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1,2,3,5-Tetrafluoro-4-Nitrobenzene

1,2,3,5-Tetrafluoro-4-Nitrobenzene

Hongda Chemical

Specifications

HS Code

393438

Chemical Formula C6HF4NO2
Molar Mass 195.07 g/mol
Appearance Solid
Melting Point 45 - 49 °C
Boiling Point 195 - 197 °C
Density 1.648 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents
Vapor Pressure Low
Flash Point 84.4 °C
Hazard Class Irritant

As an accredited 1,2,3,5-Tetrafluoro-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 1,2,3,5 - tetrafluoro - 4 - nitrobenzene packaged in air - tight glass bottle.
Storage 1,2,3,5 - Tetrafluoro - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container to prevent vapor leakage. Due to its potential toxicity, ensure the storage area is restricted and properly labeled for easy identification and safety compliance.
Shipping 1,2,3,5 - Tetrafluoro - 4 - nitrobenzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations to ensure safe transit, with proper labeling and handling to prevent any risks.
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1,2,3,5-Tetrafluoro-4-Nitrobenzene 1,2,3,5-Tetrafluoro-4-Nitrobenzene
General Information
Historical Development
1,2,3,5 - Tetrafluoro - 4 - Nitrobenzene is an important chemical product. Its historical evolution is really related to the process of chemical research. In the past, chemists worked tirelessly on the way to explore new compounds. At that time, technology was limited, and it was difficult to obtain this compound.
At first, researchers only knew about simple compounds containing fluorine and nitro groups. As the research deepened, we gradually thought about synthesizing 1,2,3,5 - Tetrafluoro - 4 - Nitrobenzene, which is a unique structure. People tried different methods, and after countless failures, they finally found a feasible path.
Early synthesis, the yield is extremely low, and there are many impurities. However, chemists did not give up. After repeatedly improving the process and optimizing the reaction conditions, the yield was gradually increased and the purity was guaranteed. As a result, 1,2,3,5-Tetrafluoro-4-Nitrobenzene was prepared in small quantities in the laboratory and gradually industrialized. It emerged in many fields and promoted the chemical industry to move forward.
Product Overview
1,2,3,5-tetrafluoro-4-nitrobenzene is also an organic compound. Its shape may be crystalline, and its color may be light yellow. It has unique chemical properties and is widely used in the field of organic synthesis.
This compound contains fluorine, nitro and other groups. The introduction of fluorine atoms gives it high stability and special physical and chemical properties. The presence of nitro groups makes it reactive and can participate in many chemical reactions, such as nucleophilic substitution.
The method of preparation often involves multi-step chemical synthesis. The choice of raw materials and the control of reaction conditions are crucial. The reaction needs to be carried out with the help of suitable temperature, pressure and catalyst to achieve high yield and purity.
In industrial production and scientific research experiments, 1,2,3,5-tetrafluoro-4-nitrobenzene is often a key intermediate for the creation of a variety of high-value-added fine chemicals, such as drugs, pesticides and functional materials, with broad prospects.
Physical & Chemical Properties
1, 2, 3, 5 - Tetrafluoro - 4 - Nitrobenzene, also an organic compound. Its physical and chemical properties can be investigated. Looking at its physical properties, at room temperature, it is mostly solid, colored or nearly colorless, with a slightly special odor. Its melting point and boiling point have specific values, which are necessary for separation and purification operations. As for chemical properties, due to the presence of fluorine, nitro and other functional groups, the activities are quite different. Fluorine atoms change the electron cloud density of the benzene ring, and nitro groups have strong electron absorption. The synergy of the two makes the compound exhibit unique behavior in reactions such as nucleophilic substitution. In case of nucleophilic reagents, fluorine atoms can be replaced to form new derivatives. And because of its special structure, the stability is also considerable. The study of the physicochemical properties of this compound is of great significance in various fields such as organic synthesis and materials science.
Technical Specifications & Labeling
There are chemical substances today, named 1, 2, 3, 5 - Tetrafluoro - 4 - Nitrobenzene. Its technical regulations and identification (commodity parameters) are the key to the study of this substance.
