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1,2-Difluoro-3-Isothiocyanatobenzene

1,2-Difluoro-3-Isothiocyanatobenzene

Hongda Chemical

    Specifications

    HS Code

    746827

    Name 1,2-Difluoro-3-Isothiocyanatobenzene
    Chemical Formula C7H3F2NS
    Molar Mass 171.17 g/mol
    Appearance Liquid (usually)
    Boiling Point Data may vary, typically in a certain range depending on purity
    Melting Point Data may vary, typically in a certain range depending on purity
    Density Data may vary, typically in a certain range depending on purity
    Solubility Soluble in some organic solvents
    Odor Pungent, characteristic odor
    Flash Point Data may vary, typically in a certain range depending on purity
    Stability Stable under normal conditions, but may react with certain substances

    As an accredited 1,2-Difluoro-3-Isothiocyanatobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 1,2 - difluoro - 3 - isothiocyanatobenzene packaged in a sealed, chemical - resistant bottle.
    Storage 1,2 - Difluoro - 3 - isothiocyanatobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It should be kept in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, acids, and bases, as it may react with them. Follow proper safety regulations and labeling for hazardous chemicals during storage.
    Shipping 1,2 - difluoro - 3 - isothiocyanatobenzene is a chemical. Shipping should be in accordance with hazardous chemical regulations. It must be properly packaged to prevent leakage, and transported by carriers licensed for such chemicals.
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    1,2-Difluoro-3-Isothiocyanatobenzene 1,2-Difluoro-3-Isothiocyanatobenzene
    General Information
    Historical Development
    The historical development of phenyl 1,2-difluoro-3-isothiocyanate can be studied in detail. In the past, chemists studied the way of organic synthesis. At first, the understanding of compounds containing fluorine and isothiocyanate groups was still shallow. However, as time went by, the sages dedicated themselves to studying the reaction mechanism and synthesis path, and they all improved.
    First, scholars dedicated themselves to exploring suitable raw materials, and after many attempts, they found usable substrates. In addition, the reaction conditions were repeatedly adjusted, such as temperature, pressure, and catalyst selection, all of which were tested countless times.
    Gradually, the method of synthesizing this 1,2-difluoro-3-isothiocyanate phenyl ester was established. As a result, this compound has been little known to the chemical community, and has emerged in the fields of organic synthesis, materials science and other fields, opening a new chapter.
    Product Overview
    1,2-Difluoro-3-isothiocyanate phenyl ester is a unique chemical product. It is above the benzene ring, with two positions and one fluorine atom, and three positions are connected to the isothiocyanate group. This product has unique chemical properties. The presence of fluorine atoms makes the molecule highly electronegative, which affects its reactivity and physical properties. The isothiocyanate group also gives it the possibility to participate in a variety of chemical reactions, such as addition reactions with compounds containing active hydrogen. It has attracted much attention in the field of organic synthesis and can be used as a key intermediate to build more complex organic molecular structures. It may have potential applications in many fields such as medicine and materials science. It is indeed a category worthy of in-depth investigation in chemical products.
    Physical & Chemical Properties
    The 1,2-difluoro-3-isothiocyanate compound benzene is a special chemical substance. Its physical properties, depending on its color, are often colorless to slightly yellow transparent liquids. Under normal temperature and pressure, its properties are stable. Smell, there is a pungent isothiocyanate-like odor, which can help identify. Its boiling point and melting point also have specific values. The boiling point is about [X] ° C, and the melting point is about [X] ° C. This temperature characteristic is crucial in separation and purification operations.
    In terms of its chemical properties, the isothiocyanate in 1,2-difluoro-3-isothiocyanate compound benzene has high reactivity. It can undergo nucleophilic addition reactions with many nucleophilic reagents, such as alcohols and amines. Due to the existence of fluorine atoms on the benzene ring, the electron cloud density of the benzene ring is affected, so its chemical behavior is also unique. The electronegativity of fluorine atoms is large, resulting in a decrease in the electron cloud density of the ortho-para-position of the benzene ring and a relative increase in the meta-position. Therefore, the electrophilic substitution reaction activity is different from that of ordinary benzene derivatives. These physicochemical properties are widely used in organic synthesis, drug research and development and other fields.
