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1,2,4-Trifluoro-5-Iodobenzene

1,2,4-Trifluoro-5-Iodobenzene

Hongda Chemical

Specifications

HS Code

667475

Chemical Formula C6H2F3I
Molecular Weight 272.0
Appearance Colorless to light yellow liquid
Boiling Point 174 - 176 °C
Melting Point N/A
Density 2.046 g/mL at 25 °C
Flash Point 72.2 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Purity Typically high - purity commercial products around 97%+
Odor Characteristic aromatic odor

As an accredited 1,2,4-Trifluoro-5-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1,2,4 - trifluoro - 5 - iodobenzene packaged in a sealed, labeled bottle.
Storage 1,2,4 - trifluoro - 5 - iodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent leakage and exposure to air or moisture, which could potentially cause decomposition. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions.
Shipping 1,2,4 - trifluoro - 5 - iodobenzene is shipped in sealed, corrosion - resistant containers. It's transported with proper hazard labeling, following strict regulations to ensure safe handling during transit due to its chemical nature.
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1,2,4-Trifluoro-5-Iodobenzene 1,2,4-Trifluoro-5-Iodobenzene
General Information
Historical Development
1,2,4-Trifluoro-5-iodobenzene is also a chemical substance. In the past, the research and development of this substance was still in its infancy. At the beginning, Zhu Xian was in the field of chemistry, and the study of aromatic compounds containing fluoride and iodine was not in depth. However, as time went by, everyone's desire for knowledge became more and more intense, and their skills gradually improved.
After repeated experiments, scholars have found a way to synthesize this compound with extreme wisdom. The initial steps or difficulties are abnormal, the selection of raw materials and the control of conditions all need to be cautious. However, with unremitting efforts, 1,2,4-trifluoro-5-iodobenzene can finally be stabilized.
The path of its application also expands with time. From the beginning, it was only a sample of chemical research, to its emergence in the fields of medicine, materials, etc., all thanks to the research of predecessors. Over the years, the historical evolution of this compound has witnessed the road of chemistry, from simple to complex, from shallow to deep, step by step.
Product Overview
Description of 1,2,4-trifluoro-5-iodobenzene
There is a product named 1,2,4-trifluoro-5-iodobenzene. Its shape, or a colorless to light yellow liquid, looks clear and shiny. Its properties are relatively stable at room temperature, and it may be dangerous when it encounters hot topics and open flames.
The preparation of this product often follows a specific chemical path. Based on the corresponding benzene derivative, accompanied by appropriate fluorine and iodine substitutes, it can only be obtained through multiple reactions. Between reactions, temperature, pressure, catalyst and other factors need to be finely regulated. If there is a slight difference, the product will be impure.
As for the use, 1,2,4-trifluoro-5-iodobenzene is very important in the field of pharmaceutical and pesticide synthesis. It can be used as a key intermediate, participating in the construction of many active compounds, and providing an important cornerstone for the research and development of new drugs and pesticides. Its position in the stage of organic synthetic chemistry cannot be ignored.
Physical & Chemical Properties
1,2,4-Trifluoro-5-iodobenzene is also an organic compound. Its physical and chemical properties are particularly important and are fundamental to many applications.
The physical properties of this compound, at room temperature, or in the form of a colorless to slightly yellow liquid, have a special odor. Its boiling point and melting point are inherent characteristics, related to the transformation of its phase state. The boiling point, or due to the force between molecules, falls in a specific temperature range, at which the liquid state can be converted to a gaseous state. The same is true for the melting point, which is the critical temperature for the conversion of solid state to liquid state.
Its chemical properties are active, and fluorine and iodine atoms give it unique reactivity. The high electronegativity of fluorine atoms makes the distribution of molecular electron clouds uneven, which easily triggers nucleophilic substitution reactions. Although the electronegativity of iodine atoms is weaker than that of fluorine atoms, its atomic radius is large, and it can participate in many organic synthesis reactions, such as coupling reactions. It is a key node in the construction of complex organic structures.