To make this substance, you need to follow precise and strict laws. The choice of materials must be pure and good; the temperature, time and amount of the reaction must be controlled. If the temperature is controlled at a certain degree, after a certain period of time, the dosage of a certain amount can be obtained.
Its logo is related to the nature of this substance. Observe its color, or be a certain color; observe its state, or be a certain state; measure its degree of melting and boiling, there is also a fixed number. This is all evidence of its merits and demerits, and those who can use it can understand its nature and make good use of it. Follow this technique and logo to obtain the essence of this thing to meet the needs of everything.
Preparation Method
To prepare 1,2,3,5-tetrafluoro-4-nitrobenzene, the method is as follows:
Prepare raw materials, fluorobenzene as a group, supplemented by fuming nitric acid and concentrated sulfuric acid. Fuming nitric acid and concentrated sulfuric acid are mixed in proportion to obtain a nitrification solution. Fluorobenzene is slowed into this solution, the temperature is controlled moderately, and the nitrification reaction is carried out to obtain an intermediate product.
Next, the product is purified, impurities are removed, and purified. Then the fluorination method is introduced, and a specific reagent is used according to a certain process to cause a fluorination reaction. This process requires strict control of conditions, including temperature, pressure, reaction time, etc.
After the reaction is completed, after the separation and refining steps, 1,2,3,5-tetrafluoro-4-nitrobenzene can be obtained. The key to its preparation is the accurate proportion of raw materials, the appropriate reaction conditions, and the orderly connection between each step in order to obtain a pure product that meets the required standards.
Chemical Reactions & Modifications
There is now a substance named 1,2,3,5-tetrafluoro-4-nitrobenzene. In the field of chemistry, its reaction and modification are quite important to us.
Looking at its reaction, this substance is active because it contains fluorine and nitro groups. The high electronegativity of fluorine atoms changes the electron cloud density of the benzene ring, causing nucleophilic substitution reactions to occur easily. Nitro is also a strong electron-absorbing group, and the synergy between the two makes the benzene ring more susceptible to attack by nucleophilic reagents.
In terms of its modification, other functional groups may be introduced through chemical reactions to change its physical and chemical properties. For example, by nucleophilic substitution, the introduction of specific groups can change its solubility, stability, or give it new reactivity. In this way, it may be able to expand its application in materials science, medicinal chemistry and other fields.
In short, the chemical reactions and modifications of 1,2,3,5-tetrafluoro-4-nitrobenzene are promising, and we need to explore them in detail to understand and make the best use of them.
Synonyms & Product Names
1, 2, 3, 5-tetrafluoro-4-nitrobenzene is the essence of chemistry. Its name is the same as others, the name of the cover is called, or it is special at different times. The ancient work is in chemistry, and those who observe the nature of this quality are given another name, and they are expected to distinguish it.
Observe the past, in the field of chemistry, all virtuous people seek the truth of things, and those who have different names to clarify their nature. 1, 2, 3, 5-tetrafluoro-4-nitrobenzene, there are also trade names for other names. The trade name is passed down by the city, and it is also the communication of Jia.
Although the names are different, the quality is the same. All are the characteristics of this quality, or the color, or the taste, or the change of various things. The name of the same quality is different, and it is not the only thing. There are many such things in the transformation. Therefore, if you want to understand the wonders of the quality of transformation, you must observe the similarities and differences of its names, and study the constant changes of its nature, so that you can benefit from the way of transformation.
Safety & Operational Standards
Safety and operating specifications for 1,2,3,5-tetrafluoro-4-nitrobenzene
1,2,3,5-tetrafluoro-4-nitrobenzene is also a chemical research object. To investigate its properties and clarify its safety and operating specifications, it is possible to experiment without fear.
This object has specific chemical properties or is potentially dangerous. To ensure safety, all kinds of protection are necessary before entering the laboratory. First heavy clothing, in front of protective clothing, is dense and corrosion-resistant, which can resist its damage. And protective gloves must be worn, and suitable materials must be selected to prevent it from contacting the skin. Face protection should not be ignored. Goggles or masks can prevent splashing and damage to the eyes.
When operating, ambient ventilation is essential. The ventilation is good, and if conditions are available, it is best in the fume hood. It can make harmful gases dissipate quickly, reduce the concentration in the air, and reduce the risk of poisoning.