    Technical Specifications & Labeling
    1,2-Difluoro-3-phenyl isothiocyanate, the process specification and identification (product parameters) of this substance are essential for chemical research. Its process specification requires a rigorous process. The selection of raw materials must be pure and free of impurities, and the ratio should be accurate to the millimeter. The reaction conditions are carefully controlled, and the temperature and pressure are all critical, or fluctuate in a specific range to ensure a smooth reaction.
    In terms of identification, the product parameters are meticulously marked. The appearance color and smell are clear for human detection. The purity index should meet a specific standard, and the impurity content should be strictly controlled at an extremely low level. And stability, solubility and other characteristics are also recorded in detail, so that the user can understand its properties, operate it safely, and use it in chemical research and application without error, in order to ensure its efficiency and safety.
    Preparation Method
    To prepare 1,2-difluoro-3-isothiocyanate benzene, the method is as follows:
    Raw materials and production process: Fluoroaromatic hydrocarbons and thiocyanates are used as raw materials. First, an appropriate amount of fluoroaromatic hydrocarbons is taken, and according to the specific ratio and reaction conditions, they are co-placed in a reaction kettle with halogenated reagents, and a halogenated aromatic hydrocarbon intermediate is obtained. Then this intermediate and thiocyanate are mixed in a suitable solvent, and under a certain temperature and catalyst action, a nucleophilic substitution reaction occurs.
    Reaction steps: During halogenation, the temperature is precisely controlled to ensure that the reaction is sufficient and the selectivity is good. When nucleophilic substitution, pay attention to the properties of the solvent, the reaction time and temperature to promote the reaction in the direction of generating
    Catalytic mechanism: A specific metal halide can be used as a catalyst for the halogenation reaction, and its empty orbit interacts with the reactants to reduce the activation energy of the reaction. The catalyst used in the nucleophilic substitution reaction can enhance the nucleophilicity of thiocyanate ions and improve the reaction efficiency. After these steps, the product of 1,2-difluoro-3-isothiocyanate benzene can be obtained.
    Chemical Reactions & Modifications
    Since modern times, chemical refinement has produced all kinds of new products. In 1,2 - Difluoro - 3 - Isothiocyanatobenzene, the chemical reaction and modification of this product are especially important to our generation.
    At the beginning, it was difficult to explore its reaction path. Its structure is exquisite, and the position of fluorine and isothiocyanate leads to specific reactivity. The method of the past, or the effect is not good, or there are many by-products.
    After repeated research, we found a good way. With a specific agent, adjust its environment and promote its reaction to the desired direction. When modifying, according to the distribution of its electron cloud, the introduction of other groups made the performance of this product greatly changed and it was widely used.
    Looking at this process, the path of chemistry, although full of thorns, will be able to find a wonderful way to make the best use of materials for the well-being of the world.
    Synonyms & Product Names
    Nowadays, there is a thing named 1,2-difluoro-3-phenyl isothiocyanate, which is widely used in the field of chemical industry. There are many different names for this thing, all of which vary according to various situations and user needs.
    In the history of Guanfu Chemical Industry, it is common to have many of the same thing. Due to the inconvenience of communication in the past, scholars and craftsmen from all over the world named each other. And today, although academics are gradually becoming more unified, the old name is still used.
    1,2-difluoro-3-phenyl isothiocyanate, or according to its properties and structural characteristics, there are other names. In the industry, various aliases and trade names are parallel, all of which represent this thing. Although the names are different, they refer to the same thing. There are many chemical products with different names but the same thing. This is also the state of the industry.
    Safety & Operational Standards
    1,2-Difluoro-3-phenyl isothiocyanate, this chemical substance is related to safety and operating standards, and it is extremely important. I will describe it in detail.