Technical Specifications & Labeling
"On the technical specifications and labels of 1,2,4-trifluoro-5-iodobenzene (commodity parameters) "
There are 1,2,4-trifluoro-5-iodobenzene now, which is related to technical specifications and needs to be made pure. The method of synthesis, the selection of raw materials must be accurate, and the reaction conditions must be strictly controlled. The temperature needs to be stable in a certain range, and the duration must be appropriate, so that the reaction is sufficient and there are few impurities.
When it comes to the logo, the product parameters should be clear and correct. The appearance color should be a certain color, and the texture should be pure and free of impurities. The content ratio, determined by an accurate method, must meet a certain standard. On the packaging, the logo is readily available, from the name to the characteristics, all need to be detailed, so that the user can see at a glance, without the risk of misuse, so as to comply with the technical specifications and the essence of the logo, in order to become a good product.
Preparation Method
1,2,4-Trifluoro-5-iodobenzene is also an organic compound. The method of its preparation is related to the raw materials and production process, reaction steps and catalytic mechanism, and is of paramount importance.
The raw materials prepared should be selected from pure ones. Based on suitable fluoride, iodide, etc. and carefully proportioned, it is the starting point. The production process needs to be controlled in a suitable reaction vessel with precise temperature and pressure. First, fluoride interacts with the substrate, and according to specific reaction steps, it is converted several times, and then iodide is introduced.
Between reaction steps, each step is closely connected. The first step of the reaction causes initial changes in the structure of the substrate, and then the reaction deepens its transformation to the introduction of iodine atoms, and then becomes the target product. The catalytic mechanism is also critical. Selecting an appropriate catalyst can promote the reaction rate and increase the purity and yield of the product. With the activity check point of the catalyst, the reaction can be efficiently carried out under mild conditions, so that 1,2,4-trifluoro-5-iodobenzene can be obtained.
Chemical Reactions & Modifications
Modern chemical refinement, in the research of various compounds, every new gain. On the chemical reaction and modification of 1, 2, 4 - Trifluoro - 5 - Iodobenzene, it is related to many wonderful principles.
Looking at its reaction, when it encounters nucleophiles, it often substitutes. The position of fluorine and iodine can be replaced by other groups. This is because the activity of fluorine and iodine is different. The strong electronegativity of fluorine makes the electron cloud density of the benzene ring change, while the departure of iodine is good. The two complement each other and promote the reaction to a specific track.
As for modification, other groups can be introduced to adjust their physical and chemical properties. If the base containing the conjugate system is added, it can change its optoelectronic properties, which may be of great use in the field of materials. Or change the position and number of its substituents, a series of derivatives can be prepared, and the relationship between their structure and properties can be explored. In order to create new compounds, expand the boundaries of chemical applications, pave stones and build roads, and use the research of micro-matter to obtain grand fruits and benefit the world.
Synonyms & Product Names
Today there is a thing named 1,2,4-trifluoro-5-iodobenzene. This thing is very important in the field of my chemical research. It also has many synonymous names and commodity names.
It is a synonymous name, or derived from its chemical structure and characteristics. Chemists have given it different names according to different perspectives and understandings in the process of exploring the nature of matter, but they all refer to the same thing.
As for the name of the commodity, it was born due to market demand. Merchants have chosen this name to make it easy to identify and promote in commercial circulation. In this way, 1,2,4-trifluoro-5-iodobenzene is a synonymous name in the field of scientific research, which is convenient for academic exchanges; in the commercial market, under the name of commodities, it is unimpeded. This is a good way to help chemical research and commercial applications.
Safety & Operational Standards
In the case of 1,2,4-trifluoro-5-iodobenzene, it is also a chemical substance. For its safe operation, I am very careful.
This physical property should not be ignored. It has a certain chemical activity, and it is afraid of accidents in case of unsuitable conditions or objects. If it exists, it should be placed in a place that is dry and well-connected, to avoid fire and to prevent it from decomposing or leading to dangerous reactions.
The operation of the car must be a protective device. Use it to prevent clothing, wear eyes and gloves to protect the body from its harm. If the skin or eyes are accidentally touched, it should be washed with a lot of water, and ask for it quickly.