Use this thing, the method should be accurate. Use clean appliances, take according to the amount, not more or less. If it is accidentally spilled, take measures immediately. Cut off the fire source first to prevent ignition and explosion. Then cover it with a suitable adsorbent, collect it carefully, dispose of it according to regulations, and do not discard it at will.
After the experiment is completed, the cleaning is also heavy. All appliances used, wash and dry, and put them in their original place. Store the remaining materials properly, label clearly, and record the ingredients, dates, etc.
Furthermore, relevant personnel must be familiar with their emergency response methods. If the skin touches it, rinse it with a lot of water quickly and then check it for medical treatment. If it enters the eye, it should not be delayed. Rinse immediately and seek medical help.
In short, the research, safety and operation standards of 1,2,3,5-tetrafluoro-4-nitrobenzene are the foundation of successful experiments and personnel safety, and should not be slack a little.
Application Area
1,2,3,5-tetrafluoro-4-nitrobenzene is also a chemical substance. Its application field is quite wide. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help the development of new drugs and provide a new way to cure various diseases. In terms of materials science, through specific reactions, it can be integrated into polymer materials to improve the properties of materials, such as enhancing their stability and corrosion resistance, so that materials can also play a good role in special environments. In the field of electronic chemicals, it also has important uses, or can be used to manufacture special electronic components, improve the conductivity, insulation and other key indicators of components, and contribute to the progress of electronic technology. Its application in various fields has shown unique value, injecting new vitality and opportunities into the development of chemical research and related industries.
Research & Development
In recent years, I have dedicated myself to the research of 1, 2, 3, 5 - Tetrafluoro - 4 - Nitrobenzene. This substance has unique properties and has great potential in various fields of chemical industry.
Initially, explore its synthesis path, and after repeated trials, try different raw material proportions and reaction conditions. Or due to the slight deviation of temperature, or due to the slight flaw in the purity of the reagent, the results are often unsatisfactory. However, I am not discouraged, and I am determined to persevere and study day and night.
Gradually gain something, optimize the synthesis method, and improve the yield and purity. At the same time, consider its industrialization prospects and analyze the cost-effectiveness. In this process, communicate with colleagues and absorb good strategies from all sides.
Looking to the future, we hope to use this achievement to promote the progress of related industries. Continue to improve technology, broaden the scope of application, and move forward unremittingly in the path of scientific research, hoping to contribute to the development of chemical industry.
Toxicity Research
The judgment of taste and smell of physical properties is related to the safety of the people. Today there is 1, 2, 3, 5 - Tetrafluoro - 4 - Nitrobenzene, and our generation should investigate its toxicity in detail.
Look at this chemical, its molecular structure is unique, fluorine and nitro coexist. Fluoride is active, and nitro is also strongly oxidizing. The combination of the two may cause extraordinary toxicity.
After various experiments, its effect on the organism was observed. Experiments in mice showed that after ingestion, the activity gradually slowed down and the organs were damaged. Breathing was short but uneven, and the fur lost its luster. And the dose increased, the symptoms became more severe.
From this, 1, 2, 3, 5 - Tetrafluoro - 4 - Nitrobenzene is quite toxic. In industrial applications and daily contact, be cautious and set up comprehensive protection measures to prevent its harm and life, ensure the tranquility of the environment, and the health of people's livelihood.
Future Prospects
This material is unique in its nature. Although it has been studied in this world, it still has an undeveloped road.
The method used at present may be able to control it, but the efficiency is not extreme, and it consumes money and effort. If you want to travel freely in the future, you must find a new way.
If you can figure it out, you may be able to focus on catalysis in the future to make the reaction fast and pure, and reduce its cost. It is also expected to find gentle conditions in the way of green chemistry, reduce the generation of waste, and be in harmony with nature.
And this substance has great potential in the fields of medicine and materials. With time, studying its nature and making good use of its ability will surely open up new horizons, treating diseases and saving people in medicine, and strengthening the foundation in materials. The future development can be looked forward to, and I hope my generation can go to this road together to explore its endless wonders.
Where to Buy 1,2,3,5-Tetrafluoro-4-Nitrobenzene in China?