    All operations involving this substance must first review the safety data sheet. This sheet contains key information such as material characteristics, hazard warnings, first aid measures, etc., which are the cornerstone of safe operation. During operation, protective equipment is essential. Experimenters need protective clothing, which should resist chemical erosion and protect the whole body. Wear protective gloves, which must be resistant to corrosion of the substance to prevent skin contact. Wear protective glasses, which can effectively block possible splashes of liquids or gases and protect the eyes from damage.
    Furthermore, the operating environment should not be ignored. It should be operated in a well-ventilated space, the best place is in the fume hood. The fume hood can quickly drain the harmful gases generated during the operation, so that the experimenter is protected from it. If you accidentally come into contact with this substance, emergency treatment must be timely and appropriate. If the skin comes into contact, you should immediately rinse with a lot of water, and the rinsing time should be long to ensure that the contaminated substance is washed, and then seek medical treatment. If the eyes come into contact, you need to race against time. Rinse with a lot of flowing water or normal saline. When rinsing, you need to turn your eyeballs to ensure that all places are cleaned, and then seek medical attention as soon as possible.
    There are also strict regulations for storing this substance. It should be stored in a cool, dry place, away from fire and heat sources. Due to its certain chemical activity, improper storage can easily lead to danger. And it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed to prevent chemical reactions and endanger safety.
    The operation of phenyl 1,2-difluoro-3-isothiocyanate, from protection to emergency, from the operating environment to storage, must strictly abide by the specifications, and must not be sloppy at all, so as to ensure safety.
    Application Area
    1,2-Difluoro-3-isothiocyanate is a new chemical compound. Its application field is particularly wide. In the field of pharmaceutical research, it can be used as a lead compound to help explore new drugs. With its special structure, it can interact with biological targets and initiate the development of new drugs.
    In materials science, it may be able to participate in the creation of new functional materials. Because of its fluorine and isothiocyanate group, it can endow materials with unique properties, such as improving the stability and affinity of materials, adding new paths to material innovation.
    In the field of organic synthesis, it can be used as a key intermediate. With its active groups, complex organic molecules are constructed through various reactions, expanding the boundaries of organic synthesis, and contributing greatly to the expansion of chemical synthesis.
    Research & Development
    In recent years, I have been studying chemical products very diligently. Today, there is a thing called 1,2-Difluoro-3-Isothiocyanatobenzene, which is specific in nature and has attracted my attention.
    At the beginning, I observed its structure. Fluorine and isothiocyanate are cleverly connected, and the order is on the benzene ring. This unique structure seems to have infinite possibilities.
    Then explore the method of its preparation. After repeated trials, it may be obtained by a certain method. However, the process is complicated and requires fine control of various conditions. Temperature and amount of reagents cannot be ignored. In the field of medicine, it can be used as a key intermediate to help the research and development of new drugs and add new ways to cure diseases. In the field of materials, it can also endow materials with different properties and lead to opportunities for material innovation.
    I must persevere and study this material in depth, hoping to make gains and expand its development to promote the progress of chemical products and benefit the world.
    Toxicity Research
    Today there is a substance called 1,2 - Difluoro - 3 - Isothiocyanatobenzene. I am a chemical researcher, specializing in the study of poisons.
    The toxicity of this substance, I will explore in detail. Its strong nature may have various effects on the body of living things. It may damage the organs, or disrupt the flow of qi and blood, or even endanger life.
    Looking at its structure, it contains isothiocyanate groups, etc., which may be the source of its toxicity. Isothiocyanates are often irritating and can cause damage to the respiratory tract, skin, etc. In addition to fluorine atoms, they add their chemical activity, and toxicity may increase accordingly.
    However, the use of poisons also exists on both sides. Appropriate use, or can help medicine, chemical industry, etc. Therefore, its toxicity, not only need to know in detail, but also should think of rational use of methods, in order to improve the advantages and eliminate the disadvantages.
    Future Prospects
    Today there is a thing named 1,2-difluoro-3-isothiocyanate. As a chemical researcher, I look at the properties of this thing, think about its future development, and have some thoughts.
    The quality of this thing is specific, and it can be used in various chemical reactions, or it can be a key agent. Although it is not widely used today, its hidden power cannot be underestimated.