When used, it is appropriate to use it in the middle of the process, to ensure that the operation is air-conditioned, and to prevent harmful evaporation and accumulation. The operator should be well-versed in the process, understand its feasibility, reverse processing, and be familiar with the various operation steps.
Furthermore, use the product, and properly install it. Do not give up, according to the relevant laws and guarantee requirements, and apply appropriate methods to prevent it from contaminating the environment.
Therefore, the safe operation of 1,2,4-trifluoro-5-iodobenzene, in terms of personal safety, environmental protection, and environmental protection, must be followed by researchers and must not be slack.
Application Area
There is now a product named 1,2,4-trifluoro-5-iodobenzene. It is quite useful in various application fields.
In the field of medicinal chemistry, this compound is often a key intermediate. With its unique structure, it can participate in many organic synthesis reactions, helping medical developers create new drugs and cure various diseases.
In the field of materials science, it also has its own shadow. It can use its fluorine and iodine-containing properties to improve the properties of materials, such as improving the stability and conductivity of materials, for the manufacture of high-end electronic materials.
In the fine chemical industry, 1,2,4-trifluoro-5-iodobenzene can be used as a raw material for the synthesis of special chemicals, and the resulting products are used in coatings, fragrances and other fields to improve their quality and characteristics. It is a widely used and important compound.
Research & Development
I have been focusing on the research of chemical products for a long time, and recently I am very interested in 1,2,4-trifluoro-5-iodobenzene. Examining its properties in detail, this substance has great potential in many fields.
After repeated research and experiments, we explored the method of its synthesis. At the beginning, we tried several paths, many of which were tortuous. However, we worked tirelessly to obtain a better method. With a certain raw material, it is gradually converted under specific reaction conditions, during which the temperature, duration and other factors are finely regulated.
The future development of this substance is expected to emerge in materials science. Or it can be a key component of new materials and improve material properties. Or it can make achievements in the field of pharmaceutical research and development, helping to create special new drugs. I will continue to advance my research, promote the development of 1,2,4-trifluoro-5-iodobenzene, and contribute to academia and industry.
Toxicity Research
In modern times, the chemical refinement has deepened, and the nature of various things has been explored more and more deeply. In this view, the study of the toxicity of 1, 2, 4 - Trifluoro - 5 - Iodobenzene is quite important.
To understand its toxicity, the first thing to do is to consider its molecular structure. Atoms of fluorine and iodine are attached to the benzene ring, or cause them to have different properties. From past examples, many benzene series containing fluoride and iodine have special toxicology. It may disturb the metabolism of organisms and invade the structure of cells.
Furthermore, try to test its toxicity by various methods. It can be applied to animals to observe their physiological changes and damage to organs; or it can be used for cell culture to see its impact on cell proliferation and apoptosis. In this way, it can obtain signs of its toxicity, such as acute toxicity or chronic harm.
And this substance may be in danger of accumulation in the environment. If it is accidentally released, it will be transmitted through water and soil, or enter the food chain, causing harm to all living things. Therefore, a detailed study of its toxicity is the basis for protection and management, and it is related to the well-being of ecology and people and should not be ignored.
Future Prospects
1,2,4-Trifluoro-5-iodobenzene is also a chemical substance. In this world, although research has been achieved, the future development is still promising.
Looking at its properties, it can be used for various chemical reactions and special chemical materials. In the future research, it may be used for new purposes in medicine and pharmaceuticals, or it can be used as a special agent to treat difficult diseases; in the field of electrical materials, it may be able to create excellent properties and assist in the improvement of tools.
The method of further research should also be changed. Although today's method is available, it has not been perfected. In the future, it may create simpler and more effective methods to reduce its consumption, improve its production, and reduce its pollution.
In this way, the development of 1,2,4-trifluoro-5-iodobenzene in the future will surely be able to shine, contribute to the progress of the world, and achieve immeasurable achievements.
Where to Buy 1,2,4-Trifluoro-5-Iodobenzene in China?
As a trusted 1,2,4-Trifluoro-5-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1,2,4-Trifluoro-5-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1,2,4-trifluoro-5-iodobenzene?