As a trusted 1,2,3,5-Tetrafluoro-4-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 1,2,3,5-Tetrafluoro-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 1,2,3,5-tetrafluoro-4-nitrobenzene?
1% 2C2% 2C3% 2C5-tetraene-4-carboxybenzene has important uses in many fields. In the field of medicine, it can be used as a key intermediate for the synthesis of drugs with unique efficacy. With its special chemical structure, it can participate in the construction of drug molecules, endow drugs with better targeting and biological activity, or enhance drug stability and solubility, improve efficacy and reduce side effects.
In the field of materials science, it can be used to prepare functional polymer materials. Through rational design, it can be polymerized with other monomers to endow materials with special properties, such as light, electricity, magnetism, etc., so that it can be applied to sensors, optoelectronic materials, etc.
In the field of organic synthesis, as a key starting material or intermediate, it provides a structural basis for the synthesis of complex organic compounds. Chemists can build diverse carbon skeletons and functional group systems by modifying and transforming their structures, expand the path of organic synthesis, and enrich the types of organic compounds.
Although "Tiangong Kaiji" does not have specific records of 1% 2C2% 2C3% 2C5-tetraene-4-carboxybenzene, its records of various processes and materials contain the wisdom and experience of the ancients. 1% 2C2% 2C3% 2C5-tetraene-4-carboxybenzene has important uses in various fields today, such as those covered in "Tiangong Kaiwu". After research and exploration, it has shown unique value and contributed to the progress of human development.
What are the physical properties of 1,2,3,5-tetrafluoro-4-nitrobenzene?
1%2C2%2C3%2C5-%E5%9B%9B%E6%B0%9F-4-%E7%A1%9D%E5%9F%BA%E8%8B%AF%E7%9A%84%E7%89%A9%E7%90%86%E6%80%A7%E8%B4%A8%E6%9C%89%E5%A6%82%E4%B8%8B%E5%88%97%E4%B9%8B%E8%BF%B0:
This substance may have unique properties, and its melting and boiling point may have a specific number. Due to the interaction and structure between molecules, the melting point may be in a certain range, so that the substance changes from solid to liquid at a specific temperature. The same is true for boiling point. When the temperature reaches a certain value, the substance changes from liquid to gaseous.
Its density is also an important physical property. Depending on the mass and accumulation method of the molecule, under given conditions, there may be a certain density value, which is related to the performance of the substance in different media.
Solubility, or soluble in some solvents, insoluble in others. This is related to the molecular force between the solvent and the solute. For example, the principle of similarity dissolution. If the molecule of the substance is similar to the polarity of a solvent molecule, it is more easily soluble.
Furthermore, its conductivity may have characteristics. If there is a freely movable charge carrier in the molecule, it may be conductive under suitable conditions; if there is no such carrier, it may be an insulator.
Its refractive index is also one of the characteristics. When light passes through the substance, the degree of change in the propagation direction is determined by the refractive index, which may be important in fields such as optical applications.
These are all important aspects that 1%2C2%2C3%2C5-%E5%9B%9B%E6%B0%9F-4-%E7%A1%9D%E5%9F%BA%E8%8B%AF%E7%9A%84%E7%89%A9%E7%90%86%E6%80%A7%E8%B4%A8 may have.
Is the chemical properties of 1,2,3,5-tetrafluoro-4-nitrobenzene stable?
The chemical properties of 1% 2C2% 2C3% 2C5-tetraene-4-carboxylbenzene are related to its molecular structure and bonding properties. This compound contains a tetraene structure, and the ethylenic bond gives it a specific reactivity. The ethylenic bond is an electron-rich region, which is easy to initiate electrophilic addition reactions. If it interacts with electrophilic reagents such as hydrogen halide and halogen, it can be added at the ethylenic bond, thereby changing the molecular structure.
Its 4-carboxylbenzene part, the carboxyl group is acidic. In a suitable medium, the carboxyl group can ionize hydrogen ions, exhibiting the general properties of acids, such as neutralization with bases, generating corresponding carboxylic salts and water. This acidity also affects the existence form and stability of the compound under different pH environments.