    I expect that in the future, technology will advance more and more, and in the field of chemical industry, the demand will be changeable. This 1,2-difluoro-3-isothiocyanate phenyl ester, or in response to new needs, has emerged in materials creation, drug research and development, etc.
    If the material is made, or it can be used as a basis to make new materials, it has unique properties and is suitable for aerospace, electronics and other important places. The research of drugs, or by virtue of its properties, to obtain innovative drugs, for the treatment of diseases, add a sharp tool.
    Therefore, I am convinced that 1,2-difluoro-3-phenyl isothiocyanate will have great potential for future development, which will contribute to the progress of chemistry and create unlimited possibilities.
    Where to Buy 1,2-Difluoro-3-Isothiocyanatobenzene in China?
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    Frequently Asked Questions

    As a leading 1,2-Difluoro-3-Isothiocyanatobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of phenyl 1,2-difluoro-3-isothiocyanate?
    1% 2C2-diene-3-isothiocyanate is a commonly used reagent in organic synthesis. Its main uses are quite extensive and of great significance in many fields.
    First, in the field of medicinal chemistry, this reagent is often a key intermediate for the synthesis of biologically active compounds. The creation of many drugs relies on its participation. Through clever chemical reactions, complex molecular structures can be constructed, laying the foundation for the development of new drugs. Due to its special chemical structure, Gai can react specifically with a variety of compounds, thereby introducing specific functional groups and endowing the target compounds with unique biological activities.
    Second, in the field of materials science, 1% 2C2-diene-3-isothiocyanate is also used. It can be used to prepare functional polymer materials. By reacting with polymer monomers, its special functional groups are introduced into the polymer chain, imparting special optical, electrical or mechanical properties to the material to meet the requirements of different application scenarios.
    Third, in organic synthetic chemistry, it is an effective reagent for constructing carbon-heteroatom bonds. It can react with compounds containing heteroatoms such as nitrogen, oxygen, and sulfur to efficiently generate corresponding heterocyclic compounds or organic molecules containing functional groups such as sulfur and nitrogen. This property allows organic chemists to easily synthesize organic compounds with diverse structures, expand the boundaries of organic synthesis, and facilitate the exploration and development of new reaction methodologies.
    In conclusion, 1% 2C2-diene-3-isothiocyanate phenyl ester plays an indispensable role in the fields of drug development, material preparation, and organic synthesis due to its unique chemical properties, and promotes the continuous progress of related science and technology.
    What are the physical properties of phenyl 1,2-difluoro-3-isothiocyanate?
    1% 2C2-diene-3-isothiocyanate phenyl ester is a kind of organic compound. Its physical properties are as follows:
    This substance is either liquid at room temperature, its color is observed, or it is colorless and transparent, or slightly yellow, with a special odor, pungent and volatile. Its boiling point, melting point and other physical properties depend on the molecular structure and interaction. Generally speaking, its boiling point may be within a specific temperature range, which is affected by intermolecular forces, such as van der Waals force, hydrogen bonds and other factors.
    Its density is different from that of water, and it exhibits specific solubility in organic solvents. Due to the presence of specific functional groups, the diene structure is active and has a conjugate effect, giving it a special electron cloud distribution, which affects its physical and chemical properties. And isothiocyanate group is also an active functional group, which makes the compound exhibit unique activity in chemical reactions.
    Its solubility, or soluble in some organic solvents, such as ethanol, ether, etc. Due to the similar principle of miscibility, the intermolecular forces are similar, so it is miscible. However, in water, due to large differences in polarity, or poor solubility.
    Its volatility causes easy diffusion in the air. When using and storing, it is necessary to pay attention to environmental ventilation and other matters to ensure safety. These physical properties are the basis for the understanding and application of 1% 2C2-diene-3-isothiocyanate phenyl ester, and are of great significance in many fields such as organic synthesis and chemical production.
    Is phenyl 1,2-difluoro-3-isothiocyanate chemically stable?
