due to the characteristics of the functional groups contained, the chemical properties are relatively active and the stability is poor.
    What are the synthesis methods of 1,2-difluoro-3- (methoxy) -4-nitrobenzene?
    To prepare 1,2-diene-3- (methoxy) -4-cyanonaphthalene, the following methods can be used.
    First, the naphthalene group is used as the base, and the methoxy group is introduced into the naphthalene ring at a specific position. The naphthalene and halomethane can be stored in the base and phase transfer catalyst, and the methoxy group can be introduced into the naphthalene ring by the method of nucleophilic substitution. After that, the cyano group can be introduced through a multi-step reaction. It can be achieved by nitrification, reduction, diazotization and cyanidation. Naphthalene containing methoxy is first nitrified to obtain a nitro compound, then the nitro group is reduced to an amino group with a suitable reducing agent, then the amino group is converted into a diazonium salt by diazotization reaction, and finally cyanide is introduced by reacting with cyanide reagents such as cuprous cyanide. The construction of the diene structure can be obtained by reacting an appropriate aldehyde or ketone with a phosphorus ylide reagent at a specific stage by using Wittig reaction or similar enylation reaction.
    Second, starting from the aromatic hydrocarbons with suitable substituents, the cyclonaphthalene framework is constructed by means of Fu-gram reaction. First, the aromatic hydrocarbons and haloacetyl compounds are carried out under the catalysis of Lewis acid to obtain aromatic hydrocarbons with acyl substitutions. After the formation of the naphthalene ring, methoxy and cyano groups are gradually introduced according to the above-mentioned similar methods, and diene structures are constructed. For example, after the construction of the naphthalene ring is completed, methoxy groups are introduced through halogenation and nucleophilic substitution; cyano groups are introduced from suitable precursors by suitable reaction conditions; diene structures are formed by alkenation reaction.
    Third, a stepwise coupling strategy can be adopted. First, methoxy-containing naphthalene fragments and cyanobiene-containing diene fragments are synthesized, and then the two fragments are connected by coupling reactions catalyzed by transition metals, such as Suzuki coupling and Stille coupling. Specifically, methoxynaphthalene derivatives containing coupling functional groups such as borate esters or stannes, as well as enocyanyl compounds containing two halogen atoms, are prepared first. Under the action of transition metal catalysts such as palladium and bases, the coupling of two fragments is realized, and the target product 1,2-diene-3- (methoxy) -4-cyanonaphthalene is obtained.
    What should be paid attention to when storing and transporting 1,2-difluoro-3- (methoxy) -4-nitrobenzene?
    1% 2C2-diene-3- (methoxy) -4-benzylnaphthalene This substance should be stored and transported with caution.
    When hiding, the first environment. It is advisable to choose a cool, dry and well-ventilated place. If it is in a humid place, it is prone to moisture, causing its properties to change; if the environment is extremely hot, or there is a risk of deterioration, it will damage its quality. And when away from fire and heat sources, because it may be flammable, it will be dangerous in case of fire and must not be prevented.
    Furthermore, it is also necessary to isolate it from other objects. Do not make it co-located with oxidizing agents, acids, alkalis, etc. Due to its chemical activity, it can react violently or even explode when exposed to oxidizing agents. When exposed to acids or alkalis, it may cause decomposition and lose its inherent properties.
    When transported, the packaging must be sturdy. When using a suitable container, it should be tightly sealed to prevent its leakage. The person handling it needs to be professionally trained, familiar with its properties, and operate it steadily and carefully. Vehicles for transportation should also be clean, dry, and equipped with fire and explosion-proof devices. Avoid bumps and vibrations on the way to prevent damage to the container.
    All the storage and transportation of this 1% 2C2-diene-3- (methoxy) -4-benzylnaphthalene are based on safety, and the above items can be followed to ensure its safety without damaging its quality.