1,2,4-Trimethyl-5-nitrobenzene has a wide range of main uses. In the chemical industry, it is often used as a key intermediate in organic synthesis. It can be derived from many high-value compounds through specific chemical transformations. For example, in pharmaceutical synthesis, it can provide key structural fragments for the preparation of specific drug molecules, helping to develop drugs with unique curative effects, such as certain antibacterial and anti-tumor drugs.
In the dye industry, it also plays an important role. On this basis, a variety of bright-colored and stable dyes can be synthesized for dyeing fabrics, leather and other materials, giving them rich colors and enhancing the aesthetics and commercial value of products.
Furthermore, in the manufacture of explosives, due to its structural characteristics, it has certain explosive properties. After appropriate formulation and process treatment, it can be used to manufacture specific types of explosives, which are used in military, mining and other fields. In military, it can be used as an ammunition component to provide strong explosive power; when mining, it can help blasting operations and improve mining efficiency.
In addition, in the preparation of pesticides, after chemical modification, it can become a pesticide ingredient with insecticidal, weeding and other effects, ensuring that crops are protected from pests and diseases, and promoting agricultural harvest.
Therefore, 1,2,4-trimethyl-5-nitrobenzene plays an indispensable role in the fields of chemicals, medicine, dyes, explosives and pesticides, promoting the development and progress of various industries.
What are the physical properties of 1,2,4-trifluoro-5-iodobenzene?
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This substance is usually a colorless to light yellow transparent liquid with a unique odor. In terms of density, it is lighter than water, usually between 0.8 and 0.9 g/cm3. In terms of solubility, it is difficult to dissolve in water, but it is easily soluble in most organic solvents such as ethanol and ether.
Its boiling point range is generally 150-200 ° C. This boiling point characteristic allows it to undergo a phase transition under certain temperature conditions. The melting point is usually low, about -50 ° C to -30 ° C, which makes it stable in liquid form at room temperature.
This substance has a certain degree of volatility and will slowly evaporate into the air in an open environment. In terms of chemical stability, it is relatively stable, but when it encounters a strong oxidizing agent, a chemical reaction will occur, which will cause changes in its structure and properties. Moreover, it is flammable, and in the case of open flames and hot topics, it is very easy to burn, and products such as carbon dioxide and water will be generated when burned.
In terms of electrical properties, it is a non-electrolyte and cannot be ionized to produce ions in water, so its aqueous solution does not have electrical conductivity. In summary, 1%2C2%2C4-%E4%B8%89%E6%B0%9F-5-%E7%A2%98%E8%8B%AF%E7%9A%84%E7%89%A9%E7%90%86%E6%80%A7%E8%B4%A8 in practical application and storage, it needs to be reasonably disposed of according to these characteristics.
Is the chemical properties of 1,2,4-trifluoro-5-iodobenzene stable?
1%2C2%2C4-%E4%B8%89%E6%B0%9F-5-%E7%A2%98%E8%8B%AF%E7%9A%84%E5%8C%96%E5%AD%A6%E6%80%A7%E8%B4%A8%E7%A8%B3%E5%AE%9A%E4%B9%9F%E3%80%82
In this substance, its molecular structure has specific chemical bonds and atomic arrangements. In terms of chemical principles, the chemical bonds within the molecule give it a relatively stable structure, making the substance less prone to spontaneous chemical changes under normal conditions. Just like the structure of a strong ship, it is difficult to disperse.
In a common chemical environment, 1%2C2%2C4-%E4%B8%89%E6%B0%9F-5-%E7%A2%98%E8%8B%AF will not easily react with surrounding substances. For example, it is like a wise man hidden in the city, content with its own state, and does not mix with the outside world at will. This is all due to the interaction between its internal atoms reaching a state of equilibrium, just like the forces of all parties have formed a stable pattern in the game, which allows the molecular structure to be maintained.
If it is under more extreme chemical conditions, such as high temperature and high concentration of specific chemical reagents, its stability may be challenged. However, in conventional natural environments and general chemical experimental environments, 1%2C2%2C4-%E4%B8%89%E6%B0%9F-5-%E7%A2%98%E8%8B%AF can maintain relatively stable chemical properties, and are not prone to structural changes or participate in chemical reactions.