    1% 2C2-diene-3-isothiocyanate phenyl ester This physical property is not stable. It has high activity, and the ethylene bond can cause an addition reaction. The isothiocyanate group is also active, and it is easy to react when it encounters nucleophiles such as water, alcohol, and amine. In case of water, the isothiocyanate group hydrolyzes into amines and carbon dioxide, and the structure changes cause physical properties to change. In air, the ethylene bond is easily oxidized to form peroxides, etc., which affects the stability and quality. Light can also initiate reactions that rearrange or decompose the molecular structure. If air, water, and light are not isolated during storage, the physical properties are easily changed. Therefore, storage requires strict control of conditions, such as low temperature, dryness, protection from light, and sealing, to maintain a relatively stable state, but even so, long-term storage may still be affected by trace impurities or environmental factors.
    What are the synthesis methods of phenyl 1,2-difluoro-3-isothiocyanate?
    The synthetic methods of 1% 2C2-diene-3-isothiocyanate phenyl ester are generally as follows.
    First, benzene is used as the starting point, and the shilling benzene and the halogenated alkane are catalyzed by Louis acid to perform the Fu-gram alkylation reaction to obtain alkylbenzene. The alkylbenzene is halogenated, a halogen atom is introduced, and then reacted with thiocyanate to produce thiocyanate. The thiocyanate can be rearranged under suitable conditions to obtain 1% 2C2-diene-3-isothiocyanate phenyl ester. The raw materials are easy to obtain in this way, but there are many steps, and the reaction conditions may need to be carefully regulated.
    Second, starting from aniline, aniline reacts with phosgene to obtain phenyl isocyanate first. Phenyl isocyanate reacts with sulfur sources, such as sodium sulfide, under specific solvents and temperatures to obtain the target product. This path is relatively direct, but phosgene is highly toxic. It requires extreme caution during operation, and has extremely high requirements for equipment and protection.
    Third, halogenated aromatics and thiourea are used as raw materials. Halogenated aromatics react with thiourea to form intermediates. The intermediates are treated with bases to undergo intramolecular rearrangement, and then 1% 2C2-diene-3-isothiocyanate phenyl ester is obtained. This method is relatively mild, the toxicity of the raw materials used is relatively low, but the reaction conditions also need to be accurately grasped in order to obtain a higher yield.
    All this synthesis method has advantages and disadvantages. When actually handling, according to the availability of raw materials, equipment conditions, cost considerations, and the high or low yield and other factors, carefully choose to seek the optimal synthesis path.
    What are the precautions for the storage and transportation of phenyl 1,2-difluoro-3-isothiocyanate?
    1% 2C2-diene-3-isothiocyanate phenyl ester is also an organic compound. During storage and transportation, many matters need to be paid attention to.
    First words storage, its nature or activity, should be stored in a cool and ventilated place. High temperature can easily cause it to undergo chemical changes, or cause danger. This compound is quite sensitive to temperature, if the temperature is too high, it may decompose, or even cause the risk of explosion. Therefore, the warehouse temperature should be controlled within the appropriate range, not too high.
    Furthermore, it should be stored away from light. Light may also promote its chemical reaction, causing its properties to change. Therefore, the appropriate storage of shading can be used in opaque containers or stored in darkrooms.
    The choice of storage container is also critical. It is necessary to use a container that is resistant to corrosion and well sealed. Because of its certain chemical activity, if the container is not resistant to corrosion, or reacts with it, it will damage the container and cause the compound to deteriorate. Good sealing can prevent volatilization and prevent it from being released into the air, endangering the environment and personal safety.
    As for transportation, choose the appropriate vehicle for transportation. Good heat insulation, sun protection and ventilation devices are required to maintain a suitable temperature and environment. The loading and unloading process must be handled with care to avoid severe vibration and collision. The structure of this compound may be fragile, and violent vibration or internal structural changes may be caused, which may cause danger.
    Transportation personnel should also be professionally trained and familiar with the characteristics of the compound and emergency treatment methods. If there is a leak during transportation, it can be disposed of quickly and properly to avoid the expansion of harm. Transportation route planning also needs to be careful to avoid densely populated areas and environmentally sensitive areas to prevent major damage in the event of an accident.