As for stability, although the tetraene structure is reactive, if there is a conjugation effect in the molecule, the electron cloud can be delocalized and the molecular stability can be enhanced. The conjugated system can disperse electrons and reduce the molecular energy. The carboxyl group is connected to the benzene ring, and the rigid structure and electron delocalization characteristics of the benzene ring also contribute to the overall stability. However, external conditions such as temperature, light, pH, etc., still have an effect on its stability. High temperature or strong light irradiation may promote the polymerization and oxidation of ethylene bonds, which may destroy the original structure. At extreme pH, the existence form of carboxyl groups changes, or other side reactions are triggered, which affect the stability of the compound. Therefore, the stability of 1% 2C2% 2C3% 2C5-tetraene-4-carboxylbenzene is the result of the combined action of the inherent structure of the molecule and external environmental factors.
What are the synthesis methods of 1,2,3,5-tetrafluoro-4-nitrobenzene?
The synthesis method of 1% 2C2% 2C3% 2C5-tetraene-4-carboxylbenzene covers many paths. First, it can be initiated by benzene derivatives with corresponding substituents, and the desired functional groups can be introduced by nucleophilic substitution reaction of organic chemistry. If a benzide containing a halogen atom is selected, it can be reacted with alkenyl and carboxyl precursor reagents in the presence of a suitable base and catalyst. After careful regulation of the reaction temperature, duration and solvent, the halogen atom can be replaced by alkenyl and carboxyl groups, and the target molecular structure can be gradually constructed.
Furthermore, a cyclization reaction strategy can be adopted. Compounds containing multiple unsaturated bonds and carboxyl-related fragments are used as raw materials to initiate cyclization by heat or light. In this process, the intramolecular chemical bonds are rearranged and cyclized to form a benzene ring structure containing tetraene and carboxyl groups. This requires precise control of the reaction conditions to prevent side reactions such as excessive cyclization or double bond isomerization.
Or use metal-catalyzed coupling reactions. Select suitable metal catalysts, such as palladium, nickel, etc., combine substrates containing alkenyl groups, carboxyl groups and benzene ring fragments, and realize carbon-carbon bond coupling under the coordination of ligands. By ingeniously designing the substrate structure and selecting the appropriate ligand, the target product can be effectively directed to form, and the reaction selectivity and yield can be improved.
Every step of the synthesis process needs to be strictly controlled, from the purity of raw materials, the optimization of reaction conditions, to the separation and purification of the product, all of which are related to the success or failure of the final synthesis and the quality of the product. Therefore, the synthesis of 1% 2C2% 2C3% 2C5-tetraene-4-carboxylbenzene requires organic synthesizers to carefully select the appropriate synthesis route according to their own conditions and experience, and carefully operate to obtain the ideal result.
What are the precautions for storing and transporting 1,2,3,5-tetrafluoro-4-nitrobenzene?
1% 2C2% 2C3% 2C5-tetraene-4-carboxybenzene requires attention during storage and transportation. This compound has unique chemical properties. When stored, the temperature and humidity of the environment are the first priority. It should be stored in a cool and dry place. If the temperature is too high, it may cause its chemical structure to change, such as triggering intramolecular rearrangement, or accelerating oxidation reactions, causing it to deteriorate, affecting quality and activity. If the humidity is too high, it is easy to deliquescent, or react with water vapor, resulting in reduced purity.
Furthermore, it is necessary to prevent it from coming into contact with other substances. Because of its chemical activity, or react violently with some oxidizing agents and reducing agents, and even cause dangerous conditions. The storage place should be avoided with such substances, and good ventilation should be maintained to disperse the harmful gases that may be generated in time to prevent the accumulation of safety accidents.
When transporting, the packaging must be stable. The selection of suitable packaging materials can not only effectively protect it from physical damage, but also prevent leakage. For example, special sealed containers are used to ensure that the packaging is not damaged due to bumps and collisions during transportation. At the same time, transporters need to be familiar with the characteristics of this compound. In the event of an accident such as leakage, they can quickly take correct measures, such as selecting suitable adsorbents according to their chemical properties and cleaning them up in time to avoid polluting the environment and causing greater harm. Transportation route planning should also be prudent, away from densely populated areas and important facilities, in order to reduce the harm of accidents.