What are the synthesis methods of 1,2,4-trifluoro-5-iodobenzene?
1%2C2%2C4-%E4%B8%89%E6%B0%9F-5-%E7%A2%98%E8%8B%AF%E7%9A%84%E5%90%88%E6%88%90%E6%96%B9%E6%B3%95%E6%9C%89%E5%A4%9A%E7%A7%8D%EF%BC%8C%E5%85%B6%E4%B8%AD%E4%B8%80%E7%A7%8D%E5%B8%B8%E7%94%A8%E6%96%B9%E6%B3%95%E5%A6%82%E4%B8%8B%EF%BC%9A
First take diethyl malonate, use sodium ethyl alcohol as a base, and make it undergo nucleophilic substitution reaction with 1,2,4-tribromobutane in ethanol solvent. Because the hydrogen on the methylene of diethyl malonate has a certain acidity, under the action of alkali, a carbon negative ion is formed. This carbon negative ion acts as a nucleophilic reagent to attack the carbon atom connected to the bromine atom of 1,2,4-tribromobutane, causing the bromine ion to leave, thereby introducing the structure of diethyl malonate into 1,2,4-tribromobutane.
Then hydrolysis reaction, under acidic conditions, such as dilute hydrochloric acid or dilute sulfuric acid as a catalyst, heating reflux, so that the ester group of diethyl malonate is hydrolyzed into a carboxylic group to obtain the corresponding carboxylic acid.
Then decarboxylation reaction, because the structure of this carboxylic acid, two carboxyl groups are connected to the same carbon atom, with special properties, under heating conditions, one of the carboxylic groups is removed in the form of carbon dioxide, and then 1%2C2%2C4-%E4%B8%89%E6%B0%9F-5-%E7%A2%98%E8%8B%AF.
In addition, other routes can be tried, such as first performing appropriate functional group conversion on 1,2,4-tribromobutane, and then reacting with suitable compounds containing benzene rings. Through a series of reaction steps, the synthesis of 1%2C2%2C4-%E4%B8%89%E6%B0%9F-5-%E7%A2%98%E8%8B%AF is finally achieved. Different synthetic routes have their own advantages and disadvantages, and they need to be selected according to the actual situation, such as the availability of raw materials, the difficulty of controlling reaction conditions, and the purity of the product.
What are the precautions for storing and transporting 1,2,4-trifluoro-5-iodobenzene?
1% 2C2% 2C4-triethyl-5-chlorobenzoic acid When storing and transporting, it is necessary to pay attention to many key matters.
When storing, the first choice of environment. It should be placed in a cool, dry and well-ventilated place. This may be disturbed by temperature, humidity and air circulation due to its nature. If the environment is humid, or it is caused by moisture and deterioration, it will damage the quality; if the temperature is too high, it may also cause chemical reactions and reduce efficiency. And it should be kept away from fire and heat sources to prevent the risk of fire and explosion. Because it may be flammable or reactive, it is prone to danger in case of open flames and hot topics.
Furthermore, it should be stored separately from oxidizing agents, alkalis and other substances. This is based on its chemical properties. If it coexists with these substances, it may cause violent chemical reactions, resulting in dangerous accidents. And the storage area should be equipped with suitable containment materials to deal with possible leakage conditions, so as to facilitate timely treatment and prevent the spread of pollution.
When transporting, the packaging must be tight and stable. Select packaging materials that meet its characteristics to ensure that there is no damage and leakage during transportation turbulence. The transportation process needs to follow relevant regulations and standards, and professional escort personnel should be equipped to monitor the transportation status at any time. The transportation vehicle should also be equipped with corresponding safety facilities and fire protection equipment to ensure complete safety. At the same time, attention should be paid to avoid mixing with other incompatible goods to prevent dangerous interactions. Transportation route planning also needs to be careful to avoid densely populated areas and environmentally sensitive areas to reduce latent risks. In this way, it is necessary to ensure the safety of 1% 2C2% 2C4 -triethyl-5 -chlorobenzoic acid storage and transportation.